Gjb1

Functionⁱ

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functionⁱ

gap junction channel activity Source: MGI
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 20578039

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell communication Source: InterPro
epididymis development Source: Ensembl
protein complex oligomerization Source: MGI
purine ribonucleotide transport Source: MGI

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190704 Oligomerization of connexins into connexons R-MMU-190861 Gap junction assembly

Reactomeⁱ

R-MMU-190704 Oligomerization of connexins into connexons
R-MMU-190861 Gap junction assembly

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gap junction beta-1 protein Alternative name(s): Connexin-32 Short name: Cx32
Gene namesⁱ	Name:Gjb1 Synonyms:Cxn-32
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:95719 Gjb1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 22	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	23 – 45	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	46 – 75	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	76 – 95	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	96 – 130	CytoplasmicSequence analysisAdd BLAST	35
Transmembraneⁱ	131 – 153	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	154 – 191	ExtracellularSequence analysisAdd BLAST	38
Transmembraneⁱ	192 – 214	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	215 – 283	CytoplasmicSequence analysisAdd BLAST	69

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice lacking both Gja12 and Gjb1 display a severe demyelination phenotype associated with oligodendrocyte death. These mice develop action tremors, tonic seizures, sporadic convulsions and loss of consciousness preceding death in the sixth week after birth.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000057851	1 – 283	Gap junction beta-1 proteinAdd BLAST		283

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	233	PhosphoserineBy similarity	1
Modified residueⁱ	258	PhosphoserineCombined sources	1
Modified residueⁱ	266	PhosphoserineCombined sources	1
Modified residueⁱ	277	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28230
PaxDbⁱ	P28230
PRIDEⁱ	P28230

PTM databases

iPTMnetⁱ	P28230
PhosphoSitePlusⁱ	P28230

Miscellaneous databases

PMAP-CutDBⁱ

P28230

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000047797
CleanExⁱ	MM_GJB1
Genevisibleⁱ	P28230 MM

Interactionⁱ

Subunit structureⁱ

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

GO - Molecular functionⁱ

protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 20578039

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P28230, 1 interactor
STRINGⁱ	10090.ENSMUSP00000062723

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28230
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the connexin family. Beta-type (group I) subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFM8 Eukaryota ENOG410Y7VN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	P28230
KEGG Orthology (KO) More...KOⁱ	K07620
OMAⁱ	YLVVRAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	P28230
TreeFamⁱ	TF329606

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002267 Connexin32 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01138 CONNEXINB1
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28230-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNWTGLYTLL SGVNRHSTAI GRVWLSVIFI FRIMVLVVAA ESVWGDEKSS 
        60         70         80         90        100
FICNTLQPGC NSVCYDHFFP ISHVRLWSLQ LILVSTPALL VAMHVAHQQH 
       110        120        130        140        150
IEKKMLRLEG HGDPLHLEEV KRHKVHISGT LWWTYVISVV FRLLFEAVFM 
       160        170        180        190        200
YVFYLLYPGY AMVRLVKCEA FPCPNTVDCF VSRPTEKTVF TVFMLAASGI 
       210        220        230        240        250
CIILNVAEVV YLIIRACARR AQRRSNPPSR KGSGFGHRLS PEYKQNEINK 
       260        270        280 
LLSEQDGSLK DILRRSPGTG AGLAEKSDRC SAC

Length:283

Mass (Da):32,004

Last modified:May 10, 2004 - v3

Checksum:ⁱC79FC46AA13BC5D7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	235	F → S in AAA37296 (PubMed:2060697).Curated		1
Sequence conflictⁱ	263 – 266	LRRS → PXPH in AAA37296 (PubMed:2060697).Curated		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63802 mRNA Translation: AAA37296.2 M81447 Genomic DNA Translation: AAA37496.1 AJ271753 Genomic DNA Translation: CAB72446.1 BC026833 mRNA Translation: AAH26833.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30314.1
PIRⁱ	B49769
NCBI Reference Sequences More...RefSeqⁱ	NP_001289425.1, NM_001302496.1 NP_001289426.1, NM_001302497.1 NP_001289427.1, NM_001302498.1 NP_032150.2, NM_008124.3
UniGeneⁱ	Mm.21198

Genome annotation databases

Ensemblⁱ	ENSMUST00000052130; ENSMUSP00000062723; ENSMUSG00000047797 ENSMUST00000119080; ENSMUSP00000113904; ENSMUSG00000047797 ENSMUST00000119190; ENSMUSP00000113516; ENSMUSG00000047797
GeneIDⁱ	14618
KEGGⁱ	mmu:14618
UCSC genome browser More...UCSCⁱ	uc009txk.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P28230	Gap junction beta-1 protein	)	HUMAN		283
Gap junction protein		PANTR		283
Gap junction protein		CALJA		283
Gap junction protein		MACMU		283
Gap junction protein		RHIRO		283
+92

Protein	Similar proteins		Species	Score	Length
P28230	Gap junction beta-1 protein	)	HUMAN		283
Gap junction protein		PANTR		283
Gap junction protein		CALJA		283
Gap junction protein		MACMU		283
Gap junction protein		RHIRO		283
+167

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63802 mRNA Translation: AAA37296.2 M81447 Genomic DNA Translation: AAA37496.1 AJ271753 Genomic DNA Translation: CAB72446.1 BC026833 mRNA Translation: AAH26833.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30314.1
PIRⁱ	B49769
NCBI Reference Sequences More...RefSeqⁱ	NP_001289425.1, NM_001302496.1 NP_001289426.1, NM_001302497.1 NP_001289427.1, NM_001302498.1 NP_032150.2, NM_008124.3
UniGeneⁱ	Mm.21198

3D structure databases

ProteinModelPortalⁱ	P28230
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P28230, 1 interactor
STRINGⁱ	10090.ENSMUSP00000062723

PTM databases

iPTMnetⁱ	P28230
PhosphoSitePlusⁱ	P28230

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28230
PaxDbⁱ	P28230
PRIDEⁱ	P28230

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000052130; ENSMUSP00000062723; ENSMUSG00000047797 ENSMUST00000119080; ENSMUSP00000113904; ENSMUSG00000047797 ENSMUST00000119190; ENSMUSP00000113516; ENSMUSG00000047797
GeneIDⁱ	14618
KEGGⁱ	mmu:14618
UCSC genome browser More...UCSCⁱ	uc009txk.2 mouse

Organism-specific databases

CTDⁱ	2705
MGIⁱ	MGI:95719 Gjb1

Phylogenomic databases

eggNOGⁱ	ENOG410IFM8 Eukaryota ENOG410Y7VN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	P28230
KEGG Orthology (KO) More...KOⁱ	K07620
OMAⁱ	YLVVRAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	P28230
TreeFamⁱ	TF329606

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190704 Oligomerization of connexins into connexons R-MMU-190861 Gap junction assembly

Reactomeⁱ

R-MMU-190704 Oligomerization of connexins into connexons
R-MMU-190861 Gap junction assembly

Miscellaneous databases

PMAP-CutDBⁱ	P28230
Protein Ontology More...PROⁱ	PR:P28230
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000047797
CleanExⁱ	MM_GJB1
Genevisibleⁱ	P28230 MM

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002267 Connexin32 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01138 CONNEXINB1
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXB1_MOUSE
Accessionⁱ	P28230Primary (citable) accession number: P28230
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	May 10, 2004
	Last modified:	June 20, 2018
	This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P28230 (CXB1_MOUSE)

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Gap junction beta-1 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ