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Protein

5-hydroxytryptamine receptor 2A

Gene

HTR2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.7 Publications
(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.1 Publication

Miscellaneous

Binds lysergic acid diethylamine (LSD) in the orthosteric pocket (Probable). Bound LSD dissociates extremely slowly, with a residence time of about 221 minutes at 37 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei229Hydrophobic barrier that decreases the speed of ligand binding and dissociation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer
Biological processBehavior, Host-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390666 Serotonin receptors
R-HSA-416476 G alpha (q) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P28223

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 2A
Short name:
5-HT-2
Short name:
5-HT-2A
Alternative name(s):
Serotonin receptor 2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR2A
Synonyms:HTR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102468.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5293 HTR2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182135 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P28223

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 75ExtracellularBy similarityAdd BLAST75
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei76 – 99Helical; Name=1By similarityAdd BLAST24
Topological domaini100 – 110CytoplasmicBy similarityAdd BLAST11
Transmembranei111 – 132Helical; Name=2By similarityAdd BLAST22
Topological domaini133 – 148ExtracellularBy similarityAdd BLAST16
Transmembranei149 – 171Helical; Name=3By similarityAdd BLAST23
Topological domaini172 – 191CytoplasmicBy similarityAdd BLAST20
Transmembranei192 – 215Helical; Name=4By similarityAdd BLAST24
Topological domaini216 – 233ExtracellularBy similarityAdd BLAST18
Transmembranei234 – 254Helical; Name=5By similarityAdd BLAST21
Topological domaini255 – 324CytoplasmicBy similarityAdd BLAST70
Transmembranei325 – 346Helical; Name=6By similarityAdd BLAST22
Topological domaini347 – 362ExtracellularBy similarityAdd BLAST16
Transmembranei363 – 384Helical; Name=7By similarityAdd BLAST22
Topological domaini385 – 471CytoplasmicBy similarityAdd BLAST87

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi229L → A: Strongly increases dissociation of bound lysergic acid diethylamine, without affecting binding affinity. Reduces signaling via arrestins, but has no effect on signaling via the phosphatidylinositol-calcium second messenger system. 1 Publication1
Mutagenesisi280S → A: Increased ability of hallucinogens to desensitize the receptor. 1 Publication1
Mutagenesisi280S → D: Reduced receptor desensitization by nonhallucinogenic agonists. 1 Publication1
Mutagenesisi463G → V: Loss of interaction with PATJ. 1 Publication1
Mutagenesisi465N → S: No effect on interaction with PATJ. Acquires the binding properties of HTR2C; when associated with S-470. 1 Publication1
Mutagenesisi470C → S: No effect on interaction with PATJ. Acquires the binding properties of HTR2C; when associated with S-465. 1 Publication1
Mutagenesisi471V → A: Loss of interaction with PATJ, CASK, APBA1, DLG1 and DLG4. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3356

MalaCards human disease database

More...
MalaCardsi
HTR2A

Open Targets

More...
OpenTargetsi
ENSG00000102468

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA193

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL224

Drug and drug target database

More...
DrugBanki
DB01614 Acepromazine
DB06288 Amisulpride
DB00321 Amitriptyline
DB00543 Amoxapine
DB08927 Amperozide
DB04599 Aniracetam
DB05026 APD125
DB05227 APD791
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB05687 BL-1020
DB09128 Brexpiprazole
DB01200 Bromocriptine
DB09016 Butriptyline
DB00248 Cabergoline
DB06016 Cariprazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB08810 Cinitapride
DB00604 Cisapride
DB01242 Clomipramine
DB00363 Clozapine
DB00924 Cyclobenzaprine
DB00434 Cyproheptadine
DB06512 Deramciclane
DB01151 Desipramine
DB01488 Dimethyltryptamine
DB00843 Donepezil
DB01142 Doxepin
DB05492 Epicept NP-1
DB00751 Epinastine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB06678 Esmirtazapine
DB04908 Flibanserin
DB00875 Flupentixol
DB04842 Fluspirilene
DB00502 Haloperidol
DB05079 HY10275
DB04946 Iloperidone
DB00458 Imipramine
DB01221 Ketamine
DB00589 Lisuride
DB00408 Loxapine
DB06077 Lumateperone
DB08815 Lurasidone
DB05743 MAP-0004
DB00934 Maprotiline
DB00933 Mesoridazine
DB01403 Methotrimeprazine
DB00247 Methysergide
DB06148 Mianserin
DB00805 Minaprine
DB00370 Mirtazapine
DB01442 MMDA
DB01618 Molindone
DB01149 Nefazodone
DB00540 Nortriptyline
DB00334 Olanzapine
DB01267 Paliperidone
DB00715 Paroxetine
DB01186 Pergolide
DB05316 Pimavanserin
DB01621 Pipotiazine
DB00413 Pramipexole
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00409 Remoxipride
DB00734 Risperidone
DB00268 Ropinirole
DB06144 Sertindole
DB01079 Tegaserod
DB01622 Thioproperazine
DB00679 Thioridazine
DB01623 Thiothixene
DB13025 Tiapride
DB00656 Trazodone
DB00726 Trimipramine
DB01392 Yohimbine
DB00246 Ziprasidone
DB01624 Zuclopenthixol

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HTR2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
543727

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000689461 – 4715-hydroxytryptamine receptor 2AAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi148 ↔ 227PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei280Phosphoserine1 Publication1
Disulfide bondi349 ↔ 353PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P28223

PeptideAtlas

More...
PeptideAtlasi
P28223

PRoteomics IDEntifications database

More...
PRIDEi
P28223

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54453

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P28223

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P28223

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain cortex (at protein level). Detected in blood platelets.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102468 Expressed in 142 organ(s), highest expression level in dorsolateral prefrontal cortex

CleanEx database of gene expression profiles

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CleanExi
HS_HTR2A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P28223 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P28223 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014011

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with MPDZ and PATJ (PubMed:11150294, PubMed:14988405). May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (PubMed:14988405). Interacts with GRM2 and DRD2; this may affect signaling (PubMed:18297054, PubMed:21645528, PubMed:22300836).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109588, 6 interactors

Database of interacting proteins

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DIPi
DIP-41844N

Protein interaction database and analysis system

More...
IntActi
P28223, 15 interactors

Molecular INTeraction database

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MINTi
P28223

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367959

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P28223

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P28223

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P28223

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni155 – 160Agonist bindingBy similarity6
Regioni336 – 340Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi172 – 174DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi376 – 380NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5
Motifi469 – 471PDZ-binding2 Publications3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154007

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000240378

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107487

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P28223

KEGG Orthology (KO)

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KOi
K04157

Identification of Orthologs from Complete Genome Data

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OMAi
AGRRTMQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06VI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P28223

TreeFam database of animal gene trees

More...
TreeFami
TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000455 5HT2A_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...
PANTHERi
PTHR24247:SF30 PTHR24247:SF30, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00516 5HT2ARECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P28223-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE
60 70 80 90 100
NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS
110 120 130 140 150
LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV
160 170 180 190 200
WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW
210 220 230 240 250
TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM
260 270 280 290 300
VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH
310 320 330 340 350
REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK
360 370 380 390 400
ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK
410 420 430 440 450
ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK
460 470
QHSEEASKDN SDGVNEKVSC V
Length:471
Mass (Da):52,603
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF8AAC0BC5379DA2
GO
Isoform 2 (identifier: P28223-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: MDILCEENTS...PVSMLTILYG → MQFLKSAKQK...ISCVDPEDKW

Show »
Length:387
Mass (Da):43,940
Checksum:iDA98167A87C1AAB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZJ9A0A087WZJ9_HUMAN
5-hydroxytryptamine receptor 2A
HTR2A
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: P28223-2)
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49D → N in BAG63991 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00344825T → N2 PublicationsCorresponds to variant dbSNP:rs1805055Ensembl.1
Natural variantiVAR_013901197I → V1 PublicationCorresponds to variant dbSNP:rs6304Ensembl.1
Natural variantiVAR_013902447A → V1 PublicationCorresponds to variant dbSNP:rs6308Ensembl.1
Natural variantiVAR_003449452H → Y3 PublicationsCorresponds to variant dbSNP:rs6314Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0466631 – 138MDILC…TILYG → MQFLKSAKQKPNYYHIMLVE DQEEGTLHQFNYCERCSESQ NNKCISCVDPEDKW in isoform 2. 1 PublicationAdd BLAST138

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X57830 mRNA Translation: CAA40963.1
S42168, S42165, S42167 Genomic DNA Translation: AAB22791.2
S71229 mRNA Translation: AAB31320.1
AF498982 mRNA Translation: AAM21129.1
AK302787 mRNA Translation: BAG63991.1
AK314132 mRNA Translation: BAG36822.1
AL160397 Genomic DNA No translation available.
AL136958 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08770.1
BC069356 mRNA Translation: AAH69356.1
BC069576 mRNA Translation: AAH69576.1
BC074848 mRNA Translation: AAH74848.1
BC074849 mRNA Translation: AAH74849.1
BC096839 mRNA Translation: AAH96839.1
M86841 mRNA Translation: AAA58354.1
S50130, S49737, S50113 Genomic DNA Translation: AAB24166.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS53867.1 [P28223-2]
CCDS9405.1 [P28223-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A43956

NCBI Reference Sequences

More...
RefSeqi
NP_000612.1, NM_000621.4 [P28223-1]
NP_001159419.1, NM_001165947.2 [P28223-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.72630

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378688; ENSP00000367959; ENSG00000102468 [P28223-1]
ENST00000542664; ENSP00000437737; ENSG00000102468 [P28223-1]
ENST00000543956; ENSP00000441861; ENSG00000102468 [P28223-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3356

UCSC genome browser

More...
UCSCi
uc001vbr.5 human [P28223-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57830 mRNA Translation: CAA40963.1
S42168, S42165, S42167 Genomic DNA Translation: AAB22791.2
S71229 mRNA Translation: AAB31320.1
AF498982 mRNA Translation: AAM21129.1
AK302787 mRNA Translation: BAG63991.1
AK314132 mRNA Translation: BAG36822.1
AL160397 Genomic DNA No translation available.
AL136958 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08770.1
BC069356 mRNA Translation: AAH69356.1
BC069576 mRNA Translation: AAH69576.1
BC074848 mRNA Translation: AAH74848.1
BC074849 mRNA Translation: AAH74849.1
BC096839 mRNA Translation: AAH96839.1
M86841 mRNA Translation: AAA58354.1
S50130, S49737, S50113 Genomic DNA Translation: AAB24166.2
CCDSiCCDS53867.1 [P28223-2]
CCDS9405.1 [P28223-1]
PIRiA43956
RefSeqiNP_000612.1, NM_000621.4 [P28223-1]
NP_001159419.1, NM_001165947.2 [P28223-2]
UniGeneiHs.72630

3D structure databases

ProteinModelPortaliP28223
SMRiP28223
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109588, 6 interactors
DIPiDIP-41844N
IntActiP28223, 15 interactors
MINTiP28223
STRINGi9606.ENSP00000367959

Chemistry databases

BindingDBiP28223
ChEMBLiCHEMBL224
DrugBankiDB01614 Acepromazine
DB06288 Amisulpride
DB00321 Amitriptyline
DB00543 Amoxapine
DB08927 Amperozide
DB04599 Aniracetam
DB05026 APD125
DB05227 APD791
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB05687 BL-1020
DB09128 Brexpiprazole
DB01200 Bromocriptine
DB09016 Butriptyline
DB00248 Cabergoline
DB06016 Cariprazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB08810 Cinitapride
DB00604 Cisapride
DB01242 Clomipramine
DB00363 Clozapine
DB00924 Cyclobenzaprine
DB00434 Cyproheptadine
DB06512 Deramciclane
DB01151 Desipramine
DB01488 Dimethyltryptamine
DB00843 Donepezil
DB01142 Doxepin
DB05492 Epicept NP-1
DB00751 Epinastine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB06678 Esmirtazapine
DB04908 Flibanserin
DB00875 Flupentixol
DB04842 Fluspirilene
DB00502 Haloperidol
DB05079 HY10275
DB04946 Iloperidone
DB00458 Imipramine
DB01221 Ketamine
DB00589 Lisuride
DB00408 Loxapine
DB06077 Lumateperone
DB08815 Lurasidone
DB05743 MAP-0004
DB00934 Maprotiline
DB00933 Mesoridazine
DB01403 Methotrimeprazine
DB00247 Methysergide
DB06148 Mianserin
DB00805 Minaprine
DB00370 Mirtazapine
DB01442 MMDA
DB01618 Molindone
DB01149 Nefazodone
DB00540 Nortriptyline
DB00334 Olanzapine
DB01267 Paliperidone
DB00715 Paroxetine
DB01186 Pergolide
DB05316 Pimavanserin
DB01621 Pipotiazine
DB00413 Pramipexole
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00409 Remoxipride
DB00734 Risperidone
DB00268 Ropinirole
DB06144 Sertindole
DB01079 Tegaserod
DB01622 Thioproperazine
DB00679 Thioridazine
DB01623 Thiothixene
DB13025 Tiapride
DB00656 Trazodone
DB00726 Trimipramine
DB01392 Yohimbine
DB00246 Ziprasidone
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi6

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP28223
PhosphoSitePlusiP28223

Polymorphism and mutation databases

BioMutaiHTR2A
DMDMi543727

Proteomic databases

PaxDbiP28223
PeptideAtlasiP28223
PRIDEiP28223
ProteomicsDBi54453

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378688; ENSP00000367959; ENSG00000102468 [P28223-1]
ENST00000542664; ENSP00000437737; ENSG00000102468 [P28223-1]
ENST00000543956; ENSP00000441861; ENSG00000102468 [P28223-2]
GeneIDi3356
KEGGihsa:3356
UCSCiuc001vbr.5 human [P28223-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3356
DisGeNETi3356
EuPathDBiHostDB:ENSG00000102468.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HTR2A
HGNCiHGNC:5293 HTR2A
HPAiHPA014011
MalaCardsiHTR2A
MIMi182135 gene
neXtProtiNX_P28223
OpenTargetsiENSG00000102468
PharmGKBiPA193

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000154007
HOGENOMiHOG000240378
HOVERGENiHBG107487
InParanoidiP28223
KOiK04157
OMAiAGRRTMQ
OrthoDBiEOG091G06VI
PhylomeDBiP28223
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-416476 G alpha (q) signalling events
SignaLinkiP28223

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
5-HT2A_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3356

Protein Ontology

More...
PROi
PR:P28223

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102468 Expressed in 142 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_HTR2A
ExpressionAtlasiP28223 baseline and differential
GenevisibleiP28223 HS

Family and domain databases

InterProiView protein in InterPro
IPR000455 5HT2A_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF30 PTHR24247:SF30, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00516 5HT2ARECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28223
Secondary accession number(s): B2RAC5
, B4DZ79, F5GWE8, Q5T8C0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 1, 1994
Last modified: December 5, 2018
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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