UniProtKB - P28223 (5HT2A_HUMAN)
5-hydroxytryptamine receptor 2A
HTR2A
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 229 | Hydrophobic barrier that decreases the speed of ligand binding and dissociation1 Publication | 1 |
GO - Molecular functioni
- 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Source: UniProtKB
- G-protein alpha-subunit binding Source: Ensembl
- G protein-coupled receptor activity Source: GO_Central
- G protein-coupled serotonin receptor activity Source: UniProtKB
- Gq/11-coupled serotonin receptor activity Source: UniProtKB
- identical protein binding Source: IntAct
- neurotransmitter receptor activity Source: GO_Central
- protein-containing complex binding Source: Ensembl
- serotonin binding Source: UniProtKB
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- activation of phospholipase C activity Source: UniProtKB
- aging Source: Ensembl
- artery smooth muscle contraction Source: Ensembl
- behavioral response to cocaine Source: Ensembl
- cell death Source: Ensembl
- cellular calcium ion homeostasis Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
- detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- G protein-coupled serotonin receptor signaling pathway Source: UniProtKB
- memory Source: Ensembl
- negative regulation of potassium ion transport Source: Ensembl
- negative regulation of synaptic transmission, glutamatergic Source: Ensembl
- phosphatidylinositol 3-kinase signaling Source: UniProtKB
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
- phospholipase C-activating serotonin receptor signaling pathway Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of fat cell differentiation Source: Ensembl
- positive regulation of glycolytic process Source: Ensembl
- positive regulation of MAP kinase activity Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
- positive regulation of vasoconstriction Source: Ensembl
- protein localization to cytoskeleton Source: Ensembl
- regulation of dopamine secretion Source: Ensembl
- regulation of synaptic vesicle exocytosis Source: Ensembl
- release of sequestered calcium ion into cytosol Source: UniProtKB
- response to drug Source: UniProtKB
- serotonin receptor signaling pathway Source: ProtInc
- sleep Source: Ensembl
- temperature homeostasis Source: Ensembl
- urinary bladder smooth muscle contraction Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer |
Biological process | Behavior, Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P28223 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P28223 |
SIGNORi | P28223 |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 2AShort name: 5-HT-2 Short name: 5-HT-2A Alternative name(s): Serotonin receptor 2A |
Gene namesi | Name:HTR2A Synonyms:HTR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102468.10 |
HGNCi | HGNC:5293, HTR2A |
MIMi | 182135, gene |
neXtProti | NX_P28223 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Other locations
- dendrite By similarity
- axon By similarity
- Cytoplasmic vesicle By similarity
- caveola By similarity
- presynapse By similarity
Cytosol
- cytosol Source: Ensembl
Plasma Membrane
- caveola Source: UniProtKB-SubCell
- integral component of plasma membrane Source: GO_Central
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- axon Source: UniProtKB-SubCell
- cell body fiber Source: Ensembl
- cytoplasmic vesicle Source: UniProtKB-KW
- dendrite Source: GO_Central
- dendritic shaft Source: Ensembl
- G protein-coupled serotonin receptor complex Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- neuronal cell body Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 75 | ExtracellularBy similarityAdd BLAST | 75 | |
Transmembranei | 76 – 99 | Helical; Name=1By similarityAdd BLAST | 24 | |
Topological domaini | 100 – 110 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 111 – 132 | Helical; Name=2By similarityAdd BLAST | 22 | |
Topological domaini | 133 – 148 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 149 – 171 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 172 – 191 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 192 – 215 | Helical; Name=4By similarityAdd BLAST | 24 | |
Topological domaini | 216 – 233 | ExtracellularBy similarityAdd BLAST | 18 | |
Transmembranei | 234 – 254 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 255 – 324 | CytoplasmicBy similarityAdd BLAST | 70 | |
Transmembranei | 325 – 346 | Helical; Name=6By similarityAdd BLAST | 22 | |
Topological domaini | 347 – 362 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 363 – 384 | Helical; Name=7By similarityAdd BLAST | 22 | |
Topological domaini | 385 – 471 | CytoplasmicBy similarityAdd BLAST | 87 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 229 | L → A: Strongly increases dissociation of bound lysergic acid diethylamine, without affecting binding affinity. Reduces signaling via arrestins, but has no effect on signaling via the phosphatidylinositol-calcium second messenger system. 1 Publication | 1 | |
Mutagenesisi | 280 | S → A: Increased ability of hallucinogens to desensitize the receptor. 1 Publication | 1 | |
Mutagenesisi | 280 | S → D: Reduced receptor desensitization by nonhallucinogenic agonists. 1 Publication | 1 | |
Mutagenesisi | 463 | G → V: Loss of interaction with PATJ. 1 Publication | 1 | |
Mutagenesisi | 465 | N → S: No effect on interaction with PATJ. Acquires the binding properties of HTR2C; when associated with S-470. 1 Publication | 1 | |
Mutagenesisi | 470 | C → S: No effect on interaction with PATJ. Acquires the binding properties of HTR2C; when associated with S-465. 1 Publication | 1 | |
Mutagenesisi | 471 | V → A: Loss of interaction with PATJ, CASK, APBA1, DLG1 and DLG4. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3356 |
MalaCardsi | HTR2A |
OpenTargetsi | ENSG00000102468 |
PharmGKBi | PA193 |
Miscellaneous databases
Pharosi | P28223, Tclin |
Chemistry databases
ChEMBLi | CHEMBL224 |
DrugBanki | DB13940, 2,5-Dimethoxy-4-ethylthioamphetamine DB01537, 4-Bromo-2,5-dimethoxyphenethylamine DB14010, 5-methoxy-N,N-dimethyltryptamine DB01614, Acepromazine DB06288, Amisulpride DB00321, Amitriptyline DB00543, Amoxapine DB08927, Amperozide DB04599, Aniracetam DB05227, APD791 DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB05687, BL-1020 DB09223, Blonanserin DB09128, Brexpiprazole DB01200, Bromocriptine DB09016, Butriptyline DB00248, Cabergoline DB09061, Cannabidiol DB06016, Cariprazine DB00477, Chlorpromazine DB01239, Chlorprothixene DB08810, Cinitapride DB00604, Cisapride DB01242, Clomipramine DB00363, Clozapine DB00924, Cyclobenzaprine DB00434, Cyproheptadine DB06512, Deramciclane DB01151, Desipramine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB01488, Dimethyltryptamine DB00843, Donepezil DB09167, Dosulepin DB06446, Dotarizine DB01142, Doxepin DB05492, Epicept NP-1 DB00751, Epinastine DB12177, Eplivanserin DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB06678, Esmirtazapine DB09194, Etoperidone DB00574, Fenfluramine DB04908, Flibanserin DB00875, Flupentixol DB00623, Fluphenazine DB04842, Fluspirilene DB12141, Gilteritinib DB00502, Haloperidol DB05079, HY10275 DB04946, Iloperidone DB00458, Imipramine DB01221, Ketamine DB12465, Ketanserin DB00555, Lamotrigine DB00589, Lisuride DB09195, Lorpiprazole DB00408, Loxapine DB06077, Lumateperone DB08815, Lurasidone DB00934, Maprotiline DB14009, Medical Cannabis DB00933, Mesoridazine DB01403, Methotrimeprazine DB00247, Methysergide DB06148, Mianserin DB01454, Midomafetamine DB00805, Minaprine DB00370, Mirtazapine DB01442, MMDA DB01618, Molindone DB13948, N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine DB14011, Nabiximols DB01149, Nefazodone DB12555, Nelotanserin DB00540, Nortriptyline DB06229, Ocaperidone DB00334, Olanzapine DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB08922, Perospirone DB05316, Pimavanserin DB09286, Pipamperone DB01621, Pipotiazine DB06153, Pizotifen DB00420, Promazine DB00777, Propiomazine DB01224, Quetiapine DB00409, Remoxipride DB00734, Risperidone DB12693, Ritanserin DB12163, Sarpogrelate DB08839, Serotonin DB06144, Sertindole DB09304, Setiptiline DB01079, Tegaserod DB01622, Thioproperazine DB00679, Thioridazine DB01623, Thiothixene DB13025, Tiapride DB00656, Trazodone DB00726, Trimipramine DB06109, YKP-1358 DB01392, Yohimbine DB00246, Ziprasidone DB00315, Zolmitriptan DB09225, Zotepine DB01624, Zuclopenthixol |
DrugCentrali | P28223 |
GuidetoPHARMACOLOGYi | 6 |
Polymorphism and mutation databases
BioMutai | HTR2A |
DMDMi | 543727 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068946 | 1 – 471 | 5-hydroxytryptamine receptor 2AAdd BLAST | 471 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 44 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 51 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 148 ↔ 227 | PROSITE-ProRule annotation | ||
Modified residuei | 280 | Phosphoserine1 Publication | 1 | |
Disulfide bondi | 349 ↔ 353 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | P28223 |
PaxDbi | P28223 |
PeptideAtlasi | P28223 |
PRIDEi | P28223 |
ProteomicsDBi | 24094 54453 [P28223-1] |
PTM databases
GlyGeni | P28223, 5 sites |
iPTMneti | P28223 |
PhosphoSitePlusi | P28223 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000102468, Expressed in dorsolateral prefrontal cortex and 158 other tissues |
ExpressionAtlasi | P28223, baseline and differential |
Genevisiblei | P28223, HS |
Organism-specific databases
HPAi | ENSG00000102468, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts (via C-terminus) with MPDZ and PATJ (PubMed:11150294, PubMed:14988405). May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (PubMed:14988405).
Interacts with GRM2 and DRD2; this may affect signaling (PubMed:18297054, PubMed:21645528, PubMed:22300836).
5 PublicationsBinary interactionsi
Hide detailsP28223
With | #Exp. | IntAct |
---|---|---|
HTR1A [P08908] | 3 | EBI-6656333,EBI-6570214 |
itself | 3 | EBI-6656333,EBI-6656333 |
HTR2B [P41595] | 3 | EBI-6656333,EBI-7474947 |
HTR2C [P28335] | 5 | EBI-6656333,EBI-994141 |
Isoform 1 [P28223-1]
GO - Molecular functioni
- G-protein alpha-subunit binding Source: Ensembl
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 109588, 7 interactors |
DIPi | DIP-41844N |
IntActi | P28223, 21 interactors |
MINTi | P28223 |
STRINGi | 9606.ENSP00000437737 |
Chemistry databases
BindingDBi | P28223 |
Miscellaneous databases
RNActi | P28223, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P28223 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 155 – 160 | Agonist bindingBy similarity | 6 | |
Regioni | 336 – 340 | Agonist bindingBy similarity | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 172 – 174 | DRY motif; important for ligand-induced conformation changesBy similarity | 3 | |
Motifi | 376 – 380 | NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity | 5 | |
Motifi | 469 – 471 | PDZ-binding2 Publications | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222369 |
HOGENOMi | CLU_009579_11_3_1 |
InParanoidi | P28223 |
OMAi | RLYNNDF |
OrthoDBi | 962038at2759 |
PhylomeDBi | P28223 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR000455, 5HT2A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF30, PTHR24247:SF30, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00516, 5HT2ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE
60 70 80 90 100
NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS
110 120 130 140 150
LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV
160 170 180 190 200
WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW
210 220 230 240 250
TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM
260 270 280 290 300
VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH
310 320 330 340 350
REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK
360 370 380 390 400
ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK
410 420 430 440 450
ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK
460 470
QHSEEASKDN SDGVNEKVSC V
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZJ9 | A0A087WZJ9_HUMAN | 5-hydroxytryptamine receptor 2A | HTR2A | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: P28223-2) | |||||
Sequence conflicti | 49 | D → N in BAG63991 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003448 | 25 | T → N2 PublicationsCorresponds to variant dbSNP:rs1805055Ensembl. | 1 | |
Natural variantiVAR_013901 | 197 | I → V1 PublicationCorresponds to variant dbSNP:rs6304Ensembl. | 1 | |
Natural variantiVAR_013902 | 447 | A → V1 PublicationCorresponds to variant dbSNP:rs6308EnsemblClinVar. | 1 | |
Natural variantiVAR_003449 | 452 | H → Y3 PublicationsCorresponds to variant dbSNP:rs6314Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046663 | 1 – 138 | MDILC…TILYG → MQFLKSAKQKPNYYHIMLVE DQEEGTLHQFNYCERCSESQ NNKCISCVDPEDKW in isoform 2. 1 PublicationAdd BLAST | 138 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57830 mRNA Translation: CAA40963.1 S42168, S42165, S42167 Genomic DNA Translation: AAB22791.2 S71229 mRNA Translation: AAB31320.1 AF498982 mRNA Translation: AAM21129.1 AK302787 mRNA Translation: BAG63991.1 AK314132 mRNA Translation: BAG36822.1 AL160397 Genomic DNA No translation available. AL136958 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08770.1 BC069356 mRNA Translation: AAH69356.1 BC069576 mRNA Translation: AAH69576.1 BC074848 mRNA Translation: AAH74848.1 BC074849 mRNA Translation: AAH74849.1 BC096839 mRNA Translation: AAH96839.1 M86841 mRNA Translation: AAA58354.1 S50130, S49737, S50113 Genomic DNA Translation: AAB24166.2 |
CCDSi | CCDS9405.1 [P28223-1] |
PIRi | A43956 |
RefSeqi | NP_000612.1, NM_000621.4 [P28223-1] NP_001159419.1, NM_001165947.2 |
Genome annotation databases
Ensembli | ENST00000378688; ENSP00000367959; ENSG00000102468 [P28223-1] ENST00000542664; ENSP00000437737; ENSG00000102468 [P28223-1] ENST00000543956; ENSP00000441861; ENSG00000102468 [P28223-2] |
GeneIDi | 3356 |
KEGGi | hsa:3356 |
UCSCi | uc001vbr.5, human [P28223-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57830 mRNA Translation: CAA40963.1 S42168, S42165, S42167 Genomic DNA Translation: AAB22791.2 S71229 mRNA Translation: AAB31320.1 AF498982 mRNA Translation: AAM21129.1 AK302787 mRNA Translation: BAG63991.1 AK314132 mRNA Translation: BAG36822.1 AL160397 Genomic DNA No translation available. AL136958 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08770.1 BC069356 mRNA Translation: AAH69356.1 BC069576 mRNA Translation: AAH69576.1 BC074848 mRNA Translation: AAH74848.1 BC074849 mRNA Translation: AAH74849.1 BC096839 mRNA Translation: AAH96839.1 M86841 mRNA Translation: AAA58354.1 S50130, S49737, S50113 Genomic DNA Translation: AAB24166.2 |
CCDSi | CCDS9405.1 [P28223-1] |
PIRi | A43956 |
RefSeqi | NP_000612.1, NM_000621.4 [P28223-1] NP_001159419.1, NM_001165947.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6A93 | X-ray | 3.00 | A/B | 70-265 | [»] | |
A/B | 313-403 | [»] | ||||
6A94 | X-ray | 2.90 | A/B | 70-265 | [»] | |
A/B | 313-403 | [»] | ||||
SMRi | P28223 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109588, 7 interactors |
DIPi | DIP-41844N |
IntActi | P28223, 21 interactors |
MINTi | P28223 |
STRINGi | 9606.ENSP00000437737 |
Chemistry databases
BindingDBi | P28223 |
ChEMBLi | CHEMBL224 |
DrugBanki | DB13940, 2,5-Dimethoxy-4-ethylthioamphetamine DB01537, 4-Bromo-2,5-dimethoxyphenethylamine DB14010, 5-methoxy-N,N-dimethyltryptamine DB01614, Acepromazine DB06288, Amisulpride DB00321, Amitriptyline DB00543, Amoxapine DB08927, Amperozide DB04599, Aniracetam DB05227, APD791 DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB05687, BL-1020 DB09223, Blonanserin DB09128, Brexpiprazole DB01200, Bromocriptine DB09016, Butriptyline DB00248, Cabergoline DB09061, Cannabidiol DB06016, Cariprazine DB00477, Chlorpromazine DB01239, Chlorprothixene DB08810, Cinitapride DB00604, Cisapride DB01242, Clomipramine DB00363, Clozapine DB00924, Cyclobenzaprine DB00434, Cyproheptadine DB06512, Deramciclane DB01151, Desipramine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB01488, Dimethyltryptamine DB00843, Donepezil DB09167, Dosulepin DB06446, Dotarizine DB01142, Doxepin DB05492, Epicept NP-1 DB00751, Epinastine DB12177, Eplivanserin DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB06678, Esmirtazapine DB09194, Etoperidone DB00574, Fenfluramine DB04908, Flibanserin DB00875, Flupentixol DB00623, Fluphenazine DB04842, Fluspirilene DB12141, Gilteritinib DB00502, Haloperidol DB05079, HY10275 DB04946, Iloperidone DB00458, Imipramine DB01221, Ketamine DB12465, Ketanserin DB00555, Lamotrigine DB00589, Lisuride DB09195, Lorpiprazole DB00408, Loxapine DB06077, Lumateperone DB08815, Lurasidone DB00934, Maprotiline DB14009, Medical Cannabis DB00933, Mesoridazine DB01403, Methotrimeprazine DB00247, Methysergide DB06148, Mianserin DB01454, Midomafetamine DB00805, Minaprine DB00370, Mirtazapine DB01442, MMDA DB01618, Molindone DB13948, N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine DB14011, Nabiximols DB01149, Nefazodone DB12555, Nelotanserin DB00540, Nortriptyline DB06229, Ocaperidone DB00334, Olanzapine DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB08922, Perospirone DB05316, Pimavanserin DB09286, Pipamperone DB01621, Pipotiazine DB06153, Pizotifen DB00420, Promazine DB00777, Propiomazine DB01224, Quetiapine DB00409, Remoxipride DB00734, Risperidone DB12693, Ritanserin DB12163, Sarpogrelate DB08839, Serotonin DB06144, Sertindole DB09304, Setiptiline DB01079, Tegaserod DB01622, Thioproperazine DB00679, Thioridazine DB01623, Thiothixene DB13025, Tiapride DB00656, Trazodone DB00726, Trimipramine DB06109, YKP-1358 DB01392, Yohimbine DB00246, Ziprasidone DB00315, Zolmitriptan DB09225, Zotepine DB01624, Zuclopenthixol |
DrugCentrali | P28223 |
GuidetoPHARMACOLOGYi | 6 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P28223, 5 sites |
iPTMneti | P28223 |
PhosphoSitePlusi | P28223 |
Polymorphism and mutation databases
BioMutai | HTR2A |
DMDMi | 543727 |
Proteomic databases
MassIVEi | P28223 |
PaxDbi | P28223 |
PeptideAtlasi | P28223 |
PRIDEi | P28223 |
ProteomicsDBi | 24094 54453 [P28223-1] |
Protocols and materials databases
Antibodypediai | 2927, 360 antibodies |
Genome annotation databases
Ensembli | ENST00000378688; ENSP00000367959; ENSG00000102468 [P28223-1] ENST00000542664; ENSP00000437737; ENSG00000102468 [P28223-1] ENST00000543956; ENSP00000441861; ENSG00000102468 [P28223-2] |
GeneIDi | 3356 |
KEGGi | hsa:3356 |
UCSCi | uc001vbr.5, human [P28223-1] |
Organism-specific databases
CTDi | 3356 |
DisGeNETi | 3356 |
EuPathDBi | HostDB:ENSG00000102468.10 |
GeneCardsi | HTR2A |
HGNCi | HGNC:5293, HTR2A |
HPAi | ENSG00000102468, Tissue enriched (brain) |
MalaCardsi | HTR2A |
MIMi | 182135, gene |
neXtProti | NX_P28223 |
OpenTargetsi | ENSG00000102468 |
PharmGKBi | PA193 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222369 |
HOGENOMi | CLU_009579_11_3_1 |
InParanoidi | P28223 |
OMAi | RLYNNDF |
OrthoDBi | 962038at2759 |
PhylomeDBi | P28223 |
TreeFami | TF316350 |
Enzyme and pathway databases
PathwayCommonsi | P28223 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P28223 |
SIGNORi | P28223 |
Miscellaneous databases
BioGRID-ORCSi | 3356, 2 hits in 843 CRISPR screens |
GeneWikii | 5-HT2A_receptor |
GenomeRNAii | 3356 |
Pharosi | P28223, Tclin |
PROi | PR:P28223 |
RNActi | P28223, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102468, Expressed in dorsolateral prefrontal cortex and 158 other tissues |
ExpressionAtlasi | P28223, baseline and differential |
Genevisiblei | P28223, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000455, 5HT2A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF30, PTHR24247:SF30, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00516, 5HT2ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT2A_HUMAN | |
Accessioni | P28223Primary (citable) accession number: P28223 Secondary accession number(s): B2RAC5 Q5T8C0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 209 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries