Su(H)

Functionⁱ

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:21262215, PubMed:1617729, PubMed:8674407, PubMed:10673509). Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:10673509). Acts as a transcriptional repressor when it is not associated with Notch proteins (PubMed:10673509). When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (PubMed:10673509). Required for transcription of Sim (PubMed:10673509). Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence (PubMed:1744127, PubMed:1617730, PubMed:1617729). Required for neurogenesis in imaginal disks (PubMed:1617730, PubMed:7813798). In the larval brain, might play a role as a transducer of Notch signaling during type II neuroblast development (PubMed:21262215). Also functions independently of the Notch pathway, in the development of the bristle sensory organ precursor cell (PubMed:12642500).8 Publications

Manual assertion based on experiment inⁱ

Ref.1
"The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence."
Furukawa T., Kawaichi M., Matsunami N., Ryo H., Nishida Y., Honjo T.
J. Biol. Chem. 266:23334-23340(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION.
Ref.2
"Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates."
Schweisguth F., Posakony J.W.
Cell 69:1199-1212(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
Ref.8
"The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development."
Furukawa T., Maruyama S., Kawaichi M., Honjo T.
Cell 69:1191-1197(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.
Ref.9
"The sequence similarity of the Drosophila suppressor of hairless protein to the integrase domain has no functional significance in vivo."
Schweisguth F., Nero P., Posakony J.W.
Dev. Biol. 166:812-814(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF TYR-315.
Ref.11
"Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling."
Gho M., Lecourtois M., Geraud G., Posakony J.W., Schweisguth F.
Development 122:1673-1682(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
Ref.12
"Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo."
Morel V., Schweisguth F.
Genes Dev. 14:377-388(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING.
Ref.13
"A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila."
Koelzer S., Klein T.
Development 130:1973-1988(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Ref.14
"The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila."
San-Juan B.P., Baonza A.
Dev. Biol. 352:70-82(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Caution

Despite some similarity with the "phage" integrase family, PubMed:7958912 showed that it has no recombinase activity.Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	132 – 139	By similarity	8
DNA bindingⁱ	266 – 275	By similarity	10
DNA bindingⁱ	339 – 371	By similarityAdd BLAST	33

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10673509
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: FlyBase
Inferred from direct assayⁱ
- 7590238
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: FlyBase
Inferred from direct assayⁱ
- 19232522
RNA polymerase II proximal promoter sequence-specific DNA binding Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21262215
RNA polymerase II sequence-specific DNA-binding transcription factor binding
Source: FlyBase
Inferred from physical interactionⁱ
- 28350987
sequence-specific DNA binding
Source: FlyBase
Inferred from direct assayⁱ
- 16763555

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

asymmetric cell division
Source: FlyBase
Traceable author statementⁱ
- 15018932
cell fate determination
Source: FlyBase
Traceable author statementⁱ
- 15018932
crystal cell differentiation
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 12445385
hemopoiesis
Source: FlyBase
Traceable author statementⁱ
- 14602069
imaginal disc-derived wing vein morphogenesis
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 16287856
long-term memory
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 19863271
negative regulation of compound eye cone cell fate specification
Source: FlyBase
Traceable author statementⁱ
- 12419199
negative regulation of transcription, DNA-templated
Source: FlyBase
Traceable author statementⁱ
- 12419199
negative regulation of transcription by RNA polymerase II
Source: FlyBase
Inferred from genetic interactionⁱ
- 19232522
Notch signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10673509
positive regulation of G1/S transition of mitotic cell cycle
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 15809036
positive regulation of transcription, DNA-templated
Source: FlyBase
Traceable author statementⁱ
- 12419199
positive regulation of transcription by RNA polymerase II
Source: FlyBase
Traceable author statementⁱ
- 10603347
- 10929403
sensory organ precursor cell fate determination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10673509
wing disc dorsal/ventral pattern formation
Source: FlyBase
Inferred from genetic interactionⁱ
- 16307735

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Repressor
Biological process	Notch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkⁱ	P28159

SignaLinkⁱ

P28159

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Suppressor of hairless protein Alternative name(s): J kappa-recombination signal-binding protein RBP-J kappa
Gene namesⁱ	Name:Su(H) Synonyms:dRBP-JK ORF Names:CG3497
Organismⁱ	Drosophila melanogaster (Fruit fly)
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome 2L

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0004837 Su(H)

FlyBaseⁱ

FBgn0004837 Su(H)

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Lethal during the first day of pupal development (PubMed:1617730). At the larval stage, results in a "neurogenic" phenotype in imaginal disks, in which too many cells adopt the sensory organ precursor cell fate (PubMed:1617730). RNAi-mediated knockdown in type II neuroblasts, results in smaller cells (PubMed:1617730).2 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	315	Y → F: No effect. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000208572	1 – 594	Suppressor of hairless proteinAdd BLAST		594

Proteomic databases

PaxDbⁱ	P28159
PRIDEⁱ	P28159

Expressionⁱ

Developmental stageⁱ

Expressed in early syncytial embryo (PubMed:1617730, PubMed:1617729). During cellularization, transient accumulation in a striped pattern (PubMed:1617730, PubMed:1617729). From late stage 11 onward, expressed gradually in a small number of segmentally reiterated cells of the peripheral nervous system (PNS) (PubMed:1617730, PubMed:1617729). This expression is specific to the external sensory organs (PubMed:1617730). In the thoracic and abdominal segments, expressed in the trichogen and tormogen cells, two outer accessory cells present in all larval external sensory organs (PubMed:1617730). During the late third larval instar, expressed in many larval and imaginal tissues (PubMed:1617730). Broadly distributed in the disks, but most abundant in the posterior region of the wing pouch (PubMed:1617730). In the leg disk, predominant in a zone largely overlapping the posterior region (PubMed:1617730). In the eye-antenna disk, low level in both the retinal field posterior to the morphogenetic furrow and the central antenna region, while higher levels appears on the margins of the disk and in the vicinity of the morphogenetic furrow (PubMed:1617730). In pupae, expressed in many tissues at this stage, including developing muscle and epidermis (PubMed:1617730). In both microchaetes and macrochaetes of 24 hr pupae, expressed on the notum and the head (PubMed:1617730). Expressed in the tormogen cell and in specific bristle cells (PubMed:1617730).2 Publications

Gene expression databases

Bgeeⁱ	FBgn0004837 Expressed in 62 organ(s), highest expression level in second segment of antenna (Drosophila)
ExpressionAtlasⁱ	P28159 baseline and differential
Genevisibleⁱ	P28159 DM

Interactionⁱ

Subunit structureⁱ

Interacts with activated cleaved Notch. Interacts with Hairless, this interaction preventing its DNA-binding activity. Interacts with insv (via BEN domain).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
insv	Q8SYK5	4	EBI-92180,EBI-192407
N	P07207	7	EBI-92180,EBI-103438
Notch1	Q01705	3	EBI-92180,EBI-1392707	From Mus musculus.

GO - Molecular functionⁱ

RNA polymerase II sequence-specific DNA-binding transcription factor binding
Source: FlyBase
Inferred from physical interactionⁱ
- 28350987

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	60899, 63 interactors
Database of interacting proteins More...DIPⁱ	DIP-177N
IntActⁱ	P28159, 12 interactors
Molecular INTeraction database More...MINTⁱ	P28159
STRINGⁱ	7227.FBpp0080261

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	107 – 116	Combined sources	10
Beta strandⁱ	120 – 131	Combined sources	12
Beta strandⁱ	146 – 151	Combined sources	6
Helixⁱ	153 – 163	Combined sources	11
Helixⁱ	167 – 171	Combined sources	5
Beta strandⁱ	172 – 178	Combined sources	7
Beta strandⁱ	187 – 189	Combined sources	3
Beta strandⁱ	195 – 198	Combined sources	4
Beta strandⁱ	211 – 213	Combined sources	3
Beta strandⁱ	216 – 221	Combined sources	6
Beta strandⁱ	226 – 231	Combined sources	6
Beta strandⁱ	235 – 238	Combined sources	4
Helixⁱ	248 – 250	Combined sources	3
Beta strandⁱ	259 – 266	Combined sources	8
Beta strandⁱ	274 – 280	Combined sources	7
Beta strandⁱ	283 – 289	Combined sources	7
Beta strandⁱ	294 – 299	Combined sources	6
Beta strandⁱ	321 – 326	Combined sources	6
Turnⁱ	327 – 329	Combined sources	3
Beta strandⁱ	336 – 342	Combined sources	7
Beta strandⁱ	345 – 347	Combined sources	3
Beta strandⁱ	359 – 364	Combined sources	6
Beta strandⁱ	367 – 375	Combined sources	9
Beta strandⁱ	378 – 383	Combined sources	6
Beta strandⁱ	388 – 395	Combined sources	8
Helixⁱ	398 – 400	Combined sources	3
Beta strandⁱ	402 – 416	Combined sources	15
Beta strandⁱ	430 – 437	Combined sources	8
Beta strandⁱ	439 – 442	Combined sources	4
Beta strandⁱ	444 – 450	Combined sources	7
Beta strandⁱ	456 – 460	Combined sources	5
Beta strandⁱ	467 – 471	Combined sources	5
Beta strandⁱ	474 – 477	Combined sources	4
Helixⁱ	483 – 488	Combined sources	6
Turnⁱ	489 – 491	Combined sources	3
Beta strandⁱ	492 – 494	Combined sources	3
Beta strandⁱ	498 – 504	Combined sources	7
Beta strandⁱ	507 – 520	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	P28159
SMRⁱ	P28159
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	429 – 519	IPT/TIGAdd BLAST		91

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	35 – 42	Gln-rich	8
Compositional biasⁱ	58 – 88	Gln-richAdd BLAST	31
Compositional biasⁱ	541 – 558	Asn-richAdd BLAST	18
Compositional biasⁱ	569 – 576	Gln-rich	8

Sequence similaritiesⁱ

Belongs to the Su(H) family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3743 Eukaryota ENOG410XV7K LUCA
InParanoidⁱ	P28159
KEGG Orthology (KO) More...KOⁱ	K06053
OMAⁱ	DMPHFGL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G057S
PhylomeDBⁱ	P28159

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01176 IPT_RBP-Jkappa, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.1450, 1 hit
InterProⁱ	View protein in InterPro IPR015350 Beta-trefoil_DNA-bd_dom IPR036358 BTD_sf IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR008967 p53-like_TF_DNA-bd IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf IPR038007 RBP-Jkappa_IPT
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09270 BTD, 1 hit PF09271 LAG1-DNAbind, 1 hit
SMARTⁱ	View protein in SMART SM01268 BTD, 1 hit SM01267 LAG1_DNAbind, 1 hit
SUPFAMⁱ	SSF110217 SSF110217, 1 hit SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P28159-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKSYSQFNLN AAAPPAIAYE TTVVNPNGSP LDPHQQQQQQ SQDMPHFGLP 
        60         70         80         90        100
GPQPPSSQQQ QQQLQVHHQQ QQQQQQQQQQ QQHQQQMQMS LLPGPYRPHI 
       110        120        130        140        150
EEKKLTRDAM EKYMRERNDM VIVILHAKVA QKSYGNEKRF FCPPPCIYLF 
       160        170        180        190        200
GSGWRRRYEE MLQQGEGEQG AQLCAFIGIG SSDQDMQQLD LNGKQYCAAK 
       210        220        230        240        250
TLFISDSDKR KHFMLSVKMF YGNGHDIGVF NSKRIKVISK PSKKKQSLKN 
       260        270        280        290        300
ADLCIASGTN VALFNRLRSQ TVSTRYLHVE NGHFHASSTQ WGAFTIHLLD 
       310        320        330        340        350
DNESESEEFQ VRDGYIHYGA TVKLVCSVTG MALPRLIIRK VDKQMALLEA 
       360        370        380        390        400
DDPVSQLHKC AFYMKDTDRM YLCLSQEKII QFQATPCPKE PNKEMINDGA 
       410        420        430        440        450
CWTIISTDKA EYQFYEGMGP VASPVTPVPI VNSLNLNGGG DVAMLELSGD 
       460        470        480        490        500
NFTPHLQVWF GDVEAETMYR CTETLLCVVP EISQFRGEWL WVRQPTQVPI 
       510        520        530        540        550
SLVRNDGIIY ATGLTFTYTP EPGPRPHCNT QAEDVMRARQ NNNNNNITSI 
       560        570        580        590 
SNNNNSNNAG SPAAGGGLQQ QQQQHQALPS ISEVQWNSHG SGLS

Length:594

Mass (Da):66,924

Last modified:July 1, 1993 - v1

Checksum:ⁱ145144F336CD8F4C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	X2JAI1	X2JAI1_DROME		Suppressor of hairless, isoform C Suppressor of hairless, isoform C	Su(H) anon-WO0257455.3, BG:DS00929.10, br7, C, CBF1	594	Annotation score:

Sequence cautionⁱ

The sequence AAA06211 differs from that shown. Reason: Frameshift at position 6.Curated

The sequence CAA41282 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	116 – 117	ER → DG in AAA06211 (PubMed:1744127).Curated	2
Sequence conflictⁱ	116 – 117	ER → DG in CAA41282 (PubMed:1744127).Curated	2
Sequence conflictⁱ	492	V → A in AAA06211 (PubMed:1744127).Curated	1
Sequence conflictⁱ	492	V → A in CAA41282 (PubMed:1744127).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	80 – 82	Missing in strain: LAMTO 3, LAMTO 4, LAMTO 12, LAMTO 18, LAMTO 19, LAMTO 21, LAMTO 31, LAMTO 35, LAMTO 101 and LAMTO 111.	3
Natural variantⁱ	81 – 82	Missing in strain: LAMTO 13, LAMTO 37 and LAMTO 134.	2
Natural variantⁱ	82	Missing in strain: LAMTO 124.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S69213 Genomic DNA Translation: AAA06211.1 Frameshift. X58393 mRNA Translation: CAA41282.1 Different initiation. M94383 mRNA Translation: AAA28919.1 AE014134 Genomic DNA Translation: AAF53434.1 AY069091 mRNA Translation: AAL39236.1 AF088255 Genomic DNA Translation: AAD39698.1 AF088256 Genomic DNA Translation: AAD39699.1 AF088257 Genomic DNA Translation: AAD39700.1 AF088258 Genomic DNA Translation: AAD39701.1 AF088259 Genomic DNA Translation: AAD39702.1 AF088260 Genomic DNA Translation: AAD39703.1 AF088261 Genomic DNA Translation: AAD39704.1 AF088262 Genomic DNA Translation: AAD39705.1 AF088263 Genomic DNA Translation: AAD39706.1 AF088264 Genomic DNA Translation: AAD39707.1 AF088265 Genomic DNA Translation: AAD39708.1 AF088266 Genomic DNA Translation: AAD39709.1 AF088267 Genomic DNA Translation: AAD39710.1 AF088268 Genomic DNA Translation: AAD39711.1 AF088269 Genomic DNA Translation: AAD39712.1 AF088270 Genomic DNA Translation: AAD39713.1 AF088271 Genomic DNA Translation: AAD39714.1 AF088272 Genomic DNA Translation: AAD39715.1 AF088273 Genomic DNA Translation: AAD39716.1 AF088274 Genomic DNA Translation: AAD39717.1
PIRⁱ	A41585 A42770
NCBI Reference Sequences More...RefSeqⁱ	NP_001285948.1, NM_001299019.1 NP_476868.1, NM_057520.4
UniGeneⁱ	Dm.2288

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0080700; FBpp0080261; FBgn0004837 FBtr0346621; FBpp0312201; FBgn0004837
GeneIDⁱ	34881
KEGGⁱ	dme:Dmel_CG3497

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28159	Suppressor of hairless, isoform C		DROME		594	UniRef100_P28159

Protein	Similar proteins		Species	Score	Length	Source
P28159	Suppressor of hairless, isoform C		DROME		594	UniRef90_P28159
suppressor of hairless protein		DROFC		598
Uncharacterized protein		DROER		597
Uncharacterized protein		DROAN		597
Su(H)		DROSI		594
+15

Protein	Similar proteins		Species	Score	Length	Source
P28159	Recombining binding protein suppressor of hairless	)	MOUSE		526	UniRef50_P31266
Suppressor of hairless protein homolog		XENLA		501
Recombining binding protein suppressor of hairless	)	HUMAN		500
Recombining binding protein suppressor of hairless		BOVIN		487
Recombining binding protein suppressor of hairless		PONAB		486
+713

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S69213 Genomic DNA Translation: AAA06211.1 Frameshift. X58393 mRNA Translation: CAA41282.1 Different initiation. M94383 mRNA Translation: AAA28919.1 AE014134 Genomic DNA Translation: AAF53434.1 AY069091 mRNA Translation: AAL39236.1 AF088255 Genomic DNA Translation: AAD39698.1 AF088256 Genomic DNA Translation: AAD39699.1 AF088257 Genomic DNA Translation: AAD39700.1 AF088258 Genomic DNA Translation: AAD39701.1 AF088259 Genomic DNA Translation: AAD39702.1 AF088260 Genomic DNA Translation: AAD39703.1 AF088261 Genomic DNA Translation: AAD39704.1 AF088262 Genomic DNA Translation: AAD39705.1 AF088263 Genomic DNA Translation: AAD39706.1 AF088264 Genomic DNA Translation: AAD39707.1 AF088265 Genomic DNA Translation: AAD39708.1 AF088266 Genomic DNA Translation: AAD39709.1 AF088267 Genomic DNA Translation: AAD39710.1 AF088268 Genomic DNA Translation: AAD39711.1 AF088269 Genomic DNA Translation: AAD39712.1 AF088270 Genomic DNA Translation: AAD39713.1 AF088271 Genomic DNA Translation: AAD39714.1 AF088272 Genomic DNA Translation: AAD39715.1 AF088273 Genomic DNA Translation: AAD39716.1 AF088274 Genomic DNA Translation: AAD39717.1
PIRⁱ	A41585 A42770
RefSeqⁱ	NP_001285948.1, NM_001299019.1 NP_476868.1, NM_057520.4
UniGeneⁱ	Dm.2288

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5E24	X-ray	2.14	E/F	99-522	[»]
ProteinModelPortalⁱ	P28159
SMRⁱ	P28159
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	60899, 63 interactors
DIPⁱ	DIP-177N
IntActⁱ	P28159, 12 interactors
MINTⁱ	P28159
STRINGⁱ	7227.FBpp0080261

Proteomic databases

PaxDbⁱ	P28159
PRIDEⁱ	P28159

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0080700; FBpp0080261; FBgn0004837 FBtr0346621; FBpp0312201; FBgn0004837
GeneIDⁱ	34881
KEGGⁱ	dme:Dmel_CG3497

Organism-specific databases

CTDⁱ	34881
FlyBaseⁱ	FBgn0004837 Su(H)

Phylogenomic databases

eggNOGⁱ	KOG3743 Eukaryota ENOG410XV7K LUCA
InParanoidⁱ	P28159
KOⁱ	K06053
OMAⁱ	DMPHFGL
OrthoDBⁱ	EOG091G057S
PhylomeDBⁱ	P28159

Enzyme and pathway databases

SignaLinkⁱ	P28159

SignaLinkⁱ

P28159

Miscellaneous databases

GenomeRNAiⁱ	34881
Protein Ontology More...PROⁱ	PR:P28159

Gene expression databases

Bgeeⁱ	FBgn0004837 Expressed in 62 organ(s), highest expression level in second segment of antenna (Drosophila)
ExpressionAtlasⁱ	P28159 baseline and differential
Genevisibleⁱ	P28159 DM

Family and domain databases

CDDⁱ	cd01176 IPT_RBP-Jkappa, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.1450, 1 hit
InterProⁱ	View protein in InterPro IPR015350 Beta-trefoil_DNA-bd_dom IPR036358 BTD_sf IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR008967 p53-like_TF_DNA-bd IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf IPR038007 RBP-Jkappa_IPT
Pfamⁱ	View protein in Pfam PF09270 BTD, 1 hit PF09271 LAG1-DNAbind, 1 hit
SMARTⁱ	View protein in SMART SM01268 BTD, 1 hit SM01267 LAG1_DNAbind, 1 hit
SUPFAMⁱ	SSF110217 SSF110217, 1 hit SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SUH_DROME
Accessionⁱ	P28159Primary (citable) accession number: P28159 Secondary accession number(s): Q3S1M8 , Q9TVK8, Q9TVY7, Q9TW34, Q9U8F9, Q9V446
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	July 1, 1993
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

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Supporting data

UniProtKB - P28159 (SUH_DROME)

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Suppressor of hairless protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ