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UniProtKB - P28246 (BCR_ECOLI)

Protein

Bicyclomycin resistance protein

Gene

bcr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance (PubMed:2694948). Probable membrane translocase. A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth (PubMed:20067529). Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide (PubMed:20067529).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dipeptide transmembrane transporter activity Source: EcoCyc
  • drug transmembrane transporter activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntibiotic resistance, Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:BCR-MONOMER
MetaCyc:BCR-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.2.7 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bicyclomycin resistance protein
Alternative name(s):
Sulfonamide resistance protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bcr
Synonyms:bicA, bicR, sur1 Publication, suxA
Ordered Locus Names:b2182, JW5363
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...EcoGenei		EG11419 bcr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 26HelicalSequence analysisAdd BLAST18
Topological domaini27 – 48PeriplasmicSequence analysisAdd BLAST22
Transmembranei49 – 65HelicalSequence analysisAdd BLAST17
Topological domaini66 – 76CytoplasmicSequence analysisAdd BLAST11
Transmembranei77 – 98HelicalSequence analysisAdd BLAST22
Topological domaini99 – 105PeriplasmicSequence analysis7
Transmembranei106 – 122HelicalSequence analysisAdd BLAST17
Topological domaini123 – 137CytoplasmicSequence analysisAdd BLAST15
Transmembranei138 – 159HelicalSequence analysisAdd BLAST22
Topological domaini160 – 165PeriplasmicSequence analysis6
Transmembranei166 – 185HelicalSequence analysisAdd BLAST20
Topological domaini186 – 214CytoplasmicSequence analysisAdd BLAST29
Transmembranei215 – 239HelicalSequence analysisAdd BLAST25
Topological domaini240 – 250PeriplasmicSequence analysisAdd BLAST11
Transmembranei251 – 268HelicalSequence analysisAdd BLAST18
Topological domaini269 – 285CytoplasmicSequence analysisAdd BLAST17
Transmembranei286 – 302HelicalSequence analysisAdd BLAST17
Topological domaini303 – 308PeriplasmicSequence analysis6
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 344CytoplasmicSequence analysisAdd BLAST12
Transmembranei345 – 366HelicalSequence analysisAdd BLAST22
Topological domaini367 – 372PeriplasmicSequence analysis6
Transmembranei373 – 390HelicalSequence analysisAdd BLAST18
Topological domaini391 – 396Cytoplasmic1 Publication6

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
View the complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001733151 – 396Bicyclomycin resistance proteinAdd BLAST396

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P28246

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P28246

PRoteomics IDEntifications database

More...PRIDEi		P28246

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4260471, 162 interactors

STRING: functional protein association networks

More...STRINGi		316385.ECDH10B_2340

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P28246

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P28246

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Bcr/CmlA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105C2C Bacteria
ENOG410XNNX LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000143171

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P28246

KEGG Orthology (KO)

More...KOi		K07552

Database for complete collections of gene phylogenies

More...PhylomeDBi		P28246

Family and domain databases

Conserved Domains Database

More...CDDi		cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004812 Efflux_drug-R_Bcr/CmlA
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004734 Multidrug-R

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690 MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00880 2_A_01_02, 1 hit
TIGR00710 efflux_Bcr_CflA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P28246-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTRQHSSFA IVFILGLLAM LMPLSIDMYL PALPVISAQF GVPAGSTQMT 
        60         70         80         90        100
LSTYILGFAL GQLIYGPMAD SFGRKPVVLG GTLVFAAAAV ACALANTIDQ 
       110        120        130        140        150
LIVMRFFHGL AAAAASVVIN ALMRDIYPKE EFSRMMSFVM LVTTIAPLMA 
       160        170        180        190        200
PIVGGWVLVW LSWHYIFWIL ALAAILASAM IFFLIKETLP PERRQPFHIR 
       210        220        230        240        250
TTIGNFAALF RHKRVLSYML ASGFSFAGMF SFLSAGPFVY IEINHVAPEN 
       260        270        280        290        300
FGYYFALNIV FLFVMTIFNS RFVRRIGALN MFRSGLWIQF IMAAWMVISA 
       310        320        330        340        350
LLGLGFWSLV VGVAAFVGCV SMVSSNAMAV ILDEFPHMAG TASSLAGTFR 
       360        370        380        390 
FGIGAIVGAL LSLATFNSAW PMIWSIAFCA TSSILFCLYA SRPKKR
Length:396
Mass (Da):43,353
Last modified:July 19, 2003 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD609AE35370E6A1D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA16406 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA45230 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99D → V in CAA45230 (PubMed:8486276).Curated1
Sequence conflicti246V → I (Ref. 1) Curated1
Sequence conflicti246V → I in CAA45230 (PubMed:8486276).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X63703 Genomic DNA Translation: CAA45230.1 Different initiation.
U00008 Genomic DNA Translation: AAA16406.1 Different initiation.
U00096 Genomic DNA Translation: AAC75243.1
AP009048 Genomic DNA Translation: BAE76647.1

Protein sequence database of the Protein Information Resource

More...PIRi		E64987

NCBI Reference Sequences

More...RefSeqi		NP_416687.1, NC_000913.3
WP_000213361.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75243; AAC75243; b2182
BAE76647; BAE76647; BAE76647

Database of genes from NCBI RefSeq genomes

More...GeneIDi		944808

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW5363
eco:b2182

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.54

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63703 Genomic DNA Translation: CAA45230.1 Different initiation.
U00008 Genomic DNA Translation: AAA16406.1 Different initiation.
U00096 Genomic DNA Translation: AAC75243.1
AP009048 Genomic DNA Translation: BAE76647.1
PIRiE64987
RefSeqiNP_416687.1, NC_000913.3
WP_000213361.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP28246
SMRiP28246
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260471, 162 interactors
STRINGi316385.ECDH10B_2340

Protein family/group databases

TCDBi2.A.1.2.7 the major facilitator superfamily (mfs)

Proteomic databases

EPDiP28246
PaxDbiP28246
PRIDEiP28246

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75243; AAC75243; b2182
BAE76647; BAE76647; BAE76647
GeneIDi944808
KEGGiecj:JW5363
eco:b2182
PATRICifig|1411691.4.peg.54

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1390
EcoGeneiEG11419 bcr

Phylogenomic databases

eggNOGiENOG4105C2C Bacteria
ENOG410XNNX LUCA
HOGENOMiHOG000143171
InParanoidiP28246
KOiK07552
PhylomeDBiP28246

Enzyme and pathway databases

BioCyciEcoCyc:BCR-MONOMER
MetaCyc:BCR-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P28246

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004812 Efflux_drug-R_Bcr/CmlA
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004734 Multidrug-R
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00880 2_A_01_02, 1 hit
TIGR00710 efflux_Bcr_CflA, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCR_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28246
Secondary accession number(s): Q2MAQ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 19, 2003
Last modified: November 7, 2018
This is version 144 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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