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Protein

Protein Wnt-7a

Gene

WNT-7A

Organism
Plethodon jordani (Red-cheeked salamander)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays an important role in embryonic development.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-7a
Gene namesi
Name:WNT-7A
OrganismiPlethodon jordani (Red-cheeked salamander)
Taxonomic identifieri8336 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaPlethodontidaePlethodontinaePlethodon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200648‹1 – ›123Protein Wnt-7aAdd BLAST›123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi89 ↔ 104By similarity
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PRIDEiP28138

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP28138
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

HOVERGENiHBG001595

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013300 Wnt7
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01891 WNT7PROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit

Sequencei

Sequence statusi: Fragment.

P28138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCTTKTCW TTLPKFRELG YVLKDKYNEA VQVEPVRASR NKRPTFLKIK
60 70 80 90 100
KPLSYLKPMD TDLVYIEKSP NYCEEDPVTG SVGTQGRMCN KTAQHSSGCD
110 120
LMCCGRGYNT HQYSRVWKCN CKF
Length:123
Mass (Da):14,047
Last modified:December 1, 1992 - v1
Checksum:iFAA9CD58D404FCC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1231

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91295 Genomic DNA Translation: AAA49463.1

Similar proteinsi

Entry informationi

Entry nameiWNT7A_PLEJO
AccessioniPrimary (citable) accession number: P28138
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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