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UniProtKB - P28222 (5HT1B_HUMAN)

Entry version 191 (07 Apr 2021)
Sequence version 1 (01 Dec 1992)
Previous versions | rss
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Protein

5-hydroxytryptamine receptor 1B

Gene

HTR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.12 Publications

Miscellaneous

A residue in the 7th transmembrane region (Thr-355 in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei355Important for species-specific agonist sensitivity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P28222

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390666, Serotonin receptors
R-HSA-418594, G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		P28222

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.3.6, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1B
Short name:
5-HT-1B
Short name:
5-HT1B
Alternative name(s):
S12
Serotonin 1D beta receptor
Short name:
5-HT-1D-beta
Serotonin receptor 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR1B
Synonyms:HTR1DB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5287, HTR1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182131, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P28222

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000135312.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49ExtracellularAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 75Helical; Name=1Add BLAST26
Topological domaini76 – 84Cytoplasmic9
Transmembranei85 – 110Helical; Name=2Add BLAST26
Topological domaini111 – 123ExtracellularAdd BLAST13
Transmembranei124 – 145Helical; Name=3Add BLAST22
Topological domaini146 – 165CytoplasmicAdd BLAST20
Transmembranei166 – 187Helical; Name=4Add BLAST22
Topological domaini188 – 205ExtracellularAdd BLAST18
Transmembranei206 – 228Helical; Name=5Add BLAST23
Topological domaini229 – 315CytoplasmicAdd BLAST87
Transmembranei316 – 336Helical; Name=6Add BLAST21
Topological domaini337 – 349ExtracellularAdd BLAST13
Transmembranei350 – 371Helical; Name=7Add BLAST22
Topological domaini372 – 390CytoplasmicAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi126L → A: No effect on agonist binding. 1 Publication1
Mutagenesisi129D → A: Abolishes agonist binding. 1 Publication1
Mutagenesisi130I → A: Abolishes agonist binding. 1 Publication1
Mutagenesisi133C → A: Abolishes agonist binding. 1 Publication1
Mutagenesisi134T → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi200V → A: No effect on agonist binding. 1 Publication1
Mutagenesisi201V → A: No effect on agonist binding. 1 Publication1
Mutagenesisi203T → A: No effect on agonist binding. 1 Publication1
Mutagenesisi209T → A: No effect on agonist binding. 1 Publication1
Mutagenesisi212S → A: No effect on agonist binding. 1 Publication1
Mutagenesisi216A → S: No effect on agonist binding. 1 Publication1
Mutagenesisi327W → A: Abolishes agonist binding. 1 Publication1
Mutagenesisi330F → A: Abolishes agonist binding. 1 Publication1
Mutagenesisi331F → A: No effect on agonist binding. 1 Publication1
Mutagenesisi334S → A: No effect on agonist binding. 1 Publication1
Mutagenesisi337M → A: No effect on agonist binding. 1 Publication1
Mutagenesisi351F → A: No effect on agonist binding. 1 Publication1
Mutagenesisi352D → A: No effect on agonist binding. 1 Publication1
Mutagenesisi355T → A: No effect on agonist binding. 1 Publication1
Mutagenesisi359Y → A: No effect on agonist binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3351

Open Targets

More...OpenTargetsi		ENSG00000135312

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29549

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P28222, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1898

Drug and drug target database

More...DrugBanki		DB00918, Almotriptan
DB00321, Amitriptyline
DB00543, Amoxapine
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB08807, Bopindolol
DB01200, Bromocriptine
DB00248, Cabergoline
DB01239, Chlorprothixene
DB00363, Clozapine
DB04884, Dapoxetine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB00320, Dihydroergotamine
DB00216, Eletriptan
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB00998, Frovatriptan
DB12141, Gilteritinib
DB01221, Ketamine
DB00589, Lisuride
DB00408, Loxapine
DB00247, Methysergide
DB00952, Naratriptan
DB06096, NXN-188
DB00334, Olanzapine
DB00904, Ondansetron
DB00715, Paroxetine
DB01359, Penbutolol
DB01186, Pergolide
DB00960, Pindolol
DB06153, Pizotifen
DB00571, Propranolol
DB01224, Quetiapine
DB00953, Rizatriptan
DB09304, Setiptiline
DB00669, Sumatriptan
DB13025, Tiapride
DB09068, Vortioxetine
DB01392, Yohimbine
DB00246, Ziprasidone
DB00315, Zolmitriptan

DrugCentral

More...DrugCentrali		P28222

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HTR1B

Domain mapping of disease mutations (DMDM)

More...DMDMi		112821

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000689161 – 3905-hydroxytryptamine receptor 1BAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi122 ↔ 199PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi388S-palmitoyl cysteineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.1 Publication
Palmitoylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P28222

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P28222

PeptideAtlas

More...PeptideAtlasi		P28222

PRoteomics IDEntifications database

More...PRIDEi		P28222

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54452

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P28222, 3 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P28222

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P28222

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135312, Expressed in popliteal artery and 94 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P28222, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P28222, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135312, Tissue enhanced (brain, placenta, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer with HTR1D.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109583, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P28222

Protein interaction database and analysis system

More...IntActi		P28222, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358963

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P28222

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P28222, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P28222

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni125 – 134Agonist binding10
Regioni327 – 331Agonist binding5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi146 – 148DRY motif; important for ligand-induced conformation changes and signaling3
Motifi365 – 369NPxxY motif; important for ligand-induced conformation changes and signaling5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222287

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P28222

Identification of Orthologs from Complete Genome Data

More...OMAi		ACWFHMA

Database of Orthologous Groups

More...OrthoDBi		354230at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P28222

TreeFam database of animal gene trees

More...TreeFami		TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002147, 5HT1B_rcpt
IPR002231, 5HT_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...PANTHERi		PTHR24247:SF16, PTHR24247:SF16, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00513, 5HT1BRECEPTR
PR01101, 5HTRECEPTOR
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P28222-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV 
        60         70         80         90        100
LLVMLLALIT LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI 
       110        120        130        140        150
LVMPISTMYT VTGRWTLGQV VCDFWLSSDI TCCTASILHL CVIALDRYWA 
       160        170        180        190        200
ITDAVEYSAK RTPKRAAVMI ALVWVFSISI SLPPFFWRQA KAEEEVSECV 
       210        220        230        240        250
VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL KQTPNRTGKR 
       260        270        280        290        300
LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE 
       310        320        330        340        350
KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI 
       360        370        380        390
FDFFTWLGYL NSLINPIIYT MSNEDFKQAF HKLIRFKCTS
Length:390
Mass (Da):43,568
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD874DC7EB44CF12
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011715124F → C1 PublicationCorresponds to variant dbSNP:rs130060Ensembl.1
Natural variantiVAR_011831219F → L. Corresponds to variant dbSNP:rs130061Ensembl.1
Natural variantiVAR_011832367I → V. Corresponds to variant dbSNP:rs130063Ensembl.1
Natural variantiVAR_011833374E → K. Corresponds to variant dbSNP:rs130064Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M89478 Genomic DNA No translation available.
D10995 Genomic DNA Translation: BAA01763.1
M83180 Genomic DNA Translation: AAA36029.1
L09732 Genomic DNA Translation: AAA36030.1
M81590 mRNA Translation: AAA60316.1
M75128 Genomic DNA Translation: AAA58675.1
AB041370 Genomic DNA Translation: BAA94455.1
AY225227 Genomic DNA Translation: AAO67712.1
AL049595 Genomic DNA No translation available.
BC069065 mRNA Translation: AAH69065.1
BC096206 mRNA Translation: AAH96206.1
BC096207 mRNA Translation: AAH96207.1
BC096208 mRNA Translation: AAH96208.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4986.1

Protein sequence database of the Protein Information Resource

More...PIRi		JN0268

NCBI Reference Sequences

More...RefSeqi		NP_000854.1, NM_000863.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369947; ENSP00000358963; ENSG00000135312

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3351

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3351

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89478 Genomic DNA No translation available.
D10995 Genomic DNA Translation: BAA01763.1
M83180 Genomic DNA Translation: AAA36029.1
L09732 Genomic DNA Translation: AAA36030.1
M81590 mRNA Translation: AAA60316.1
M75128 Genomic DNA Translation: AAA58675.1
AB041370 Genomic DNA Translation: BAA94455.1
AY225227 Genomic DNA Translation: AAO67712.1
AL049595 Genomic DNA No translation available.
BC069065 mRNA Translation: AAH69065.1
BC096206 mRNA Translation: AAH96206.1
BC096207 mRNA Translation: AAH96207.1
BC096208 mRNA Translation: AAH96208.1
CCDSiCCDS4986.1
PIRiJN0268
RefSeqiNP_000854.1, NM_000863.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G1Xmodel-A1-390[»]
4IAQX-ray2.80A33-239[»]
A304-390[»]
4IARX-ray2.70A33-239[»]
A306-390[»]
5V54X-ray3.90A/B37-390[»]
6G79electron microscopy3.78S34-390[»]
7C61X-ray3.00A33-239[»]
A306-390[»]
SMRiP28222
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109583, 7 interactors
CORUMiP28222
IntActiP28222, 7 interactors
STRINGi9606.ENSP00000358963

Chemistry databases

BindingDBiP28222
ChEMBLiCHEMBL1898
DrugBankiDB00918, Almotriptan
DB00321, Amitriptyline
DB00543, Amoxapine
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB08807, Bopindolol
DB01200, Bromocriptine
DB00248, Cabergoline
DB01239, Chlorprothixene
DB00363, Clozapine
DB04884, Dapoxetine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB00320, Dihydroergotamine
DB00216, Eletriptan
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB00998, Frovatriptan
DB12141, Gilteritinib
DB01221, Ketamine
DB00589, Lisuride
DB00408, Loxapine
DB00247, Methysergide
DB00952, Naratriptan
DB06096, NXN-188
DB00334, Olanzapine
DB00904, Ondansetron
DB00715, Paroxetine
DB01359, Penbutolol
DB01186, Pergolide
DB00960, Pindolol
DB06153, Pizotifen
DB00571, Propranolol
DB01224, Quetiapine
DB00953, Rizatriptan
DB09304, Setiptiline
DB00669, Sumatriptan
DB13025, Tiapride
DB09068, Vortioxetine
DB01392, Yohimbine
DB00246, Ziprasidone
DB00315, Zolmitriptan
DrugCentraliP28222
GuidetoPHARMACOLOGYi2

Protein family/group databases

TCDBi9.A.14.3.6, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP28222, 3 sites, 1 O-linked glycan (1 site)
iPTMnetiP28222
PhosphoSitePlusiP28222

Genetic variation databases

BioMutaiHTR1B
DMDMi112821

Proteomic databases

MassIVEiP28222
PaxDbiP28222
PeptideAtlasiP28222
PRIDEiP28222
ProteomicsDBi54452

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18374, 290 antibodies

The DNASU plasmid repository

More...DNASUi		3351

Genome annotation databases

EnsembliENST00000369947; ENSP00000358963; ENSG00000135312
GeneIDi3351
KEGGihsa:3351

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3351
DisGeNETi3351

GeneCards: human genes, protein and diseases

More...GeneCardsi		HTR1B
HGNCiHGNC:5287, HTR1B
HPAiENSG00000135312, Tissue enhanced (brain, placenta, stomach)
MIMi182131, gene
neXtProtiNX_P28222
OpenTargetsiENSG00000135312
PharmGKBiPA29549
VEuPathDBiHostDB:ENSG00000135312.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01010000222287
HOGENOMiCLU_009579_11_1_1
InParanoidiP28222
OMAiACWFHMA
OrthoDBi354230at2759
PhylomeDBiP28222
TreeFamiTF316350

Enzyme and pathway databases

PathwayCommonsiP28222
ReactomeiR-HSA-390666, Serotonin receptors
R-HSA-418594, G alpha (i) signalling events
SIGNORiP28222

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3351, 10 hits in 987 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		5-HT1B_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3351
PharosiP28222, Tclin

Protein Ontology

More...PROi		PR:P28222
RNActiP28222, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135312, Expressed in popliteal artery and 94 other tissues
ExpressionAtlasiP28222, baseline and differential
GenevisibleiP28222, HS

Family and domain databases

InterProiView protein in InterPro
IPR002147, 5HT1B_rcpt
IPR002231, 5HT_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF16, PTHR24247:SF16, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00513, 5HT1BRECEPTR
PR01101, 5HTRECEPTOR
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28222
Secondary accession number(s): Q4VAY7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 7, 2021
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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