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Protein

Protein Wnt-4

Gene

WNT4

Organism
Meleagris gallopavo (Wild turkey)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-4
Gene namesi
Name:WNT4
OrganismiMeleagris gallopavo (Wild turkey)
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
Proteomesi
  • UP000001645 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200624‹1 – ›119Protein Wnt-4Add BLAST›119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi85 ↔ 100By similarity
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9103.ENSMGAP00000006855

Structurei

3D structure databases

SMRiP28127
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
HOVERGENiHBG001595
InParanoidiP28127

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
SMARTiView protein in SMART
SM00097 WNT1, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P28127-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SGSCEFKTCW KAMPPFRKVG NVLKEKFDGA TEVEQSEIGS TKVLVPKNSQ
60 70 80 90 100
FKPHTDEDLV YLDSSPDFCD HDLKNGVLGT SGRQCNKTSK AIDGCELMCC
110
GRGFHTDEVE VVERCSCKF
Length:119
Mass (Da):13,188
Last modified:December 1, 1992 - v1
Checksum:i4312D822F2200356
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1N4Q9G1N4Q9_MELGA
Protein Wnt
WNT4
352Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91283 Genomic DNA Translation: AAA49632.1

Similar proteinsi

Entry informationi

Entry nameiWNT4_MELGA
AccessioniPrimary (citable) accession number: P28127
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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