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Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-417973 Adenosine P1 receptors
R-BTA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:25686 ADORA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 326CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4975

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689881 – 326Adenosine receptor A1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP28190
PRIDEiP28190

Expressioni

Gene expression databases

BgeeiENSBTAG00000011461 Expressed in 5 organ(s), highest expression level in prefrontal cortex

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015230

Chemistry databases

BindingDBiP28190

Structurei

3D structure databases

ProteinModelPortaliP28190
SMRiP28190
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP28190
KOiK04265
OMAiVYAFRIH
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Family and domain databases

InterProiView protein in InterPro
IPR001068 Adeno_A1_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00552 ADENOSINEA1R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28190-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPRTYFHTC LKVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT PRRAVVAITG CWILSFVVGL TPMFGWNNLS
160 170 180 190 200
AVERDWLANG SVGEPVIECQ FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
MEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PSCHMPRILI YIAIFLSHGN SAMNPIVYAF RIQKFRVTFL
310 320
KIWNDHFRCQ PAPPVDEDAP AERPDD
Length:326
Mass (Da):36,593
Last modified:November 13, 2007 - v3
Checksum:i6F4557FCEFEBC66E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212N → S in CAA45135 (PubMed:1551415).Curated1
Sequence conflicti212N → S in AAA30350 (PubMed:1587851).Curated1
Sequence conflicti315V → I in CAA45135 (PubMed:1551415).Curated1
Sequence conflicti315V → I in AAA30350 (PubMed:1587851).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63592 mRNA Translation: CAA45135.1
M86261 mRNA Translation: AAA30350.1
BT021759 mRNA Translation: AAX46606.1
BC142208 mRNA Translation: AAI42209.1
BC142265 mRNA Translation: AAI42266.1
PIRiA38144
RefSeqiNP_776922.2, NM_174497.3
XP_005216709.1, XM_005216652.3
XP_005216710.1, XM_005216653.3
XP_010811315.1, XM_010813013.2
UniGeneiBt.76442

Genome annotation databases

EnsembliENSBTAT00000015230; ENSBTAP00000015230; ENSBTAG00000011461
GeneIDi282133
KEGGibta:282133

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63592 mRNA Translation: CAA45135.1
M86261 mRNA Translation: AAA30350.1
BT021759 mRNA Translation: AAX46606.1
BC142208 mRNA Translation: AAI42209.1
BC142265 mRNA Translation: AAI42266.1
PIRiA38144
RefSeqiNP_776922.2, NM_174497.3
XP_005216709.1, XM_005216652.3
XP_005216710.1, XM_005216653.3
XP_010811315.1, XM_010813013.2
UniGeneiBt.76442

3D structure databases

ProteinModelPortaliP28190
SMRiP28190
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015230

Chemistry databases

BindingDBiP28190
ChEMBLiCHEMBL4975

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP28190
PRIDEiP28190

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015230; ENSBTAP00000015230; ENSBTAG00000011461
GeneIDi282133
KEGGibta:282133

Organism-specific databases

CTDi134
VGNCiVGNC:25686 ADORA1

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP28190
KOiK04265
OMAiVYAFRIH
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Enzyme and pathway databases

ReactomeiR-BTA-417973 Adenosine P1 receptors
R-BTA-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P28190

Gene expression databases

BgeeiENSBTAG00000011461 Expressed in 5 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR001068 Adeno_A1_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00552 ADENOSINEA1R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAA1R_BOVIN
AccessioniPrimary (citable) accession number: P28190
Secondary accession number(s): A5PJR1, Q58D38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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