UniProtKB - P28331 (NDUS1_HUMAN)
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
NDUFS1
Functioni
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30879903, PubMed:31557978).
Essential for catalysing the entry and efficient transfer of electrons within complex I (PubMed:31557978).
Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:30879903, PubMed:31557978).
2 PublicationsCatalytic activityi
- EC:7.1.1.22 Publications
Cofactori
Protein has several cofactor binding sites:- [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
- [4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 64 | Iron-sulfur (2Fe-2S)By similarity | 1 | |
Metal bindingi | 75 | Iron-sulfur (2Fe-2S)By similarity | 1 | |
Metal bindingi | 78 | Iron-sulfur (2Fe-2S)By similarity | 1 | |
Metal bindingi | 92 | Iron-sulfur (2Fe-2S)By similarity | 1 | |
Metal bindingi | 124 | Iron-sulfur (4Fe-4S) 1; via tele nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 128 | Iron-sulfur (4Fe-4S) 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 131 | Iron-sulfur (4Fe-4S) 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 137 | Iron-sulfur (4Fe-4S) 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 176 | Iron-sulfur (4Fe-4S) 2By similarity | 1 | |
Metal bindingi | 179 | Iron-sulfur (4Fe-4S) 2By similarity | 1 | |
Metal bindingi | 182 | Iron-sulfur (4Fe-4S) 2By similarity | 1 | |
Metal bindingi | 226 | Iron-sulfur (4Fe-4S) 2By similarity | 1 |
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
- 4 iron, 4 sulfur cluster binding Source: GO_Central
- electron transfer activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
GO - Biological processi
- aerobic respiration Source: ComplexPortal
- apoptotic mitochondrial changes Source: UniProtKB
- ATP metabolic process Source: UniProtKB
- cellular respiration Source: UniProtKB
- mitochondrial ATP synthesis coupled proton transport Source: ComplexPortal
- mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
- mitochondrial respiratory chain complex I assembly Source: UniProtKB
- reactive oxygen species metabolic process Source: UniProtKB
- regulation of mitochondrial membrane potential Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase, Translocase |
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | 2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone |
Enzyme and pathway databases
PathwayCommonsi | P28331 |
Reactomei | R-HSA-611105, Respiratory electron transport R-HSA-6799198, Complex I biogenesis |
SignaLinki | P28331 |
SIGNORi | P28331 |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC:7.1.1.22 Publications)Alternative name(s): Complex I-75kD Short name: CI-75kD |
Gene namesi | Name:NDUFS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7707, NDUFS1 |
MIMi | 157655, gene |
neXtProti | NX_P28331 |
VEuPathDBi | HostDB:ENSG00000023228 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 2 Publications; Peripheral membrane protein By similarity; Matrix side By similarity
Mitochondrion
- mitochondrial inner membrane Source: ComplexPortal
- mitochondrial intermembrane space Source: UniProtKB
- mitochondrial matrix Source: Reactome
- mitochondrial respiratory chain complex I Source: UniProtKB
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Involvement in diseasei
Mitochondrial complex I deficiency, nuclear type 5 (MC1DN5)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_084177 | 228 | V → A in MC1DN5; loss of catalytic activity. 1 Publication | 1 | |
Natural variantiVAR_019532 | 241 | R → W in MC1DN5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199422225EnsemblClinVar. | 1 | |
Natural variantiVAR_019533 | 252 | D → G in MC1DN5; also found in a patient with muscular hypotonia; loss of catalytic activity. 2 PublicationsCorresponds to variant dbSNP:rs199422224EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Primary mitochondrial diseaseOrganism-specific databases
DisGeNETi | 4719 |
GeneReviewsi | NDUFS1 |
MalaCardsi | NDUFS1 |
MIMi | 618226, phenotype |
OpenTargetsi | ENSG00000023228 |
Orphaneti | 2609, Isolated complex I deficiency 255241, Leigh syndrome with leukodystrophy |
PharmGKBi | PA31518 |
Miscellaneous databases
Pharosi | P28331, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH |
DrugCentrali | P28331 |
Genetic variation databases
BioMutai | NDUFS1 |
DMDMi | 92090799 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 23 | MitochondrionCombined sourcesAdd BLAST | 23 | |
ChainiPRO_0000019968 | 24 – 727 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialAdd BLAST | 704 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 84 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 467 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 499 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 709 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
CPTACi | CPTAC-413 CPTAC-414 |
EPDi | P28331 |
jPOSTi | P28331 |
MassIVEi | P28331 |
MaxQBi | P28331 |
PaxDbi | P28331 |
PeptideAtlasi | P28331 |
PRIDEi | P28331 |
ProteomicsDBi | 17145 54470 [P28331-1] 54471 [P28331-2] 54472 [P28331-3] 54473 [P28331-4] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00604664 P28331 |
UCD-2DPAGEi | P28331 |
PTM databases
CarbonylDBi | P28331 |
GlyGeni | P28331, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P28331 |
MetOSitei | P28331 |
PhosphoSitePlusi | P28331 |
SwissPalmi | P28331 |
Expressioni
Gene expression databases
Bgeei | ENSG00000023228, Expressed in heart and 255 other tissues |
ExpressionAtlasi | P28331, baseline and differential |
Genevisiblei | P28331, HS |
Organism-specific databases
HPAi | ENSG00000023228, Tissue enhanced (skeletal muscle, tongue) |
Interactioni
Subunit structurei
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (PubMed:12611891). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Complex I associates with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:30879903, PubMed:31557978).
Interacts with MDM2 (PubMed:30879903).
Interacts with AKAP1 (By similarity).
By similarity3 PublicationsBinary interactionsi
P28331
With | #Exp. | IntAct |
---|---|---|
OSMR [Q99650] | 4 | EBI-1043922,EBI-2804080 |
Isoform 2 [P28331-2]
Isoform 5 [P28331-5]
With | #Exp. | IntAct |
---|---|---|
BOD1 - isoform 2 [Q96IK1-2] | 3 | EBI-25876328,EBI-18924329 |
HTT [P42858] | 6 | EBI-25876328,EBI-466029 |
KIF1B - isoform 2 [O60333-2] | 3 | EBI-25876328,EBI-10975473 |
WFS1 [O76024] | 3 | EBI-25876328,EBI-720609 |
Protein-protein interaction databases
BioGRIDi | 110799, 328 interactors |
ComplexPortali | CPX-577, Mitochondrial respiratory chain complex I |
CORUMi | P28331 |
IntActi | P28331, 108 interactors |
MINTi | P28331 |
STRINGi | 9606.ENSP00000392709 |
Chemistry databases
BindingDBi | P28331 |
Miscellaneous databases
RNActi | P28331, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P28331 |
SMRi | P28331 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 108 | 2Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 108 – 147 | 4Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 245 – 301 | 4Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST | 57 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2282, Eukaryota |
GeneTreei | ENSGT00940000153514 |
HOGENOMi | CLU_000422_11_2_1 |
InParanoidi | P28331 |
OMAi | HKNVGPL |
OrthoDBi | 1095510at2759 |
PhylomeDBi | P28331 |
TreeFami | TF105756 |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006656, Mopterin_OxRdtase IPR006963, Mopterin_OxRdtase_4Fe-4S_dom IPR000283, NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228, NADH_UbQ_OxRdtase_Gsu IPR019574, NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd IPR015405, NuoG_C |
Pfami | View protein in Pfam PF00384, Molybdopterin, 1 hit PF10588, NADH-G_4Fe-4S_3, 1 hit PF09326, NADH_dhqG_C, 1 hit |
SMARTi | View protein in SMART SM00929, NADH-G_4Fe-4S_3, 1 hit |
SUPFAMi | SSF54292, SSF54292, 1 hit |
TIGRFAMsi | TIGR01973, NuoG, 1 hit |
PROSITEi | View protein in PROSITE PS51085, 2FE2S_FER_2, 1 hit PS51839, 4FE4S_HC3, 1 hit PS51669, 4FE4S_MOW_BIS_MGD, 1 hit PS00641, COMPLEX1_75K_1, 1 hit PS00642, COMPLEX1_75K_2, 1 hit PS00643, COMPLEX1_75K_3, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL
60 70 80 90 100
QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW
110 120 130 140 150
NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR
160 170 180 190 200
SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR
210 220 230 240 250
GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA RPWETRKTES
260 270 280 290 300
IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ
310 320 330 340 350
RLTEPMVRNE KGLLTYTSWE DALSRVAGML QSFQGKDVAA IAGGLVDAEA
360 370 380 390 400
LVALKDLLNR VDSDTLCTEE VFPTAGAGTD LRSNYLLNTT IAGVEEADVV
410 420 430 440 450
LLVGTNPRFE APLFNARIRK SWLHNDLKVA LIGSPVDLTY TYDHLGDSPK
460 470 480 490 500
ILQDIASGSH PFSQVLKEAK KPMVVLGSSA LQRNDGAAIL AAVSSIAQKI
510 520 530 540 550
RMTSGVTGDW KVMNILHRIA SQVAALDLGY KPGVEAIRKN PPKVLFLLGA
560 570 580 590 600
DGGCITRQDL PKDCFIIYQG HHGDVGAPIA DVILPGAAYT EKSATYVNTE
610 620 630 640 650
GRAQQTKVAV TPPGLAREDW KIIRALSEIA GMTLPYDTLD QVRNRLEEVS
660 670 680 690 700
PNLVRYDDIE GANYFQQANE LSKLVNQQLL ADPLVPPQLT IKDFYMTDSI
710 720
SRASQTMAKC VKAVTEGAQA VEEPSIC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JPQ5 | C9JPQ5_HUMAN | NADH-ubiquinone oxidoreductase 75 k... | NDUFS1 | 130 | Annotation score: | ||
F8WDL5 | F8WDL5_HUMAN | NADH-ubiquinone oxidoreductase 75 k... | NDUFS1 | 91 | Annotation score: | ||
B4DJ81 | B4DJ81_HUMAN | NADH-ubiquinone oxidoreductase 75 k... | NDUFS1 | 611 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | K → R in CAA43412 (PubMed:1935949).Curated | 1 | |
Sequence conflicti | 417 | R → W in CAA43412 (PubMed:1935949).Curated | 1 | |
Sequence conflicti | 572 | H → L in BAG58551 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 691 | I → L in CAA43412 (PubMed:1935949).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_084177 | 228 | V → A in MC1DN5; loss of catalytic activity. 1 Publication | 1 | |
Natural variantiVAR_025511 | 241 | R → Q1 PublicationCorresponds to variant dbSNP:rs17856901Ensembl. | 1 | |
Natural variantiVAR_019532 | 241 | R → W in MC1DN5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199422225EnsemblClinVar. | 1 | |
Natural variantiVAR_019533 | 252 | D → G in MC1DN5; also found in a patient with muscular hypotonia; loss of catalytic activity. 2 PublicationsCorresponds to variant dbSNP:rs199422224EnsemblClinVar. | 1 | |
Natural variantiVAR_069506 | 253 | V → G1 PublicationCorresponds to variant dbSNP:rs786205666EnsemblClinVar. | 1 | |
Natural variantiVAR_018463 | 649 | V → F1 PublicationCorresponds to variant dbSNP:rs1044049Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043727 | 1 – 57 | Missing in isoform 4. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_043728 | 1 – 2 | ML → MW in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_042682 | 1 | M → MRIRGSSGTLSRINM in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_043729 | 3 – 113 | Missing in isoform 3. 1 PublicationAdd BLAST | 111 | |
Alternative sequenceiVSP_045864 | 52 – 87 | Missing in isoform 5. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61100 mRNA Translation: CAA43412.1 AK295705 mRNA Translation: BAG58551.1 AK295987 mRNA Translation: BAG58762.1 AK298320 mRNA Translation: BAG60573.1 AK300585 mRNA Translation: BAG62283.1 AC007383 Genomic DNA Translation: AAY15061.1 CH471063 Genomic DNA Translation: EAW70379.1 BC022368 mRNA Translation: AAH22368.1 BC030833 mRNA Translation: AAH30833.1 |
CCDSi | CCDS2366.1 [P28331-1] CCDS56162.1 [P28331-4] CCDS56163.1 [P28331-3] CCDS56164.1 [P28331-5] CCDS56165.1 [P28331-2] |
PIRi | S17854 |
RefSeqi | NP_001186910.1, NM_001199981.1 [P28331-5] NP_001186911.1, NM_001199982.1 [P28331-3] NP_001186912.1, NM_001199983.1 [P28331-4] NP_001186913.1, NM_001199984.1 [P28331-2] NP_004997.4, NM_005006.6 [P28331-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61100 mRNA Translation: CAA43412.1 AK295705 mRNA Translation: BAG58551.1 AK295987 mRNA Translation: BAG58762.1 AK298320 mRNA Translation: BAG60573.1 AK300585 mRNA Translation: BAG62283.1 AC007383 Genomic DNA Translation: AAY15061.1 CH471063 Genomic DNA Translation: EAW70379.1 BC022368 mRNA Translation: AAH22368.1 BC030833 mRNA Translation: AAH30833.1 |
CCDSi | CCDS2366.1 [P28331-1] CCDS56162.1 [P28331-4] CCDS56163.1 [P28331-3] CCDS56164.1 [P28331-5] CCDS56165.1 [P28331-2] |
PIRi | S17854 |
RefSeqi | NP_001186910.1, NM_001199981.1 [P28331-5] NP_001186911.1, NM_001199982.1 [P28331-3] NP_001186912.1, NM_001199983.1 [P28331-4] NP_001186913.1, NM_001199984.1 [P28331-2] NP_004997.4, NM_005006.6 [P28331-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XTB | electron microscopy | 3.40 | M | 30-716 | [»] | |
5XTD | electron microscopy | 3.70 | M | 30-716 | [»] | |
5XTH | electron microscopy | 3.90 | M | 30-716 | [»] | |
5XTI | electron microscopy | 17.40 | BM/M | 30-716 | [»] | |
AlphaFoldDBi | P28331 | |||||
SMRi | P28331 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110799, 328 interactors |
ComplexPortali | CPX-577, Mitochondrial respiratory chain complex I |
CORUMi | P28331 |
IntActi | P28331, 108 interactors |
MINTi | P28331 |
STRINGi | 9606.ENSP00000392709 |
Chemistry databases
BindingDBi | P28331 |
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH |
DrugCentrali | P28331 |
PTM databases
CarbonylDBi | P28331 |
GlyGeni | P28331, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P28331 |
MetOSitei | P28331 |
PhosphoSitePlusi | P28331 |
SwissPalmi | P28331 |
Genetic variation databases
BioMutai | NDUFS1 |
DMDMi | 92090799 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00604664 P28331 |
UCD-2DPAGEi | P28331 |
Proteomic databases
CPTACi | CPTAC-413 CPTAC-414 |
EPDi | P28331 |
jPOSTi | P28331 |
MassIVEi | P28331 |
MaxQBi | P28331 |
PaxDbi | P28331 |
PeptideAtlasi | P28331 |
PRIDEi | P28331 |
ProteomicsDBi | 17145 54470 [P28331-1] 54471 [P28331-2] 54472 [P28331-3] 54473 [P28331-4] |
Protocols and materials databases
Antibodypediai | 34175, 310 antibodies from 37 providers |
DNASUi | 4719 |
Genome annotation databases
Organism-specific databases
CTDi | 4719 |
DisGeNETi | 4719 |
GeneCardsi | NDUFS1 |
GeneReviewsi | NDUFS1 |
HGNCi | HGNC:7707, NDUFS1 |
HPAi | ENSG00000023228, Tissue enhanced (skeletal muscle, tongue) |
MalaCardsi | NDUFS1 |
MIMi | 157655, gene 618226, phenotype |
neXtProti | NX_P28331 |
OpenTargetsi | ENSG00000023228 |
Orphaneti | 2609, Isolated complex I deficiency 255241, Leigh syndrome with leukodystrophy |
PharmGKBi | PA31518 |
VEuPathDBi | HostDB:ENSG00000023228 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2282, Eukaryota |
GeneTreei | ENSGT00940000153514 |
HOGENOMi | CLU_000422_11_2_1 |
InParanoidi | P28331 |
OMAi | HKNVGPL |
OrthoDBi | 1095510at2759 |
PhylomeDBi | P28331 |
TreeFami | TF105756 |
Enzyme and pathway databases
PathwayCommonsi | P28331 |
Reactomei | R-HSA-611105, Respiratory electron transport R-HSA-6799198, Complex I biogenesis |
SignaLinki | P28331 |
SIGNORi | P28331 |
Miscellaneous databases
BioGRID-ORCSi | 4719, 274 hits in 1090 CRISPR screens |
ChiTaRSi | NDUFS1, human |
GeneWikii | NDUFS1 |
GenomeRNAii | 4719 |
Pharosi | P28331, Tclin |
PROi | PR:P28331 |
RNActi | P28331, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000023228, Expressed in heart and 255 other tissues |
ExpressionAtlasi | P28331, baseline and differential |
Genevisiblei | P28331, HS |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006656, Mopterin_OxRdtase IPR006963, Mopterin_OxRdtase_4Fe-4S_dom IPR000283, NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228, NADH_UbQ_OxRdtase_Gsu IPR019574, NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd IPR015405, NuoG_C |
Pfami | View protein in Pfam PF00384, Molybdopterin, 1 hit PF10588, NADH-G_4Fe-4S_3, 1 hit PF09326, NADH_dhqG_C, 1 hit |
SMARTi | View protein in SMART SM00929, NADH-G_4Fe-4S_3, 1 hit |
SUPFAMi | SSF54292, SSF54292, 1 hit |
TIGRFAMsi | TIGR01973, NuoG, 1 hit |
PROSITEi | View protein in PROSITE PS51085, 2FE2S_FER_2, 1 hit PS51839, 4FE4S_HC3, 1 hit PS51669, 4FE4S_MOW_BIS_MGD, 1 hit PS00641, COMPLEX1_75K_1, 1 hit PS00642, COMPLEX1_75K_2, 1 hit PS00643, COMPLEX1_75K_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NDUS1_HUMAN | |
Accessioni | P28331Primary (citable) accession number: P28331 Secondary accession number(s): B4DIN9 Q8TCC9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | March 7, 2006 | |
Last modified: | May 25, 2022 | |
This is version 226 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families