HTR1D

Functionⁱ

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.3 Publications

GO - Molecular functionⁱ

G-protein coupled serotonin receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 1652050
neurotransmitter receptor activity Source: GO_Central
serotonin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 1652050
chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 1565658
G-protein coupled receptor signaling pathway Source: Reactome
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: ProtInc
Traceable author statementⁱ
- 1565658
intestine smooth muscle contraction
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9186750
regulation of behavior Source: InterPro
regulation of locomotion Source: InterPro
response to toxic substance Source: Ensembl
vasoconstriction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P28221

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 1D Short name: 5-HT-1D Short name: 5-HT1D Alternative name(s): Serotonin 1D alpha receptor Short name: 5-HT-1D-alpha Serotonin receptor 1D
Gene namesⁱ	Name:HTR1D Synonyms:HTR1DA, HTRL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179546.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5289 HTR1D
MIMⁱ	182133 gene
neXtProtⁱ	NX_P28221

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 38	ExtracellularBy similarityAdd BLAST	38
Transmembraneⁱ	39 – 64	Helical; Name=1By similarityAdd BLAST	26
Topological domainⁱ	65 – 75	CytoplasmicBy similarityAdd BLAST	11
Transmembraneⁱ	76 – 98	Helical; Name=2By similarityAdd BLAST	23
Topological domainⁱ	99 – 112	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	113 – 134	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	135 – 154	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	155 – 176	Helical; Name=4By similarityAdd BLAST	22
Topological domainⁱ	177 – 194	ExtracellularBy similarityAdd BLAST	18
Transmembraneⁱ	195 – 217	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	218 – 302	CytoplasmicBy similarityAdd BLAST	85
Transmembraneⁱ	303 – 326	Helical; Name=6By similarityAdd BLAST	24
Topological domainⁱ	327 – 335	ExtracellularBy similarity	9
Transmembraneⁱ	336 – 360	Helical; Name=7By similarityAdd BLAST	25
Topological domainⁱ	361 – 377	CytoplasmicBy similarityAdd BLAST	17

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3352
Open Targets More...OpenTargetsⁱ	ENSG00000179546
PharmGKBⁱ	PA29550

Chemistry databases

ChEMBLⁱ	CHEMBL1983
Drug and drug target database More...DrugBankⁱ	DB00918 Almotriptan DB00321 Amitriptyline DB00714 Apomorphine DB01238 Aripiprazole DB01200 Bromocriptine DB00248 Cabergoline DB00363 Clozapine DB00320 Dihydroergotamine DB00216 Eletriptan DB01049 Ergoloid mesylate DB00696 Ergotamine DB00998 Frovatriptan DB01221 Ketamine DB00589 Lisuride DB00408 Loxapine DB05743 MAP-0004 DB00952 Naratriptan DB06096 NXN-188 DB00334 Olanzapine DB01267 Paliperidone DB01186 Pergolide DB00413 Pramipexole DB01224 Quetiapine DB00734 Risperidone DB00953 Rizatriptan DB00268 Ropinirole DB00669 Sumatriptan DB13025 Tiapride DB00726 Trimipramine DB01392 Yohimbine DB00246 Ziprasidone DB00315 Zolmitriptan
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	3

Polymorphism and mutation databases

BioMutaⁱ	HTR1D
DMDMⁱ	112819

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068927	1 – 377	5-hydroxytryptamine receptor 1DAdd BLAST		377

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	17	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	21	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	111 ↔ 188	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P28221
PRIDEⁱ	P28221
ProteomicsDBⁱ	54451

PTM databases

iPTMnetⁱ	P28221
PhosphoSitePlusⁱ	P28221

Expressionⁱ

Tissue specificityⁱ

Detected in brain neocortex and caudate nucleus (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000179546 Expressed in 35 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_HTR1D
Genevisibleⁱ	P28221 HS

Interactionⁱ

Subunit structureⁱ

Homodimer. Heterodimer with HTR1B.1 Publication

Protein-protein interaction databases

BioGridⁱ	109584, 3 interactors
CORUMⁱ	P28221
STRINGⁱ	9606.ENSP00000313661

Chemistry databases

BindingDBⁱ	P28221

BindingDBⁱ

P28221

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28221
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	114 – 123	Agonist bindingBy similarity		10
Regionⁱ	314 – 318	Agonist bindingBy similarity		5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	135 – 137	DRY motif; important for ligand-induced conformation changesBy similarity		3
Motifⁱ	352 – 356	NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity		5

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P28221
KEGG Orthology (KO) More...KOⁱ	K04153
OMAⁱ	YGKRFTT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P28221
TreeFamⁱ	TF316350

Family and domain databases

InterProⁱ	View protein in InterPro IPR000505 5HT1D_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF17 PTHR24247:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00514 5HT1DRECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28221-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL 
        60         70         80         90        100
ATVLSNAFVL TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI 
       110        120        130        140        150
THTWNFGQIL CDIWLSSDIT CCTASILHLC VIALDRYWAI TDALEYSKRR 
       160        170        180        190        200
TAGHAATMIA IVWAISICIS IPPLFWRQAK AQEEMSDCLV NTSQISYTIY 
       210        220        230        240        250
STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT TAHLITGSAG 
       260        270        280        290        300
SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT 
       310        320        330        340        350
KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL 
       360        370 
INPIIYTVFN EEFRQAFQKI VPFRKAS

Length:377

Mass (Da):41,907

Last modified:December 1, 1992 - v1

Checksum:ⁱ0A4FCF81FFE2322A

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011834	265	S → L1 PublicationCorresponds to variant dbSNP:rs6299Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M89955 Genomic DNA Translation: AAA35491.1 M81589 mRNA Translation: AAA60315.1 AF498979 mRNA Translation: AAM21126.1 BT007027 mRNA Translation: AAP35673.1 AL049576 Genomic DNA No translation available. BC007720 mRNA Translation: AAH07720.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS231.1
PIRⁱ	A53279
NCBI Reference Sequences More...RefSeqⁱ	NP_000855.1, NM_000864.4
UniGeneⁱ	Hs.121482

Genome annotation databases

Ensemblⁱ	ENST00000374619; ENSP00000363748; ENSG00000179546
GeneIDⁱ	3352
KEGGⁱ	hsa:3352
UCSC genome browser More...UCSCⁱ	uc001bgn.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28221	5-hydroxytryptamine receptor 1D		RABIT		377	UniRef90_P28221
5-hydroxytryptamine receptor 1D		CAVPO		376
5-hydroxytryptamine receptor 1D		MOUSE		374
5-hydroxytryptamine receptor 1D		RAT		374
HTR1D (Fragment)		MACMU		102
+95

Protein	Similar proteins		Species	Score	Length	Source
P28221	5-hydroxytryptamine receptor 1D		RABIT		377	UniRef50_P28221
5-hydroxytryptamine receptor 1D		CAVPO		376
5-hydroxytryptamine receptor 1D		MOUSE		374
5-hydroxytryptamine receptor 1D		RAT		374
5-hydroxytryptamine receptor 1D		TAKRU		379
+310

Entry informationⁱ

Entry nameⁱ	5HT1D_HUMAN
Accessionⁱ	P28221Primary (citable) accession number: P28221
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	September 12, 2018
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P28221 (5HT1D_HUMAN)

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5-hydroxytryptamine receptor 1D

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ