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UniProtKB - P28166 (ZFH1_DROME)

Entry version 187 (10 Feb 2021)
Sequence version 2 (15 Mar 2004)
Previous versions | rss
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Protein

Zinc finger protein 1

Gene

zfh1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri74 – 97C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 407C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri628 – 651C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi699 – 758HomeoboxPROSITE-ProRule annotationAdd BLAST60
Zinc fingeri967 – 989C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri995 – 1017C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1023 – 1044C2H2-type 9PROSITE-ProRule annotationAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P28166

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 1
Alternative name(s):
Zinc finger homeodomain protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:zfh1
Synonyms:zfh-1
ORF Names:CG1322
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0004606, zfh1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472411 – 1054Zinc finger protein 1Add BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei582Phosphoserine1 Publication1
Modified residuei586Phosphoserine1 Publication1
Modified residuei934Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P28166

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P28166

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mesoderm and mesodermally-derived structures in the embryo including the dorsal vessel, support cells of the gonads, and segment-specific arrays of adult muscle precursor. Also identified in motor neurons of developing CNS.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0004606, Expressed in embryo and 72 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P28166, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		68501, 26 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P28166

Protein interaction database and analysis system

More...IntActi		P28166, 12 interactors

Molecular INTeraction database

More...MINTi		P28166

STRING: functional protein association networks

More...STRINGi		7227.FBpp0085063

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P28166

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi222 – 246Gln-rich (OPA repeat)Add BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 97C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 407C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri628 – 651C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri967 – 989C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri995 – 1017C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1023 – 1044C2H2-type 9PROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3623, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00870000136508

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010698_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P28166

Identification of Orthologs from Complete Genome Data

More...OMAi		WDRVKED

Database for complete collections of gene phylogenies

More...PhylomeDBi		P28166

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046, Homeodomain, 1 hit
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit
SSF57667, SSF57667, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: P28166-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSCLAPSSS RFGQEDTIIQ QSMPSTSPFA MQFPSLASTL LHHNQSPKHS 
        60         70         80         90        100
NPGSSGIQDA HPNQPGAAAD AFLVKCTQCH KRFPEYQSLS EHIASEHPHD 
       110        120        130        140        150
KLNCGAAQPE SDAEDEQSNM SGSSRRYAKS PLASNNNSST ANANNNSTSS 
       160        170        180        190        200
QSMNNNSELA KNHNSANKMS PMCSPGSLTP GDLFAQLQHP PPQLPPHLHA 
       210        220        230        240        250
QFMAAAASLA MQSARTASSP SQQQQQQLQQ QQQLQQQQQH QMAMQQLLPP 
       260        270        280        290        300
QLPGSNSSVG SNSAYDLDLS APRSTSSPGS TTGDLSGAYP CMQCTASFAS 
       310        320        330        340        350
REQLEQHEQL HSPCGPAAVS NVSQTCRICH KAFANVYRLQ RHMISHDESA 
       360        370        380        390        400
LLRKFKCKEC DKAFKFKHHL KEHVRIHSGE KPFGCDNCGK RFSHSGSFSS 
       410        420        430        440        450
HMTSKKCISM GLKLNNNRAL LKRLEKSPGS ASSASRRSPS DHGKGKLPEQ 
       460        470        480        490        500
PSLPGLPHPM SYFASDAQVQ GGSAAPAPFP PFHPNYMNAA LLAFPHNFMA 
       510        520        530        540        550
AAAGLDPRVH PYSIQRLLQL SAAGQQQREE EREEQQKQQQ HDEEETPDEP 
       560        570        580        590        600
KLVMDIEEPE TKEMAPTPEA TEAATPIKRE ESREASPDPE SYRSSSQAIK 
       610        620        630        640        650
QEQEPLNVAE ERQTPVEEHA PVEHAADLRC SRCSKQFNHP TELVQHEKVL 
       660        670        680        690        700
CGLIKEELEQ HFQQQQATSF ALASASEEDE EDEEMDVEEE PRQESGERKV 
       710        720        730        740        750
RVRTAINEEQ QQQLKQHYSL NARPSRDEFR MIAARLQLDP RVVQVWFQNN 
       760        770        780        790        800
RSRERKMQSF QNNQAAGAAP PMPIDSQASL TREDQPLDLS VKRDPLTPKS 
       810        820        830        840        850
ESSPPYIAPP SGEALNPEAI NLSRKFSTSA SMSPASISPS SAAALYFGAA 
       860        870        880        890        900
PPPSPPNSQL DSTPRSGQAF PGLPPYMLPM SLPMEALFKM RPGGDFASNH 
       910        920        930        940        950
ALMNSIKLPD YRGTSLSPGG SEKRSWRDDD SRISHEDEFG AGVLMPPKPR 
       960        970        980        990       1000
RGKAETHGHA GDPDLPYVCD QCDKAFAKQS SLARHKYEHS GQRPYQCIEC 
      1010       1020       1030       1040       1050
PKAFKHKHHL TEHKRLHSGE KPFQCSKCLK RFSHSGSYSQ HMNHRYSYCK 

PYRE
Length:1,054
Mass (Da):116,598
Last modified:March 15, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5189AB2214AB5B8B
GO
Isoform A (identifier: P28166-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-324: EQLHSPCGPAAVSNVSQ → MSAAACLLSSSTSSFEK

Show »
Length:747
Mass (Da):83,777
Checksum:i2F34280BBA626A89
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM50023 differs from that shown. Contaminating sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78Q → K in AAR82746 (Ref. 4) Curated1
Sequence conflicti147S → T in AAR82746 (Ref. 4) Curated1
Sequence conflicti239Q → QMQQQQQ in AAA29050 (PubMed:1680376).Curated1
Sequence conflicti625A → S in AAA29050 (PubMed:1680376).Curated1
Sequence conflicti625A → S in AAR82746 (Ref. 4) Curated1
Sequence conflicti625A → S in AAM50023 (PubMed:12537569).Curated1
Sequence conflicti954A → V in AAA29050 (PubMed:1680376).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0096701 – 307Missing in isoform A. 1 PublicationAdd BLAST307
Alternative sequenceiVSP_009671308 – 324EQLHS…SNVSQ → MSAAACLLSSSTSSFEK in isoform A. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M63449 Genomic DNA Translation: AAA29050.1
AE014297 Genomic DNA Translation: AAF57083.1
AE014297 Genomic DNA Translation: AAF57084.1
BT003277 mRNA Translation: AAO25034.1
BT011080 mRNA Translation: AAR82746.1
AY118654 mRNA Translation: AAM50023.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...PIRi		S33641

NCBI Reference Sequences

More...RefSeqi		NP_476850.1, NM_057502.5 [P28166-1]
NP_733402.1, NM_170523.3 [P28166-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0085701; FBpp0085063; FBgn0004606 [P28166-1]
FBtr0085702; FBpp0085064; FBgn0004606 [P28166-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		43650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1322

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63449 Genomic DNA Translation: AAA29050.1
AE014297 Genomic DNA Translation: AAF57083.1
AE014297 Genomic DNA Translation: AAF57084.1
BT003277 mRNA Translation: AAO25034.1
BT011080 mRNA Translation: AAR82746.1
AY118654 mRNA Translation: AAM50023.1 Sequence problems.
PIRiS33641
RefSeqiNP_476850.1, NM_057502.5 [P28166-1]
NP_733402.1, NM_170523.3 [P28166-2]

3D structure databases

SMRiP28166
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi68501, 26 interactors
ELMiP28166
IntActiP28166, 12 interactors
MINTiP28166
STRINGi7227.FBpp0085063

PTM databases

iPTMnetiP28166

Proteomic databases

PaxDbiP28166

Genome annotation databases

EnsemblMetazoaiFBtr0085701; FBpp0085063; FBgn0004606 [P28166-1]
FBtr0085702; FBpp0085064; FBgn0004606 [P28166-2]
GeneIDi43650
KEGGidme:Dmel_CG1322

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		43650
FlyBaseiFBgn0004606, zfh1

Phylogenomic databases

eggNOGiKOG3623, Eukaryota
GeneTreeiENSGT00870000136508
HOGENOMiCLU_010698_0_0_1
InParanoidiP28166
OMAiWDRVKED
PhylomeDBiP28166

Enzyme and pathway databases

SignaLinkiP28166

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		43650, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		43650

Protein Ontology

More...PROi		PR:P28166

Gene expression databases

BgeeiFBgn0004606, Expressed in embryo and 72 other tissues
GenevisibleiP28166, DM

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 9 hits
SUPFAMiSSF46689, SSF46689, 1 hit
SSF57667, SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFH1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28166
Secondary accession number(s): Q59DT3
, Q6NP51, Q8MSQ8, Q9VA39, Q9VA40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: March 15, 2004
Last modified: February 10, 2021
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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