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Protein

Protein Wnt-1

Gene

WNT-1

Organism
Pituophis melanoleucus (Pine snake) (Coluber melanoleucus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-1
Gene namesi
Name:WNT-1
OrganismiPituophis melanoleucus (Pine snake) (Coluber melanoleucus)
Taxonomic identifieri8595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaColubridaeColubrinaePituophis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200605‹1 – ›126Protein Wnt-1Add BLAST›126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi92 ↔ 107By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Palmitoleoylation is necessary for proper trafficking to cell surface (By similarity). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

HOVERGENiHBG001595

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009139 Wnt1
PANTHERiPTHR12027 PTHR12027, 2 hits
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01841 WNT1PROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit

Sequencei

Sequence statusi: Fragment.

P28139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCTVKTCW MRLPTFRTVG DFLKDRFDGA SRVIYGNKGS NRASRMELHH
60 70 80 90 100
LEPENPAHKP PSPHDLVYFE KSPNFCTYSG KTGTAGTAGR FCNSTSPALD
110 120
GCELLCCGRG YRTRTQRVTE RCNCTF
Length:126
Mass (Da):14,020
Last modified:December 1, 1992 - v1
Checksum:i4C1AEDC4FECFB8B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91296 Genomic DNA Translation: AAA49454.1

Similar proteinsi

Entry informationi

Entry nameiWNT1_PITME
AccessioniPrimary (citable) accession number: P28139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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