UniProtKB - P28222 (5HT1B_HUMAN)
Protein
5-hydroxytryptamine receptor 1B
Gene
HTR1B
Organism
Homo sapiens (Human)
Status
Functioni
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.12 Publications
Miscellaneous
A residue in the 7th transmembrane region (Thr-355 in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 355 | Important for species-specific agonist sensitivity | 1 |
GO - Molecular functioni
- drug binding Source: Ensembl
- G protein-coupled receptor activity Source: GO_Central
- G protein-coupled serotonin receptor activity Source: UniProtKB
- neurotransmitter receptor activity Source: GO_Central
- serotonin binding Source: Ensembl
- voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Source: Ensembl
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
- adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
- bone remodeling Source: Ensembl
- cellular response to alkaloid Source: UniProtKB
- cellular response to drug Source: UniProtKB
- cellular response to temperature stimulus Source: Ensembl
- chemical synaptic transmission Source: GO_Central
- drinking behavior Source: Ensembl
- G protein-coupled receptor internalization Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- negative regulation of serotonin secretion Source: UniProtKB
- negative regulation of synaptic transmission, GABAergic Source: Ensembl
- negative regulation of synaptic transmission, glutamatergic Source: Ensembl
- positive regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
- presynaptic modulation of chemical synaptic transmission Source: Ensembl
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- regulation of behavior Source: InterPro
- regulation of dopamine secretion Source: Ensembl
- regulation of synaptic vesicle exocytosis Source: Ensembl
- response to cocaine Source: Ensembl
- response to ethanol Source: Ensembl
- response to mineralocorticoid Source: Ensembl
- vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Behavior |
Enzyme and pathway databases
Reactomei | R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events |
Protein family/group databases
TCDBi | 9.A.14.3.6 the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 1BShort name: 5-HT-1B Short name: 5-HT1B Alternative name(s): S12 Serotonin 1D beta receptor Short name: 5-HT-1D-beta Serotonin receptor 1B |
Gene namesi | Name:HTR1B Synonyms:HTR1DB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000135312.5 |
HGNCi | HGNC:5287 HTR1B |
MIMi | 182131 gene |
neXtProti | NX_P28222 |
Subcellular locationi
Plasma membrane
- Cell membrane 10 Publications; Multi-pass membrane protein 10 Publications
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: HPA
Other locations
- calyx of Held Source: Ensembl
- cytoplasm Source: Ensembl
- dendrite Source: GO_Central
- serotonergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 49 | ExtracellularAdd BLAST | 49 | |
Transmembranei | 50 – 75 | Helical; Name=1Add BLAST | 26 | |
Topological domaini | 76 – 84 | Cytoplasmic | 9 | |
Transmembranei | 85 – 110 | Helical; Name=2Add BLAST | 26 | |
Topological domaini | 111 – 123 | ExtracellularAdd BLAST | 13 | |
Transmembranei | 124 – 145 | Helical; Name=3Add BLAST | 22 | |
Topological domaini | 146 – 165 | CytoplasmicAdd BLAST | 20 | |
Transmembranei | 166 – 187 | Helical; Name=4Add BLAST | 22 | |
Topological domaini | 188 – 205 | ExtracellularAdd BLAST | 18 | |
Transmembranei | 206 – 228 | Helical; Name=5Add BLAST | 23 | |
Topological domaini | 229 – 315 | CytoplasmicAdd BLAST | 87 | |
Transmembranei | 316 – 336 | Helical; Name=6Add BLAST | 21 | |
Topological domaini | 337 – 349 | ExtracellularAdd BLAST | 13 | |
Transmembranei | 350 – 371 | Helical; Name=7Add BLAST | 22 | |
Topological domaini | 372 – 390 | CytoplasmicAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 126 | L → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 129 | D → A: Abolishes agonist binding. 1 Publication | 1 | |
Mutagenesisi | 130 | I → A: Abolishes agonist binding. 1 Publication | 1 | |
Mutagenesisi | 133 | C → A: Abolishes agonist binding. 1 Publication | 1 | |
Mutagenesisi | 134 | T → A: Slightly decreases agonist binding. 1 Publication | 1 | |
Mutagenesisi | 200 | V → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 201 | V → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 203 | T → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 209 | T → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 212 | S → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 216 | A → S: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 327 | W → A: Abolishes agonist binding. 1 Publication | 1 | |
Mutagenesisi | 330 | F → A: Abolishes agonist binding. 1 Publication | 1 | |
Mutagenesisi | 331 | F → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 334 | S → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 337 | M → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 351 | F → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 352 | D → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 355 | T → A: No effect on agonist binding. 1 Publication | 1 | |
Mutagenesisi | 359 | Y → A: No effect on agonist binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3351 |
OpenTargetsi | ENSG00000135312 |
PharmGKBi | PA29549 |
Chemistry databases
ChEMBLi | CHEMBL1898 |
DrugBanki | DB00918 Almotriptan DB00321 Amitriptyline DB00543 Amoxapine DB00714 Apomorphine DB01238 Aripiprazole DB06216 Asenapine DB08807 Bopindolol DB01200 Bromocriptine DB00248 Cabergoline DB00363 Clozapine DB04884 Dapoxetine DB00320 Dihydroergotamine DB00216 Eletriptan DB01049 Ergoloid mesylate DB00696 Ergotamine DB00998 Frovatriptan DB01221 Ketamine DB00589 Lisuride DB00408 Loxapine DB05743 MAP-0004 DB00247 Methysergide DB00952 Naratriptan DB06096 NXN-188 DB00334 Olanzapine DB00904 Ondansetron DB01359 Penbutolol DB01186 Pergolide DB00960 Pindolol DB00413 Pramipexole DB00571 Propranolol DB01224 Quetiapine DB00953 Rizatriptan DB00268 Ropinirole DB00669 Sumatriptan DB13025 Tiapride DB09068 Vortioxetine DB01392 Yohimbine DB00246 Ziprasidone DB00315 Zolmitriptan |
GuidetoPHARMACOLOGYi | 2 |
Polymorphism and mutation databases
BioMutai | HTR1B |
DMDMi | 112821 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068916 | 1 – 390 | 5-hydroxytryptamine receptor 1BAdd BLAST | 390 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 24 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 122 ↔ 199 | PROSITE-ProRule annotation1 Publication | ||
Lipidationi | 388 | S-palmitoyl cysteineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.1 Publication
Palmitoylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P28222 |
PRIDEi | P28222 |
ProteomicsDBi | 54452 |
PTM databases
iPTMneti | P28222 |
PhosphoSitePlusi | P28222 |
Expressioni
Tissue specificityi
Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.3 Publications
Gene expression databases
Bgeei | ENSG00000135312 Expressed in 72 organ(s), highest expression level in popliteal artery |
ExpressionAtlasi | P28222 baseline and differential |
Genevisiblei | P28222 HS |
Organism-specific databases
HPAi | HPA028808 |
Interactioni
Subunit structurei
Homodimer. Heterodimer with HTR1D.1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
MDFI | Q99750 | 6 | EBI-1056863,EBI-724076 |
Protein-protein interaction databases
BioGridi | 109583, 5 interactors |
CORUMi | P28222 |
IntActi | P28222, 6 interactors |
STRINGi | 9606.ENSP00000358963 |
Chemistry databases
BindingDBi | P28222 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2G1X | model | - | A | 1-390 | [»] | |
4IAQ | X-ray | 2.80 | A | 33-239 | [»] | |
A | 304-390 | [»] | ||||
4IAR | X-ray | 2.70 | A | 33-239 | [»] | |
A | 306-390 | [»] | ||||
5V54 | X-ray | 3.90 | A/B | 37-390 | [»] | |
6G79 | electron microscopy | 3.78 | S | 34-390 | [»] | |
ProteinModelPortali | P28222 | |||||
SMRi | P28222 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 125 – 134 | Agonist binding | 10 | |
Regioni | 327 – 331 | Agonist binding | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 146 – 148 | DRY motif; important for ligand-induced conformation changes and signaling | 3 | |
Motifi | 365 – 369 | NPxxY motif; important for ligand-induced conformation changes and signaling | 5 |
Domaini
Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.1 Publication
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000154624 |
HOGENOMi | HOG000239242 |
HOVERGENi | HBG106962 |
InParanoidi | P28222 |
KOi | K04153 |
OMAi | ACWFHMA |
OrthoDBi | 703991at2759 |
PhylomeDBi | P28222 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR002147 5HT1B_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF16 PTHR24247:SF16, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00513 5HT1BRECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P28222-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV
60 70 80 90 100
LLVMLLALIT LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI
110 120 130 140 150
LVMPISTMYT VTGRWTLGQV VCDFWLSSDI TCCTASILHL CVIALDRYWA
160 170 180 190 200
ITDAVEYSAK RTPKRAAVMI ALVWVFSISI SLPPFFWRQA KAEEEVSECV
210 220 230 240 250
VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL KQTPNRTGKR
260 270 280 290 300
LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE
310 320 330 340 350
KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI
360 370 380 390
FDFFTWLGYL NSLINPIIYT MSNEDFKQAF HKLIRFKCTS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011715 | 124 | F → C1 PublicationCorresponds to variant dbSNP:rs130060Ensembl. | 1 | |
Natural variantiVAR_011831 | 219 | F → L. Corresponds to variant dbSNP:rs130061Ensembl. | 1 | |
Natural variantiVAR_011832 | 367 | I → V. Corresponds to variant dbSNP:rs130063Ensembl. | 1 | |
Natural variantiVAR_011833 | 374 | E → K. Corresponds to variant dbSNP:rs130064Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M89478 Genomic DNA No translation available. D10995 Genomic DNA Translation: BAA01763.1 M83180 Genomic DNA Translation: AAA36029.1 L09732 Genomic DNA Translation: AAA36030.1 M81590 mRNA Translation: AAA60316.1 M75128 Genomic DNA Translation: AAA58675.1 AB041370 Genomic DNA Translation: BAA94455.1 AY225227 Genomic DNA Translation: AAO67712.1 AL049595 Genomic DNA No translation available. BC069065 mRNA Translation: AAH69065.1 BC096206 mRNA Translation: AAH96206.1 BC096207 mRNA Translation: AAH96207.1 BC096208 mRNA Translation: AAH96208.1 |
CCDSi | CCDS4986.1 |
PIRi | JN0268 |
RefSeqi | NP_000854.1, NM_000863.2 |
UniGenei | Hs.123016 |
Genome annotation databases
Ensembli | ENST00000369947; ENSP00000358963; ENSG00000135312 |
GeneIDi | 3351 |
KEGGi | hsa:3351 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M89478 Genomic DNA No translation available. D10995 Genomic DNA Translation: BAA01763.1 M83180 Genomic DNA Translation: AAA36029.1 L09732 Genomic DNA Translation: AAA36030.1 M81590 mRNA Translation: AAA60316.1 M75128 Genomic DNA Translation: AAA58675.1 AB041370 Genomic DNA Translation: BAA94455.1 AY225227 Genomic DNA Translation: AAO67712.1 AL049595 Genomic DNA No translation available. BC069065 mRNA Translation: AAH69065.1 BC096206 mRNA Translation: AAH96206.1 BC096207 mRNA Translation: AAH96207.1 BC096208 mRNA Translation: AAH96208.1 |
CCDSi | CCDS4986.1 |
PIRi | JN0268 |
RefSeqi | NP_000854.1, NM_000863.2 |
UniGenei | Hs.123016 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2G1X | model | - | A | 1-390 | [»] | |
4IAQ | X-ray | 2.80 | A | 33-239 | [»] | |
A | 304-390 | [»] | ||||
4IAR | X-ray | 2.70 | A | 33-239 | [»] | |
A | 306-390 | [»] | ||||
5V54 | X-ray | 3.90 | A/B | 37-390 | [»] | |
6G79 | electron microscopy | 3.78 | S | 34-390 | [»] | |
ProteinModelPortali | P28222 | |||||
SMRi | P28222 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 109583, 5 interactors |
CORUMi | P28222 |
IntActi | P28222, 6 interactors |
STRINGi | 9606.ENSP00000358963 |
Chemistry databases
BindingDBi | P28222 |
ChEMBLi | CHEMBL1898 |
DrugBanki | DB00918 Almotriptan DB00321 Amitriptyline DB00543 Amoxapine DB00714 Apomorphine DB01238 Aripiprazole DB06216 Asenapine DB08807 Bopindolol DB01200 Bromocriptine DB00248 Cabergoline DB00363 Clozapine DB04884 Dapoxetine DB00320 Dihydroergotamine DB00216 Eletriptan DB01049 Ergoloid mesylate DB00696 Ergotamine DB00998 Frovatriptan DB01221 Ketamine DB00589 Lisuride DB00408 Loxapine DB05743 MAP-0004 DB00247 Methysergide DB00952 Naratriptan DB06096 NXN-188 DB00334 Olanzapine DB00904 Ondansetron DB01359 Penbutolol DB01186 Pergolide DB00960 Pindolol DB00413 Pramipexole DB00571 Propranolol DB01224 Quetiapine DB00953 Rizatriptan DB00268 Ropinirole DB00669 Sumatriptan DB13025 Tiapride DB09068 Vortioxetine DB01392 Yohimbine DB00246 Ziprasidone DB00315 Zolmitriptan |
GuidetoPHARMACOLOGYi | 2 |
Protein family/group databases
TCDBi | 9.A.14.3.6 the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
iPTMneti | P28222 |
PhosphoSitePlusi | P28222 |
Polymorphism and mutation databases
BioMutai | HTR1B |
DMDMi | 112821 |
Proteomic databases
PaxDbi | P28222 |
PRIDEi | P28222 |
ProteomicsDBi | 54452 |
Protocols and materials databases
DNASUi | 3351 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000369947; ENSP00000358963; ENSG00000135312 |
GeneIDi | 3351 |
KEGGi | hsa:3351 |
Organism-specific databases
CTDi | 3351 |
DisGeNETi | 3351 |
EuPathDBi | HostDB:ENSG00000135312.5 |
GeneCardsi | HTR1B |
HGNCi | HGNC:5287 HTR1B |
HPAi | HPA028808 |
MIMi | 182131 gene |
neXtProti | NX_P28222 |
OpenTargetsi | ENSG00000135312 |
PharmGKBi | PA29549 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000154624 |
HOGENOMi | HOG000239242 |
HOVERGENi | HBG106962 |
InParanoidi | P28222 |
KOi | K04153 |
OMAi | ACWFHMA |
OrthoDBi | 703991at2759 |
PhylomeDBi | P28222 |
TreeFami | TF316350 |
Enzyme and pathway databases
Reactomei | R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events |
Miscellaneous databases
GeneWikii | 5-HT1B_receptor |
GenomeRNAii | 3351 |
PROi | PR:P28222 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135312 Expressed in 72 organ(s), highest expression level in popliteal artery |
ExpressionAtlasi | P28222 baseline and differential |
Genevisiblei | P28222 HS |
Family and domain databases
InterProi | View protein in InterPro IPR002147 5HT1B_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF16 PTHR24247:SF16, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00513 5HT1BRECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | 5HT1B_HUMAN | |
Accessioni | P28222Primary (citable) accession number: P28222 Secondary accession number(s): Q4VAY7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 13, 2019 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries