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Entry version 170 (22 Apr 2020)
Sequence version 3 (20 Mar 2007)
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Protein

Protein ITPRID2

Gene

ITPRID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ITPRID2Curated
Alternative name(s):
Cleavage signal-1 protein1 Publication
Short name:
CS-11 Publication
ITPR-interacting domain-containing protein 2Curated
Ki-ras-induced actin-interacting protein1 Publication
Sperm-specific antigen 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITPRID2Imported
Synonyms:CS11 Publication, KIAA1927, KRAP1 Publication, SSFA2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11319 ITPRID2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
118990 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P28290

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6744

Open Targets

More...
OpenTargetsi
ENSG00000138434

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36143

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P28290 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SSFA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134047924

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000722111 – 1259Protein ITPRID2Add BLAST1259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei87PhosphothreonineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei111PhosphoserineBy similarity1
Modified residuei209PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki360Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei466PhosphoserineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1
Modified residuei737PhosphoserineCombined sources1
Modified residuei739PhosphoserineCombined sources1
Modified residuei746PhosphoserineCombined sources1
Modified residuei759PhosphoserineCombined sources1
Modified residuei767PhosphoserineCombined sources1
Modified residuei803PhosphoserineCombined sources1
Cross-linki808Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei869PhosphoserineBy similarity1
Modified residuei902PhosphoserineCombined sources1
Modified residuei1040PhosphoserineBy similarity1
Modified residuei1055PhosphoserineBy similarity1
Modified residuei1060PhosphoserineBy similarity1
Modified residuei1063PhosphoserineCombined sources1
Modified residuei1118PhosphoserineCombined sources1
Modified residuei1134PhosphoserineCombined sources1
Modified residuei1156PhosphothreonineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1168PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A 33 kDa peptide corresponding to the C-terminus of this protein is found in the testis and seems to be cleaved into 2 peptides of 14 kDa and 18 kDa found on the surface of mature sperm cells. This sperm surface antigen may be involved in some step of early cleavage of the fertilized oocyte.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P28290

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P28290

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P28290

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P28290

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P28290

PeptideAtlas

More...
PeptideAtlasi
P28290

PRoteomics IDEntifications database

More...
PRIDEi
P28290

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54458 [P28290-1]
54459 [P28290-2]
54460 [P28290-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P28290

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P28290

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in pancreas and testis. Present in colon cancer cells (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by activated KRAS.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138434 Expressed in body of pancreas and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P28290 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P28290 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138434 Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112622, 70 interactors

Database of interacting proteins

More...
DIPi
DIP-47271N

Protein interaction database and analysis system

More...
IntActi
P28290, 68 interactors

Molecular INTeraction database

More...
MINTi
P28290

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000388731

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P28290 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili959 – 1037Sequence analysisAdd BLAST79

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IERU Eukaryota
ENOG410ZSFW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158532

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007016_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P28290

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNMSSHS

Database of Orthologous Groups

More...
OrthoDBi
94956at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P28290

TreeFam database of animal gene trees

More...
TreeFami
TF331566

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029325 ITPR-bd
IPR026648 ITPRID2
IPR029326 SSFA2_C

The PANTHER Classification System

More...
PANTHERi
PTHR17469:SF11 PTHR17469:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14722 KRAP_IP3R_bind, 1 hit
PF14723 SSFA2_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01257 KRAP_IP3R_bind, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P28290-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRPLSSSAE AEEELEWQVA SRRRKAWAKC RSSWQASETE DLSTEATTQD
60 70 80 90 100
EEEDEEEDLP GAQLPAAGGR GNVPNEKIAI WLKDCRTPLG ASLDEQSSST
110 120 130 140 150
LKGVLVRNGG SFEDDLSLGA EANHLHESDA QIENCNNILA KERRLQFHQK
160 170 180 190 200
GRSMNSTGSG KSSGTVSSVS ELLELYEEDP EEILYNLGFG RDEPDIASKI
210 220 230 240 250
PSRFFNSSSF AKGIDIKVFL SAQMQRMEVE NPNYALTSRF RQIEVLTTVA
260 270 280 290 300
NAFSSLYSQV SGTPLQRIGS MSSVTSNKET DPPPPLTRSN TANRLMKTLS
310 320 330 340 350
KLNLCVDKTE KGESSSPSPS AEKGKILNVS VIEESGNKND QKSQKIMKKK
360 370 380 390 400
ESSSMLATVK EEVSGSSAAV TENADSDRIS DEANSNFNQG TENEQSKETQ
410 420 430 440 450
SHESKLGEES GIVESKLDSD FNISSHSELE NSSELKSVHI STPEKEPCAP
460 470 480 490 500
LTIPSIRNIM TQQKDSFEME EVQSTEGEAP HVPATYQLGL TKSKRDHLLR
510 520 530 540 550
TASQHSDSSG FAEDSTDCLS LNHLQVQESL QAMGSSADSC DSETTVTSLG
560 570 580 590 600
EDLATPTAQD QPYFNESEEE SLVPLQKGLE KAAAVADKRK SGSQDFPQCN
610 620 630 640 650
TIENTGTKQS TCSPGDHIIE ITEVEEDLFP AETVELLREA SAESDVGKSS
660 670 680 690 700
ESEFTQYTTH HILKSLASIE AKCSDMSSEN TTGPPSSMDR VNTALQRAQM
710 720 730 740 750
KVCSLSNQRM GRSLLKSKDL LKQRYLFAKA GYPLRRSQSL PTTLLSPVRV
760 770 780 790 800
VSSVNVRLSP GKETRCSPPS FTYKYTPEEE QELEKRVMEH DGQSLVKSTI
810 820 830 840 850
FISPSSVKKE EAPQSEAPRV EECHHGRTPT CSRLAPPPMS QSTCSLHSIH
860 870 880 890 900
SEWQERPLCE HTRTLSTHSV PNISGATCSA FASPFGCPYS HRHATYPYRV
910 920 930 940 950
CSVNPPSAIE MQLRRVLHDI RNSLQNLSQY PMMRGPDPAA APYSTQKSSV
960 970 980 990 1000
LPLYENTFQE LQVMRRSLNL FRTQMMDLEL AMLRQQTMVY HHMTEEERFE
1010 1020 1030 1040 1050
VDQLQGLRNS VRMELQDLEL QLEERLLGLE EQLRAVRMPS PFRSSALMGM
1060 1070 1080 1090 1100
CGSRSADNLS CPSPLNVMEP VTELMQEQSY LKSELGLGLG EMGFEIPPGE
1110 1120 1130 1140 1150
SSESVFSQAT SESSSVCSGP SHANRRTGVP STASVGKSKT PLVARKKVFR
1160 1170 1180 1190 1200
ASVALTPTAP SRTGSVQTPP DLESSEEVDA AEGAPEVVGP KSEVEEGHGK
1210 1220 1230 1240 1250
LPSMPAAEEM HKNVEQDELQ QVIREIKESI VGEIRREIVS GLLAAVSSSK

ASNSKQDYH
Length:1,259
Mass (Da):138,386
Last modified:March 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5843D9D6D5414D7
GO
Isoform 2 (identifier: P28290-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Show »
Length:1,106
Mass (Da):121,453
Checksum:iF262E608310E9AB0
GO
Isoform 3 (identifier: P28290-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1226-1251: IKESIVGEIRREIVSGLLAAVSSSKA → VGMDPISCVILELSMICTGGGVICALEDTCC
     1252-1259: Missing.

Show »
Length:1,256
Mass (Da):137,860
Checksum:iEF4E3976E7A73534
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHV5E9PHV5_HUMAN
Protein ITPRID2
ITPRID2
1,237Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUL7E7EUL7_HUMAN
Protein ITPRID2
ITPRID2
768Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ26H7BZ26_HUMAN
Protein ITPRID2
ITPRID2
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z295F2Z295_HUMAN
Protein ITPRID2
ITPRID2
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB00773 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH12947 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB67820 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC05308 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292A → V in CAH18314 (PubMed:17974005).Curated1
Sequence conflicti353S → P in BAC05027 (PubMed:14702039).Curated1
Sequence conflicti405K → E in BAC05027 (PubMed:14702039).Curated1
Sequence conflicti513E → G in CAH18314 (PubMed:17974005).Curated1
Sequence conflicti993M → L in AAB00773 (PubMed:1555770).Curated1
Sequence conflicti1056A → T in AAB00773 (PubMed:1555770).Curated1
Sequence conflicti1108 – 1110QAT → KQR in AAB00773 (PubMed:1555770).Curated3
Sequence conflicti1116V → I in AAB00773 (PubMed:1555770).Curated1
Sequence conflicti1193E → ESE in AAB00773 (PubMed:1555770).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056998817A → V. Corresponds to variant dbSNP:rs16867510Ensembl.1
Natural variantiVAR_031186833R → W1 PublicationCorresponds to variant dbSNP:rs13419020Ensembl.1
Natural variantiVAR_031187836P → L2 PublicationsCorresponds to variant dbSNP:rs17647806Ensembl.1
Natural variantiVAR_0597241258Y → N. Corresponds to variant dbSNP:rs2303554Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0238651 – 153Missing in isoform 2. 2 PublicationsAdd BLAST153
Alternative sequenceiVSP_0238661226 – 1251IKESI…SSSKA → VGMDPISCVILELSMICTGG GVICALEDTCC in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_0238671252 – 1259Missing in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB116937 mRNA Translation: BAC81767.1
AB067514 mRNA Translation: BAB67820.2 Different initiation.
AK091197 mRNA Translation: BAC03607.1
AK097375 mRNA Translation: BAC05027.1
AK098455 mRNA Translation: BAC05308.1 Different initiation.
AK291745 mRNA Translation: BAF84434.1
CR749488 mRNA Translation: CAH18314.1
AC009962 Genomic DNA Translation: AAY14913.1
CH471058 Genomic DNA Translation: EAX10980.1
BC012947 mRNA Translation: AAH12947.1 Different initiation.
BC028706 mRNA Translation: AAH28706.1
BC052581 mRNA Translation: AAH52581.1
BC064499 mRNA Translation: AAH64499.1
M61199 mRNA Translation: AAB00773.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2284.1 [P28290-3]
CCDS46467.1 [P28290-1]

NCBI Reference Sequences

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RefSeqi
NP_001123917.1, NM_001130445.2 [P28290-1]
NP_001274432.1, NM_001287503.1
NP_001274433.1, NM_001287504.1
NP_006742.2, NM_006751.6 [P28290-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000320370; ENSP00000314669; ENSG00000138434 [P28290-3]
ENST00000431877; ENSP00000388731; ENSG00000138434 [P28290-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6744

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6744

UCSC genome browser

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UCSCi
uc002uoh.5 human [P28290-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116937 mRNA Translation: BAC81767.1
AB067514 mRNA Translation: BAB67820.2 Different initiation.
AK091197 mRNA Translation: BAC03607.1
AK097375 mRNA Translation: BAC05027.1
AK098455 mRNA Translation: BAC05308.1 Different initiation.
AK291745 mRNA Translation: BAF84434.1
CR749488 mRNA Translation: CAH18314.1
AC009962 Genomic DNA Translation: AAY14913.1
CH471058 Genomic DNA Translation: EAX10980.1
BC012947 mRNA Translation: AAH12947.1 Different initiation.
BC028706 mRNA Translation: AAH28706.1
BC052581 mRNA Translation: AAH52581.1
BC064499 mRNA Translation: AAH64499.1
M61199 mRNA Translation: AAB00773.1 Different initiation.
CCDSiCCDS2284.1 [P28290-3]
CCDS46467.1 [P28290-1]
RefSeqiNP_001123917.1, NM_001130445.2 [P28290-1]
NP_001274432.1, NM_001287503.1
NP_001274433.1, NM_001287504.1
NP_006742.2, NM_006751.6 [P28290-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112622, 70 interactors
DIPiDIP-47271N
IntActiP28290, 68 interactors
MINTiP28290
STRINGi9606.ENSP00000388731

PTM databases

iPTMnetiP28290
PhosphoSitePlusiP28290

Polymorphism and mutation databases

BioMutaiSSFA2
DMDMi134047924

Proteomic databases

EPDiP28290
jPOSTiP28290
MassIVEiP28290
MaxQBiP28290
PaxDbiP28290
PeptideAtlasiP28290
PRIDEiP28290
ProteomicsDBi54458 [P28290-1]
54459 [P28290-2]
54460 [P28290-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33982 94 antibodies

Genome annotation databases

EnsembliENST00000320370; ENSP00000314669; ENSG00000138434 [P28290-3]
ENST00000431877; ENSP00000388731; ENSG00000138434 [P28290-1]
GeneIDi6744
KEGGihsa:6744
UCSCiuc002uoh.5 human [P28290-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6744
DisGeNETi6744

GeneCards: human genes, protein and diseases

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GeneCardsi
ITPRID2
HGNCiHGNC:11319 ITPRID2
HPAiENSG00000138434 Tissue enhanced (pancreas)
MIMi118990 gene
neXtProtiNX_P28290
OpenTargetsiENSG00000138434
PharmGKBiPA36143

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IERU Eukaryota
ENOG410ZSFW LUCA
GeneTreeiENSGT00940000158532
HOGENOMiCLU_007016_0_0_1
InParanoidiP28290
OMAiFNMSSHS
OrthoDBi94956at2759
PhylomeDBiP28290
TreeFamiTF331566

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SSFA2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SSFA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6744
PharosiP28290 Tbio

Protein Ontology

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PROi
PR:P28290
RNActiP28290 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000138434 Expressed in body of pancreas and 235 other tissues
ExpressionAtlasiP28290 baseline and differential
GenevisibleiP28290 HS

Family and domain databases

InterProiView protein in InterPro
IPR029325 ITPR-bd
IPR026648 ITPRID2
IPR029326 SSFA2_C
PANTHERiPTHR17469:SF11 PTHR17469:SF11, 1 hit
PfamiView protein in Pfam
PF14722 KRAP_IP3R_bind, 1 hit
PF14723 SSFA2_C, 1 hit
SMARTiView protein in SMART
SM01257 KRAP_IP3R_bind, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITPI2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28290
Secondary accession number(s): A8K6T0
, Q68DA6, Q7Z7L2, Q8N1L3, Q8N263, Q8N7H2, Q8NEN5, Q96E36, Q96PW1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: March 20, 2007
Last modified: April 22, 2020
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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