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Protein

Gap junction gamma-1 protein

Gene

Gjc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  • gap junction channel activity Source: MGI
  • gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: BHF-UCL
  • ion channel activity Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-112303 Electric Transmission Across Gap Junctions
R-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name:
Cx45
Gap junction alpha-7 protein
Gene namesi
Name:Gjc1
Synonyms:Cxn-45, Gja7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95718 Gjc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Topological domaini96 – 175CytoplasmicSequence analysisAdd BLAST80
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Topological domaini199 – 228ExtracellularSequence analysisAdd BLAST30
Transmembranei229 – 248HelicalSequence analysisAdd BLAST20
Topological domaini249 – 396CytoplasmicSequence analysisAdd BLAST148

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578271 – 396Gap junction gamma-1 proteinAdd BLAST396

Proteomic databases

PaxDbiP28229
PeptideAtlasiP28229
PRIDEiP28229

PTM databases

iPTMnetiP28229
PhosphoSitePlusiP28229

Expressioni

Gene expression databases

BgeeiENSMUSG00000034520 Expressed in 269 organ(s), highest expression level in metanephric renal vesicle
CleanExiMM_GJC1
GenevisibleiP28229 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gja1P232422EBI-1767271,EBI-298630

Protein-protein interaction databases

BioGridi199928, 1 interactor
IntActiP28229, 5 interactors
MINTiP28229
STRINGi10090.ENSMUSP00000066901

Structurei

3D structure databases

ProteinModelPortaliP28229
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3 Eukaryota
ENOG410Z7PN LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231126
HOVERGENiHBG009576
InParanoidiP28229
KOiK07616
OMAiIMYGVSC
OrthoDBiEOG091G08B8
PhylomeDBiP28229
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002265 Connexin45
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01136 CONNEXINA6
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28229-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
KMEHGEADKK AARSKPYAMR WKQHRALEET EEDHEEDPMM YPEMELESEK
160 170 180 190 200
ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLIGQYFLYG
210 220 230 240 250
FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM
260 270 280 290 300
LHLGFGTIRD SLNSKRRELD DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
310 320 330 340 350
YTELSNAKIA YKQNKANIAQ EQQYGSHEEH LPADLETLQR EIRMAQERLD
360 370 380 390
LAIQAYHHQN NPHGPREKKA KVGSKSGSNK SSISSKSGDG KTSVWI
Length:396
Mass (Da):45,666
Last modified:December 1, 1992 - v1
Checksum:i9CD5721BB071B65C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63100 mRNA Translation: CAA44814.1
AJ300716 Genomic DNA Translation: CAC21557.1
BC050840 mRNA Translation: AAH50840.1
BC071230 mRNA Translation: AAH71230.1
CCDSiCCDS25504.1
PIRiS23589
RefSeqiNP_001152854.1, NM_001159382.1
NP_001152855.1, NM_001159383.1
NP_032148.1, NM_008122.3
XP_006532289.1, XM_006532226.3
XP_006532290.1, XM_006532227.3
XP_011247038.1, XM_011248736.2
UniGeneiMm.390369

Genome annotation databases

EnsembliENSMUST00000068933; ENSMUSP00000066901; ENSMUSG00000034520
ENSMUST00000092567; ENSMUSP00000090228; ENSMUSG00000034520
ENSMUST00000107075; ENSMUSP00000102690; ENSMUSG00000034520
GeneIDi14615
KEGGimmu:14615
UCSCiuc007lsk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63100 mRNA Translation: CAA44814.1
AJ300716 Genomic DNA Translation: CAC21557.1
BC050840 mRNA Translation: AAH50840.1
BC071230 mRNA Translation: AAH71230.1
CCDSiCCDS25504.1
PIRiS23589
RefSeqiNP_001152854.1, NM_001159382.1
NP_001152855.1, NM_001159383.1
NP_032148.1, NM_008122.3
XP_006532289.1, XM_006532226.3
XP_006532290.1, XM_006532227.3
XP_011247038.1, XM_011248736.2
UniGeneiMm.390369

3D structure databases

ProteinModelPortaliP28229
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199928, 1 interactor
IntActiP28229, 5 interactors
MINTiP28229
STRINGi10090.ENSMUSP00000066901

PTM databases

iPTMnetiP28229
PhosphoSitePlusiP28229

Proteomic databases

PaxDbiP28229
PeptideAtlasiP28229
PRIDEiP28229

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068933; ENSMUSP00000066901; ENSMUSG00000034520
ENSMUST00000092567; ENSMUSP00000090228; ENSMUSG00000034520
ENSMUST00000107075; ENSMUSP00000102690; ENSMUSG00000034520
GeneIDi14615
KEGGimmu:14615
UCSCiuc007lsk.2 mouse

Organism-specific databases

CTDi10052
MGIiMGI:95718 Gjc1

Phylogenomic databases

eggNOGiENOG410IFK3 Eukaryota
ENOG410Z7PN LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231126
HOVERGENiHBG009576
InParanoidiP28229
KOiK07616
OMAiIMYGVSC
OrthoDBiEOG091G08B8
PhylomeDBiP28229
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-MMU-112303 Electric Transmission Across Gap Junctions
R-MMU-190861 Gap junction assembly

Miscellaneous databases

ChiTaRSiGjc1 mouse
PROiPR:P28229
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034520 Expressed in 269 organ(s), highest expression level in metanephric renal vesicle
CleanExiMM_GJC1
GenevisibleiP28229 MM

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002265 Connexin45
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01136 CONNEXINA6
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXG1_MOUSE
AccessioniPrimary (citable) accession number: P28229
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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