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Protein

Glutathione S-transferase Mu 2

Gene

GSTM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50GlutathioneBy similarity1
Binding sitei116SubstrateBy similarity1
Sitei210Important for substrate specificity1

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • glutathione binding Source: BHF-UCL
  • glutathione peroxidase activity Source: BHF-UCL
  • glutathione transferase activity Source: UniProtKB
  • protein homodimerization activity Source: BHF-UCL
  • signaling receptor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
SABIO-RKiP28161

Chemistry databases

SwissLipidsiSLP:000001614

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 2 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 2
GSTM2-2
Gene namesi
Name:GSTM2
Synonyms:GST4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000213366.12
HGNCiHGNC:4634 GSTM2
MIMi138380 gene
neXtProtiNX_P28161

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi210T → C, F, H, I, K, L, R, Y or W: Reduced enzyme activity. 1 Publication1

Organism-specific databases

DisGeNETi2946
OpenTargetsiENSG00000213366
PharmGKBiPA29023

Chemistry databases

ChEMBLiCHEMBL4589
DrugBankiDB00143 Glutathione
DB03310 Oxidized Glutathione Disulfide
DB04701 S-METHYL-GLUTATHIONE

Polymorphism and mutation databases

BioMutaiGSTM2
DMDMi232204

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858181 – 218Glutathione S-transferase Mu 2Add BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei44PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP28161
MaxQBiP28161
PaxDbiP28161
PeptideAtlasiP28161
PRIDEiP28161
ProteomicsDBi54450

2D gel databases

OGPiP28161
REPRODUCTION-2DPAGEiP28161

PTM databases

iPTMnetiP28161
PhosphoSitePlusiP28161

Expressioni

Tissue specificityi

Muscle.

Gene expression databases

BgeeiENSG00000213366 Expressed in 88 organ(s), highest expression level in endocervix
CleanExiHS_GSTM2
ExpressionAtlasiP28161 baseline and differential
GenevisibleiP28161 HS

Organism-specific databases

HPAiCAB040547
HPA055972
HPA055973

Interactioni

Subunit structurei

Homodimer.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109201, 6 interactors
IntActiP28161, 2 interactors
STRINGi9606.ENSP00000241337

Chemistry databases

BindingDBiP28161

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP28161
SMRiP28161
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28161

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 88GST N-terminalAdd BLAST87
Domaini90 – 208GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione binding2 Publications2
Regioni43 – 46Glutathione binding2 Publications4
Regioni59 – 60Glutathione binding2 Publications2
Regioni72 – 73Glutathione binding2 Publications2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated

Phylogenomic databases

eggNOGiENOG410IN5J Eukaryota
ENOG4110YU0 LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115735
HOVERGENiHBG106842
InParanoidiP28161
KOiK00799
OMAiFWAMARI
PhylomeDBiP28161
TreeFamiTF353040

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003081 GST_mu
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01267 GSTRNSFRASEM
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P28161-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPMTLGYWNI RGLAHSIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGTHKI TQSNAILRYI ARKHNLCGES EKEQIREDIL
110 120 130 140 150
ENQFMDSRMQ LAKLCYDPDF EKLKPEYLQA LPEMLKLYSQ FLGKQPWFLG
160 170 180 190 200
DKITFVDFIA YDVLERNQVF EPSCLDAFPN LKDFISRFEG LEKISAYMKS
210
SRFLPRPVFT KMAVWGNK
Length:218
Mass (Da):25,745
Last modified:January 23, 2007 - v2
Checksum:i15203709D4A63789
GO
Isoform 2 (identifier: P28161-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-218: GLEKISAYMKSSRFLPRPVFTKMAVWGNK → HS

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):22,644
Checksum:i9267243C014F878F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6XZQ7F6XZQ7_HUMAN
Glutathione S-transferase
GSTM2
220Annotation score:
E9PHN6E9PHN6_HUMAN
Glutathione S-transferase
GSTM2
193Annotation score:
E9PHN7E9PHN7_HUMAN
Glutathione S-transferase Mu 2
GSTM2
181Annotation score:
E9PLF1E9PLF1_HUMAN
Glutathione S-transferase Mu 2
GSTM2
147Annotation score:
E9PGV1E9PGV1_HUMAN
Glutathione S-transferase Mu 2
GSTM2
87Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2P → S in AAV38750 (Ref. 3) Curated1
Sequence conflicti9N → D in AAV38750 (Ref. 3) Curated1
Sequence conflicti51F → L in BAG61446 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049486173S → N. Corresponds to variant dbSNP:rs2229050Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045614190 – 218GLEKI…VWGNK → HS in isoform 2. CuratedAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63509 mRNA Translation: AAA60963.1
AK299482 mRNA Translation: BAG61446.1
BT019947 mRNA Translation: AAV38750.1
AC000031 Genomic DNA No translation available.
AC000032 Genomic DNA No translation available.
BC105038 mRNA Translation: AAI05039.1
BC105066 mRNA Translation: AAI05067.1
CCDSiCCDS44192.1 [P28161-2]
CCDS808.1 [P28161-1]
PIRiA39375
RefSeqiNP_000839.1, NM_000848.3 [P28161-1]
NP_001135840.1, NM_001142368.1 [P28161-2]
UniGeneiHs.279837

Genome annotation databases

EnsembliENST00000241337; ENSP00000241337; ENSG00000213366 [P28161-1]
ENST00000442650; ENSP00000416883; ENSG00000213366 [P28161-2]
ENST00000460717; ENSP00000435910; ENSG00000213366 [P28161-2]
GeneIDi2946
KEGGihsa:2946
UCSCiuc001dyj.4 human [P28161-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63509 mRNA Translation: AAA60963.1
AK299482 mRNA Translation: BAG61446.1
BT019947 mRNA Translation: AAV38750.1
AC000031 Genomic DNA No translation available.
AC000032 Genomic DNA No translation available.
BC105038 mRNA Translation: AAI05039.1
BC105066 mRNA Translation: AAI05067.1
CCDSiCCDS44192.1 [P28161-2]
CCDS808.1 [P28161-1]
PIRiA39375
RefSeqiNP_000839.1, NM_000848.3 [P28161-1]
NP_001135840.1, NM_001142368.1 [P28161-2]
UniGeneiHs.279837

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HNAX-ray1.85A2-218[»]
1HNBX-ray3.50A/B2-218[»]
1HNCX-ray3.00A/B/C/D2-218[»]
1XW5X-ray1.80A/B2-218[»]
1YKCX-ray2.10A/B2-218[»]
2AB6X-ray2.50A/B/C/D2-218[»]
2C4JX-ray1.35A/B/C/D2-218[»]
2GTUX-ray2.55A/B2-218[»]
3GTUX-ray2.80A/C2-218[»]
3GURX-ray2.50A/B/C/D2-218[»]
5HWLX-ray1.60A/B2-218[»]
ProteinModelPortaliP28161
SMRiP28161
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109201, 6 interactors
IntActiP28161, 2 interactors
STRINGi9606.ENSP00000241337

Chemistry databases

BindingDBiP28161
ChEMBLiCHEMBL4589
DrugBankiDB00143 Glutathione
DB03310 Oxidized Glutathione Disulfide
DB04701 S-METHYL-GLUTATHIONE
SwissLipidsiSLP:000001614

PTM databases

iPTMnetiP28161
PhosphoSitePlusiP28161

Polymorphism and mutation databases

BioMutaiGSTM2
DMDMi232204

2D gel databases

OGPiP28161
REPRODUCTION-2DPAGEiP28161

Proteomic databases

EPDiP28161
MaxQBiP28161
PaxDbiP28161
PeptideAtlasiP28161
PRIDEiP28161
ProteomicsDBi54450

Protocols and materials databases

DNASUi2946
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241337; ENSP00000241337; ENSG00000213366 [P28161-1]
ENST00000442650; ENSP00000416883; ENSG00000213366 [P28161-2]
ENST00000460717; ENSP00000435910; ENSG00000213366 [P28161-2]
GeneIDi2946
KEGGihsa:2946
UCSCiuc001dyj.4 human [P28161-1]

Organism-specific databases

CTDi2946
DisGeNETi2946
EuPathDBiHostDB:ENSG00000213366.12
GeneCardsiGSTM2
HGNCiHGNC:4634 GSTM2
HPAiCAB040547
HPA055972
HPA055973
MIMi138380 gene
neXtProtiNX_P28161
OpenTargetsiENSG00000213366
PharmGKBiPA29023
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN5J Eukaryota
ENOG4110YU0 LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115735
HOVERGENiHBG106842
InParanoidiP28161
KOiK00799
OMAiFWAMARI
PhylomeDBiP28161
TreeFamiTF353040

Enzyme and pathway databases

BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
SABIO-RKiP28161

Miscellaneous databases

ChiTaRSiGSTM2 human
EvolutionaryTraceiP28161
GeneWikiiGSTM2
GenomeRNAii2946
PROiPR:P28161
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213366 Expressed in 88 organ(s), highest expression level in endocervix
CleanExiHS_GSTM2
ExpressionAtlasiP28161 baseline and differential
GenevisibleiP28161 HS

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003081 GST_mu
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01267 GSTRNSFRASEM
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSTM2_HUMAN
AccessioniPrimary (citable) accession number: P28161
Secondary accession number(s): B4DRY4
, E9PEM9, Q2M318, Q5TZY5, Q8WWE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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