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Protein

Protein UL56

Gene

UL56

Organism
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the transport and release of virions form the host cytoplasm to the extracellular space. Relocalizes host NEDD4, a cytosolic E3 ligase, to cytoplasmic vesicles.3 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL56
Gene namesi
Name:UL56
OrganismiHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Taxonomic identifieri10315 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000001874 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001161251 – 235Protein UL56Add BLAST235

Proteomic databases

PRIDEiP28282

Interactioni

Subunit structurei

Interacts with host ITCH; this interaction mediates ITCH degradation (PubMed:20682038). Interacts with host NEDD4; this interaction increases NEDD4 ubiquitination (PubMed:18353951).2 Publications

Protein-protein interaction databases

BioGridi1677950, 2 interactors
ELMiP28282

Structurei

3D structure databases

SMRiP28282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae UL56 family.Curated

Phylogenomic databases

OrthoDBiVOG090002R0

Family and domain databases

InterProiView protein in InterPro
IPR007620 Herpes_UL56
PfamiView protein in Pfam
PF04534 Herpes_UL56, 1 hit

Sequencei

Sequence statusi: Complete.

P28282-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGAGHAHA CRDDGDDSVI DAPPPYESVA GASAGQFVVI DIDTPTDSPP
60 70 80 90 100
PYSAGTSPVG LVSPASSGDG EVCERGRSRR AAWRAARRAR RRAERRARRR
110 120 130 140 150
SFGPGGLFVE TPLFLPETMI GAHPGVGGDL PSGLPTYAEA TSDRPPTYAM
160 170 180 190 200
VMAACPTEPP GGSVGPADQP RVQSSRTWRP PLVNSRELYR AQRAARCASS
210 220 230
SDTPQAPGWC GGTCRHAVFG VVAVVVVIIL AFLWR
Length:235
Mass (Da):24,715
Last modified:December 1, 1992 - v1
Checksum:iFABB671E49610BC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10471 Genomic DNA Translation: BAA01271.1
Z86099 Genomic DNA Translation: CAB06704.1
PIRiJQ1500 WMBEXC
RefSeqiYP_009137209.1, NC_001798.2

Genome annotation databases

GeneIDi1487345
KEGGivg:1487345

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10471 Genomic DNA Translation: BAA01271.1
Z86099 Genomic DNA Translation: CAB06704.1
PIRiJQ1500 WMBEXC
RefSeqiYP_009137209.1, NC_001798.2

3D structure databases

SMRiP28282
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1677950, 2 interactors
ELMiP28282

Proteomic databases

PRIDEiP28282

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1487345
KEGGivg:1487345

Phylogenomic databases

OrthoDBiVOG090002R0

Family and domain databases

InterProiView protein in InterPro
IPR007620 Herpes_UL56
PfamiView protein in Pfam
PF04534 Herpes_UL56, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUL56_HHV2H
AccessioniPrimary (citable) accession number: P28282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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