Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxidase

Gene

CIP1

Organism
Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+Note: Binds 2 calcium ions per subunit.
  • heme bNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei71Transition state stabilizer1
Active sitei75Proton acceptor1
Metal bindingi76Calcium 11
Metal bindingi94Calcium 1; via carbonyl oxygen1
Metal bindingi96Calcium 11
Metal bindingi98Calcium 11
Metal bindingi203Iron (heme axial ligand)1
Metal bindingi204Calcium 21
Metal bindingi221Calcium 21
Metal bindingi223Calcium 21
Metal bindingi226Calcium 2; via carbonyl oxygen1
Metal bindingi228Calcium 21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Protein family/group databases

CAZyiAA2 Auxiliary Activities 2
mycoCLAPiPRX2A_COPCI
PeroxiBasei2403 CcinCIIBA

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase (EC:1.11.1.7)
Gene namesi
Name:CIP1
OrganismiCoprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)
Taxonomic identifieri5346 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000002366721 – 363PeroxidaseAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi31 ↔ 43
Disulfide bondi42 ↔ 312
Disulfide bondi62 ↔ 148
Glycosylationi162N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Disulfide bondi276 ↔ 341
Glycosylationi358O-linked (Man...) serine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

PTM databases

iPTMnetiP28314

Structurei

Secondary structure

1363
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP28314
SMRiP28314
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28314

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Ligninase subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II1B Eukaryota
ENOG410ZS1R LUCA

Family and domain databases

CDDicd00692 ligninase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR001621 Ligninase
IPR024589 Ligninase_C
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PF11895 Peroxidase_ext, 1 hit
PRINTSiPR00462 LIGNINASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28314-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLSLLSTFA AVIIGALALP QGPGGGGSVT CPGGQSTSNS QCCVWFDVLD
60 70 80 90 100
DLQTNFYQGS KCESPVRKIL RIVFHDAIGF SPALTAAGQF GGGGADGSII
110 120 130 140 150
AHSNIELAFP ANGGLTDTVE ALRAVGINHG VSFGDLIQFA TAVGMSNCPG
160 170 180 190 200
SPRLEFLTGR SNSSQPSPPS LIPGPGNTVT AILDRMGDAG FSPDEVVDLL
210 220 230 240 250
AAHSLASQEG LNSAIFRSPL DSTPQVFDTQ FYIETLLKGT TQPGPSLGFA
260 270 280 290 300
EELSPFPGEF RMRSDALLAR DSRTACRWQS MTSSNEVMGQ RYRAAMAKMS
310 320 330 340 350
VLGFDRNALT DCSDVIPSAV SNNAAPVIPG GLTVDDIEVS CPSEPFPEIA
360
TASGPLPSLA PAP
Length:363
Mass (Da):37,640
Last modified:July 1, 1993 - v2
Checksum:iE56EB53B963C3DB5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119V → I in CAA50060 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti99I → V. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69457 mRNA Translation: CAA49216.1
X70789 Genomic DNA Translation: CAA50060.1
PIRiS31780

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69457 mRNA Translation: CAA49216.1
X70789 Genomic DNA Translation: CAA50060.1
PIRiS31780

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H3JX-ray2.00A/B22-363[»]
1LY8X-ray2.05A/B21-363[»]
1LY9X-ray2.00A/B21-363[»]
1LYCX-ray1.57A/B21-363[»]
1LYKX-ray2.00A/B21-363[»]
ProteinModelPortaliP28314
SMRiP28314
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiAA2 Auxiliary Activities 2
mycoCLAPiPRX2A_COPCI
PeroxiBasei2403 CcinCIIBA

PTM databases

iPTMnetiP28314

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410II1B Eukaryota
ENOG410ZS1R LUCA

Miscellaneous databases

EvolutionaryTraceiP28314

Family and domain databases

CDDicd00692 ligninase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR001621 Ligninase
IPR024589 Ligninase_C
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PF11895 Peroxidase_ext, 1 hit
PRINTSiPR00462 LIGNINASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER_COPCI
AccessioniPrimary (citable) accession number: P28314
Secondary accession number(s): P28315, Q12575
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again