HTR1B

Functionⁱ

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.12 Publications

Miscellaneous

A residue in the 7th transmembrane region (Thr-355 in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	355	Important for species-specific agonist sensitivity		1

GO - Molecular functionⁱ

drug binding Source: Ensembl
G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1315531
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
serotonin binding Source: Ensembl
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 8882600
adenylate cyclase-inhibiting serotonin receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 1315531
bone remodeling Source: Ensembl
cellular response to alkaloid
Source: UniProtKB
Inferred from direct assayⁱ
- 1315531
cellular response to drug
Source: UniProtKB
Inferred from direct assayⁱ
- 1315531
cellular response to temperature stimulus Source: Ensembl
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
drinking behavior Source: Ensembl
G protein-coupled receptor internalization Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of serotonin secretion Source: UniProtKB
negative regulation of synaptic transmission, GABAergic Source: Ensembl
negative regulation of synaptic transmission, glutamatergic Source: Ensembl
positive regulation of vascular smooth muscle cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 25871906
presynaptic modulation of chemical synaptic transmission Source: Ensembl
protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
regulation of behavior Source: InterPro
regulation of dopamine secretion Source: Ensembl
regulation of synaptic vesicle exocytosis Source: Ensembl
response to cocaine Source: Ensembl
response to ethanol Source: Ensembl
response to mineralocorticoid Source: Ensembl
vasoconstriction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Behavior

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events

Protein family/group databases

TCDBⁱ

9.A.14.3.6 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 1B Short name: 5-HT-1B Short name: 5-HT1B Alternative name(s): S12 Serotonin 1D beta receptor Short name: 5-HT-1D-beta Serotonin receptor 1B
Gene namesⁱ	Name:HTR1B Synonyms:HTR1DB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135312.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5287 HTR1B
MIMⁱ	182131 gene
neXtProtⁱ	NX_P28222

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 49	ExtracellularAdd BLAST	49
Transmembraneⁱ	50 – 75	Helical; Name=1Add BLAST	26
Topological domainⁱ	76 – 84	Cytoplasmic	9
Transmembraneⁱ	85 – 110	Helical; Name=2Add BLAST	26
Topological domainⁱ	111 – 123	ExtracellularAdd BLAST	13
Transmembraneⁱ	124 – 145	Helical; Name=3Add BLAST	22
Topological domainⁱ	146 – 165	CytoplasmicAdd BLAST	20
Transmembraneⁱ	166 – 187	Helical; Name=4Add BLAST	22
Topological domainⁱ	188 – 205	ExtracellularAdd BLAST	18
Transmembraneⁱ	206 – 228	Helical; Name=5Add BLAST	23
Topological domainⁱ	229 – 315	CytoplasmicAdd BLAST	87
Transmembraneⁱ	316 – 336	Helical; Name=6Add BLAST	21
Topological domainⁱ	337 – 349	ExtracellularAdd BLAST	13
Transmembraneⁱ	350 – 371	Helical; Name=7Add BLAST	22
Topological domainⁱ	372 – 390	CytoplasmicAdd BLAST	19

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	126	L → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	129	D → A: Abolishes agonist binding. 1 Publication	1
Mutagenesisⁱ	130	I → A: Abolishes agonist binding. 1 Publication	1
Mutagenesisⁱ	133	C → A: Abolishes agonist binding. 1 Publication	1
Mutagenesisⁱ	134	T → A: Slightly decreases agonist binding. 1 Publication	1
Mutagenesisⁱ	200	V → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	201	V → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	203	T → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	209	T → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	212	S → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	216	A → S: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	327	W → A: Abolishes agonist binding. 1 Publication	1
Mutagenesisⁱ	330	F → A: Abolishes agonist binding. 1 Publication	1
Mutagenesisⁱ	331	F → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	334	S → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	337	M → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	351	F → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	352	D → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	355	T → A: No effect on agonist binding. 1 Publication	1
Mutagenesisⁱ	359	Y → A: No effect on agonist binding. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3351
Open Targets More...OpenTargetsⁱ	ENSG00000135312
PharmGKBⁱ	PA29549

Chemistry databases

ChEMBLⁱ	CHEMBL1898
Drug and drug target database More...DrugBankⁱ	DB00918 Almotriptan DB00321 Amitriptyline DB00543 Amoxapine DB00714 Apomorphine DB01238 Aripiprazole DB06216 Asenapine DB08807 Bopindolol DB01200 Bromocriptine DB00248 Cabergoline DB00363 Clozapine DB04884 Dapoxetine DB00320 Dihydroergotamine DB00216 Eletriptan DB01049 Ergoloid mesylate DB00696 Ergotamine DB00998 Frovatriptan DB01221 Ketamine DB00589 Lisuride DB00408 Loxapine DB05743 MAP-0004 DB00247 Methysergide DB00952 Naratriptan DB06096 NXN-188 DB00334 Olanzapine DB00904 Ondansetron DB01359 Penbutolol DB01186 Pergolide DB00960 Pindolol DB00413 Pramipexole DB00571 Propranolol DB01224 Quetiapine DB00953 Rizatriptan DB00268 Ropinirole DB00669 Sumatriptan DB13025 Tiapride DB09068 Vortioxetine DB01392 Yohimbine DB00246 Ziprasidone DB00315 Zolmitriptan
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2

Polymorphism and mutation databases

BioMutaⁱ	HTR1B
DMDMⁱ	112821

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068916	1 – 390	5-hydroxytryptamine receptor 1BAdd BLAST		390

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	24	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	32	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	122 ↔ 199	PROSITE-ProRule annotation1 Publication
Lipidationⁱ	388	S-palmitoyl cysteineSequence analysis	1

Post-translational modificationⁱ

Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.1 Publication

Palmitoylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbⁱ	P28222
PRIDEⁱ	P28222
ProteomicsDBⁱ	54452

PTM databases

iPTMnetⁱ	P28222
PhosphoSitePlusⁱ	P28222

Expressionⁱ

Tissue specificityⁱ

Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000135312 Expressed in 72 organ(s), highest expression level in popliteal artery
CleanExⁱ	HS_HTR1B
ExpressionAtlasⁱ	P28222 baseline and differential
Genevisibleⁱ	P28222 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028808

HPAⁱ

HPA028808

Interactionⁱ

Subunit structureⁱ

Homodimer. Heterodimer with HTR1D.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MDFI	Q99750	6	EBI-1056863,EBI-724076

With

Entry

#Exp.

IntAct

Notes

MDFI

Q99750

6

EBI-1056863,EBI-724076

Protein-protein interaction databases

BioGridⁱ	109583, 5 interactors
CORUMⁱ	P28222
IntActⁱ	P28222, 6 interactors
STRINGⁱ	9606.ENSP00000358963

Chemistry databases

BindingDBⁱ

P28222

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	40 – 43	Combined sources	4
Helixⁱ	46 – 76	Combined sources	31
Helixⁱ	78 – 80	Combined sources	3
Helixⁱ	83 – 101	Combined sources	19
Helixⁱ	104 – 112	Combined sources	9
Helixⁱ	118 – 152	Combined sources	35
Helixⁱ	154 – 158	Combined sources	5
Helixⁱ	163 – 181	Combined sources	19
Helixⁱ	206 – 216	Combined sources	11
Helixⁱ	218 – 239	Combined sources	22
Helixⁱ	311 – 336	Combined sources	26
Helixⁱ	349 – 372	Combined sources	24
Helixⁱ	374 – 383	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P28222
SMRⁱ	P28222
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	125 – 134	Agonist binding		10
Regionⁱ	327 – 331	Agonist binding		5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	146 – 148	DRY motif; important for ligand-induced conformation changes and signaling		3
Motifⁱ	365 – 369	NPxxY motif; important for ligand-induced conformation changes and signaling		5

Domainⁱ

Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.1 Publication

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P28222
KEGG Orthology (KO) More...KOⁱ	K04153
OMAⁱ	ACWFHMA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P28222
TreeFamⁱ	TF316350

Family and domain databases

InterProⁱ	View protein in InterPro IPR002147 5HT1B_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF16 PTHR24247:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00513 5HT1BRECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28222-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV 
        60         70         80         90        100
LLVMLLALIT LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI 
       110        120        130        140        150
LVMPISTMYT VTGRWTLGQV VCDFWLSSDI TCCTASILHL CVIALDRYWA 
       160        170        180        190        200
ITDAVEYSAK RTPKRAAVMI ALVWVFSISI SLPPFFWRQA KAEEEVSECV 
       210        220        230        240        250
VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL KQTPNRTGKR 
       260        270        280        290        300
LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE 
       310        320        330        340        350
KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI 
       360        370        380        390
FDFFTWLGYL NSLINPIIYT MSNEDFKQAF HKLIRFKCTS

Length:390

Mass (Da):43,568

Last modified:December 1, 1992 - v1

Checksum:ⁱCD874DC7EB44CF12

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_011715	124	F → C1 PublicationCorresponds to variant dbSNP:rs130060Ensembl.	1
Natural variantⁱVAR_011831	219	F → L. Corresponds to variant dbSNP:rs130061Ensembl.	1
Natural variantⁱVAR_011832	367	I → V. Corresponds to variant dbSNP:rs130063Ensembl.	1
Natural variantⁱVAR_011833	374	E → K. Corresponds to variant dbSNP:rs130064Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M89478 Genomic DNA No translation available. D10995 Genomic DNA Translation: BAA01763.1 M83180 Genomic DNA Translation: AAA36029.1 L09732 Genomic DNA Translation: AAA36030.1 M81590 mRNA Translation: AAA60316.1 M75128 Genomic DNA Translation: AAA58675.1 AB041370 Genomic DNA Translation: BAA94455.1 AY225227 Genomic DNA Translation: AAO67712.1 AL049595 Genomic DNA No translation available. BC069065 mRNA Translation: AAH69065.1 BC096206 mRNA Translation: AAH96206.1 BC096207 mRNA Translation: AAH96207.1 BC096208 mRNA Translation: AAH96208.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4986.1
PIRⁱ	JN0268
NCBI Reference Sequences More...RefSeqⁱ	NP_000854.1, NM_000863.2
UniGeneⁱ	Hs.123016

Genome annotation databases

Ensemblⁱ	ENST00000369947; ENSP00000358963; ENSG00000135312
GeneIDⁱ	3351
KEGGⁱ	hsa:3351

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28222	5-hydroxytryptamine receptor 1B		PANTR		390	UniRef100_P28222
5-hydroxytryptamine (Serotonin) receptor 1B (Fragment)		HUMAN		390
Uncharacterized protein		PANPA		390
HTR1B isoform 1		PANTR		390

Protein	Similar proteins		Species	Score	Length	Source
P28222	5-hydroxytryptamine receptor 1B		PANTR		390	UniRef90_P28222
5-hydroxytryptamine receptor 1B		RABIT		390
5-hydroxytryptamine receptor 1B		HORSE		390
5-hydroxytryptamine receptor 1B		GORGO		390
5-hydroxytryptamine receptor 1B		CANLF		389
+113

Protein	Similar proteins		Species	Score	Length	Source
P28222	5-hydroxytryptamine receptor 1B		PANTR		390	UniRef50_P28222
5-hydroxytryptamine receptor 1B		GORGO		390
5-hydroxytryptamine receptor 1B		HORSE		390
5-hydroxytryptamine receptor 1B		RABIT		390
5-hydroxytryptamine receptor 1B		CANLF		389
+314

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M89478 Genomic DNA No translation available. D10995 Genomic DNA Translation: BAA01763.1 M83180 Genomic DNA Translation: AAA36029.1 L09732 Genomic DNA Translation: AAA36030.1 M81590 mRNA Translation: AAA60316.1 M75128 Genomic DNA Translation: AAA58675.1 AB041370 Genomic DNA Translation: BAA94455.1 AY225227 Genomic DNA Translation: AAO67712.1 AL049595 Genomic DNA No translation available. BC069065 mRNA Translation: AAH69065.1 BC096206 mRNA Translation: AAH96206.1 BC096207 mRNA Translation: AAH96207.1 BC096208 mRNA Translation: AAH96208.1
CCDSⁱ	CCDS4986.1
PIRⁱ	JN0268
RefSeqⁱ	NP_000854.1, NM_000863.2
UniGeneⁱ	Hs.123016

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2G1X	model	-	A	1-390	[»]
	4IAQ	X-ray	2.80	A	33-239	[»]
				A	304-390	[»]
	4IAR	X-ray	2.70	A	33-239	[»]
				A	306-390	[»]
	5V54	X-ray	3.90	A/B	37-390	[»]
	6G79	electron microscopy	3.78	S	34-390	[»]
ProteinModelPortalⁱ	P28222
SMRⁱ	P28222
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109583, 5 interactors
CORUMⁱ	P28222
IntActⁱ	P28222, 6 interactors
STRINGⁱ	9606.ENSP00000358963

Chemistry databases

BindingDBⁱ	P28222
ChEMBLⁱ	CHEMBL1898
DrugBankⁱ	DB00918 Almotriptan DB00321 Amitriptyline DB00543 Amoxapine DB00714 Apomorphine DB01238 Aripiprazole DB06216 Asenapine DB08807 Bopindolol DB01200 Bromocriptine DB00248 Cabergoline DB00363 Clozapine DB04884 Dapoxetine DB00320 Dihydroergotamine DB00216 Eletriptan DB01049 Ergoloid mesylate DB00696 Ergotamine DB00998 Frovatriptan DB01221 Ketamine DB00589 Lisuride DB00408 Loxapine DB05743 MAP-0004 DB00247 Methysergide DB00952 Naratriptan DB06096 NXN-188 DB00334 Olanzapine DB00904 Ondansetron DB01359 Penbutolol DB01186 Pergolide DB00960 Pindolol DB00413 Pramipexole DB00571 Propranolol DB01224 Quetiapine DB00953 Rizatriptan DB00268 Ropinirole DB00669 Sumatriptan DB13025 Tiapride DB09068 Vortioxetine DB01392 Yohimbine DB00246 Ziprasidone DB00315 Zolmitriptan
GuidetoPHARMACOLOGYⁱ	2

Protein family/group databases

TCDBⁱ	9.A.14.3.6 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	P28222
PhosphoSitePlusⁱ	P28222

Polymorphism and mutation databases

BioMutaⁱ	HTR1B
DMDMⁱ	112821

Proteomic databases

PaxDbⁱ	P28222
PRIDEⁱ	P28222
ProteomicsDBⁱ	54452

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3351
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369947; ENSP00000358963; ENSG00000135312
GeneIDⁱ	3351
KEGGⁱ	hsa:3351

Organism-specific databases

CTDⁱ	3351
DisGeNETⁱ	3351
EuPathDBⁱ	HostDB:ENSG00000135312.5
GeneCardsⁱ	HTR1B
HGNCⁱ	HGNC:5287 HTR1B
HPAⁱ	HPA028808
MIMⁱ	182131 gene
neXtProtⁱ	NX_P28222
OpenTargetsⁱ	ENSG00000135312
PharmGKBⁱ	PA29549
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P28222
KOⁱ	K04153
OMAⁱ	ACWFHMA
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P28222
TreeFamⁱ	TF316350

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiⁱ	5-HT1B_receptor
GenomeRNAiⁱ	3351
Protein Ontology More...PROⁱ	PR:P28222
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135312 Expressed in 72 organ(s), highest expression level in popliteal artery
CleanExⁱ	HS_HTR1B
ExpressionAtlasⁱ	P28222 baseline and differential
Genevisibleⁱ	P28222 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002147 5HT1B_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF16 PTHR24247:SF16, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00513 5HT1BRECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT1B_HUMAN
Accessionⁱ	P28222Primary (citable) accession number: P28222 Secondary accession number(s): Q4VAY7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P28222 (5HT1B_HUMAN)

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5-hydroxytryptamine receptor 1B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ