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Protein

5-hydroxytryptamine receptor 1D

Gene

HTR1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.3 Publications

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • G protein-coupled serotonin receptor activity Source: UniProtKB
  • neurotransmitter receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP28221

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1D
Short name:
5-HT-1D
Short name:
5-HT1D
Alternative name(s):
Serotonin 1D alpha receptor
Short name:
5-HT-1D-alpha
Serotonin receptor 1D
Gene namesi
Name:HTR1D
Synonyms:HTR1DA, HTRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000179546.4
HGNCiHGNC:5289 HTR1D
MIMi182133 gene
neXtProtiNX_P28221

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularBy similarityAdd BLAST38
Transmembranei39 – 64Helical; Name=1By similarityAdd BLAST26
Topological domaini65 – 75CytoplasmicBy similarityAdd BLAST11
Transmembranei76 – 98Helical; Name=2By similarityAdd BLAST23
Topological domaini99 – 112ExtracellularBy similarityAdd BLAST14
Transmembranei113 – 134Helical; Name=3By similarityAdd BLAST22
Topological domaini135 – 154CytoplasmicBy similarityAdd BLAST20
Transmembranei155 – 176Helical; Name=4By similarityAdd BLAST22
Topological domaini177 – 194ExtracellularBy similarityAdd BLAST18
Transmembranei195 – 217Helical; Name=5By similarityAdd BLAST23
Topological domaini218 – 302CytoplasmicBy similarityAdd BLAST85
Transmembranei303 – 326Helical; Name=6By similarityAdd BLAST24
Topological domaini327 – 335ExtracellularBy similarity9
Transmembranei336 – 360Helical; Name=7By similarityAdd BLAST25
Topological domaini361 – 377CytoplasmicBy similarityAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3352
OpenTargetsiENSG00000179546
PharmGKBiPA29550

Chemistry databases

ChEMBLiCHEMBL1983
DrugBankiDB00918 Almotriptan
DB00321 Amitriptyline
DB00714 Apomorphine
DB01238 Aripiprazole
DB01200 Bromocriptine
DB00248 Cabergoline
DB00363 Clozapine
DB00320 Dihydroergotamine
DB00216 Eletriptan
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB00998 Frovatriptan
DB01221 Ketamine
DB00589 Lisuride
DB00408 Loxapine
DB05743 MAP-0004
DB00952 Naratriptan
DB06096 NXN-188
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB00413 Pramipexole
DB01224 Quetiapine
DB00734 Risperidone
DB00953 Rizatriptan
DB00268 Ropinirole
DB00669 Sumatriptan
DB13025 Tiapride
DB00726 Trimipramine
DB01392 Yohimbine
DB00246 Ziprasidone
DB00315 Zolmitriptan
GuidetoPHARMACOLOGYi3

Polymorphism and mutation databases

BioMutaiHTR1D
DMDMi112819

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689271 – 3775-hydroxytryptamine receptor 1DAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28221
PRIDEiP28221
ProteomicsDBi54451

PTM databases

iPTMnetiP28221
PhosphoSitePlusiP28221

Expressioni

Tissue specificityi

Detected in brain neocortex and caudate nucleus (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000179546 Expressed in 35 organ(s), highest expression level in caudate nucleus
CleanExiHS_HTR1D
GenevisibleiP28221 HS

Interactioni

Subunit structurei

Homodimer. Heterodimer with HTR1B.1 Publication

Protein-protein interaction databases

BioGridi109584, 3 interactors
CORUMiP28221
STRINGi9606.ENSP00000313661

Chemistry databases

BindingDBiP28221

Structurei

3D structure databases

ProteinModelPortaliP28221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 123Agonist bindingBy similarity10
Regioni314 – 318Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi135 – 137DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi352 – 356NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP28221
KOiK04153
OMAiLHEGHSH
OrthoDBiEOG091G06VI
PhylomeDBiP28221
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR000505 5HT1D_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF17 PTHR24247:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00514 5HT1DRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL
60 70 80 90 100
ATVLSNAFVL TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI
110 120 130 140 150
THTWNFGQIL CDIWLSSDIT CCTASILHLC VIALDRYWAI TDALEYSKRR
160 170 180 190 200
TAGHAATMIA IVWAISICIS IPPLFWRQAK AQEEMSDCLV NTSQISYTIY
210 220 230 240 250
STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT TAHLITGSAG
260 270 280 290 300
SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT
310 320 330 340 350
KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL
360 370
INPIIYTVFN EEFRQAFQKI VPFRKAS
Length:377
Mass (Da):41,907
Last modified:December 1, 1992 - v1
Checksum:i0A4FCF81FFE2322A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011834265S → L1 PublicationCorresponds to variant dbSNP:rs6299Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89955 Genomic DNA Translation: AAA35491.1
M81589 mRNA Translation: AAA60315.1
AF498979 mRNA Translation: AAM21126.1
BT007027 mRNA Translation: AAP35673.1
AL049576 Genomic DNA No translation available.
BC007720 mRNA Translation: AAH07720.1
CCDSiCCDS231.1
PIRiA53279
RefSeqiNP_000855.1, NM_000864.4
UniGeneiHs.121482

Genome annotation databases

EnsembliENST00000374619; ENSP00000363748; ENSG00000179546
GeneIDi3352
KEGGihsa:3352
UCSCiuc001bgn.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89955 Genomic DNA Translation: AAA35491.1
M81589 mRNA Translation: AAA60315.1
AF498979 mRNA Translation: AAM21126.1
BT007027 mRNA Translation: AAP35673.1
AL049576 Genomic DNA No translation available.
BC007720 mRNA Translation: AAH07720.1
CCDSiCCDS231.1
PIRiA53279
RefSeqiNP_000855.1, NM_000864.4
UniGeneiHs.121482

3D structure databases

ProteinModelPortaliP28221
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109584, 3 interactors
CORUMiP28221
STRINGi9606.ENSP00000313661

Chemistry databases

BindingDBiP28221
ChEMBLiCHEMBL1983
DrugBankiDB00918 Almotriptan
DB00321 Amitriptyline
DB00714 Apomorphine
DB01238 Aripiprazole
DB01200 Bromocriptine
DB00248 Cabergoline
DB00363 Clozapine
DB00320 Dihydroergotamine
DB00216 Eletriptan
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB00998 Frovatriptan
DB01221 Ketamine
DB00589 Lisuride
DB00408 Loxapine
DB05743 MAP-0004
DB00952 Naratriptan
DB06096 NXN-188
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB00413 Pramipexole
DB01224 Quetiapine
DB00734 Risperidone
DB00953 Rizatriptan
DB00268 Ropinirole
DB00669 Sumatriptan
DB13025 Tiapride
DB00726 Trimipramine
DB01392 Yohimbine
DB00246 Ziprasidone
DB00315 Zolmitriptan
GuidetoPHARMACOLOGYi3

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP28221
PhosphoSitePlusiP28221

Polymorphism and mutation databases

BioMutaiHTR1D
DMDMi112819

Proteomic databases

PaxDbiP28221
PRIDEiP28221
ProteomicsDBi54451

Protocols and materials databases

DNASUi3352
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374619; ENSP00000363748; ENSG00000179546
GeneIDi3352
KEGGihsa:3352
UCSCiuc001bgn.3 human

Organism-specific databases

CTDi3352
DisGeNETi3352
EuPathDBiHostDB:ENSG00000179546.4
GeneCardsiHTR1D
HGNCiHGNC:5289 HTR1D
MIMi182133 gene
neXtProtiNX_P28221
OpenTargetsiENSG00000179546
PharmGKBiPA29550
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP28221
KOiK04153
OMAiLHEGHSH
OrthoDBiEOG091G06VI
PhylomeDBiP28221
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP28221

Miscellaneous databases

GeneWikii5-HT1D_receptor
GenomeRNAii3352
PROiPR:P28221
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179546 Expressed in 35 organ(s), highest expression level in caudate nucleus
CleanExiHS_HTR1D
GenevisibleiP28221 HS

Family and domain databases

InterProiView protein in InterPro
IPR000505 5HT1D_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF17 PTHR24247:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00514 5HT1DRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5HT1D_HUMAN
AccessioniPrimary (citable) accession number: P28221
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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