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UniProtKB - P28223 (5HT2A_HUMAN)

Entry version 209 (02 Dec 2020)
Sequence version 2 (01 Jun 1994)
Previous versions | rss
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Protein

5-hydroxytryptamine receptor 2A

Gene

HTR2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.7 Publications
(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.1 Publication

Miscellaneous

Binds lysergic acid diethylamine (LSD) in the orthosteric pocket (Probable). Bound LSD dissociates extremely slowly, with a residence time of about 221 minutes at 37 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei229Hydrophobic barrier that decreases the speed of ligand binding and dissociation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer
Biological processBehavior, Host-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P28223

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390666, Serotonin receptors
R-HSA-416476, G alpha (q) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P28223

SIGNOR Signaling Network Open Resource

More...SIGNORi		P28223

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 2A
Short name:
5-HT-2
Short name:
5-HT-2A
Alternative name(s):
Serotonin receptor 2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR2A
Synonyms:HTR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000102468.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:5293, HTR2A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182135, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P28223

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 75ExtracellularBy similarityAdd BLAST75
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei76 – 99Helical; Name=1By similarityAdd BLAST24
Topological domaini100 – 110CytoplasmicBy similarityAdd BLAST11
Transmembranei111 – 132Helical; Name=2By similarityAdd BLAST22
Topological domaini133 – 148ExtracellularBy similarityAdd BLAST16
Transmembranei149 – 171Helical; Name=3By similarityAdd BLAST23
Topological domaini172 – 191CytoplasmicBy similarityAdd BLAST20
Transmembranei192 – 215Helical; Name=4By similarityAdd BLAST24
Topological domaini216 – 233ExtracellularBy similarityAdd BLAST18
Transmembranei234 – 254Helical; Name=5By similarityAdd BLAST21
Topological domaini255 – 324CytoplasmicBy similarityAdd BLAST70
Transmembranei325 – 346Helical; Name=6By similarityAdd BLAST22
Topological domaini347 – 362ExtracellularBy similarityAdd BLAST16
Transmembranei363 – 384Helical; Name=7By similarityAdd BLAST22
Topological domaini385 – 471CytoplasmicBy similarityAdd BLAST87

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi229L → A: Strongly increases dissociation of bound lysergic acid diethylamine, without affecting binding affinity. Reduces signaling via arrestins, but has no effect on signaling via the phosphatidylinositol-calcium second messenger system. 1 Publication1
Mutagenesisi280S → A: Increased ability of hallucinogens to desensitize the receptor. 1 Publication1
Mutagenesisi280S → D: Reduced receptor desensitization by nonhallucinogenic agonists. 1 Publication1
Mutagenesisi463G → V: Loss of interaction with PATJ. 1 Publication1
Mutagenesisi465N → S: No effect on interaction with PATJ. Acquires the binding properties of HTR2C; when associated with S-470. 1 Publication1
Mutagenesisi470C → S: No effect on interaction with PATJ. Acquires the binding properties of HTR2C; when associated with S-465. 1 Publication1
Mutagenesisi471V → A: Loss of interaction with PATJ, CASK, APBA1, DLG1 and DLG4. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3356

MalaCards human disease database

More...MalaCardsi		HTR2A

Open Targets

More...OpenTargetsi		ENSG00000102468

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA193

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P28223, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL224

Drug and drug target database

More...DrugBanki		DB13940, 2,5-Dimethoxy-4-ethylthioamphetamine
DB01537, 4-Bromo-2,5-dimethoxyphenethylamine
DB14010, 5-methoxy-N,N-dimethyltryptamine
DB01614, Acepromazine
DB06288, Amisulpride
DB00321, Amitriptyline
DB00543, Amoxapine
DB08927, Amperozide
DB04599, Aniracetam
DB05227, APD791
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB05687, BL-1020
DB09223, Blonanserin
DB09128, Brexpiprazole
DB01200, Bromocriptine
DB09016, Butriptyline
DB00248, Cabergoline
DB09061, Cannabidiol
DB06016, Cariprazine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB08810, Cinitapride
DB00604, Cisapride
DB01242, Clomipramine
DB00363, Clozapine
DB00924, Cyclobenzaprine
DB00434, Cyproheptadine
DB06512, Deramciclane
DB01151, Desipramine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB01488, Dimethyltryptamine
DB00843, Donepezil
DB09167, Dosulepin
DB06446, Dotarizine
DB01142, Doxepin
DB05492, Epicept NP-1
DB00751, Epinastine
DB12177, Eplivanserin
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB06678, Esmirtazapine
DB09194, Etoperidone
DB00574, Fenfluramine
DB04908, Flibanserin
DB00875, Flupentixol
DB00623, Fluphenazine
DB04842, Fluspirilene
DB12141, Gilteritinib
DB00502, Haloperidol
DB05079, HY10275
DB04946, Iloperidone
DB00458, Imipramine
DB01221, Ketamine
DB12465, Ketanserin
DB00555, Lamotrigine
DB00589, Lisuride
DB09195, Lorpiprazole
DB00408, Loxapine
DB06077, Lumateperone
DB08815, Lurasidone
DB00934, Maprotiline
DB14009, Medical Cannabis
DB00933, Mesoridazine
DB01403, Methotrimeprazine
DB00247, Methysergide
DB06148, Mianserin
DB01454, Midomafetamine
DB00805, Minaprine
DB00370, Mirtazapine
DB01442, MMDA
DB01618, Molindone
DB13948, N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine
DB14011, Nabiximols
DB01149, Nefazodone
DB12555, Nelotanserin
DB00540, Nortriptyline
DB06229, Ocaperidone
DB00334, Olanzapine
DB01267, Paliperidone
DB00715, Paroxetine
DB01186, Pergolide
DB08922, Perospirone
DB05316, Pimavanserin
DB09286, Pipamperone
DB01621, Pipotiazine
DB06153, Pizotifen
DB00420, Promazine
DB00777, Propiomazine
DB01224, Quetiapine
DB00409, Remoxipride
DB00734, Risperidone
DB12693, Ritanserin
DB12163, Sarpogrelate
DB08839, Serotonin
DB06144, Sertindole
DB09304, Setiptiline
DB01079, Tegaserod
DB01622, Thioproperazine
DB00679, Thioridazine
DB01623, Thiothixene
DB13025, Tiapride
DB00656, Trazodone
DB00726, Trimipramine
DB06109, YKP-1358
DB01392, Yohimbine
DB00246, Ziprasidone
DB00315, Zolmitriptan
DB09225, Zotepine
DB01624, Zuclopenthixol

DrugCentral

More...DrugCentrali		P28223

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HTR2A

Domain mapping of disease mutations (DMDM)

More...DMDMi		543727

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000689461 – 4715-hydroxytryptamine receptor 2AAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi148 ↔ 227PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei280Phosphoserine1 Publication1
Disulfide bondi349 ↔ 353PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P28223

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P28223

PeptideAtlas

More...PeptideAtlasi		P28223

PRoteomics IDEntifications database

More...PRIDEi		P28223

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24094
54453 [P28223-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P28223, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P28223

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P28223

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain cortex (at protein level). Detected in blood platelets.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000102468, Expressed in dorsolateral prefrontal cortex and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P28223, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P28223, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000102468, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with MPDZ and PATJ (PubMed:11150294, PubMed:14988405). May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (PubMed:14988405).

Interacts with GRM2 and DRD2; this may affect signaling (PubMed:18297054, PubMed:21645528, PubMed:22300836).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109588, 7 interactors

Database of interacting proteins

More...DIPi		DIP-41844N

Protein interaction database and analysis system

More...IntActi		P28223, 21 interactors

Molecular INTeraction database

More...MINTi		P28223

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000437737

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P28223

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P28223, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1471
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P28223

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni155 – 160Agonist bindingBy similarity6
Regioni336 – 340Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi172 – 174DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi376 – 380NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5
Motifi469 – 471PDZ-binding2 Publications3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222369

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P28223

Identification of Orthologs from Complete Genome Data

More...OMAi		RLYNNDF

Database of Orthologous Groups

More...OrthoDBi		962038at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P28223

TreeFam database of animal gene trees

More...TreeFami		TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000455, 5HT2A_rcpt
IPR002231, 5HT_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...PANTHERi		PTHR24247:SF30, PTHR24247:SF30, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00516, 5HT2ARECEPTR
PR01101, 5HTRECEPTOR
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P28223-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE 
        60         70         80         90        100
NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS 
       110        120        130        140        150
LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV 
       160        170        180        190        200
WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW 
       210        220        230        240        250
TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM 
       260        270        280        290        300
VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH 
       310        320        330        340        350
REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK 
       360        370        380        390        400
ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK 
       410        420        430        440        450
ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK 
       460        470 
QHSEEASKDN SDGVNEKVSC V
Length:471
Mass (Da):52,603
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF8AAC0BC5379DA2
GO
Isoform 2 (identifier: P28223-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: MDILCEENTS...PVSMLTILYG → MQFLKSAKQK...ISCVDPEDKW

Show »
Length:387
Mass (Da):43,940
Checksum:iDA98167A87C1AAB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZJ9A0A087WZJ9_HUMAN
5-hydroxytryptamine receptor 2A
HTR2A
110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: P28223-2)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49D → N in BAG63991 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00344825T → N2 PublicationsCorresponds to variant dbSNP:rs1805055Ensembl.1
Natural variantiVAR_013901197I → V1 PublicationCorresponds to variant dbSNP:rs6304Ensembl.1
Natural variantiVAR_013902447A → V1 PublicationCorresponds to variant dbSNP:rs6308EnsemblClinVar.1
Natural variantiVAR_003449452H → Y3 PublicationsCorresponds to variant dbSNP:rs6314Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0466631 – 138MDILC…TILYG → MQFLKSAKQKPNYYHIMLVE DQEEGTLHQFNYCERCSESQ NNKCISCVDPEDKW in isoform 2. 1 PublicationAdd BLAST138

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X57830 mRNA Translation: CAA40963.1
S42168, S42165, S42167 Genomic DNA Translation: AAB22791.2
S71229 mRNA Translation: AAB31320.1
AF498982 mRNA Translation: AAM21129.1
AK302787 mRNA Translation: BAG63991.1
AK314132 mRNA Translation: BAG36822.1
AL160397 Genomic DNA No translation available.
AL136958 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08770.1
BC069356 mRNA Translation: AAH69356.1
BC069576 mRNA Translation: AAH69576.1
BC074848 mRNA Translation: AAH74848.1
BC074849 mRNA Translation: AAH74849.1
BC096839 mRNA Translation: AAH96839.1
M86841 mRNA Translation: AAA58354.1
S50130, S49737, S50113 Genomic DNA Translation: AAB24166.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9405.1 [P28223-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A43956

NCBI Reference Sequences

More...RefSeqi		NP_000612.1, NM_000621.4 [P28223-1]
NP_001159419.1, NM_001165947.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000378688; ENSP00000367959; ENSG00000102468 [P28223-1]
ENST00000542664; ENSP00000437737; ENSG00000102468 [P28223-1]
ENST00000543956; ENSP00000441861; ENSG00000102468 [P28223-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3356

UCSC genome browser

More...UCSCi		uc001vbr.5, human [P28223-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57830 mRNA Translation: CAA40963.1
S42168, S42165, S42167 Genomic DNA Translation: AAB22791.2
S71229 mRNA Translation: AAB31320.1
AF498982 mRNA Translation: AAM21129.1
AK302787 mRNA Translation: BAG63991.1
AK314132 mRNA Translation: BAG36822.1
AL160397 Genomic DNA No translation available.
AL136958 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08770.1
BC069356 mRNA Translation: AAH69356.1
BC069576 mRNA Translation: AAH69576.1
BC074848 mRNA Translation: AAH74848.1
BC074849 mRNA Translation: AAH74849.1
BC096839 mRNA Translation: AAH96839.1
M86841 mRNA Translation: AAA58354.1
S50130, S49737, S50113 Genomic DNA Translation: AAB24166.2
CCDSiCCDS9405.1 [P28223-1]
PIRiA43956
RefSeqiNP_000612.1, NM_000621.4 [P28223-1]
NP_001159419.1, NM_001165947.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6A93X-ray3.00A/B70-265[»]
A/B313-403[»]
6A94X-ray2.90A/B70-265[»]
A/B313-403[»]
SMRiP28223
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109588, 7 interactors
DIPiDIP-41844N
IntActiP28223, 21 interactors
MINTiP28223
STRINGi9606.ENSP00000437737

Chemistry databases

BindingDBiP28223
ChEMBLiCHEMBL224
DrugBankiDB13940, 2,5-Dimethoxy-4-ethylthioamphetamine
DB01537, 4-Bromo-2,5-dimethoxyphenethylamine
DB14010, 5-methoxy-N,N-dimethyltryptamine
DB01614, Acepromazine
DB06288, Amisulpride
DB00321, Amitriptyline
DB00543, Amoxapine
DB08927, Amperozide
DB04599, Aniracetam
DB05227, APD791
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB05687, BL-1020
DB09223, Blonanserin
DB09128, Brexpiprazole
DB01200, Bromocriptine
DB09016, Butriptyline
DB00248, Cabergoline
DB09061, Cannabidiol
DB06016, Cariprazine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB08810, Cinitapride
DB00604, Cisapride
DB01242, Clomipramine
DB00363, Clozapine
DB00924, Cyclobenzaprine
DB00434, Cyproheptadine
DB06512, Deramciclane
DB01151, Desipramine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB01488, Dimethyltryptamine
DB00843, Donepezil
DB09167, Dosulepin
DB06446, Dotarizine
DB01142, Doxepin
DB05492, Epicept NP-1
DB00751, Epinastine
DB12177, Eplivanserin
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB06678, Esmirtazapine
DB09194, Etoperidone
DB00574, Fenfluramine
DB04908, Flibanserin
DB00875, Flupentixol
DB00623, Fluphenazine
DB04842, Fluspirilene
DB12141, Gilteritinib
DB00502, Haloperidol
DB05079, HY10275
DB04946, Iloperidone
DB00458, Imipramine
DB01221, Ketamine
DB12465, Ketanserin
DB00555, Lamotrigine
DB00589, Lisuride
DB09195, Lorpiprazole
DB00408, Loxapine
DB06077, Lumateperone
DB08815, Lurasidone
DB00934, Maprotiline
DB14009, Medical Cannabis
DB00933, Mesoridazine
DB01403, Methotrimeprazine
DB00247, Methysergide
DB06148, Mianserin
DB01454, Midomafetamine
DB00805, Minaprine
DB00370, Mirtazapine
DB01442, MMDA
DB01618, Molindone
DB13948, N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine
DB14011, Nabiximols
DB01149, Nefazodone
DB12555, Nelotanserin
DB00540, Nortriptyline
DB06229, Ocaperidone
DB00334, Olanzapine
DB01267, Paliperidone
DB00715, Paroxetine
DB01186, Pergolide
DB08922, Perospirone
DB05316, Pimavanserin
DB09286, Pipamperone
DB01621, Pipotiazine
DB06153, Pizotifen
DB00420, Promazine
DB00777, Propiomazine
DB01224, Quetiapine
DB00409, Remoxipride
DB00734, Risperidone
DB12693, Ritanserin
DB12163, Sarpogrelate
DB08839, Serotonin
DB06144, Sertindole
DB09304, Setiptiline
DB01079, Tegaserod
DB01622, Thioproperazine
DB00679, Thioridazine
DB01623, Thiothixene
DB13025, Tiapride
DB00656, Trazodone
DB00726, Trimipramine
DB06109, YKP-1358
DB01392, Yohimbine
DB00246, Ziprasidone
DB00315, Zolmitriptan
DB09225, Zotepine
DB01624, Zuclopenthixol
DrugCentraliP28223
GuidetoPHARMACOLOGYi6

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP28223, 5 sites
iPTMnetiP28223
PhosphoSitePlusiP28223

Polymorphism and mutation databases

BioMutaiHTR2A
DMDMi543727

Proteomic databases

MassIVEiP28223
PaxDbiP28223
PeptideAtlasiP28223
PRIDEiP28223
ProteomicsDBi24094
54453 [P28223-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2927, 360 antibodies

Genome annotation databases

EnsembliENST00000378688; ENSP00000367959; ENSG00000102468 [P28223-1]
ENST00000542664; ENSP00000437737; ENSG00000102468 [P28223-1]
ENST00000543956; ENSP00000441861; ENSG00000102468 [P28223-2]
GeneIDi3356
KEGGihsa:3356
UCSCiuc001vbr.5, human [P28223-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3356
DisGeNETi3356
EuPathDBiHostDB:ENSG00000102468.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		HTR2A
HGNCiHGNC:5293, HTR2A
HPAiENSG00000102468, Tissue enriched (brain)
MalaCardsiHTR2A
MIMi182135, gene
neXtProtiNX_P28223
OpenTargetsiENSG00000102468
PharmGKBiPA193

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01010000222369
HOGENOMiCLU_009579_11_3_1
InParanoidiP28223
OMAiRLYNNDF
OrthoDBi962038at2759
PhylomeDBiP28223
TreeFamiTF316350

Enzyme and pathway databases

PathwayCommonsiP28223
ReactomeiR-HSA-390666, Serotonin receptors
R-HSA-416476, G alpha (q) signalling events
SignaLinkiP28223
SIGNORiP28223

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3356, 2 hits in 843 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		5-HT2A_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3356
PharosiP28223, Tclin

Protein Ontology

More...PROi		PR:P28223
RNActiP28223, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000102468, Expressed in dorsolateral prefrontal cortex and 158 other tissues
ExpressionAtlasiP28223, baseline and differential
GenevisibleiP28223, HS

Family and domain databases

InterProiView protein in InterPro
IPR000455, 5HT2A_rcpt
IPR002231, 5HT_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF30, PTHR24247:SF30, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00516, 5HT2ARECEPTR
PR01101, 5HTRECEPTOR
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28223
Secondary accession number(s): B2RAC5
, B4DZ79, F5GWE8, Q5T8C0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 1, 1994
Last modified: December 2, 2020
This is version 209 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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