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Protein

Protein Wnt-3a

Gene

WNT-3A

Organism
Plethodon jordani (Red-cheeked salamander)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-3a
Gene namesi
Name:WNT-3A
OrganismiPlethodon jordani (Red-cheeked salamander)
Taxonomic identifieri8336 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaPlethodontidaePlethodontinaePlethodon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200615‹1 – ›123Protein Wnt-3aAdd BLAST›123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serineBy similarity1
Disulfide bondi89 ↔ 104By similarity
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding.By similarity
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PRIDEiP28133

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP28133
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

HOVERGENiHBG001595

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
SMARTiView protein in SMART
SM00097 WNT1, 1 hit

Sequencei

Sequence statusi: Fragment.

P28133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCEVKTCW WSQPDFRVIG DFLKDKYDSA SEMVVEKHRE SRGWVETLRP
60 70 80 90 100
KYTFFKPPTE RDLVYYESSP NFCEPNPETG SFGTRDRICN VTSHGIDGCD
110 120
LLCCGRGHNT RTEKRKEKCH CIF
Length:123
Mass (Da):14,266
Last modified:December 1, 1992 - v1
Checksum:iC11F8ABB26B2A8BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1231

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91290 Genomic DNA Translation: AAA49458.1

Similar proteinsi

Entry informationi

Entry nameiWNT3A_PLEJO
AccessioniPrimary (citable) accession number: P28133
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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