UniProtKB - P28336 (NMBR_HUMAN)
Protein
Neuromedin-B receptor
Gene
NMBR
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for neuromedin-B.
GO - Molecular functioni
- bombesin receptor activity Source: ProtInc
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events |
SIGNORi | P28336 |
Names & Taxonomyi
Protein namesi | Recommended name: Neuromedin-B receptorShort name: NMB-R Alternative name(s): Epididymis tissue protein Li 185a Neuromedin-B-preferring bombesin receptor |
Gene namesi | Name:NMBR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000135577.4 |
HGNCi | HGNC:7843 NMBR |
MIMi | 162341 gene |
neXtProti | NX_P28336 |
Subcellular locationi
Plasma membrane
Cytosol
- cytosol Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 42 – 65 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 66 – 79 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 80 – 99 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 100 – 117 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 118 – 139 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 140 – 156 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 157 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 211 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 212 – 235 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 236 – 266 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 267 – 287 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 288 – 299 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 300 – 327 | Helical; Name=7Sequence analysisAdd BLAST | 28 | |
Topological domaini | 328 – 390 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4829 |
OpenTargetsi | ENSG00000135577 |
PharmGKBi | PA31655 |
Chemistry databases
ChEMBLi | CHEMBL3636 |
GuidetoPHARMACOLOGYi | 38 |
Polymorphism and mutation databases
BioMutai | NMBR |
DMDMi | 212286370 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069903 | 1 – 390 | Neuromedin-B receptorAdd BLAST | 390 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 16 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 116 ↔ 198 | PROSITE-ProRule annotation | ||
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 341 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 352 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P28336 |
PeptideAtlasi | P28336 |
PRIDEi | P28336 |
ProteomicsDBi | 54477 |
PTM databases
iPTMneti | P28336 |
PhosphoSitePlusi | P28336 |
Expressioni
Tissue specificityi
Expressed in epididymis (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000135577 Expressed in 40 organ(s), highest expression level in nucleus accumbens |
Genevisiblei | P28336 HS |
Organism-specific databases
HPAi | HPA026665 |
Interactioni
Protein-protein interaction databases
BioGridi | 110893, 1 interactor |
STRINGi | 9606.ENSP00000258042 |
Chemistry databases
BindingDBi | P28336 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000153205 |
HOGENOMi | HOG000230781 |
HOVERGENi | HBG004898 |
InParanoidi | P28336 |
KOi | K04168 |
OMAi | MSFANSC |
OrthoDBi | 1011220at2759 |
PhylomeDBi | P28336 |
TreeFami | TF331292 |
Family and domain databases
InterProi | View protein in InterPro IPR001556 Bombsn_rcpt-like IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001642 NeuroB_rcpt |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00358 BOMBESINR PR00237 GPCRRHODOPSN PR00639 NEUROMEDINBR |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P28336-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSKSLSNLS VTTGANESGS VPEGWERDFL PASDGTTTEL VIRCVIPSLY
60 70 80 90 100
LLIITVGLLG NIMLVKIFIT NSAMRSVPNI FISNLAAGDL LLLLTCVPVD
110 120 130 140 150
ASRYFFDEWM FGKVGCKLIP VIQLTSVGVS VFTLTALSAD RYRAIVNPMD
160 170 180 190 200
MQTSGALLRT CVKAMGIWVV SVLLAVPEAV FSEVARISSL DNSSFTACIP
210 220 230 240 250
YPQTDELHPK IHSVLIFLVY FLIPLAIISI YYYHIAKTLI KSAHNLPGEY
260 270 280 290 300
NEHTKKQMET RKRLAKIVLV FVGCFIFCWF PNHILYMYRS FNYNEIDPSL
310 320 330 340 350
GHMIVTLVAR VLSFGNSCVN PFALYLLSES FRRHFNSQLC CGRKSYQERG
360 370 380 390
TSYLLSSSAV RMTSLKSNAK NMVTNSVLLN GHSMKQEMAL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_044513 | 390 | L → M1 PublicationCorresponds to variant dbSNP:rs7453944Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73482 mRNA Translation: AAA59939.1 GU727635 mRNA Translation: ADU87637.1 AL589674 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47886.1 |
CCDSi | CCDS5196.1 |
PIRi | B41007 |
RefSeqi | NP_001311236.1, NM_001324307.1 NP_001311237.1, NM_001324308.1 NP_002502.2, NM_002511.3 |
UniGenei | Hs.552106 Hs.654478 |
Genome annotation databases
Ensembli | ENST00000258042; ENSP00000258042; ENSG00000135577 |
GeneIDi | 4829 |
KEGGi | hsa:4829 |
UCSCi | uc003qiu.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73482 mRNA Translation: AAA59939.1 GU727635 mRNA Translation: ADU87637.1 AL589674 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47886.1 |
CCDSi | CCDS5196.1 |
PIRi | B41007 |
RefSeqi | NP_001311236.1, NM_001324307.1 NP_001311237.1, NM_001324308.1 NP_002502.2, NM_002511.3 |
UniGenei | Hs.552106 Hs.654478 |
3D structure databases
ProteinModelPortali | P28336 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 110893, 1 interactor |
STRINGi | 9606.ENSP00000258042 |
Chemistry databases
BindingDBi | P28336 |
ChEMBLi | CHEMBL3636 |
GuidetoPHARMACOLOGYi | 38 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | P28336 |
PhosphoSitePlusi | P28336 |
Polymorphism and mutation databases
BioMutai | NMBR |
DMDMi | 212286370 |
Proteomic databases
PaxDbi | P28336 |
PeptideAtlasi | P28336 |
PRIDEi | P28336 |
ProteomicsDBi | 54477 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000258042; ENSP00000258042; ENSG00000135577 |
GeneIDi | 4829 |
KEGGi | hsa:4829 |
UCSCi | uc003qiu.3 human |
Organism-specific databases
CTDi | 4829 |
DisGeNETi | 4829 |
EuPathDBi | HostDB:ENSG00000135577.4 |
GeneCardsi | NMBR |
H-InvDBi | HIX0032977 |
HGNCi | HGNC:7843 NMBR |
HPAi | HPA026665 |
MIMi | 162341 gene |
neXtProti | NX_P28336 |
OpenTargetsi | ENSG00000135577 |
PharmGKBi | PA31655 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000153205 |
HOGENOMi | HOG000230781 |
HOVERGENi | HBG004898 |
InParanoidi | P28336 |
KOi | K04168 |
OMAi | MSFANSC |
OrthoDBi | 1011220at2759 |
PhylomeDBi | P28336 |
TreeFami | TF331292 |
Enzyme and pathway databases
Reactomei | R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events |
SIGNORi | P28336 |
Miscellaneous databases
GeneWikii | Neuromedin_B_receptor |
GenomeRNAii | 4829 |
PROi | PR:P28336 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135577 Expressed in 40 organ(s), highest expression level in nucleus accumbens |
Genevisiblei | P28336 HS |
Family and domain databases
InterProi | View protein in InterPro IPR001556 Bombsn_rcpt-like IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001642 NeuroB_rcpt |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00358 BOMBESINR PR00237 GPCRRHODOPSN PR00639 NEUROMEDINBR |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | NMBR_HUMAN | |
Accessioni | P28336Primary (citable) accession number: P28336 Secondary accession number(s): E9KL38, Q5VUK8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | July 22, 2008 | |
Last modified: | February 13, 2019 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries