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Protein

Tyrosine-protein phosphatase 1

Gene

ptp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei920SubstrateBy similarity1
Active sitei952Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei996SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-CEL-182971 EGFR downregulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 1
Gene namesi
Name:ptp-1
ORF Names:C48D5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC48D5.2a ; CE17578 ; WBGene00004213 ; ptp-1
C48D5.2b ; CE23603 ; WBGene00004213 ; ptp-1
C48D5.2c ; CE31450 ; WBGene00004213 ; ptp-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194421 – 1026Tyrosine-protein phosphatase 1Add BLAST1026

Proteomic databases

EPDiP28191
PaxDbiP28191
PeptideAtlasiP28191

PTM databases

iPTMnetiP28191

Expressioni

Gene expression databases

BgeeiWBGene00004213

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.C48D5.2a

Structurei

3D structure databases

ProteinModelPortaliP28191
SMRiP28191
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 315FERMPROSITE-ProRule annotationAdd BLAST287
Domaini617 – 689PDZPROSITE-ProRule annotationAdd BLAST73
Domaini753 – 1011Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni952 – 958Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KDUQ Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000007048
InParanoidiP28191
KOiK18037
OMAiHTCTDFW
OrthoDBiEOG091G016K
PhylomeDBiP28191

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P28191-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLGSNSYDV QRTEAIGQTP VKTPPPNQIR CTVTFLDSTS YHFEIEKNSL
60 70 80 90 100
GIVLLEKVFN YLEIIEKDYF GLVFIAVDNS SAQQKKWLDP SKNLRKQMIC
110 120 130 140 150
PPYHLFFRVK FYVRDPNRLR DEFTRFQFYQ QVRQNLEEGR LPCNEGSLAL
160 170 180 190 200
LASYVVQAEV GDFEEKTHGM SRTCLCYKIQ FATLPDDFSD RVAELHQLHI
210 220 230 240 250
GQTPDVAEQN FLDHARRLEM YGMDVYDGVD ANHLPIEIGV GAVGIKVFHE
260 270 280 290 300
GIKMNEYAWV RIRKLSFKKK QFQVLVANED GVSETIMIFN IMSAKICKLL
310 320 330 340 350
WKCCIEQHTF FRLKTPPKTP QRKVFNFGSK FRYSGRTEYQ TLEENEHRKS
360 370 380 390 400
AGHRNFHRSL SKSSFLRSTF SGNTQSIDSS RYTNTTTTDS PELPSSGQLL
410 420 430 440 450
ARRLLSAARH DTDSSDALGY ASDGAVVCAP LTTPLSPRRT RDYATDSESS
460 470 480 490 500
APSLRQQRLS KEAIYYGTQE SCDEKSWTPS MACTSTSPGI HASTASVRPV
510 520 530 540 550
SSGSTPNGAS RKSANSGYSG YGYATQTQQP TSTTNASYSP YLNGTISRSS
560 570 580 590 600
GAAVAKAAAR GLPPTNQQAY NTSSPRNSVA SYSSFASAGI GGSPPRSKRS
610 620 630 640 650
PQSNKSSSPV GEDQVVTIKM RPDRHGRFGF NVKGGADQNY PVIVSRVAPG
660 670 680 690 700
SSADKCQPRL NEGDQVLFID GRDVSTMSHD HVVQFIRSAR SGLNGGELHL
710 720 730 740 750
TIRPNVYRLG EEVDEPDSTM VPEPARVADS VPNSDKLSKS LQLLADSLNS
760 770 780 790 800
GKVVDHFEML YRKKPGMSMN ICRLTANLAK NRYRDVCPYD DTRVTLQASP
810 820 830 840 850
SGDYINANYV NMEIPSSGIV NRYIACQGPL AHTSSDFWVM VWEQHCTTIV
860 870 880 890 900
MLTTITERGR VKCHQYWPRV FETQEYGRLM IKCIKDKQTT NCCYREFSIR
910 920 930 940 950
DRNSSEERRV TQMQYIAWPD HGVPDDPKHF IQFVDEVRKA RQGSVDPIVV
960 970 980 990 1000
HCSAGIGRTG VLILMETAAC LVESNEPVYP LDIVRTMRDQ RAMLIQTPGQ
1010 1020
YTFVCESILR AYHDGTIKPL AEYSKR
Note: No experimental confirmation available.
Length:1,026
Mass (Da):115,094
Last modified:May 30, 2000 - v3
Checksum:i2F43F7A614EDBC59
GO
Isoform b (identifier: P28191-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MRLGSNSYDV...LDSTSYHFEI → MEVPAFVGKA...DEKLPPRAFR
     46-447: Missing.

Note: No experimental confirmation available.
Show »
Length:624
Mass (Da):68,783
Checksum:i04DD488377E2E8B0
GO
Isoform c (identifier: P28191-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-9: LGSNSYD → RRRTART
     10-446: Missing.

Note: No experimental confirmation available.
Show »
Length:589
Mass (Da):65,125
Checksum:i1DD1659D73A8BC75
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0206411 – 45MRLGS…YHFEI → MEVPAFVGKACLKLKGLCVN VWTATVATCQENAEIDEKLP PRAFR in isoform b. CuratedAdd BLAST45
Alternative sequenceiVSP_0206423 – 9LGSNSYD → RRRTART in isoform c. Curated7
Alternative sequenceiVSP_02064310 – 446Missing in isoform c. CuratedAdd BLAST437
Alternative sequenceiVSP_02064446 – 447Missing in isoform b. CuratedAdd BLAST402

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36237, Z48241 Genomic DNA Translation: CAA85272.1
Z36237, Z48241 Genomic DNA Translation: CAD44107.1
Z48241 Genomic DNA Translation: CAB54194.1
M38013 mRNA Translation: AAA28127.1
PIRiT19630
T19631
RefSeqiNP_497732.1, NM_065331.3 [P28191-1]
NP_497733.1, NM_065332.3 [P28191-2]
NP_741112.1, NM_171099.3 [P28191-3]
UniGeneiCel.17439

Genome annotation databases

EnsemblMetazoaiC48D5.2a.1; C48D5.2a.1; WBGene00004213 [P28191-1]
C48D5.2a.2; C48D5.2a.2; WBGene00004213 [P28191-1]
C48D5.2a.3; C48D5.2a.3; WBGene00004213 [P28191-1]
GeneIDi175463
KEGGicel:CELE_C48D5.2
UCSCiC48D5.2a c. elegans [P28191-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTP1_CAEEL
AccessioniPrimary (citable) accession number: P28191
Secondary accession number(s): P45449, Q8MM81, Q9U3N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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