Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction beta-3 protein

Gene

Gjb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-3 protein
Alternative name(s):
Connexin-31
Short name:
Cx31
Gene namesi
Name:Gjb3
Synonyms:Cxn-31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95721 Gjb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 126CytoplasmicSequence analysisAdd BLAST28
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Topological domaini150 – 188ExtracellularSequence analysisAdd BLAST39
Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
Topological domaini212 – 270CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578631 – 270Gap junction beta-3 proteinAdd BLAST270

Proteomic databases

MaxQBiP28231
PaxDbiP28231
PeptideAtlasiP28231
PRIDEiP28231

PTM databases

iPTMnetiP28231
PhosphoSitePlusiP28231

Expressioni

Gene expression databases

BgeeiENSMUSG00000042367 Expressed in 126 organ(s), highest expression level in placenta
CleanExiMM_GJB3
GenevisibleiP28231 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gja1P232422EBI-1767245,EBI-298630

Protein-protein interaction databases

BioGridi199933, 3 interactors
IntActiP28231, 2 interactors
STRINGi10090.ENSMUSP00000046755

Structurei

3D structure databases

ProteinModelPortaliP28231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP28231
KOiK07622
OMAiHTLWHGF
OrthoDBiEOG091G0FKH
PhylomeDBiP28231
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002269 Connexin31
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF65 PTHR11984:SF65, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01140 CONNEXINB3
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28231-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDWKKLQDLL SGVNQYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDNFFP ISNIRLWALQ LIFVTCPSML VILHVAYREE
110 120 130 140 150
RERKHRQKHG EQCAKLYSHP GKKHGGLWWT YLFSLIFKLI IELVFLYVLH
160 170 180 190 200
TLWHGFTMPR LVQCASIVPC PNTVDCYIAR PTEKKVFTYF MVGASAVCII
210 220 230 240 250
LTICEICYLI FHRIMRGISK GKSTKSISSP KSSSRASTCR CHHKLLESGD
260 270
PEADPASEKL QASAPSLTPI
Length:270
Mass (Da):30,902
Last modified:December 1, 1992 - v1
Checksum:iA91AB784E03E5869
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63099 mRNA Translation: CAA44813.1
AK083716 mRNA Translation: BAC39002.1
BC024387 mRNA Translation: AAH24387.1
CCDSiCCDS18668.1
PIRiS23590
RefSeqiNP_001153484.1, NM_001160012.1
NP_032152.1, NM_008126.2
UniGeneiMm.90003

Genome annotation databases

EnsembliENSMUST00000046532; ENSMUSP00000046755; ENSMUSG00000042367
ENSMUST00000106091; ENSMUSP00000101697; ENSMUSG00000042367
GeneIDi14620
KEGGimmu:14620
UCSCiuc008uus.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63099 mRNA Translation: CAA44813.1
AK083716 mRNA Translation: BAC39002.1
BC024387 mRNA Translation: AAH24387.1
CCDSiCCDS18668.1
PIRiS23590
RefSeqiNP_001153484.1, NM_001160012.1
NP_032152.1, NM_008126.2
UniGeneiMm.90003

3D structure databases

ProteinModelPortaliP28231
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199933, 3 interactors
IntActiP28231, 2 interactors
STRINGi10090.ENSMUSP00000046755

PTM databases

iPTMnetiP28231
PhosphoSitePlusiP28231

Proteomic databases

MaxQBiP28231
PaxDbiP28231
PeptideAtlasiP28231
PRIDEiP28231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046532; ENSMUSP00000046755; ENSMUSG00000042367
ENSMUST00000106091; ENSMUSP00000101697; ENSMUSG00000042367
GeneIDi14620
KEGGimmu:14620
UCSCiuc008uus.2 mouse

Organism-specific databases

CTDi2707
MGIiMGI:95721 Gjb3

Phylogenomic databases

eggNOGiENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP28231
KOiK07622
OMAiHTLWHGF
OrthoDBiEOG091G0FKH
PhylomeDBiP28231
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Miscellaneous databases

PROiPR:P28231
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042367 Expressed in 126 organ(s), highest expression level in placenta
CleanExiMM_GJB3
GenevisibleiP28231 MM

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002269 Connexin31
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF65 PTHR11984:SF65, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01140 CONNEXINB3
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXB3_MOUSE
AccessioniPrimary (citable) accession number: P28231
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again