Gjb3

Functionⁱ

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processⁱ

cell communication Source: InterPro
cellular response to retinoic acid Source: Ensembl
in utero embryonic development Source: Ensembl
placenta development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15895417
skin development Source: Ensembl
spermatogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190861 Gap junction assembly

Reactomeⁱ

R-MMU-190861 Gap junction assembly

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gap junction beta-3 protein Alternative name(s): Connexin-31 Short name: Cx31
Gene namesⁱ	Name:Gjb3 Synonyms:Cxn-31
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:95721 Gjb3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 20	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	21 – 40	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	41 – 75	ExtracellularSequence analysisAdd BLAST	35
Transmembraneⁱ	76 – 98	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	99 – 126	CytoplasmicSequence analysisAdd BLAST	28
Transmembraneⁱ	127 – 149	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	150 – 188	ExtracellularSequence analysisAdd BLAST	39
Transmembraneⁱ	189 – 211	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	212 – 270	CytoplasmicSequence analysisAdd BLAST	59

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000057863	1 – 270	Gap junction beta-3 proteinAdd BLAST		270

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28231
PaxDbⁱ	P28231
PeptideAtlas More...PeptideAtlasⁱ	P28231
PRIDEⁱ	P28231

PTM databases

iPTMnetⁱ	P28231
PhosphoSitePlusⁱ	P28231

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000042367 Expressed in 126 organ(s), highest expression level in placenta
CleanExⁱ	MM_GJB3
Genevisibleⁱ	P28231 MM

Interactionⁱ

Subunit structureⁱ

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Gja1	P23242	2	EBI-1767245,EBI-298630

With

Entry

#Exp.

IntAct

Notes

Gja1

P23242

2

EBI-1767245,EBI-298630

Protein-protein interaction databases

BioGridⁱ	199933, 3 interactors
IntActⁱ	P28231, 2 interactors
STRINGⁱ	10090.ENSMUSP00000046755

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28231
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the connexin family. Beta-type (group I) subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IE21 Eukaryota ENOG410Y9C2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	P28231
KEGG Orthology (KO) More...KOⁱ	K07622
OMAⁱ	HTLWHGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	P28231
TreeFamⁱ	TF329606

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002269 Connexin31 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit PTHR11984:SF65 PTHR11984:SF65, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01140 CONNEXINB3
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28231-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDWKKLQDLL SGVNQYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD 
        60         70         80         90        100
FDCNTRQPGC TNVCYDNFFP ISNIRLWALQ LIFVTCPSML VILHVAYREE 
       110        120        130        140        150
RERKHRQKHG EQCAKLYSHP GKKHGGLWWT YLFSLIFKLI IELVFLYVLH 
       160        170        180        190        200
TLWHGFTMPR LVQCASIVPC PNTVDCYIAR PTEKKVFTYF MVGASAVCII 
       210        220        230        240        250
LTICEICYLI FHRIMRGISK GKSTKSISSP KSSSRASTCR CHHKLLESGD 
       260        270
PEADPASEKL QASAPSLTPI

Length:270

Mass (Da):30,902

Last modified:December 1, 1992 - v1

Checksum:ⁱA91AB784E03E5869

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63099 mRNA Translation: CAA44813.1 AK083716 mRNA Translation: BAC39002.1 BC024387 mRNA Translation: AAH24387.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18668.1
PIRⁱ	S23590
NCBI Reference Sequences More...RefSeqⁱ	NP_001153484.1, NM_001160012.1 NP_032152.1, NM_008126.2
UniGeneⁱ	Mm.90003

Genome annotation databases

Ensemblⁱ	ENSMUST00000046532; ENSMUSP00000046755; ENSMUSG00000042367 ENSMUST00000106091; ENSMUSP00000101697; ENSMUSG00000042367
GeneIDⁱ	14620
KEGGⁱ	mmu:14620
UCSC genome browser More...UCSCⁱ	uc008uus.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28231	Gap junction beta-3 protein		RAT		270	UniRef90_P28231
Gap junction protein		MESAU		270
Gap junction protein		NEOLE		270
Gap junction protein		CRIGR		268
Connexin 31 (Fragment)		MOUSE		31
+6

Protein	Similar proteins		Species	Score	Length	Source
P28231	Gap junction beta-3 protein		HUMAN		270	UniRef50_O75712
Gap junction beta-3 protein		RAT		270
Gap junction beta-3 protein		BOVIN		270
Gap junction beta-5 protein		MOUSE		271
Gap junction protein		PANTR		270
+402

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63099 mRNA Translation: CAA44813.1 AK083716 mRNA Translation: BAC39002.1 BC024387 mRNA Translation: AAH24387.1
CCDSⁱ	CCDS18668.1
PIRⁱ	S23590
RefSeqⁱ	NP_001153484.1, NM_001160012.1 NP_032152.1, NM_008126.2
UniGeneⁱ	Mm.90003

3D structure databases

ProteinModelPortalⁱ	P28231
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199933, 3 interactors
IntActⁱ	P28231, 2 interactors
STRINGⁱ	10090.ENSMUSP00000046755

PTM databases

iPTMnetⁱ	P28231
PhosphoSitePlusⁱ	P28231

Proteomic databases

MaxQBⁱ	P28231
PaxDbⁱ	P28231
PeptideAtlasⁱ	P28231
PRIDEⁱ	P28231

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000046532; ENSMUSP00000046755; ENSMUSG00000042367 ENSMUST00000106091; ENSMUSP00000101697; ENSMUSG00000042367
GeneIDⁱ	14620
KEGGⁱ	mmu:14620
UCSCⁱ	uc008uus.2 mouse

Organism-specific databases

CTDⁱ	2707
MGIⁱ	MGI:95721 Gjb3

Phylogenomic databases

eggNOGⁱ	ENOG410IE21 Eukaryota ENOG410Y9C2 LUCA
GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	P28231
KOⁱ	K07622
OMAⁱ	HTLWHGF
OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	P28231
TreeFamⁱ	TF329606

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190861 Gap junction assembly

Reactomeⁱ

R-MMU-190861 Gap junction assembly

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P28231
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000042367 Expressed in 126 organ(s), highest expression level in placenta
CleanExⁱ	MM_GJB3
Genevisibleⁱ	P28231 MM

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002269 Connexin31 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit PTHR11984:SF65 PTHR11984:SF65, 1 hit
Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01140 CONNEXINB3
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXB3_MOUSE
Accessionⁱ	P28231Primary (citable) accession number: P28231
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	September 12, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P28231 (CXB3_MOUSE)

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Gap junction beta-3 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ