UniProtKB - P28221 (5HT1D_HUMAN)
5-hydroxytryptamine receptor 1D
HTR1D
Functioni
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
3 PublicationsGO - Molecular functioni
- G protein-coupled serotonin receptor activity Source: UniProtKB
- neurotransmitter receptor activity Source: GO_Central
- serotonin binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
- adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- intestine smooth muscle contraction Source: UniProtKB
- regulation of behavior Source: InterPro
- regulation of locomotion Source: InterPro
- vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P28221 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P28221 |
SIGNORi | P28221 |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 1DShort name: 5-HT-1D Short name: 5-HT1D Alternative name(s): Serotonin 1D alpha receptor Short name: 5-HT-1D-alpha Serotonin receptor 1D |
Gene namesi | Name:HTR1D Synonyms:HTR1DA, HTRL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5289, HTR1D |
MIMi | 182133, gene |
neXtProti | NX_P28221 |
VEuPathDBi | HostDB:ENSG00000179546 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Multi-pass membrane protein 3 Publications
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularBy similarityAdd BLAST | 38 | |
Transmembranei | 39 – 64 | Helical; Name=1By similarityAdd BLAST | 26 | |
Topological domaini | 65 – 75 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 76 – 98 | Helical; Name=2By similarityAdd BLAST | 23 | |
Topological domaini | 99 – 112 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 113 – 134 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 135 – 154 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 155 – 176 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 177 – 194 | ExtracellularBy similarityAdd BLAST | 18 | |
Transmembranei | 195 – 217 | Helical; Name=5By similarityAdd BLAST | 23 | |
Topological domaini | 218 – 302 | CytoplasmicBy similarityAdd BLAST | 85 | |
Transmembranei | 303 – 326 | Helical; Name=6By similarityAdd BLAST | 24 | |
Topological domaini | 327 – 335 | ExtracellularBy similarity | 9 | |
Transmembranei | 336 – 360 | Helical; Name=7By similarityAdd BLAST | 25 | |
Topological domaini | 361 – 377 | CytoplasmicBy similarityAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3352 |
OpenTargetsi | ENSG00000179546 |
PharmGKBi | PA29550 |
Miscellaneous databases
Pharosi | P28221, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1983 |
DrugBanki | DB00918, Almotriptan DB00321, Amitriptyline DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB01200, Bromocriptine DB00248, Cabergoline DB01239, Chlorprothixene DB00363, Clozapine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00320, Dihydroergotamine DB00216, Eletriptan DB01049, Ergoloid mesylate DB00696, Ergotamine DB00574, Fenfluramine DB00998, Frovatriptan DB12141, Gilteritinib DB01221, Ketamine DB00589, Lisuride DB04948, Lofexidine DB00408, Loxapine DB00952, Naratriptan DB06096, NXN-188 DB00334, Olanzapine DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB06153, Pizotifen DB01224, Quetiapine DB00734, Risperidone DB00953, Rizatriptan DB09304, Setiptiline DB00669, Sumatriptan DB13025, Tiapride DB00726, Trimipramine DB01392, Yohimbine DB00246, Ziprasidone DB00315, Zolmitriptan |
DrugCentrali | P28221 |
GuidetoPHARMACOLOGYi | 3 |
Genetic variation databases
BioMutai | HTR1D |
DMDMi | 112819 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068927 | 1 – 377 | 5-hydroxytryptamine receptor 1DAdd BLAST | 377 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 17 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 111 ↔ 188 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P28221 |
PeptideAtlasi | P28221 |
PRIDEi | P28221 |
PTM databases
GlyGeni | P28221, 3 sites |
iPTMneti | P28221 |
PhosphoSitePlusi | P28221 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000179546, Expressed in duodenum and 59 other tissues |
Genevisiblei | P28221, HS |
Organism-specific databases
HPAi | ENSG00000179546, Group enriched (brain, intestine) |
Interactioni
Subunit structurei
Homodimer. Heterodimer with HTR1B.
1 PublicationProtein-protein interaction databases
BioGRIDi | 109584, 3 interactors |
CORUMi | P28221 |
STRINGi | 9606.ENSP00000363748 |
Chemistry databases
BindingDBi | P28221 |
Miscellaneous databases
RNActi | P28221, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 114 – 123 | Agonist bindingBy similarity | 10 | |
Regioni | 314 – 318 | Agonist bindingBy similarity | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 135 – 137 | DRY motif; important for ligand-induced conformation changesBy similarity | 3 | |
Motifi | 352 – 356 | NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity | 5 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000154484 |
HOGENOMi | CLU_009579_11_1_1 |
InParanoidi | P28221 |
OMAi | GSPLFMN |
OrthoDBi | 703991at2759 |
PhylomeDBi | P28221 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR000505, 5HT1D_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF17, PTHR24247:SF17, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00514, 5HT1DRECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL
60 70 80 90 100
ATVLSNAFVL TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI
110 120 130 140 150
THTWNFGQIL CDIWLSSDIT CCTASILHLC VIALDRYWAI TDALEYSKRR
160 170 180 190 200
TAGHAATMIA IVWAISICIS IPPLFWRQAK AQEEMSDCLV NTSQISYTIY
210 220 230 240 250
STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT TAHLITGSAG
260 270 280 290 300
SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT
310 320 330 340 350
KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL
360 370
INPIIYTVFN EEFRQAFQKI VPFRKAS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011834 | 265 | S → L1 PublicationCorresponds to variant dbSNP:rs6299EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M89955 Genomic DNA Translation: AAA35491.1 M81589 mRNA Translation: AAA60315.1 AF498979 mRNA Translation: AAM21126.1 BT007027 mRNA Translation: AAP35673.1 AL049576 Genomic DNA No translation available. BC007720 mRNA Translation: AAH07720.1 |
CCDSi | CCDS231.1 |
PIRi | A53279 |
RefSeqi | NP_000855.1, NM_000864.4 |
Genome annotation databases
Ensembli | ENST00000374619; ENSP00000363748; ENSG00000179546 |
GeneIDi | 3352 |
KEGGi | hsa:3352 |
MANE-Selecti | ENST00000374619.2; ENSP00000363748.1; NM_000864.5; NP_000855.1 |
UCSCi | uc001bgn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M89955 Genomic DNA Translation: AAA35491.1 M81589 mRNA Translation: AAA60315.1 AF498979 mRNA Translation: AAM21126.1 BT007027 mRNA Translation: AAP35673.1 AL049576 Genomic DNA No translation available. BC007720 mRNA Translation: AAH07720.1 |
CCDSi | CCDS231.1 |
PIRi | A53279 |
RefSeqi | NP_000855.1, NM_000864.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7E32 | electron microscopy | 2.90 | R | 2-377 | [»] | |
SMRi | P28221 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109584, 3 interactors |
CORUMi | P28221 |
STRINGi | 9606.ENSP00000363748 |
Chemistry databases
BindingDBi | P28221 |
ChEMBLi | CHEMBL1983 |
DrugBanki | DB00918, Almotriptan DB00321, Amitriptyline DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB01200, Bromocriptine DB00248, Cabergoline DB01239, Chlorprothixene DB00363, Clozapine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00320, Dihydroergotamine DB00216, Eletriptan DB01049, Ergoloid mesylate DB00696, Ergotamine DB00574, Fenfluramine DB00998, Frovatriptan DB12141, Gilteritinib DB01221, Ketamine DB00589, Lisuride DB04948, Lofexidine DB00408, Loxapine DB00952, Naratriptan DB06096, NXN-188 DB00334, Olanzapine DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB06153, Pizotifen DB01224, Quetiapine DB00734, Risperidone DB00953, Rizatriptan DB09304, Setiptiline DB00669, Sumatriptan DB13025, Tiapride DB00726, Trimipramine DB01392, Yohimbine DB00246, Ziprasidone DB00315, Zolmitriptan |
DrugCentrali | P28221 |
GuidetoPHARMACOLOGYi | 3 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P28221, 3 sites |
iPTMneti | P28221 |
PhosphoSitePlusi | P28221 |
Genetic variation databases
BioMutai | HTR1D |
DMDMi | 112819 |
Proteomic databases
PaxDbi | P28221 |
PeptideAtlasi | P28221 |
PRIDEi | P28221 |
Protocols and materials databases
Antibodypediai | 15559, 228 antibodies from 28 providers |
DNASUi | 3352 |
Genome annotation databases
Ensembli | ENST00000374619; ENSP00000363748; ENSG00000179546 |
GeneIDi | 3352 |
KEGGi | hsa:3352 |
MANE-Selecti | ENST00000374619.2; ENSP00000363748.1; NM_000864.5; NP_000855.1 |
UCSCi | uc001bgn.3, human |
Organism-specific databases
CTDi | 3352 |
DisGeNETi | 3352 |
GeneCardsi | HTR1D |
HGNCi | HGNC:5289, HTR1D |
HPAi | ENSG00000179546, Group enriched (brain, intestine) |
MIMi | 182133, gene |
neXtProti | NX_P28221 |
OpenTargetsi | ENSG00000179546 |
PharmGKBi | PA29550 |
VEuPathDBi | HostDB:ENSG00000179546 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000154484 |
HOGENOMi | CLU_009579_11_1_1 |
InParanoidi | P28221 |
OMAi | GSPLFMN |
OrthoDBi | 703991at2759 |
PhylomeDBi | P28221 |
TreeFami | TF316350 |
Enzyme and pathway databases
PathwayCommonsi | P28221 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P28221 |
SIGNORi | P28221 |
Miscellaneous databases
BioGRID-ORCSi | 3352, 5 hits in 1037 CRISPR screens |
GeneWikii | 5-HT1D_receptor |
GenomeRNAii | 3352 |
Pharosi | P28221, Tclin |
PROi | PR:P28221 |
RNActi | P28221, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179546, Expressed in duodenum and 59 other tissues |
Genevisiblei | P28221, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000505, 5HT1D_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF17, PTHR24247:SF17, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00514, 5HT1DRECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT1D_HUMAN | |
Accessioni | P28221Primary (citable) accession number: P28221 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families