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Protein

5-hydroxytryptamine receptor 2C

Gene

HTR2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390666 Serotonin receptors
R-HSA-416476 G alpha (q) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P28335

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P28335

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 2C
Short name:
5-HT-2C
Short name:
5-HT2C
Short name:
5-HTR2C
Alternative name(s):
5-hydroxytryptamine receptor 1C
Short name:
5-HT-1C
Short name:
5-HT1C
Serotonin receptor 2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR2C
Synonyms:HTR1C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147246.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5295 HTR2C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
312861 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P28335

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 52ExtracellularBy similarityAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei53 – 78Helical; Name=1By similarityAdd BLAST26
Topological domaini79 – 89CytoplasmicBy similarityAdd BLAST11
Transmembranei90 – 110Helical; Name=2By similarityAdd BLAST21
Topological domaini111 – 127ExtracellularBy similarityAdd BLAST17
Transmembranei128 – 150Helical; Name=3By similarityAdd BLAST23
Topological domaini151 – 170CytoplasmicBy similarityAdd BLAST20
Transmembranei171 – 193Helical; Name=4By similarityAdd BLAST23
Topological domaini194 – 213ExtracellularBy similarityAdd BLAST20
Transmembranei214 – 235Helical; Name=5By similarityAdd BLAST22
Topological domaini236 – 311CytoplasmicBy similarityAdd BLAST76
Transmembranei312 – 333Helical; Name=6By similarityAdd BLAST22
Topological domaini334 – 348ExtracellularBy similarityAdd BLAST15
Transmembranei349 – 371Helical; Name=7By similarityAdd BLAST23
Topological domaini372 – 458CytoplasmicBy similarityAdd BLAST87

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi159P → A: Decreases interaction with ARRB2. 1 Publication1
Mutagenesisi456S → A: Loss of interaction with MPDZ. 1 Publication1
Mutagenesisi456S → T: No effect on interaction with MPDZ. 1 Publication1
Mutagenesisi457S → A: No effect on interaction with MPDZ. 1 Publication1
Mutagenesisi458V → A: Loss of interaction with MPDZ. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3358

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA194

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL225

Drug and drug target database

More...
DrugBanki
DB06594 Agomelatine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB09014 Captodiame
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB01242 Clomipramine
DB00363 Clozapine
DB00434 Cyproheptadine
DB04884 Dapoxetine
DB06512 Deramciclane
DB01151 Desipramine
DB01191 Dexfenfluramine
DB01142 Doxepin
DB05492 Epicept NP-1
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB06678 Esmirtazapine
DB00574 Fenfluramine
DB00458 Imipramine
DB01221 Ketamine
DB00589 Lisuride
DB04871 Lorcaserin
DB00408 Loxapine
DB00934 Maprotiline
DB01403 Methotrimeprazine
DB00247 Methysergide
DB06148 Mianserin
DB00805 Minaprine
DB00370 Mirtazapine
DB01149 Nefazodone
DB00540 Nortriptyline
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB00413 Pramipexole
DB00420 Promazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB06144 Sertindole
DB01079 Tegaserod
DB13025 Tiapride
DB00193 Tramadol
DB00656 Trazodone
DB00726 Trimipramine
DB01392 Yohimbine
DB00246 Ziprasidone

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HTR2C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
112816

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 321 PublicationAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000006895833 – 4585-hydroxytryptamine receptor 2CAdd BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi127 ↔ 207PROSITE-ProRule annotation
Disulfide bondi337 ↔ 341PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P28335

PeptideAtlas

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PeptideAtlasi
P28335

PRoteomics IDEntifications database

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PRIDEi
P28335

ProteomicsDB human proteome resource

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ProteomicsDBi
54476

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P28335

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P28335

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147246 Expressed in 68 organ(s), highest expression level in choroid plexus epithelium

CleanEx database of gene expression profiles

More...
CleanExi
HS_HTR2C

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P28335 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MPDZ. Interacts with ARRB2.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109590, 101 interactors

Protein interaction database and analysis system

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IntActi
P28335, 9 interactors

Molecular INTeraction database

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MINTi
P28335

STRING: functional protein association networks

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STRINGi
9606.ENSP00000276198

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P28335

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P28335

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P28335

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni134 – 139Agonist bindingBy similarity6
Regioni324 – 328Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi151 – 153DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi364 – 368NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5
Motifi456 – 458PDZ-binding3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain-binding motif is involved in the interaction with MPDZ.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000240378

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107487

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P28335

KEGG Orthology (KO)

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KOi
K04157

Database of Orthologous Groups

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OrthoDBi
EOG091G06VI

Database for complete collections of gene phylogenies

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PhylomeDBi
P28335

TreeFam database of animal gene trees

More...
TreeFami
TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000377 5HT2C_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

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PANTHERi
PTHR24247:SF32 PTHR24247:SF32, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00517 5HT2CRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P28335-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVNLRNAVHS FLVHLIGLLV WQCDISVSPV AAIVTDIFNT SDGGRFKFPD
60 70 80 90 100
GVQNWPALSI VIIIIMTIGG NILVIMAVSM EKKLHNATNY FLMSLAIADM
110 120 130 140 150
LVGLLVMPLS LLAILYDYVW PLPRYLCPVW ISLDVLFSTA SIMHLCAISL
160 170 180 190 200
DRYVAIRNPI EHSRFNSRTK AIMKIAIVWA ISIGVSVPIP VIGLRDEEKV
210 220 230 240 250
FVNNTTCVLN DPNFVLIGSF VAFFIPLTIM VITYCLTIYV LRRQALMLLH
260 270 280 290 300
GHTEEPPGLS LDFLKCCKRN TAEEENSANP NQDQNARRRK KKERRPRGTM
310 320 330 340 350
QAINNERKAS KVLGIVFFVF LIMWCPFFIT NILSVLCEKS CNQKLMEKLL
360 370 380 390 400
NVFVWIGYVC SGINPLVYTL FNKIYRRAFS NYLRCNYKVE KKPPVRQIPR
410 420 430 440 450
VAATALSGRE LNVNIYRHTN EPVIEKASDN EPGIEMQVEN LELPVNPSSV

VSERISSV
Length:458
Mass (Da):51,821
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E76B3FFD3E09C93
GO
Isoform 2 (identifier: P28335-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-458: YVAIRNPIEH...SVVSERISSV → CISSYPCDWT...YGRGRELCKP

Show »
Length:248
Mass (Da):28,055
Checksum:i8A8C81B80DA6B59E
GO

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at positions 156, 158 and 160.1 Publication
Partially edited. RNA editing generates receptor isoforms that differ in their ability to interact with the phospholipase C signaling cascade in a transfected cell line, suggesting that this RNA processing event may contribute to the modulation of serotonergic neurotransmission in the central nervous system.

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for Ser.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00345023C → S5 PublicationsCorresponds to variant dbSNP:rs6318EnsemblClinVar.1
Natural variantiVAR_010166156I → V in RNA edited version. 1
Natural variantiVAR_010167158N → S in RNA edited version. 1
Natural variantiVAR_010168160I → V in RNA edited version. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045171153 – 458YVAIR…RISSV → CISSYPCDWTEGRRKGVREQ HDVRAQRPKFRSYWVLRSFL HTADDYGDYVLPDHLRSAPT SFDVTARPHRGTAWTKSGFP EVLQEEYGRGRELCKP in isoform 2. 1 PublicationAdd BLAST306

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M81778 mRNA Translation: AAA60317.1
X80763 Genomic DNA Translation: CAB59978.1
U49516 mRNA Translation: AAB40898.1
AF208053 mRNA Translation: AAF35842.1
AF498983 mRNA Translation: AAM21130.1
AK295753 mRNA Translation: BAG58583.1
AC007022 Genomic DNA No translation available.
AC007025 Genomic DNA No translation available.
AL591402 Genomic DNA No translation available.
AL355812, AC004822, AL590097 Genomic DNA Translation: CAI41334.1
AC004822 Genomic DNA Translation: AAC71658.1
AL355812, AL590097, AC004822 Genomic DNA Translation: CAI41335.1
AL590097, AC004822, AL355812 Genomic DNA Translation: CAH70193.1
BC095543 mRNA Translation: AAH95543.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14564.1 [P28335-1]
CCDS59174.1 [P28335-2]

Protein sequence database of the Protein Information Resource

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PIRi
JS0616

NCBI Reference Sequences

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RefSeqi
NP_000859.1, NM_000868.3 [P28335-1]
NP_001243689.1, NM_001256760.2 [P28335-1]
NP_001243690.1, NM_001256761.2 [P28335-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.149037

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000276198; ENSP00000276198; ENSG00000147246
ENST00000371950; ENSP00000361018; ENSG00000147246
ENST00000371951; ENSP00000361019; ENSG00000147246

Database of genes from NCBI RefSeq genomes

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GeneIDi
3358

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3358

UCSC genome browser

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UCSCi
uc004epu.1 human [P28335-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81778 mRNA Translation: AAA60317.1
X80763 Genomic DNA Translation: CAB59978.1
U49516 mRNA Translation: AAB40898.1
AF208053 mRNA Translation: AAF35842.1
AF498983 mRNA Translation: AAM21130.1
AK295753 mRNA Translation: BAG58583.1
AC007022 Genomic DNA No translation available.
AC007025 Genomic DNA No translation available.
AL591402 Genomic DNA No translation available.
AL355812, AC004822, AL590097 Genomic DNA Translation: CAI41334.1
AC004822 Genomic DNA Translation: AAC71658.1
AL355812, AL590097, AC004822 Genomic DNA Translation: CAI41335.1
AL590097, AC004822, AL355812 Genomic DNA Translation: CAH70193.1
BC095543 mRNA Translation: AAH95543.1
CCDSiCCDS14564.1 [P28335-1]
CCDS59174.1 [P28335-2]
PIRiJS0616
RefSeqiNP_000859.1, NM_000868.3 [P28335-1]
NP_001243689.1, NM_001256760.2 [P28335-1]
NP_001243690.1, NM_001256761.2 [P28335-2]
UniGeneiHs.149037

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BQGX-ray3.00A40-245[»]
A301-393[»]
6BQHX-ray2.70A40-245[»]
A301-393[»]
ProteinModelPortaliP28335
SMRiP28335
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109590, 101 interactors
IntActiP28335, 9 interactors
MINTiP28335
STRINGi9606.ENSP00000276198

Chemistry databases

BindingDBiP28335
ChEMBLiCHEMBL225
DrugBankiDB06594 Agomelatine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB09014 Captodiame
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB01242 Clomipramine
DB00363 Clozapine
DB00434 Cyproheptadine
DB04884 Dapoxetine
DB06512 Deramciclane
DB01151 Desipramine
DB01191 Dexfenfluramine
DB01142 Doxepin
DB05492 Epicept NP-1
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB06678 Esmirtazapine
DB00574 Fenfluramine
DB00458 Imipramine
DB01221 Ketamine
DB00589 Lisuride
DB04871 Lorcaserin
DB00408 Loxapine
DB00934 Maprotiline
DB01403 Methotrimeprazine
DB00247 Methysergide
DB06148 Mianserin
DB00805 Minaprine
DB00370 Mirtazapine
DB01149 Nefazodone
DB00540 Nortriptyline
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB00413 Pramipexole
DB00420 Promazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB06144 Sertindole
DB01079 Tegaserod
DB13025 Tiapride
DB00193 Tramadol
DB00656 Trazodone
DB00726 Trimipramine
DB01392 Yohimbine
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi8

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiP28335
PhosphoSitePlusiP28335

Polymorphism and mutation databases

BioMutaiHTR2C
DMDMi112816

Proteomic databases

PaxDbiP28335
PeptideAtlasiP28335
PRIDEiP28335
ProteomicsDBi54476

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276198; ENSP00000276198; ENSG00000147246
ENST00000371950; ENSP00000361018; ENSG00000147246
ENST00000371951; ENSP00000361019; ENSG00000147246
GeneIDi3358
KEGGihsa:3358
UCSCiuc004epu.1 human [P28335-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3358
DisGeNETi3358
EuPathDBiHostDB:ENSG00000147246.9

GeneCards: human genes, protein and diseases

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GeneCardsi
HTR2C
HGNCiHGNC:5295 HTR2C
MIMi312861 gene
neXtProtiNX_P28335
PharmGKBiPA194

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000240378
HOVERGENiHBG107487
InParanoidiP28335
KOiK04157
OrthoDBiEOG091G06VI
PhylomeDBiP28335
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-416476 G alpha (q) signalling events
SignaLinkiP28335
SIGNORiP28335

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HTR2C human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
5-HT2C_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3358

Protein Ontology

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PROi
PR:P28335

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000147246 Expressed in 68 organ(s), highest expression level in choroid plexus epithelium
CleanExiHS_HTR2C
GenevisibleiP28335 HS

Family and domain databases

InterProiView protein in InterPro
IPR000377 5HT2C_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF32 PTHR24247:SF32, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00517 5HT2CRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT2C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28335
Secondary accession number(s): B1AMW4, Q5VUF8, Q9NP28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: December 5, 2018
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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