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Protein

Gap junction alpha-4 protein

Gene

Gja4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • blood vessel development Source: MGI
  • calcium ion transport Source: MGI
  • cell-cell signaling Source: MGI
  • endothelium development Source: Ensembl
  • response to pain Source: Ensembl

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-4 protein
Alternative name(s):
Connexin-37
Short name:
Cx37
Gene namesi
Name:Gja4
Synonyms:Cxn-37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95715 Gja4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Topological domaini100 – 148CytoplasmicSequence analysisAdd BLAST49
Transmembranei149 – 171HelicalSequence analysisAdd BLAST23
Topological domaini172 – 208ExtracellularSequence analysisAdd BLAST37
Transmembranei209 – 231HelicalSequence analysisAdd BLAST23
Topological domaini232 – 333CytoplasmicSequence analysisAdd BLAST102

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578151 – 333Gap junction alpha-4 proteinAdd BLAST333

Proteomic databases

PaxDbiP28235
PRIDEiP28235

PTM databases

iPTMnetiP28235
PhosphoSitePlusiP28235

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

BgeeiENSMUSG00000050234 Expressed in 162 organ(s), highest expression level in primary oocyte
CleanExiMM_GJA4
ExpressionAtlasiP28235 baseline and differential
GenevisibleiP28235 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062320

Structurei

3D structure databases

ProteinModelPortaliP28235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF97 Eukaryota
ENOG4110JTW LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP28235
KOiK07613
OMAiSDFECNT
OrthoDBiEOG091G0FKH
PhylomeDBiP28235
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002263 Connexin37
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01134 CONNEXINA4
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28235-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS
60 70 80 90 100
DFECNTAQPG CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS
110 120 130 140 150
RREERLRQKE GELRALPSKD LHVERALAAI EHQMAKISVA EDGRLRIRGA
160 170 180 190 200
LMGTYVVSVL CKSVLEAGFL YGQWRLYGWT MEPVFVCQRA PCPHIVDCYV
210 220 230 240 250
SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI KARRDHDARP
260 270 280 290 300
AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL
310 320 330
TSSRPPPFVN TAPQGGRKSP SRPNSSASKK QYV
Length:333
Mass (Da):37,596
Last modified:January 23, 2007 - v2
Checksum:iC73D2B2AC0D926C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti54C → Q Requires 2 nucleotide substitutions. 1 Publication1
Natural varianti59P → A1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57971 Genomic DNA Translation: CAA41037.1
AF216832 mRNA Translation: AAF91221.1
CCDSiCCDS18667.1
PIRiA40548
RefSeqiNP_032146.1, NM_008120.3
UniGeneiMm.24615

Genome annotation databases

EnsembliENSMUST00000053753; ENSMUSP00000062320; ENSMUSG00000050234
GeneIDi14612
KEGGimmu:14612
UCSCiuc008uur.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57971 Genomic DNA Translation: CAA41037.1
AF216832 mRNA Translation: AAF91221.1
CCDSiCCDS18667.1
PIRiA40548
RefSeqiNP_032146.1, NM_008120.3
UniGeneiMm.24615

3D structure databases

ProteinModelPortaliP28235
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062320

PTM databases

iPTMnetiP28235
PhosphoSitePlusiP28235

Proteomic databases

PaxDbiP28235
PRIDEiP28235

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053753; ENSMUSP00000062320; ENSMUSG00000050234
GeneIDi14612
KEGGimmu:14612
UCSCiuc008uur.2 mouse

Organism-specific databases

CTDi2701
MGIiMGI:95715 Gja4

Phylogenomic databases

eggNOGiENOG410IF97 Eukaryota
ENOG4110JTW LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP28235
KOiK07613
OMAiSDFECNT
OrthoDBiEOG091G0FKH
PhylomeDBiP28235
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Miscellaneous databases

ChiTaRSiGja4 mouse
PROiPR:P28235
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050234 Expressed in 162 organ(s), highest expression level in primary oocyte
CleanExiMM_GJA4
ExpressionAtlasiP28235 baseline and differential
GenevisibleiP28235 MM

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002263 Connexin37
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01134 CONNEXINA4
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXA4_MOUSE
AccessioniPrimary (citable) accession number: P28235
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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