UniProtKB - P28088 (EDNRB_BOVIN)
Protein
Endothelin receptor type B
Gene
EDNRB
Organism
Bos taurus (Bovine)
Status
Functioni
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Caution
N-terminal sequencing (PubMed:9422751) indicates the presence of a signal peptide but an unprocessed form where the signal sequence is not cleaved has also been detected (PubMed:8529649). It is unclear if this exists in vivo.2 Publications
GO - Molecular functioni
- endothelin receptor activity Source: UniProtKB
- peptide hormone binding Source: Ensembl
GO - Biological processi
- calcium-mediated signaling Source: UniProtKB
- endothelin receptor signaling pathway Source: UniProtKB
- enteric nervous system development Source: Ensembl
- enteric smooth muscle cell differentiation Source: Ensembl
- macrophage chemotaxis Source: Ensembl
- melanocyte differentiation Source: Ensembl
- negative regulation of cellular protein metabolic process Source: Ensembl
- negative regulation of neuron maturation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neural crest cell migration Source: Ensembl
- peripheral nervous system development Source: Ensembl
- posterior midgut development Source: Ensembl
- regulation of blood pressure Source: Ensembl
- regulation of pH Source: Ensembl
- vein smooth muscle contraction Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-BTA-375276, Peptide ligand-binding receptors R-BTA-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin receptor type BCuratedShort name: ET-B Short name: ET-BR Alternative name(s): Endothelin receptor non-selective type |
Gene namesi | Name:EDNRB |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:28330, EDNRB |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein
Note: internalized after activation by endothelins.By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 100 | ExtracellularSequence analysisAdd BLAST | 74 | |
Transmembranei | 101 – 125 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 126 – 136 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 137 – 162 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 163 – 174 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 175 – 196 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 197 – 217 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 218 – 242 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 243 – 270 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 271 – 295 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 296 – 323 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 324 – 349 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 350 – 361 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 362 – 388 | Helical; Name=7Sequence analysisAdd BLAST | 27 | |
Topological domaini | 389 – 441 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 2 PublicationsAdd BLAST | 26 | |
ChainiPRO_0000012726 | 27 – 441 | Endothelin receptor type BAdd BLAST | 415 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 173 ↔ 254 | PROSITE-ProRule annotation | ||
Modified residuei | 304 | Phosphoserine1 Publication | 1 | |
Lipidationi | 402 | S-palmitoyl cysteine1 Publication | 1 | |
Lipidationi | 404 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 418 | Phosphoserine1 Publication | 1 | |
Modified residuei | 434 | PhosphoserineCurated | 1 | |
Modified residuei | 435 | PhosphoserineCurated | 1 | |
Modified residuei | 438 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 439 | Phosphoserine1 Publication | 1 | |
Modified residuei | 440 | Phosphoserine1 Publication | 1 | |
Modified residuei | 441 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
It is not sure whether phosphorylation is on Ser-434 or Ser-435.1 Publication
Keywords - PTMi
Disulfide bond, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P28088 |
PRIDEi | P28088 |
PTM databases
iPTMneti | P28088 |
SwissPalmi | P28088 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000005299, Expressed in lung and 17 other tissues |
Interactioni
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000006979 |
Chemistry databases
BindingDBi | P28088 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230470 |
HOGENOMi | CLU_009579_28_0_1 |
InParanoidi | P28088 |
OMAi | GFDMITT |
OrthoDBi | 876925at2759 |
TreeFami | TF331292 |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P28088-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPLPSLCGR ALVALILACG VAGIQAEERE FPPAGATQPL PGTGEMMETP
60 70 80 90 100
TETSWPGRSN ASDPRSSATP QIPRGGRMAG IPPRTPPPCD GPIEIKETFK
110 120 130 140 150
YINTVVSCLV FVLGIIGNST LLRIIYKNKC MRNGPNILIA SLALGDLLHI
160 170 180 190 200
IIDIPINTYK LLAKDWPFGV EMCKLVPFIQ KASVGITVLS LCALSIDRYR
210 220 230 240 250
AVASWSRIKG IGVPKWTAVE IVLIWVVSVV LAVPEAVGFD IITSDHIGNK
260 270 280 290 300
LRICLLHPTQ KTAFMQFYKT AKDWWLFSFY FCLPLAITAL FYTLMTCEML
310 320 330 340 350
RKKSGMQIAL NDHLKQRREV AKTVFCLVLV FALCWLPLHL SRILKLTLYD
360 370 380 390 400
QHDPRRCEFL SFLLVLDYIG INMASLNSCI NPIALYLVSK RFKNCFKSCL
410 420 430 440
CCWCQSFEEK QSLEEKQSCL KFKANDHGYD NFRSSNKYSS S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10994 Genomic DNA Translation: BAA01762.1 D90456 mRNA Translation: BAA14422.1 BC120256 mRNA Translation: AAI20257.1 |
PIRi | A41591 |
RefSeqi | NP_776734.1, NM_174309.2 XP_005213931.1, XM_005213874.3 |
Genome annotation databases
Ensembli | ENSBTAT00000006979; ENSBTAP00000006979; ENSBTAG00000005299 ENSBTAT00000070002; ENSBTAP00000064163; ENSBTAG00000005299 |
GeneIDi | 281750 |
KEGGi | bta:281750 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10994 Genomic DNA Translation: BAA01762.1 D90456 mRNA Translation: BAA14422.1 BC120256 mRNA Translation: AAI20257.1 |
PIRi | A41591 |
RefSeqi | NP_776734.1, NM_174309.2 XP_005213931.1, XM_005213874.3 |
3D structure databases
SMRi | P28088 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000006979 |
Chemistry databases
BindingDBi | P28088 |
ChEMBLi | CHEMBL4401 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | P28088 |
SwissPalmi | P28088 |
Proteomic databases
PaxDbi | P28088 |
PRIDEi | P28088 |
Genome annotation databases
Ensembli | ENSBTAT00000006979; ENSBTAP00000006979; ENSBTAG00000005299 ENSBTAT00000070002; ENSBTAP00000064163; ENSBTAG00000005299 |
GeneIDi | 281750 |
KEGGi | bta:281750 |
Organism-specific databases
CTDi | 1910 |
VGNCi | VGNC:28330, EDNRB |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230470 |
HOGENOMi | CLU_009579_28_0_1 |
InParanoidi | P28088 |
OMAi | GFDMITT |
OrthoDBi | 876925at2759 |
TreeFami | TF331292 |
Enzyme and pathway databases
Reactomei | R-BTA-375276, Peptide ligand-binding receptors R-BTA-416476, G alpha (q) signalling events |
Miscellaneous databases
PROi | PR:P28088 |
Gene expression databases
Bgeei | ENSBTAG00000005299, Expressed in lung and 17 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EDNRB_BOVIN | |
Accessioni | P28088Primary (citable) accession number: P28088 Secondary accession number(s): Q0VCB3, Q9TSB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families