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Protein

Major curlin subunit

Gene

csgA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin.

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • amyloid fibril formation Source: EcoCyc
  • cell adhesion Source: EcoCyc
  • single-species biofilm formation Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:EG11489-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Major curlin subunit
Gene namesi
Name:csgA
Ordered Locus Names:b1042, JW1025
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11489 csgA

Subcellular locationi

  • Fimbrium
  • Note: Part of the curli surface structure.

GO - Cellular componenti

  • pilus Source: EcoCyc

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000000636921 – 151Major curlin subunitAdd BLAST131

Proteomic databases

PaxDbiP28307
PRIDEiP28307

Expressioni

Inductioni

Under control of the CsgD transcription factor, part of the csgBAC/ymdA operon.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-15647673,EBI-15647673

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4260065, 16 interactors
DIPiDIP-9325N
IntActiP28307, 1 interactor
STRINGi316385.ECDH10B_1114

Structurei

3D structure databases

ProteinModelPortaliP28307
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CsgA/CsgB family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105G76 Bacteria
ENOG4111QFZ LUCA
HOGENOMiHOG000118951
InParanoidiP28307
KOiK04334
OMAiNSEIQIY
PhylomeDBiP28307

Family and domain databases

InterProiView protein in InterPro
IPR009742 Curlin_rpt
PfamiView protein in Pfam
PF07012 Curlin_rpt, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLKVAAIA AIVFSGSALA GVVPQYGGGG NHGGGGNNSG PNSELNIYQY
60 70 80 90 100
GGGNSALALQ TDARNSDLTI TQHGGGNGAD VGQGSDDSSI DLTQRGFGNS
110 120 130 140 150
ATLDQWNGKN SEMTVKQFGG GNGAAVDQTA SNSSVNVTQV GFGNNATAHQ

Y
Length:151
Mass (Da):15,049
Last modified:October 1, 1996 - v3
Checksum:iC003470D208D395F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → E in AAA23616 (PubMed:8459772).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04979 Genomic DNA Translation: AAA23616.1
X90754 Genomic DNA Translation: CAA62282.1
U00096 Genomic DNA Translation: AAC74126.1
AP009048 Genomic DNA Translation: BAA35832.1
PIRiS70788
RefSeqiNP_415560.1, NC_000913.3
WP_000771437.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74126; AAC74126; b1042
BAA35832; BAA35832; BAA35832
GeneIDi949055
KEGGiecj:JW1025
eco:b1042
PATRICifig|1411691.4.peg.1227

Similar proteinsi

Entry informationi

Entry nameiCSGA_ECOLI
AccessioniPrimary (citable) accession number: P28307
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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