NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

• [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
• [4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters per subunit.By similarity

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
• 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
• electron transfer activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 1935949
• iron-sulfur cluster binding Source: GO_Central
• metal ion binding Source: UniProtKB-KW
• NADH dehydrogenase (ubiquinone) activity Source: UniProtKBNon-traceable author statementⁱ
  • 9878551

GO - Biological processⁱ

• apoptotic mitochondrial changes Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15186778
• ATP metabolic process Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 15186778
• cellular respiration Source: UniProtKBInferred from mutant phenotypeⁱ
  • 15186778
  • 16478720
• mitochondrial electron transport, NADH to ubiquinone Source: UniProtKBNon-traceable author statementⁱ
  • 9878551
• mitochondrial respiratory chain complex I assembly Source: Reactome
• reactive oxygen species metabolic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • 15186778
  • 16478720
  • 16870178
• regulation of mitochondrial membrane potential Source: UniProtKBInferred from mutant phenotypeⁱ
  • 15186778
  • 16478720

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 5 described isoforms and 3 potential isoforms that are <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL 
        60         70         80         90        100
QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW 
       110        120        130        140        150
NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR 
       160        170        180        190        200
SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR 
       210        220        230        240        250
GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA RPWETRKTES 
       260        270        280        290        300
IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ 
       310        320        330        340        350
RLTEPMVRNE KGLLTYTSWE DALSRVAGML QSFQGKDVAA IAGGLVDAEA 
       360        370        380        390        400
LVALKDLLNR VDSDTLCTEE VFPTAGAGTD LRSNYLLNTT IAGVEEADVV 
       410        420        430        440        450
LLVGTNPRFE APLFNARIRK SWLHNDLKVA LIGSPVDLTY TYDHLGDSPK 
       460        470        480        490        500
ILQDIASGSH PFSQVLKEAK KPMVVLGSSA LQRNDGAAIL AAVSSIAQKI 
       510        520        530        540        550
RMTSGVTGDW KVMNILHRIA SQVAALDLGY KPGVEAIRKN PPKVLFLLGA 
       560        570        580        590        600
DGGCITRQDL PKDCFIIYQG HHGDVGAPIA DVILPGAAYT EKSATYVNTE 
       610        620        630        640        650
GRAQQTKVAV TPPGLAREDW KIIRALSEIA GMTLPYDTLD QVRNRLEEVS 
       660        670        680        690        700
PNLVRYDDIE GANYFQQANE LSKLVNQQLL ADPLVPPQLT IKDFYMTDSI 
       710        720 
SRASQTMAKC VKAVTEGAQA VEEPSIC                          

        10         20         30         40         50
MRIRGSSGTL SRINMLRIPV RKALVGLSKS PKGCVRTTAT AASNLIEVFV 
        60         70         80         90        100
DGQSVMVEPG TTVLQACEKV GMQIPRFCYH ERLSVAGNCR MCLVEIEKAP 
       110        120        130        140        150
KVVAACAMPV MKGWNILTNS EKSKKAREGV MEFLLANHPL DCPICDQGGE 
       160        170        180        190        200
CDLQDQSMMF GNDRSRFLEG KRAVEDKNIG PLVKTIMTRC IQCTRCIRFA 
       210        220        230        240        250
SEIAGVDDLG TTGRGNDMQV GTYIEKMFMS ELSGNIIDIC PVGALTSKPY 
       260        270        280        290        300
AFTARPWETR KTESIDVMDA VGSNIVVSTR TGEVMRILPR MHEDINEEWI 
       310        320        330        340        350
SDKTRFAYDG LKRQRLTEPM VRNEKGLLTY TSWEDALSRV AGMLQSFQGK 
       360        370        380        390        400
DVAAIAGGLV DAEALVALKD LLNRVDSDTL CTEEVFPTAG AGTDLRSNYL 
       410        420        430        440        450
LNTTIAGVEE ADVVLLVGTN PRFEAPLFNA RIRKSWLHND LKVALIGSPV 
       460        470        480        490        500
DLTYTYDHLG DSPKILQDIA SGSHPFSQVL KEAKKPMVVL GSSALQRNDG 
       510        520        530        540        550
AAILAAVSSI AQKIRMTSGV TGDWKVMNIL HRIASQVAAL DLGYKPGVEA 
       560        570        580        590        600
IRKNPPKVLF LLGADGGCIT RQDLPKDCFI IYQGHHGDVG APIADVILPG 
       610        620        630        640        650
AAYTEKSATY VNTEGRAQQT KVAVTPPGLA REDWKIIRAL SEIAGMTLPY 
       660        670        680        690        700
DTLDQVRNRL EEVSPNLVRY DDIEGANYFQ QANELSKLVN QQLLADPLVP 
       710        720        730        740 
PQLTIKDFYM TDSISRASQT MAKCVKAVTE GAQAVEEPSI C          

        10         20         30         40         50
MWEGVMEFLL ANHPLDCPIC DQGGECDLQD QSMMFGNDRS RFLEGKRAVE 
        60         70         80         90        100
DKNIGPLVKT IMTRCIQCTR CIRFASEIAG VDDLGTTGRG NDMQVGTYIE 
       110        120        130        140        150
KMFMSELSGN IIDICPVGAL TSKPYAFTAR PWETRKTESI DVMDAVGSNI 
       160        170        180        190        200
VVSTRTGEVM RILPRMHEDI NEEWISDKTR FAYDGLKRQR LTEPMVRNEK 
       210        220        230        240        250
GLLTYTSWED ALSRVAGMLQ SFQGKDVAAI AGGLVDAEAL VALKDLLNRV 
       260        270        280        290        300
DSDTLCTEEV FPTAGAGTDL RSNYLLNTTI AGVEEADVVL LVGTNPRFEA 
       310        320        330        340        350
PLFNARIRKS WLHNDLKVAL IGSPVDLTYT YDHLGDSPKI LQDIASGSHP 
       360        370        380        390        400
FSQVLKEAKK PMVVLGSSAL QRNDGAAILA AVSSIAQKIR MTSGVTGDWK 
       410        420        430        440        450
VMNILHRIAS QVAALDLGYK PGVEAIRKNP PKVLFLLGAD GGCITRQDLP 
       460        470        480        490        500
KDCFIIYQGH HGDVGAPIAD VILPGAAYTE KSATYVNTEG RAQQTKVAVT 
       510        520        530        540        550
PPGLAREDWK IIRALSEIAG MTLPYDTLDQ VRNRLEEVSP NLVRYDDIEG 
       560        570        580        590        600
ANYFQQANEL SKLVNQQLLA DPLVPPQLTI KDFYMTDSIS RASQTMAKCV 
       610 
KAVTEGAQAV EEPSIC                                      

        10         20         30         40         50
MQIPRFCYHE RLSVAGNCRM CLVEIEKAPK VVAACAMPVM KGWNILTNSE 
        60         70         80         90        100
KSKKAREGVM EFLLANHPLD CPICDQGGEC DLQDQSMMFG NDRSRFLEGK 
       110        120        130        140        150
RAVEDKNIGP LVKTIMTRCI QCTRCIRFAS EIAGVDDLGT TGRGNDMQVG 
       160        170        180        190        200
TYIEKMFMSE LSGNIIDICP VGALTSKPYA FTARPWETRK TESIDVMDAV 
       210        220        230        240        250
GSNIVVSTRT GEVMRILPRM HEDINEEWIS DKTRFAYDGL KRQRLTEPMV 
       260        270        280        290        300
RNEKGLLTYT SWEDALSRVA GMLQSFQGKD VAAIAGGLVD AEALVALKDL 
       310        320        330        340        350
LNRVDSDTLC TEEVFPTAGA GTDLRSNYLL NTTIAGVEEA DVVLLVGTNP 
       360        370        380        390        400
RFEAPLFNAR IRKSWLHNDL KVALIGSPVD LTYTYDHLGD SPKILQDIAS 
       410        420        430        440        450
GSHPFSQVLK EAKKPMVVLG SSALQRNDGA AILAAVSSIA QKIRMTSGVT 
       460        470        480        490        500
GDWKVMNILH RIASQVAALD LGYKPGVEAI RKNPPKVLFL LGADGGCITR 
       510        520        530        540        550
QDLPKDCFII YQGHHGDVGA PIADVILPGA AYTEKSATYV NTEGRAQQTK 
       560        570        580        590        600
VAVTPPGLAR EDWKIIRALS EIAGMTLPYD TLDQVRNRLE EVSPNLVRYD 
       610        620        630        640        650
DIEGANYFQQ ANELSKLVNQ QLLADPLVPP QLTIKDFYMT DSISRASQTM 
       660        670
AKCVKAVTEG AQAVEEPSIC                                  

        10         20         30         40         50
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL 
        60         70         80         90        100
QVVAACAMPV MKGWNILTNS EKSKKAREGV MEFLLANHPL DCPICDQGGE 
       110        120        130        140        150
CDLQDQSMMF GNDRSRFLEG KRAVEDKNIG PLVKTIMTRC IQCTRCIRFA 
       160        170        180        190        200
SEIAGVDDLG TTGRGNDMQV GTYIEKMFMS ELSGNIIDIC PVGALTSKPY 
       210        220        230        240        250
AFTARPWETR KTESIDVMDA VGSNIVVSTR TGEVMRILPR MHEDINEEWI 
       260        270        280        290        300
SDKTRFAYDG LKRQRLTEPM VRNEKGLLTY TSWEDALSRV AGMLQSFQGK 
       310        320        330        340        350
DVAAIAGGLV DAEALVALKD LLNRVDSDTL CTEEVFPTAG AGTDLRSNYL 
       360        370        380        390        400
LNTTIAGVEE ADVVLLVGTN PRFEAPLFNA RIRKSWLHND LKVALIGSPV 
       410        420        430        440        450
DLTYTYDHLG DSPKILQDIA SGSHPFSQVL KEAKKPMVVL GSSALQRNDG 
       460        470        480        490        500
AAILAAVSSI AQKIRMTSGV TGDWKVMNIL HRIASQVAAL DLGYKPGVEA 
       510        520        530        540        550
IRKNPPKVLF LLGADGGCIT RQDLPKDCFI IYQGHHGDVG APIADVILPG 
       560        570        580        590        600
AAYTEKSATY VNTEGRAQQT KVAVTPPGLA REDWKIIRAL SEIAGMTLPY 
       610        620        630        640        650
DTLDQVRNRL EEVSPNLVRY DDIEGANYFQ QANELSKLVN QQLLADPLVP 
       660        670        680        690 
PQLTIKDFYM TDSISRASQT MAKCVKAVTE GAQAVEEPSI C          

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ