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Protein

Protein ITPRID2

Gene

ITPRID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin filament binding Source: CACAO
  • signaling receptor binding Source: InterPro

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ITPRID2Curated
Alternative name(s):
Cleavage signal-1 protein1 Publication
Short name:
CS-11 Publication
ITPR-interacting domain-containing protein 2Curated
Ki-ras-induced actin-interacting protein1 Publication
Sperm-specific antigen 2
Gene namesi
Name:ITPRID2Imported
Synonyms:CS11 Publication, KIAA1927, KRAP1 Publication, SSFA2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138434.16
HGNCiHGNC:11319 ITPRID2
MIMi118990 gene
neXtProtiNX_P28290

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6744
OpenTargetsiENSG00000138434
PharmGKBiPA36143

Polymorphism and mutation databases

BioMutaiSSFA2
DMDMi134047924

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722111 – 1259Protein ITPRID2Add BLAST1259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphothreonineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei111PhosphoserineBy similarity1
Modified residuei209PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Cross-linki360Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei466PhosphoserineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1
Modified residuei737PhosphoserineCombined sources1
Modified residuei739PhosphoserineCombined sources1
Modified residuei746PhosphoserineCombined sources1
Modified residuei759PhosphoserineCombined sources1
Modified residuei767PhosphoserineCombined sources1
Modified residuei803PhosphoserineCombined sources1
Cross-linki808Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei869PhosphoserineBy similarity1
Modified residuei902PhosphoserineCombined sources1
Modified residuei1040PhosphoserineBy similarity1
Modified residuei1055PhosphoserineBy similarity1
Modified residuei1060PhosphoserineBy similarity1
Modified residuei1063PhosphoserineCombined sources1
Modified residuei1118PhosphoserineCombined sources1
Modified residuei1134PhosphoserineCombined sources1
Modified residuei1156PhosphothreonineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1168PhosphothreonineCombined sources1

Post-translational modificationi

A 33 kDa peptide corresponding to the C-terminus of this protein is found in the testis and seems to be cleaved into 2 peptides of 14 kDa and 18 kDa found on the surface of mature sperm cells. This sperm surface antigen may be involved in some step of early cleavage of the fertilized oocyte.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP28290
MaxQBiP28290
PaxDbiP28290
PeptideAtlasiP28290
PRIDEiP28290
ProteomicsDBi54458
54459 [P28290-2]
54460 [P28290-3]

PTM databases

iPTMnetiP28290
PhosphoSitePlusiP28290

Expressioni

Tissue specificityi

Strongly expressed in pancreas and testis. Present in colon cancer cells (at protein level).1 Publication

Inductioni

Up-regulated by activated KRAS.1 Publication

Gene expression databases

BgeeiENSG00000138434 Expressed in 236 organ(s), highest expression level in body of pancreas
ExpressionAtlasiP28290 baseline and differential
GenevisibleiP28290 HS

Organism-specific databases

HPAiHPA034665
HPA039989

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112622, 65 interactors
DIPiDIP-47271N
IntActiP28290, 39 interactors
MINTiP28290
STRINGi9606.ENSP00000388731

Structurei

3D structure databases

ProteinModelPortaliP28290
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili959 – 1037Sequence analysisAdd BLAST79

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IERU Eukaryota
ENOG410ZSFW LUCA
GeneTreeiENSGT00530000063345
HOVERGENiHBG082646
InParanoidiP28290
OMAiYPYRACS
OrthoDBiEOG091G011N
PhylomeDBiP28290
TreeFamiTF331566

Family and domain databases

InterProiView protein in InterPro
IPR029325 ITPR-bd
IPR026648 SSFA2
IPR029326 SSFA2_C
PANTHERiPTHR17469:SF11 PTHR17469:SF11, 1 hit
PfamiView protein in Pfam
PF14722 KRAP_IP3R_bind, 1 hit
PF14723 SSFA2_C, 1 hit
SMARTiView protein in SMART
SM01257 KRAP_IP3R_bind, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P28290-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRPLSSSAE AEEELEWQVA SRRRKAWAKC RSSWQASETE DLSTEATTQD
60 70 80 90 100
EEEDEEEDLP GAQLPAAGGR GNVPNEKIAI WLKDCRTPLG ASLDEQSSST
110 120 130 140 150
LKGVLVRNGG SFEDDLSLGA EANHLHESDA QIENCNNILA KERRLQFHQK
160 170 180 190 200
GRSMNSTGSG KSSGTVSSVS ELLELYEEDP EEILYNLGFG RDEPDIASKI
210 220 230 240 250
PSRFFNSSSF AKGIDIKVFL SAQMQRMEVE NPNYALTSRF RQIEVLTTVA
260 270 280 290 300
NAFSSLYSQV SGTPLQRIGS MSSVTSNKET DPPPPLTRSN TANRLMKTLS
310 320 330 340 350
KLNLCVDKTE KGESSSPSPS AEKGKILNVS VIEESGNKND QKSQKIMKKK
360 370 380 390 400
ESSSMLATVK EEVSGSSAAV TENADSDRIS DEANSNFNQG TENEQSKETQ
410 420 430 440 450
SHESKLGEES GIVESKLDSD FNISSHSELE NSSELKSVHI STPEKEPCAP
460 470 480 490 500
LTIPSIRNIM TQQKDSFEME EVQSTEGEAP HVPATYQLGL TKSKRDHLLR
510 520 530 540 550
TASQHSDSSG FAEDSTDCLS LNHLQVQESL QAMGSSADSC DSETTVTSLG
560 570 580 590 600
EDLATPTAQD QPYFNESEEE SLVPLQKGLE KAAAVADKRK SGSQDFPQCN
610 620 630 640 650
TIENTGTKQS TCSPGDHIIE ITEVEEDLFP AETVELLREA SAESDVGKSS
660 670 680 690 700
ESEFTQYTTH HILKSLASIE AKCSDMSSEN TTGPPSSMDR VNTALQRAQM
710 720 730 740 750
KVCSLSNQRM GRSLLKSKDL LKQRYLFAKA GYPLRRSQSL PTTLLSPVRV
760 770 780 790 800
VSSVNVRLSP GKETRCSPPS FTYKYTPEEE QELEKRVMEH DGQSLVKSTI
810 820 830 840 850
FISPSSVKKE EAPQSEAPRV EECHHGRTPT CSRLAPPPMS QSTCSLHSIH
860 870 880 890 900
SEWQERPLCE HTRTLSTHSV PNISGATCSA FASPFGCPYS HRHATYPYRV
910 920 930 940 950
CSVNPPSAIE MQLRRVLHDI RNSLQNLSQY PMMRGPDPAA APYSTQKSSV
960 970 980 990 1000
LPLYENTFQE LQVMRRSLNL FRTQMMDLEL AMLRQQTMVY HHMTEEERFE
1010 1020 1030 1040 1050
VDQLQGLRNS VRMELQDLEL QLEERLLGLE EQLRAVRMPS PFRSSALMGM
1060 1070 1080 1090 1100
CGSRSADNLS CPSPLNVMEP VTELMQEQSY LKSELGLGLG EMGFEIPPGE
1110 1120 1130 1140 1150
SSESVFSQAT SESSSVCSGP SHANRRTGVP STASVGKSKT PLVARKKVFR
1160 1170 1180 1190 1200
ASVALTPTAP SRTGSVQTPP DLESSEEVDA AEGAPEVVGP KSEVEEGHGK
1210 1220 1230 1240 1250
LPSMPAAEEM HKNVEQDELQ QVIREIKESI VGEIRREIVS GLLAAVSSSK

ASNSKQDYH
Length:1,259
Mass (Da):138,386
Last modified:March 20, 2007 - v3
Checksum:iD5843D9D6D5414D7
GO
Isoform 2 (identifier: P28290-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Show »
Length:1,106
Mass (Da):121,453
Checksum:iF262E608310E9AB0
GO
Isoform 3 (identifier: P28290-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1226-1251: IKESIVGEIRREIVSGLLAAVSSSKA → VGMDPISCVILELSMICTGGGVICALEDTCC
     1252-1259: Missing.

Show »
Length:1,256
Mass (Da):137,860
Checksum:iEF4E3976E7A73534
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHV5E9PHV5_HUMAN
Protein ITPRID2
ITPRID2
1,237Annotation score:
E7EUL7E7EUL7_HUMAN
Protein ITPRID2
ITPRID2
768Annotation score:
H7BZ26H7BZ26_HUMAN
Protein ITPRID2
ITPRID2
201Annotation score:
F2Z295F2Z295_HUMAN
Protein ITPRID2
ITPRID2
46Annotation score:

Sequence cautioni

The sequence AAB00773 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH12947 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB67820 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC05308 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti292A → V in CAH18314 (PubMed:17974005).Curated1
Sequence conflicti353S → P in BAC05027 (PubMed:14702039).Curated1
Sequence conflicti405K → E in BAC05027 (PubMed:14702039).Curated1
Sequence conflicti513E → G in CAH18314 (PubMed:17974005).Curated1
Sequence conflicti993M → L in AAB00773 (PubMed:1555770).Curated1
Sequence conflicti1056A → T in AAB00773 (PubMed:1555770).Curated1
Sequence conflicti1108 – 1110QAT → KQR in AAB00773 (PubMed:1555770).Curated3
Sequence conflicti1116V → I in AAB00773 (PubMed:1555770).Curated1
Sequence conflicti1193E → ESE in AAB00773 (PubMed:1555770).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056998817A → V. Corresponds to variant dbSNP:rs16867510Ensembl.1
Natural variantiVAR_031186833R → W1 PublicationCorresponds to variant dbSNP:rs13419020Ensembl.1
Natural variantiVAR_031187836P → L2 PublicationsCorresponds to variant dbSNP:rs17647806Ensembl.1
Natural variantiVAR_0597241258Y → N. Corresponds to variant dbSNP:rs2303554Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0238651 – 153Missing in isoform 2. 2 PublicationsAdd BLAST153
Alternative sequenceiVSP_0238661226 – 1251IKESI…SSSKA → VGMDPISCVILELSMICTGG GVICALEDTCC in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_0238671252 – 1259Missing in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116937 mRNA Translation: BAC81767.1
AB067514 mRNA Translation: BAB67820.2 Different initiation.
AK091197 mRNA Translation: BAC03607.1
AK097375 mRNA Translation: BAC05027.1
AK098455 mRNA Translation: BAC05308.1 Different initiation.
AK291745 mRNA Translation: BAF84434.1
CR749488 mRNA Translation: CAH18314.1
AC009962 Genomic DNA Translation: AAY14913.1
CH471058 Genomic DNA Translation: EAX10980.1
BC012947 mRNA Translation: AAH12947.1 Different initiation.
BC028706 mRNA Translation: AAH28706.1
BC052581 mRNA Translation: AAH52581.1
BC064499 mRNA Translation: AAH64499.1
M61199 mRNA Translation: AAB00773.1 Different initiation.
CCDSiCCDS2284.1 [P28290-3]
CCDS46467.1 [P28290-1]
RefSeqiNP_001123917.1, NM_001130445.2 [P28290-1]
NP_001274432.1, NM_001287503.1
NP_001274433.1, NM_001287504.1
NP_006742.2, NM_006751.6 [P28290-3]
UniGeneiHs.196983

Genome annotation databases

EnsembliENST00000320370; ENSP00000314669; ENSG00000138434 [P28290-3]
ENST00000431877; ENSP00000388731; ENSG00000138434 [P28290-1]
GeneIDi6744
KEGGihsa:6744
UCSCiuc002uoh.5 human [P28290-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116937 mRNA Translation: BAC81767.1
AB067514 mRNA Translation: BAB67820.2 Different initiation.
AK091197 mRNA Translation: BAC03607.1
AK097375 mRNA Translation: BAC05027.1
AK098455 mRNA Translation: BAC05308.1 Different initiation.
AK291745 mRNA Translation: BAF84434.1
CR749488 mRNA Translation: CAH18314.1
AC009962 Genomic DNA Translation: AAY14913.1
CH471058 Genomic DNA Translation: EAX10980.1
BC012947 mRNA Translation: AAH12947.1 Different initiation.
BC028706 mRNA Translation: AAH28706.1
BC052581 mRNA Translation: AAH52581.1
BC064499 mRNA Translation: AAH64499.1
M61199 mRNA Translation: AAB00773.1 Different initiation.
CCDSiCCDS2284.1 [P28290-3]
CCDS46467.1 [P28290-1]
RefSeqiNP_001123917.1, NM_001130445.2 [P28290-1]
NP_001274432.1, NM_001287503.1
NP_001274433.1, NM_001287504.1
NP_006742.2, NM_006751.6 [P28290-3]
UniGeneiHs.196983

3D structure databases

ProteinModelPortaliP28290
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112622, 65 interactors
DIPiDIP-47271N
IntActiP28290, 39 interactors
MINTiP28290
STRINGi9606.ENSP00000388731

PTM databases

iPTMnetiP28290
PhosphoSitePlusiP28290

Polymorphism and mutation databases

BioMutaiSSFA2
DMDMi134047924

Proteomic databases

EPDiP28290
MaxQBiP28290
PaxDbiP28290
PeptideAtlasiP28290
PRIDEiP28290
ProteomicsDBi54458
54459 [P28290-2]
54460 [P28290-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320370; ENSP00000314669; ENSG00000138434 [P28290-3]
ENST00000431877; ENSP00000388731; ENSG00000138434 [P28290-1]
GeneIDi6744
KEGGihsa:6744
UCSCiuc002uoh.5 human [P28290-1]

Organism-specific databases

CTDi6744
DisGeNETi6744
EuPathDBiHostDB:ENSG00000138434.16
GeneCardsiSSFA2
HGNCiHGNC:11319 ITPRID2
HPAiHPA034665
HPA039989
MIMi118990 gene
neXtProtiNX_P28290
OpenTargetsiENSG00000138434
PharmGKBiPA36143
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IERU Eukaryota
ENOG410ZSFW LUCA
GeneTreeiENSGT00530000063345
HOVERGENiHBG082646
InParanoidiP28290
OMAiYPYRACS
OrthoDBiEOG091G011N
PhylomeDBiP28290
TreeFamiTF331566

Miscellaneous databases

ChiTaRSiSSFA2 human
GeneWikiiSSFA2
GenomeRNAii6744
PROiPR:P28290
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138434 Expressed in 236 organ(s), highest expression level in body of pancreas
ExpressionAtlasiP28290 baseline and differential
GenevisibleiP28290 HS

Family and domain databases

InterProiView protein in InterPro
IPR029325 ITPR-bd
IPR026648 SSFA2
IPR029326 SSFA2_C
PANTHERiPTHR17469:SF11 PTHR17469:SF11, 1 hit
PfamiView protein in Pfam
PF14722 KRAP_IP3R_bind, 1 hit
PF14723 SSFA2_C, 1 hit
SMARTiView protein in SMART
SM01257 KRAP_IP3R_bind, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITPI2_HUMAN
AccessioniPrimary (citable) accession number: P28290
Secondary accession number(s): A8K6T0
, Q68DA6, Q7Z7L2, Q8N1L3, Q8N263, Q8N7H2, Q8NEN5, Q96E36, Q96PW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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