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Entry version 151 (13 Nov 2019)
Sequence version 2 (01 Jun 1994)
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Protein

5-oxoprolinase

Gene

OXP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.2 Publications

Miscellaneous

Present with 3180 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=159 µM for 5-oxoproline1 Publication
  1. Vmax=3.5 nmol/h/µg enzyme1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 5-oxoprolinase (ATP-hydrolyzing) activity Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31973-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.2.9 984

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-174403 Glutathione synthesis and recycling

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P28273

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-oxoprolinase (EC:3.5.2.9)
Alternative name(s):
5-oxo-L-prolinase
Short name:
5-OPase
Pyroglutamase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OXP1
Ordered Locus Names:YKL215C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YKL215C

Saccharomyces Genome Database

More...
SGDi
S000001698 OXP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11D → A: Impairs ATPase and 5-oxoprolinase activity. 1 Publication1
Mutagenesisi324D → A: Impairs ATPase and 5-oxoprolinase activity. 1 Publication1
Mutagenesisi497G → A: Impairs ATPase and 5-oxoprolinase activity; when associated with A-498. 1 Publication1
Mutagenesisi498G → A: Impairs ATPase and 5-oxoprolinase activity; when associated with A-497. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002085821 – 12865-oxoprolinaseAdd BLAST1286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei930PhosphoserineCombined sources1
Modified residuei1077PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P28273

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P28273

PRoteomics IDEntifications database

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PRIDEi
P28273

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P28273

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33950, 58 interactors

Database of interacting proteins

More...
DIPi
DIP-6558N

Protein interaction database and analysis system

More...
IntActi
P28273, 5 interactors

Molecular INTeraction database

More...
MINTi
P28273

STRING: functional protein association networks

More...
STRINGi
4932.YKL215C

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the oxoprolinase family.Curated

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P28273

KEGG Orthology (KO)

More...
KOi
K01469

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRYMYAI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008040 Hydant_A_N
IPR002821 Hydantoinase_A
IPR003692 Hydantoinase_B

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05378 Hydant_A_N, 1 hit
PF01968 Hydantoinase_A, 1 hit
PF02538 Hydantoinase_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P28273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKGNIRIAI DKGGTFTDCV GNIGTGKQEH DTVIKLLSVD PKNYPDAPLE
60 70 80 90 100
GIRRLLEVLE HKTIPRGIPL DISNVRSLRM GTTLATNCAL ERNGERCAFI
110 120 130 140 150
TTKGFKDSLL IGDQTRPDIF NLNIKKVVPL YDTVVEIDER VTLEDFSEDP
160 170 180 190 200
YFTKSSPNEQ EGILEGNSGE MVRVIKKPDE SSVRSILKVL YASGIKSIAI
210 220 230 240 250
AFLHSYTFPD HERIVGNIAR EIGFSHVSLS SEVSPMIKFL PRAHSSVADA
260 270 280 290 300
YLTPVIKKYL NSISAGLSHA EDTHIQFMQS DGGLVDGGKF SGLKSILSGP
310 320 330 340 350
AGGVIGYSST CYDKNNNIPL IGFDMGGTST DVSRYGDGRL EHVFETVTAG
360 370 380 390 400
IIIQSPQLDI HTVAAGGSSI LSWKNGLFRV GPDSAAADPG PAAYRKGGPL
410 420 430 440 450
TITDANLFLG RLVPEFFPKI FGPNEDESLD LETTTLKFRE LTDVINKDLN
460 470 480 490 500
SNLTMEEVAY GFIKVANECM ARPVRAITEA KGHVVSQHRL VSFGGAGGQH
510 520 530 540 550
AIAVADSLGI DTVLIHRYSS ILSAYGIFLA DVIEENQEPC SFILGEPETI
560 570 580 590 600
LKVKKRFLEL SKNSIKNLLS QSFSREDIVL ERYLNLRYEG TETSLMILQK
610 620 630 640 650
YDDQWNFREW FSEAHKKEFG FSFDDKRIII DDIRIRAIGK SGVRKEKTVD
660 670 680 690 700
EQLIEISHFK KADVSKDASF TQKAYFDNKW VDTAVFKIDD LPAGTIIEGP
710 720 730 740 750
AILADGTQTN IILPNSQATI LNSHIFIKIN QKAAKTLSKS GYELDIDPIL
760 770 780 790 800
LSIFSHRFMD IALQMGTQLR KTSVSTNVKE RLDFSCALFD SKGNLVANAP
810 820 830 840 850
HVPVHLGSMS TCISAQAKLW EGKLKPGDVL ITNHPDIGGT HLPDITVITP
860 870 880 890 900
SFSSTGELIF YVASRAHHAD IGGILPGSVP PNSKELYEEG TAIYSELVVK
910 920 930 940 950
EGIFQEELIY KLFVEDPGKY PGCSGSRRFS DNISDLKAQV AANTKGIQLI
960 970 980 990 1000
GSLTKEYDLA TILKYMAAIQ TNASESIKKM LAKMVEHFGT TKFSGEDRLD
1010 1020 1030 1040 1050
DGSLIKLQVI IRPEKEEYIF NFDGTSPQVY GNLNAPEAIT NSAILYCLRC
1060 1070 1080 1090 1100
LVGEDIPLNQ GCLKPLTIKI PAGSLLSPRS GAAVVGGNVL TSQRVTDVIL
1110 1120 1130 1140 1150
KTFNVMADSQ GDCNNFTFGT GGNSGNKTDK QIKGFGYYET ICGGSGAGAD
1160 1170 1180 1190 1200
SWRGSGWNGS DAVHTNMTNT RMTDTEVFER RYPVLLKEFS IRRGSGGKGK
1210 1220 1230 1240 1250
YTGGNGVVRD VQFRKAVTAS ILSERRVIGP HGIKGGQDGS RGENLWVRHS
1260 1270 1280
TGALINVGGK NTIYAQPGDR FIIKTPGGGG FGQYKD
Length:1,286
Mass (Da):140,428
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A0B8C609B5D6FFF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75951 Genomic DNA Translation: CAA53558.1
Z28215 Genomic DNA Translation: CAA82060.1
X59371 Genomic DNA Translation: CAA42015.1
M83295 Genomic DNA Translation: AAA34567.1
BK006944 Genomic DNA Translation: DAA08954.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S38058

NCBI Reference Sequences

More...
RefSeqi
NP_012707.1, NM_001179780.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL215C_mRNA; YKL215C; YKL215C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853665

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL215C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75951 Genomic DNA Translation: CAA53558.1
Z28215 Genomic DNA Translation: CAA82060.1
X59371 Genomic DNA Translation: CAA42015.1
M83295 Genomic DNA Translation: AAA34567.1
BK006944 Genomic DNA Translation: DAA08954.1
PIRiS38058
RefSeqiNP_012707.1, NM_001179780.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi33950, 58 interactors
DIPiDIP-6558N
IntActiP28273, 5 interactors
MINTiP28273
STRINGi4932.YKL215C

PTM databases

iPTMnetiP28273

Proteomic databases

MaxQBiP28273
PaxDbiP28273
PRIDEiP28273

Genome annotation databases

EnsemblFungiiYKL215C_mRNA; YKL215C; YKL215C
GeneIDi853665
KEGGisce:YKL215C

Organism-specific databases

EuPathDBiFungiDB:YKL215C
SGDiS000001698 OXP1

Phylogenomic databases

InParanoidiP28273
KOiK01469
OMAiHRYMYAI

Enzyme and pathway databases

BioCyciYEAST:G3O-31973-MONOMER
BRENDAi3.5.2.9 984
ReactomeiR-SCE-174403 Glutathione synthesis and recycling
SABIO-RKiP28273

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P28273

Family and domain databases

InterProiView protein in InterPro
IPR008040 Hydant_A_N
IPR002821 Hydantoinase_A
IPR003692 Hydantoinase_B
PfamiView protein in Pfam
PF05378 Hydant_A_N, 1 hit
PF01968 Hydantoinase_A, 1 hit
PF02538 Hydantoinase_B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPLA_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28273
Secondary accession number(s): D6VWY8, O60212
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 1, 1994
Last modified: November 13, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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