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UniProtKB - P28304 (QOR1_ECOLI)
Protein
Quinone oxidoreductase 1
Gene
qorA
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:1.6.5.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 130 | NADP1 Publication | 1 | |
Binding sitei | 192 | NADP1 Publication | 1 | |
Binding sitei | 216 | NADP; via carbonyl oxygen1 Publication | 1 | |
Binding sitei | 317 | NADP1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 42 – 46 | NADP1 Publication | 5 | |
Nucleotide bindingi | 152 – 153 | NADP1 Publication | 2 | |
Nucleotide bindingi | 173 – 177 | NADP1 Publication | 5 | |
Nucleotide bindingi | 238 – 241 | NADP1 Publication | 4 | |
Nucleotide bindingi | 264 – 266 | NADP1 Publication | 3 |
GO - Molecular functioni
- NADPH:quinone reductase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- cellular response to oxidative stress Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Enzyme and pathway databases
BioCyci | EcoCyc:QOR-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Quinone oxidoreductase 1 (EC:1.6.5.5)Alternative name(s): NADPH:quinone reductase 1 Zeta-crystallin homolog protein |
Gene namesi | Name:qorA Synonyms:hcz, qor, qor1 Ordered Locus Names:b4051, JW4011 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160901 | 1 – 327 | Quinone oxidoreductase 1Add BLAST | 327 |
Proteomic databases
jPOSTi | P28304 |
PaxDbi | P28304 |
PRIDEi | P28304 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
P28304
With | #Exp. | IntAct |
---|---|---|
dnaK [P0A6Y8] | 2 | EBI-556687,EBI-542092 |
Protein-protein interaction databases
BioGRIDi | 4260805, 36 interactors 852850, 2 interactors |
DIPi | DIP-10631N |
IntActi | P28304, 5 interactors |
STRINGi | 511145.b4051 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P28304 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28304 |
Family & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.Curated
Phylogenomic databases
eggNOGi | COG0604, Bacteria |
HOGENOMi | CLU_026673_3_1_6 |
InParanoidi | P28304 |
PhylomeDBi | P28304 |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
i Sequence
Sequence statusi: Complete.
P28304-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATRIEFHKH GGPEVLQAVE FTPADPAENE IQVENKAIGI NFIDTYIRSG
60 70 80 90 100
LYPPPSLPSG LGTEAAGIVS KVGSGVKHIK AGDRVVYAQS ALGAYSSVHN
110 120 130 140 150
IIADKAAILP AAISFEQAAA SFLKGLTVYY LLRKTYEIKP DEQFLFHAAA
160 170 180 190 200
GGVGLIACQW AKALGAKLIG TVGTAQKAQS ALKAGAWQVI NYREEDLVER
210 220 230 240 250
LKEITGGKKV RVVYDSVGRD TWERSLDCLQ RRGLMVSFGN SSGAVTGVNL
260 270 280 290 300
GILNQKGSLY VTRPSLQGYI TTREELTEAS NELFSLIASG VIKVDVAEQQ
310 320
KYPLKDAQRA HEILESRATQ GSSLLIP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02312 Genomic DNA Translation: AAA23691.1 U00006 Genomic DNA Translation: AAC43145.1 U00096 Genomic DNA Translation: AAC77021.1 AP009048 Genomic DNA Translation: BAE78053.1 |
PIRi | S45529 |
RefSeqi | NP_418475.1, NC_000913.3 WP_000235508.1, NZ_SSZK01000016.1 |
Genome annotation databases
EnsemblBacteriai | AAC77021; AAC77021; b4051 BAE78053; BAE78053; BAE78053 |
GeneIDi | 948556 |
KEGGi | ecj:JW4011 eco:b4051 |
PATRICi | fig|511145.12.peg.4169 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02312 Genomic DNA Translation: AAA23691.1 U00006 Genomic DNA Translation: AAC43145.1 U00096 Genomic DNA Translation: AAC77021.1 AP009048 Genomic DNA Translation: BAE78053.1 |
PIRi | S45529 |
RefSeqi | NP_418475.1, NC_000913.3 WP_000235508.1, NZ_SSZK01000016.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QOR | X-ray | 2.20 | A/B | 1-327 | [»] | |
SMRi | P28304 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260805, 36 interactors 852850, 2 interactors |
DIPi | DIP-10631N |
IntActi | P28304, 5 interactors |
STRINGi | 511145.b4051 |
Proteomic databases
jPOSTi | P28304 |
PaxDbi | P28304 |
PRIDEi | P28304 |
Genome annotation databases
EnsemblBacteriai | AAC77021; AAC77021; b4051 BAE78053; BAE78053; BAE78053 |
GeneIDi | 948556 |
KEGGi | ecj:JW4011 eco:b4051 |
PATRICi | fig|511145.12.peg.4169 |
Organism-specific databases
EchoBASEi | EB1455 |
Phylogenomic databases
eggNOGi | COG0604, Bacteria |
HOGENOMi | CLU_026673_3_1_6 |
InParanoidi | P28304 |
PhylomeDBi | P28304 |
Enzyme and pathway databases
BioCyci | EcoCyc:QOR-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P28304 |
PROi | PR:P28304 |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QOR1_ECOLI | |
Accessioni | P28304Primary (citable) accession number: P28304 Secondary accession number(s): Q2M6Q3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | June 2, 2021 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families