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Protein

Protein-lysine 6-oxidase

Gene

LOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).By similarity1 Publication

Miscellaneous

The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi292CopperSequence analysis1
Metal bindingi294CopperSequence analysis1
Metal bindingi296CopperSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • copper ion binding Source: ProtInc
  • protein-lysine 6-oxidase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandCopper, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.4.3.13 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1566948 Elastic fibre formation
R-HSA-2243919 Crosslinking of collagen fibrils

SIGNOR Signaling Network Open Resource

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SIGNORi
P28300

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-lysine 6-oxidase (EC:1.4.3.131 Publication)
Alternative name(s):
Lysyl oxidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000113083.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6664 LOX

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
153455 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P28300

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Aortic aneurysm, familial thoracic 10 (AAT10)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of thoracic aortic aneurysm, a disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
See also OMIM:617168
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07753479A → T in AAT10; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs752839330EnsemblClinVar.1
Natural variantiVAR_077535154L → F in AAT10; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767855588Ensembl.1
Natural variantiVAR_077536248T → I in AAT10; unknown pathological significance; 8% decrease of lysyl oxidase activity. 1 Publication1
Natural variantiVAR_077537267Q → P in AAT10. 1 PublicationCorresponds to variant dbSNP:rs886040967EnsemblClinVar.1
Natural variantiVAR_077538280S → I in AAT10; 50% decrease of lysyl oxidase activity. 1 PublicationCorresponds to variant dbSNP:rs886040965EnsemblClinVar.1
Natural variantiVAR_077539298M → R in AAT10. 1 PublicationCorresponds to variant dbSNP:rs876657852EnsemblClinVar.1
Natural variantiVAR_077540348S → R in AAT10; 21% decrease of lysyl oxidase activity. 1 Publication1

Keywords - Diseasei

Aortic aneurysm, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4015

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
LOX

MalaCards human disease database

More...
MalaCardsi
LOX
MIMi617168 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113083

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
91387 Familial thoracic aortic aneurysm and aortic dissection

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30427

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2249

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LOX

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001852022 – 168By similarityAdd BLAST147
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000018521169 – 417Protein-lysine 6-oxidaseAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi238 ↔ 244By similarity
Disulfide bondi291 ↔ 340By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki320 ↔ 355Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi324 ↔ 330By similarity
Disulfide bondi351 ↔ 361By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3552',4',5'-topaquinoneBy similarity1
Disulfide bondi398 ↔ 412By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.By similarity
Proteolytically activated by BMP1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, LTQ, TPQ

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P28300

MaxQB - The MaxQuant DataBase

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MaxQBi
P28300

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P28300

PeptideAtlas

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PeptideAtlasi
P28300

PRoteomics IDEntifications database

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PRIDEi
P28300

ProteomicsDB human proteome resource

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ProteomicsDBi
54461

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
816

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P28300

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P28300

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P28300

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P28300

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart, placenta, skeletal muscle, kidney, lung and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113083 Expressed in 177 organ(s), highest expression level in smooth muscle tissue

CleanEx database of gene expression profiles

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CleanExi
HS_LOX

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P28300 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P28300 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043930

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MFAP4 (PubMed:26601954).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110199, 20 interactors

Database of interacting proteins

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DIPi
DIP-49007N

Protein interaction database and analysis system

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IntActi
P28300, 43 interactors

Molecular INTeraction database

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MINTi
P28300

STRING: functional protein association networks

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STRINGi
9606.ENSP00000231004

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P28300

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P28300

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P28300

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni213 – 417Lysyl-oxidase likeAdd BLAST205

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHTH Eukaryota
ENOG41101E4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154779

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234262

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000226

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P28300

KEGG Orthology (KO)

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KOi
K00277

Identification of Orthologs from Complete Genome Data

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OMAi
LQWSHNG

Database of Orthologous Groups

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OrthoDBi
EOG091G02XD

Database for complete collections of gene phylogenies

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PhylomeDBi
P28300

TreeFam database of animal gene trees

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TreeFami
TF326061

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001695 Lysyl_oxidase
IPR019828 Lysyl_oxidase_CS

Pfam protein domain database

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Pfami
View protein in Pfam
PF01186 Lysyl_oxidase, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00074 LYSYLOXIDASE

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00926 LYSYL_OXIDASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P28300-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFAWTVLLL GPLQLCALVH CAPPAAGQQQ PPREPPAAPG AWRQQIQWEN
60 70 80 90 100
NGQVFSLLSL GSQYQPQRRR DPGAAVPGAA NASAQQPRTP ILLIRDNRTA
110 120 130 140 150
AARTRTAGSS GVTAGRPRPT ARHWFQAGYS TSRAREAGAS RAENQTAPGE
160 170 180 190 200
VPALSNLRPP SRVDGMVGDD PYNPYKYSDD NPYYNYYDTY ERPRPGGRYR
210 220 230 240 250
PGYGTGYFQY GLPDLVADPY YIQASTYVQK MSMYNLRCAA EENCLASTAY
260 270 280 290 300
RADVRDYDHR VLLRFPQRVK NQGTSDFLPS RPRYSWEWHS CHQHYHSMDE
310 320 330 340 350
FSHYDLLDAN TQRRVAEGHK ASFCLEDTSC DYGYHRRFAC TAHTQGLSPG
360 370 380 390 400
CYDTYGADID CQWIDITDVK PGNYILKVSV NPSYLVPESD YTNNVVRCDI
410
RYTGHHAYAS GCTISPY
Length:417
Mass (Da):46,944
Last modified:October 1, 1993 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6412A78443E03F04
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAL3H0YAL3_HUMAN
Protein-lysine 6-oxidase
LOX
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30Q → H (PubMed:7706256).Curated1
Sequence conflicti31P → A (PubMed:7706256).Curated1
Sequence conflicti95R → A (PubMed:7706256).Curated1
Sequence conflicti102A → G in AAB21243 (PubMed:1685472).Curated1
Sequence conflicti137A → R in AAA59525 (PubMed:1357535).Curated1
Sequence conflicti137A → R in AAB23549 (PubMed:1357535).Curated1
Sequence conflicti139A → P in AAB21243 (PubMed:1685472).Curated1
Sequence conflicti304 – 305YD → LY in AAB21243 (PubMed:1685472).Curated2
Sequence conflicti315V → W in AAB21243 (PubMed:1685472).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07753479A → T in AAT10; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs752839330EnsemblClinVar.1
Natural variantiVAR_077535154L → F in AAT10; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767855588Ensembl.1
Natural variantiVAR_004282158R → Q2 PublicationsCorresponds to variant dbSNP:rs1800449EnsemblClinVar.1
Natural variantiVAR_077536248T → I in AAT10; unknown pathological significance; 8% decrease of lysyl oxidase activity. 1 Publication1
Natural variantiVAR_077537267Q → P in AAT10. 1 PublicationCorresponds to variant dbSNP:rs886040967EnsemblClinVar.1
Natural variantiVAR_077538280S → I in AAT10; 50% decrease of lysyl oxidase activity. 1 PublicationCorresponds to variant dbSNP:rs886040965EnsemblClinVar.1
Natural variantiVAR_077539298M → R in AAT10. 1 PublicationCorresponds to variant dbSNP:rs876657852EnsemblClinVar.1
Natural variantiVAR_077540348S → R in AAT10; 21% decrease of lysyl oxidase activity. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S78694 mRNA Translation: AAB21243.1
M94054 mRNA Translation: AAA59525.1
S45875 mRNA Translation: AAB23549.1
AF039291 mRNA Translation: AAD02130.1
AK312269 mRNA Translation: BAG35200.1
BC074820 mRNA Translation: AAH74820.1
BC074872 mRNA Translation: AAH74872.1
BC089436 mRNA Translation: AAH89436.1
L16895 Genomic DNA Translation: AAA16870.1
M84150 Genomic DNA Translation: AAA59541.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4129.1

Protein sequence database of the Protein Information Resource

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PIRi
A47529 OXHUL

NCBI Reference Sequences

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RefSeqi
NP_002308.2, NM_002317.6

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.102267

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000231004; ENSP00000231004; ENSG00000113083
ENST00000639739; ENSP00000492324; ENSG00000113083

Database of genes from NCBI RefSeq genomes

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GeneIDi
4015

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4015

UCSC genome browser

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UCSCi
uc003ksu.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78694 mRNA Translation: AAB21243.1
M94054 mRNA Translation: AAA59525.1
S45875 mRNA Translation: AAB23549.1
AF039291 mRNA Translation: AAD02130.1
AK312269 mRNA Translation: BAG35200.1
BC074820 mRNA Translation: AAH74820.1
BC074872 mRNA Translation: AAH74872.1
BC089436 mRNA Translation: AAH89436.1
L16895 Genomic DNA Translation: AAA16870.1
M84150 Genomic DNA Translation: AAA59541.1
CCDSiCCDS4129.1
PIRiA47529 OXHUL
RefSeqiNP_002308.2, NM_002317.6
UniGeneiHs.102267

3D structure databases

ProteinModelPortaliP28300
SMRiP28300
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110199, 20 interactors
DIPiDIP-49007N
IntActiP28300, 43 interactors
MINTiP28300
STRINGi9606.ENSP00000231004

Chemistry databases

BindingDBiP28300
ChEMBLiCHEMBL2249

PTM databases

GlyConnecti816
iPTMnetiP28300
PhosphoSitePlusiP28300
UniCarbKBiP28300

Polymorphism and mutation databases

BioMutaiLOX

Proteomic databases

EPDiP28300
MaxQBiP28300
PaxDbiP28300
PeptideAtlasiP28300
PRIDEiP28300
ProteomicsDBi54461

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231004; ENSP00000231004; ENSG00000113083
ENST00000639739; ENSP00000492324; ENSG00000113083
GeneIDi4015
KEGGihsa:4015
UCSCiuc003ksu.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4015
DisGeNETi4015
EuPathDBiHostDB:ENSG00000113083.12

GeneCards: human genes, protein and diseases

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GeneCardsi
LOX
GeneReviewsiLOX
HGNCiHGNC:6664 LOX
HPAiHPA043930
MalaCardsiLOX
MIMi153455 gene
617168 phenotype
neXtProtiNX_P28300
OpenTargetsiENSG00000113083
Orphaneti91387 Familial thoracic aortic aneurysm and aortic dissection
PharmGKBiPA30427

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHTH Eukaryota
ENOG41101E4 LUCA
GeneTreeiENSGT00940000154779
HOGENOMiHOG000234262
HOVERGENiHBG000226
InParanoidiP28300
KOiK00277
OMAiLQWSHNG
OrthoDBiEOG091G02XD
PhylomeDBiP28300
TreeFamiTF326061

Enzyme and pathway databases

BRENDAi1.4.3.13 2681
ReactomeiR-HSA-1566948 Elastic fibre formation
R-HSA-2243919 Crosslinking of collagen fibrils
SIGNORiP28300

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LOX human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Lysyl_oxidase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4015
PMAP-CutDBiP28300

Protein Ontology

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PROi
PR:P28300

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113083 Expressed in 177 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_LOX
ExpressionAtlasiP28300 baseline and differential
GenevisibleiP28300 HS

Family and domain databases

InterProiView protein in InterPro
IPR001695 Lysyl_oxidase
IPR019828 Lysyl_oxidase_CS
PfamiView protein in Pfam
PF01186 Lysyl_oxidase, 1 hit
PRINTSiPR00074 LYSYLOXIDASE
PROSITEiView protein in PROSITE
PS00926 LYSYL_OXIDASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYOX_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28300
Secondary accession number(s): B2R5Q3, Q5FWF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 1, 1993
Last modified: December 5, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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