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Protein

Inorganic pyrophosphatase, mitochondrial

Gene

PPA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis.

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi152Magnesium 1By similarity1
Metal bindingi157Magnesium 1By similarity1
Metal bindingi157Magnesium 2By similarity1
Metal bindingi189Magnesium 1By similarity1

GO - Molecular functioni

  • inorganic diphosphatase activity Source: SGD
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • aerobic respiration Source: SGD
  • phosphate-containing compound metabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YMR267W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase, mitochondrial (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:PPA2
Synonyms:IPP2
Ordered Locus Names:YMR267W
ORF Names:YM8156.09
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR267W
SGDiS000004880 PPA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000002541331 – 310Inorganic pyrophosphatase, mitochondrialAdd BLAST280

Proteomic databases

MaxQBiP28239
PaxDbiP28239
PRIDEiP28239

Interactioni

Subunit structurei

Homodimer that binds non-covalently to a protein complex in the inner mitochondrial membrane.By similarity

Protein-protein interaction databases

BioGridi35445, 418 interactors
DIPiDIP-1522N
IntActiP28239, 6 interactors
MINTiP28239
STRINGi4932.YMR267W

Structurei

3D structure databases

ProteinModelPortaliP28239
SMRiP28239
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000017004
HOGENOMiHOG000195569
InParanoidiP28239
KOiK01507
OMAiDGGEINC
OrthoDBiEOG092C3VG0

Family and domain databases

CDDicd00412 pyrophosphatase, 1 hit
Gene3Di3.90.80.10, 1 hit
InterProiView protein in InterPro
IPR008162 Pyrophosphatase
IPR036649 Pyrophosphatase_sf
PANTHERiPTHR10286 PTHR10286, 1 hit
PfamiView protein in Pfam
PF00719 Pyrophosphatase, 1 hit
SUPFAMiSSF50324 SSF50324, 1 hit
PROSITEiView protein in PROSITE
PS00387 PPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLRMNALT SKARSIERLK QTLNILSIRN HRQFSTIQQG SKYTLGFKKY
60 70 80 90 100
LTLLNGEVGS FFHDVPLDLN EHEKTVNMIV EVPRWTTGKF EISKELRFNP
110 120 130 140 150
IVQDTKNGKL RFVNNIFPYH GYIHNYGAIP QTWEDPTIEH KLGKCDVALK
160 170 180 190 200
GDNDPLDCCE IGSDVLEMGS IKKVKVLGSL ALIDDGELDW KVIVIDVNDP
210 220 230 240 250
LSSKIDDLEK IEEYFPGILD TTREWFRKYK VPAGKPLNSF AFHEQYQNSN
260 270 280 290 300
KTIQTIKKCH NSWKNLISGS LQEKYDNLPN TERAGNGVTL EDSVKPPSQI
310
PPEVQKWYYV
Length:310
Mass (Da):35,573
Last modified:December 1, 1992 - v1
Checksum:i985F6E9BDD50BA25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81880 Genomic DNA Translation: AAA34893.1
Z49260 Genomic DNA Translation: CAA89250.1
BK006946 Genomic DNA Translation: DAA10167.1
PIRiA40867
RefSeqiNP_013994.1, NM_001182774.1

Genome annotation databases

EnsemblFungiiYMR267W; YMR267W; YMR267W
GeneIDi855309
KEGGisce:YMR267W

Similar proteinsi

Entry informationi

Entry nameiIPYR2_YEAST
AccessioniPrimary (citable) accession number: P28239
Secondary accession number(s): D6W093
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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