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UniProtKB - P28264 (FTSA_BACSU)
Protein
Cell division protein FtsA
Gene
ftsA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Cell division protein that is required for the assembly of the Z ring (PubMed:16159787).
May serve as a membrane anchor for the Z ring (By similarity).
Binds and hydrolyzes ATP (PubMed:11298280).
Also involved in sporulation (Probable).
By similarity2 Publications2 PublicationsMiscellaneous
In B.subtilis, unlike the situation in E.coli, the role of FtsA in the recruitment of other division proteins to the division site appears to be an indirect one, through ensuring that FtsZ forms a proper ring.1 Publication
GO - Molecular functioni
- ATP hydrolysis activity Source: CACAO
GO - Biological processi
- cell division Source: GO_Central
- FtsZ-dependent cytokinesis Source: UniProtKB-UniRule
- sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Keywordsi
Biological process | Cell cycle, Cell division, Sporulation |
Enzyme and pathway databases
BioCyci | BSUB:BSU15280-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division protein FtsAUniRule annotation |
Gene namesi | Name:ftsAUniRule annotation Ordered Locus Names:BSU15280 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Localizes to the Z ring in an FtsZ-dependent manner (PubMed:11298280). In sporulating cells, preferentially localizes to only one of the two potential polar division sites (PubMed:11298280). Targeted to the membrane through a conserved C-terminal amphipathic helix (By similarity).By similarity1 Publication
Plasma Membrane
- cytoplasmic side of plasma membrane Source: GO_Central
Other locations
- cell division site Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000062729 | 1 – 440 | Cell division protein FtsAAdd BLAST | 440 |
Proteomic databases
jPOSTi | P28264 |
PaxDbi | P28264 |
PRIDEi | P28264 |
Expressioni
Inductioni
Transcription is controlled by three promoters. Two of these promoters, P1 and P3 are expressed mainly during vegetative growth. The third one, P2, is up-regulated around the onset of sporulation.2 Publications
Interactioni
Subunit structurei
Binary interactionsi
Protein-protein interaction databases
IntActi | P28264, 25 interactors |
STRINGi | 224308.BSU15280 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 396 – 440 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 399 – 431 | Basic and acidic residuesSequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0849, Bacteria |
InParanoidi | P28264 |
OMAi | DGIIRHT |
PhylomeDBi | P28264 |
Family and domain databases
HAMAPi | MF_02033, FtsA, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR020823, Cell_div_FtsA IPR003494, SHS2_FtsA |
Pfami | View protein in Pfam PF02491, SHS2_FTSA, 1 hit |
PIRSFi | PIRSF003101, FtsA, 1 hit |
SMARTi | View protein in SMART SM00842, FtsA, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR01174, ftsA, 1 hit |
i Sequence
Sequence statusi: Complete.
P28264-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNNELYVSL DIGTSNTKVI VGEMTDDSLN IIGVGNVPSE GLKKGSIVDI
60 70 80 90 100
DETVHSIRKA FDQAERMVGF PLRKAIVGVN GNYINIQDTN GVVAVSSENK
110 120 130 140 150
EIQVEDVRRV MEAAQVVSVP HEQLIVDVIP KQFIVDGRDE ITDPKKMLGV
160 170 180 190 200
RLEVEGTLIT GSKTILHNLL RCVERAGIEI TDICLQPLAA GSAALSKDEK
210 220 230 240 250
NLGVALIDIG GGSTTIAVFQ NGHLTSTRVI PLGGENITKD ISIGLRTSTE
260 270 280 290 300
EAERVKKQLG HAYYDEASED EIFEVTVIGT NQKQTFTQQE AANIIEARVE
310 320 330 340 350
EILEIVSEEL RSMGITDLPG GFVLTGGQAA MPGVMSLAQD VLQNNVRVAS
360 370 380 390 400
PNYIGVRDPQ YMTGVGLIQF ACRNARIQGR KIGFKMPEEA IQEIAVSSSE
410 420 430 440
EQEQHHHQNE VQQRPKGKQK TQAEHNKQSK MKKLLSMFWE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | I → L in AAA22456 (PubMed:3139638).Curated | 1 | |
Sequence conflicti | 26 | D → G in AAA22456 (PubMed:3139638).Curated | 1 | |
Sequence conflicti | 112 | E → A in AAA22456 (PubMed:3139638).Curated | 1 | |
Sequence conflicti | 349 – 350 | AS → QG in AAA22456 (PubMed:3139638).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22630 Genomic DNA Translation: AAA22456.1 AL009126 Genomic DNA Translation: CAB13401.2 X66239 Genomic DNA Translation: CAA46968.1 S39431 Genomic DNA Translation: AAD13818.1 |
PIRi | I39847 |
RefSeqi | NP_389411.2, NC_000964.3 WP_009967186.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB13401; CAB13401; BSU_15280 |
GeneIDi | 936145 |
KEGGi | bsu:BSU15280 |
PATRICi | fig|224308.179.peg.1666 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22630 Genomic DNA Translation: AAA22456.1 AL009126 Genomic DNA Translation: CAB13401.2 X66239 Genomic DNA Translation: CAA46968.1 S39431 Genomic DNA Translation: AAD13818.1 |
PIRi | I39847 |
RefSeqi | NP_389411.2, NC_000964.3 WP_009967186.1, NZ_JNCM01000035.1 |
3D structure databases
SMRi | P28264 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P28264, 25 interactors |
STRINGi | 224308.BSU15280 |
Proteomic databases
jPOSTi | P28264 |
PaxDbi | P28264 |
PRIDEi | P28264 |
Genome annotation databases
EnsemblBacteriai | CAB13401; CAB13401; BSU_15280 |
GeneIDi | 936145 |
KEGGi | bsu:BSU15280 |
PATRICi | fig|224308.179.peg.1666 |
Phylogenomic databases
eggNOGi | COG0849, Bacteria |
InParanoidi | P28264 |
OMAi | DGIIRHT |
PhylomeDBi | P28264 |
Enzyme and pathway databases
BioCyci | BSUB:BSU15280-MONOMER |
Family and domain databases
HAMAPi | MF_02033, FtsA, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR020823, Cell_div_FtsA IPR003494, SHS2_FtsA |
Pfami | View protein in Pfam PF02491, SHS2_FTSA, 1 hit |
PIRSFi | PIRSF003101, FtsA, 1 hit |
SMARTi | View protein in SMART SM00842, FtsA, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR01174, ftsA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FTSA_BACSU | |
Accessioni | P28264Primary (citable) accession number: P28264 Secondary accession number(s): Q45573 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | June 16, 2009 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families