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Protein

Metallothionein-3

Gene

Mt3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Divalent metal cation; cluster BBy similarity1
Metal bindingi8Divalent metal cation; cluster BBy similarity1
Metal bindingi14Divalent metal cation; cluster BBy similarity1
Metal bindingi16Divalent metal cation; cluster BBy similarity1
Metal bindingi20Divalent metal cation; cluster BBy similarity1
Metal bindingi22Divalent metal cation; cluster BBy similarity1
Metal bindingi25Divalent metal cation; cluster BBy similarity1
Metal bindingi27Divalent metal cation; cluster BBy similarity1
Metal bindingi30Divalent metal cation; cluster BBy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi35Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi38Divalent metal cation; cluster ABy similarity1
Metal bindingi42Divalent metal cation; cluster ABy similarity1
Metal bindingi45Divalent metal cation; cluster ABy similarity1
Metal bindingi49Divalent metal cation; cluster ABy similarity1
Metal bindingi51Divalent metal cation; cluster ABy similarity1
Metal bindingi64Divalent metal cation; cluster ABy similarity1
Metal bindingi66Divalent metal cation; cluster ABy similarity1
Metal bindingi67Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Growth inhibitory factor
Short name:
GIF
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:Mt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:97173 Mt3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972511 – 68Metallothionein-3Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei33PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP28184
PaxDbiP28184
PeptideAtlasiP28184
PRIDEiP28184

PTM databases

iPTMnetiP28184
PhosphoSitePlusiP28184

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSMUSG00000031760 Expressed in 258 organ(s), highest expression level in Ammon's horn
CleanExiMM_MT3
ExpressionAtlasiP28184 baseline and differential
GenevisibleiP28184 MM

Interactioni

Protein-protein interaction databases

BioGridi201581, 5 interactors
CORUMiP28184
STRINGi10090.ENSMUSP00000034211

Structurei

Secondary structure

168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP28184
SMRiP28184
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28184

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 30BetaAdd BLAST30
Regioni31 – 68AlphaAdd BLAST38

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000111484
HOGENOMiHOG000236262
HOVERGENiHBG094960
InParanoidiP28184
KOiK14740
OMAiVCKGEEG

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P28184-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPETCPCPT GGSCTCSDKC KCKGCKCTNC KKSCCSCCPA GCEKCAKDCV
60
CKGEEGAKAE AEKCSCCQ
Length:68
Mass (Da):7,009
Last modified:December 1, 1992 - v1
Checksum:i791AF60E38FED3CA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLI5A0A1D5RLI5_MOUSE
Metallothionein
Mt3
43Annotation score:
A0A1D5RLF4A0A1D5RLF4_MOUSE
Metallothionein
Mt3
80Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93310 Genomic DNA Translation: AAA39529.1
S72046 Genomic DNA Translation: AAB31397.1
BC059725 mRNA Translation: AAH59725.1
CCDSiCCDS40436.1
PIRiA46034
RefSeqiNP_038631.1, NM_013603.2
UniGeneiMm.2064

Genome annotation databases

EnsembliENSMUST00000034211; ENSMUSP00000034211; ENSMUSG00000031760
GeneIDi17751
KEGGimmu:17751
UCSCiuc009mvu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93310 Genomic DNA Translation: AAA39529.1
S72046 Genomic DNA Translation: AAB31397.1
BC059725 mRNA Translation: AAH59725.1
CCDSiCCDS40436.1
PIRiA46034
RefSeqiNP_038631.1, NM_013603.2
UniGeneiMm.2064

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JI9NMR-A32-68[»]
ProteinModelPortaliP28184
SMRiP28184
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201581, 5 interactors
CORUMiP28184
STRINGi10090.ENSMUSP00000034211

PTM databases

iPTMnetiP28184
PhosphoSitePlusiP28184

Proteomic databases

EPDiP28184
PaxDbiP28184
PeptideAtlasiP28184
PRIDEiP28184

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034211; ENSMUSP00000034211; ENSMUSG00000031760
GeneIDi17751
KEGGimmu:17751
UCSCiuc009mvu.2 mouse

Organism-specific databases

CTDi4504
MGIiMGI:97173 Mt3

Phylogenomic databases

GeneTreeiENSGT00730000111484
HOGENOMiHOG000236262
HOVERGENiHBG094960
InParanoidiP28184
KOiK14740
OMAiVCKGEEG

Enzyme and pathway databases

ReactomeiR-MMU-5661231 Metallothioneins bind metals

Miscellaneous databases

EvolutionaryTraceiP28184
PROiPR:P28184
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031760 Expressed in 258 organ(s), highest expression level in Ammon's horn
CleanExiMM_MT3
ExpressionAtlasiP28184 baseline and differential
GenevisibleiP28184 MM

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT3_MOUSE
AccessioniPrimary (citable) accession number: P28184
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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