NMBR

Functionⁱ

Receptor for neuromedin-B.

GO - Molecular functionⁱ

bombesin receptor activity
Source: ProtInc
Traceable author statementⁱ
- 7838118
G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phospholipase C-activating G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 7838118

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	P28336

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuromedin-B receptor Short name: NMB-R Alternative name(s): Epididymis tissue protein Li 185a Neuromedin-B-preferring bombesin receptor
Gene namesⁱ	Name:NMBR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135577.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7843 NMBR
MIMⁱ	162341 gene
neXtProtⁱ	NX_P28336

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 41	ExtracellularSequence analysisAdd BLAST	41
Transmembraneⁱ	42 – 65	Helical; Name=1Sequence analysisAdd BLAST	24
Topological domainⁱ	66 – 79	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	80 – 99	Helical; Name=2Sequence analysisAdd BLAST	20
Topological domainⁱ	100 – 117	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	118 – 139	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	140 – 156	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	157 – 177	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	178 – 211	ExtracellularSequence analysisAdd BLAST	34
Transmembraneⁱ	212 – 235	Helical; Name=5Sequence analysisAdd BLAST	24
Topological domainⁱ	236 – 266	CytoplasmicSequence analysisAdd BLAST	31
Transmembraneⁱ	267 – 287	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	288 – 299	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	300 – 327	Helical; Name=7Sequence analysisAdd BLAST	28
Topological domainⁱ	328 – 390	CytoplasmicSequence analysisAdd BLAST	63

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4829
Open Targets More...OpenTargetsⁱ	ENSG00000135577
PharmGKBⁱ	PA31655

Chemistry databases

ChEMBLⁱ	CHEMBL3636
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	38

Polymorphism and mutation databases

BioMutaⁱ	NMBR
DMDMⁱ	212286370

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069903	1 – 390	Neuromedin-B receptorAdd BLAST		390

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	8	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	16	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	116 ↔ 198	PROSITE-ProRule annotation
Glycosylationⁱ	192	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	341	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	352	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbⁱ	P28336
PeptideAtlas More...PeptideAtlasⁱ	P28336
PRIDEⁱ	P28336
ProteomicsDBⁱ	54477

PTM databases

iPTMnetⁱ	P28336
PhosphoSitePlusⁱ	P28336

Expressionⁱ

Tissue specificityⁱ

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000135577 Expressed in 40 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_NMBR
Genevisibleⁱ	P28336 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026665

HPAⁱ

HPA026665

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	110893, 1 interactor
STRINGⁱ	9606.ENSP00000258042

Chemistry databases

BindingDBⁱ

P28336

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28336
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119177
HOGENOMⁱ	HOG000230781
HOVERGENⁱ	HBG004898
InParanoidⁱ	P28336
KEGG Orthology (KO) More...KOⁱ	K04168
OMAⁱ	MSFANSC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G085Y
PhylomeDBⁱ	P28336
TreeFamⁱ	TF331292

Family and domain databases

InterProⁱ	View protein in InterPro IPR001556 Bombsn_rcpt-like IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001642 NeuroB_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00358 BOMBESINR PR00237 GPCRRHODOPSN PR00639 NEUROMEDINBR
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28336-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPSKSLSNLS VTTGANESGS VPEGWERDFL PASDGTTTEL VIRCVIPSLY 
        60         70         80         90        100
LLIITVGLLG NIMLVKIFIT NSAMRSVPNI FISNLAAGDL LLLLTCVPVD 
       110        120        130        140        150
ASRYFFDEWM FGKVGCKLIP VIQLTSVGVS VFTLTALSAD RYRAIVNPMD 
       160        170        180        190        200
MQTSGALLRT CVKAMGIWVV SVLLAVPEAV FSEVARISSL DNSSFTACIP 
       210        220        230        240        250
YPQTDELHPK IHSVLIFLVY FLIPLAIISI YYYHIAKTLI KSAHNLPGEY 
       260        270        280        290        300
NEHTKKQMET RKRLAKIVLV FVGCFIFCWF PNHILYMYRS FNYNEIDPSL 
       310        320        330        340        350
GHMIVTLVAR VLSFGNSCVN PFALYLLSES FRRHFNSQLC CGRKSYQERG 
       360        370        380        390
TSYLLSSSAV RMTSLKSNAK NMVTNSVLLN GHSMKQEMAL

Length:390

Mass (Da):43,435

Last modified:July 22, 2008 - v2

Checksum:ⁱ8BA9AAD4F3B7309F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_044513	390	L → M1 PublicationCorresponds to variant dbSNP:rs7453944Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M73482 mRNA Translation: AAA59939.1 GU727635 mRNA Translation: ADU87637.1 AL589674 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47886.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5196.1
PIRⁱ	B41007
NCBI Reference Sequences More...RefSeqⁱ	NP_001311236.1, NM_001324307.1 NP_001311237.1, NM_001324308.1 NP_002502.2, NM_002511.3
UniGeneⁱ	Hs.552106 Hs.654478

Genome annotation databases

Ensemblⁱ	ENST00000258042; ENSP00000258042; ENSG00000135577
GeneIDⁱ	4829
KEGGⁱ	hsa:4829
UCSC genome browser More...UCSCⁱ	uc003qiu.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28336	Neuromedin-B receptor (Fragment)		NEOVI		91	UniRef100_P28336
UPI0000E0A597		HUMAN		242

Protein	Similar proteins		Species	Score	Length	Source
P28336	Neuromedin-B receptor (Fragment)		NEOVI		91	UniRef90_P28336
Neuromedin B receptor-like protein		CAMFR		402
LOW QUALITY PROTEIN: neuromedin-B receptor		BALAS		393
Neuromedin B receptor		PIG		390
Neuromedin-B receptor		MYOBR		390
+24

Protein	Similar proteins		Species	Score	Length	Source
P28336	Gastrin-releasing peptide receptor		MOUSE		384	UniRef50_P21729
Gastrin-releasing peptide receptor		RAT		384
Bombesin receptor subtype-3		HUMAN		399
Bombesin receptor subtype-3		CAVPO		399
Bombesin receptor subtype-3		MACMU		398
+653

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M73482 mRNA Translation: AAA59939.1 GU727635 mRNA Translation: ADU87637.1 AL589674 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47886.1
CCDSⁱ	CCDS5196.1
PIRⁱ	B41007
RefSeqⁱ	NP_001311236.1, NM_001324307.1 NP_001311237.1, NM_001324308.1 NP_002502.2, NM_002511.3
UniGeneⁱ	Hs.552106 Hs.654478

3D structure databases

ProteinModelPortalⁱ	P28336
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110893, 1 interactor
STRINGⁱ	9606.ENSP00000258042

Chemistry databases

BindingDBⁱ	P28336
ChEMBLⁱ	CHEMBL3636
GuidetoPHARMACOLOGYⁱ	38

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P28336
PhosphoSitePlusⁱ	P28336

Polymorphism and mutation databases

BioMutaⁱ	NMBR
DMDMⁱ	212286370

Proteomic databases

PaxDbⁱ	P28336
PeptideAtlasⁱ	P28336
PRIDEⁱ	P28336
ProteomicsDBⁱ	54477

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000258042; ENSP00000258042; ENSG00000135577
GeneIDⁱ	4829
KEGGⁱ	hsa:4829
UCSCⁱ	uc003qiu.3 human

Organism-specific databases

CTDⁱ	4829
DisGeNETⁱ	4829
EuPathDBⁱ	HostDB:ENSG00000135577.4
GeneCardsⁱ	NMBR
H-InvDBⁱ	HIX0032977
HGNCⁱ	HGNC:7843 NMBR
HPAⁱ	HPA026665
MIMⁱ	162341 gene
neXtProtⁱ	NX_P28336
OpenTargetsⁱ	ENSG00000135577
PharmGKBⁱ	PA31655
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000119177
HOGENOMⁱ	HOG000230781
HOVERGENⁱ	HBG004898
InParanoidⁱ	P28336
KOⁱ	K04168
OMAⁱ	MSFANSC
OrthoDBⁱ	EOG091G085Y
PhylomeDBⁱ	P28336
TreeFamⁱ	TF331292

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	P28336

Miscellaneous databases

GeneWikiⁱ	Neuromedin_B_receptor
GenomeRNAiⁱ	4829
Protein Ontology More...PROⁱ	PR:P28336
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135577 Expressed in 40 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_NMBR
Genevisibleⁱ	P28336 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001556 Bombsn_rcpt-like IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001642 NeuroB_rcpt
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00358 BOMBESINR PR00237 GPCRRHODOPSN PR00639 NEUROMEDINBR
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NMBR_HUMAN
Accessionⁱ	P28336Primary (citable) accession number: P28336 Secondary accession number(s): E9KL38, Q5VUK8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	July 22, 2008
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniParc

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UniRef

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Supporting data

UniProtKB - P28336 (NMBR_HUMAN)

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Neuromedin-B receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ