Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P28221 (5HT1D_HUMAN)

Entry version 176 (12 Aug 2020)
Sequence version 1 (01 Dec 1992)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

5-hydroxytryptamine receptor 1D

Gene

HTR1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P28221

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390666, Serotonin receptors
R-HSA-418594, G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		P28221

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1D
Short name:
5-HT-1D
Short name:
5-HT1D
Alternative name(s):
Serotonin 1D alpha receptor
Short name:
5-HT-1D-alpha
Serotonin receptor 1D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR1D
Synonyms:HTR1DA, HTRL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000179546.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:5289, HTR1D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182133, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P28221

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38ExtracellularBy similarityAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 64Helical; Name=1By similarityAdd BLAST26
Topological domaini65 – 75CytoplasmicBy similarityAdd BLAST11
Transmembranei76 – 98Helical; Name=2By similarityAdd BLAST23
Topological domaini99 – 112ExtracellularBy similarityAdd BLAST14
Transmembranei113 – 134Helical; Name=3By similarityAdd BLAST22
Topological domaini135 – 154CytoplasmicBy similarityAdd BLAST20
Transmembranei155 – 176Helical; Name=4By similarityAdd BLAST22
Topological domaini177 – 194ExtracellularBy similarityAdd BLAST18
Transmembranei195 – 217Helical; Name=5By similarityAdd BLAST23
Topological domaini218 – 302CytoplasmicBy similarityAdd BLAST85
Transmembranei303 – 326Helical; Name=6By similarityAdd BLAST24
Topological domaini327 – 335ExtracellularBy similarity9
Transmembranei336 – 360Helical; Name=7By similarityAdd BLAST25
Topological domaini361 – 377CytoplasmicBy similarityAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3352

Open Targets

More...OpenTargetsi		ENSG00000179546

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29550

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P28221, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1983

Drug and drug target database

More...DrugBanki		DB00918, Almotriptan
DB00321, Amitriptyline
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB01200, Bromocriptine
DB00248, Cabergoline
DB00363, Clozapine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB00320, Dihydroergotamine
DB00216, Eletriptan
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB00998, Frovatriptan
DB12141, Gilteritinib
DB01221, Ketamine
DB00589, Lisuride
DB04948, Lofexidine
DB00408, Loxapine
DB00952, Naratriptan
DB06096, NXN-188
DB00334, Olanzapine
DB01267, Paliperidone
DB00715, Paroxetine
DB01186, Pergolide
DB06153, Pizotifen
DB01224, Quetiapine
DB00734, Risperidone
DB00953, Rizatriptan
DB09304, Setiptiline
DB00669, Sumatriptan
DB13025, Tiapride
DB00726, Trimipramine
DB01392, Yohimbine
DB00246, Ziprasidone
DB00315, Zolmitriptan

DrugCentral

More...DrugCentrali		P28221

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HTR1D

Domain mapping of disease mutations (DMDM)

More...DMDMi		112819

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000689271 – 3775-hydroxytryptamine receptor 1DAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi111 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P28221

PeptideAtlas

More...PeptideAtlasi		P28221

PRoteomics IDEntifications database

More...PRIDEi		P28221

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54451

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P28221, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P28221

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P28221

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain neocortex and caudate nucleus (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000179546, Expressed in duodenum and 59 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P28221, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000179546, Tissue enhanced (brain, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer with HTR1B.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109584, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P28221

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363748

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P28221

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P28221, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni114 – 123Agonist bindingBy similarity10
Regioni314 – 318Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi135 – 137DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi352 – 356NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154484

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P28221

KEGG Orthology (KO)

More...KOi		K04153

Identification of Orthologs from Complete Genome Data

More...OMAi		ITFCTAS

Database of Orthologous Groups

More...OrthoDBi		703991at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P28221

TreeFam database of animal gene trees

More...TreeFami		TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000505, 5HT1D_rcpt
IPR002231, 5HT_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...PANTHERi		PTHR24247:SF17, PTHR24247:SF17, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00514, 5HT1DRECEPTR
PR01101, 5HTRECEPTOR
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P28221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL 
        60         70         80         90        100
ATVLSNAFVL TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI 
       110        120        130        140        150
THTWNFGQIL CDIWLSSDIT CCTASILHLC VIALDRYWAI TDALEYSKRR 
       160        170        180        190        200
TAGHAATMIA IVWAISICIS IPPLFWRQAK AQEEMSDCLV NTSQISYTIY 
       210        220        230        240        250
STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT TAHLITGSAG 
       260        270        280        290        300
SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT 
       310        320        330        340        350
KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL 
       360        370 
INPIIYTVFN EEFRQAFQKI VPFRKAS
Length:377
Mass (Da):41,907
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A4FCF81FFE2322A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011834265S → L1 PublicationCorresponds to variant dbSNP:rs6299Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M89955 Genomic DNA Translation: AAA35491.1
M81589 mRNA Translation: AAA60315.1
AF498979 mRNA Translation: AAM21126.1
BT007027 mRNA Translation: AAP35673.1
AL049576 Genomic DNA No translation available.
BC007720 mRNA Translation: AAH07720.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS231.1

Protein sequence database of the Protein Information Resource

More...PIRi		A53279

NCBI Reference Sequences

More...RefSeqi		NP_000855.1, NM_000864.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374619; ENSP00000363748; ENSG00000179546

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3352

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3352

UCSC genome browser

More...UCSCi		uc001bgn.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89955 Genomic DNA Translation: AAA35491.1
M81589 mRNA Translation: AAA60315.1
AF498979 mRNA Translation: AAM21126.1
BT007027 mRNA Translation: AAP35673.1
AL049576 Genomic DNA No translation available.
BC007720 mRNA Translation: AAH07720.1
CCDSiCCDS231.1
PIRiA53279
RefSeqiNP_000855.1, NM_000864.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi109584, 3 interactors
CORUMiP28221
STRINGi9606.ENSP00000363748

Chemistry databases

BindingDBiP28221
ChEMBLiCHEMBL1983
DrugBankiDB00918, Almotriptan
DB00321, Amitriptyline
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB01200, Bromocriptine
DB00248, Cabergoline
DB00363, Clozapine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB00320, Dihydroergotamine
DB00216, Eletriptan
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB00998, Frovatriptan
DB12141, Gilteritinib
DB01221, Ketamine
DB00589, Lisuride
DB04948, Lofexidine
DB00408, Loxapine
DB00952, Naratriptan
DB06096, NXN-188
DB00334, Olanzapine
DB01267, Paliperidone
DB00715, Paroxetine
DB01186, Pergolide
DB06153, Pizotifen
DB01224, Quetiapine
DB00734, Risperidone
DB00953, Rizatriptan
DB09304, Setiptiline
DB00669, Sumatriptan
DB13025, Tiapride
DB00726, Trimipramine
DB01392, Yohimbine
DB00246, Ziprasidone
DB00315, Zolmitriptan
DrugCentraliP28221
GuidetoPHARMACOLOGYi3

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP28221, 3 sites
iPTMnetiP28221
PhosphoSitePlusiP28221

Polymorphism and mutation databases

BioMutaiHTR1D
DMDMi112819

Proteomic databases

PaxDbiP28221
PeptideAtlasiP28221
PRIDEiP28221
ProteomicsDBi54451

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15559, 226 antibodies

The DNASU plasmid repository

More...DNASUi		3352

Genome annotation databases

EnsembliENST00000374619; ENSP00000363748; ENSG00000179546
GeneIDi3352
KEGGihsa:3352
UCSCiuc001bgn.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3352
DisGeNETi3352
EuPathDBiHostDB:ENSG00000179546.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		HTR1D
HGNCiHGNC:5289, HTR1D
HPAiENSG00000179546, Tissue enhanced (brain, intestine)
MIMi182133, gene
neXtProtiNX_P28221
OpenTargetsiENSG00000179546
PharmGKBiPA29550

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000154484
HOGENOMiCLU_009579_11_1_1
InParanoidiP28221
KOiK04153
OMAiITFCTAS
OrthoDBi703991at2759
PhylomeDBiP28221
TreeFamiTF316350

Enzyme and pathway databases

PathwayCommonsiP28221
ReactomeiR-HSA-390666, Serotonin receptors
R-HSA-418594, G alpha (i) signalling events
SIGNORiP28221

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3352, 2 hits in 869 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		5-HT1D_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3352
PharosiP28221, Tclin

Protein Ontology

More...PROi		PR:P28221
RNActiP28221, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000179546, Expressed in duodenum and 59 other tissues
GenevisibleiP28221, HS

Family and domain databases

InterProiView protein in InterPro
IPR000505, 5HT1D_rcpt
IPR002231, 5HT_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF17, PTHR24247:SF17, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00514, 5HT1DRECEPTR
PR01101, 5HTRECEPTOR
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT1D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28221
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: August 12, 2020
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again