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Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis (By similarity).By similarity

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutinin
Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin glycoprotein
Gene namesi
Name:H
OrganismiMeasles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri11239 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37IntravirionSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 620Virion surfaceSequence analysisAdd BLAST562

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426021 – 620Hemagglutinin glycoproteinAdd BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with human NECTIN4; this interaction allows virus infection of the respiratory epithelium. Interacts with human MCP/CD46 antigen and SLAMF1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP28081
SMRiP28081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

P28081-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPQRDRTNA FYKDNPHPKG SRIVINREHL MIDRPYVLLA ILFVMFLSLI
60 70 80 90 100
GLLAIAGIRL HQAAIHTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG
110 120 130 140 150
DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLNWCI NPPERIKLDY
160 170 180 190 200
DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN
210 220 230 240 250
MSTSLLDLYL SRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS
260 270 280 290 300
MYRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDLSNCMVA LGEFKLAALC
310 320 330 340 350
HREDSITIPY QGSGKGVSFQ LVNLGVWKSP TDMQSWIPLS TDDPVIDRLY
360 370 380 390 400
LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA
410 420 430 440 450
PLKDNRIPSY GVLSVDLSPT VELKIKIASG FGPLITHGSG MDLYKSNHNN
460 470 480 490 500
VYWLTIPPMK NLALGVINTL EWIPRFKVSP NLFTVPIKEA GKDCHAPTYL
510 520 530 540 550
PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPGRSFS
560 570 580 590 600
YFYPFRLPIR GVPIELQVEC FTWDQKLWCR HFCVLANSES GGHITHSGMV
610 620
GMGVSCTVTR EDGTNRRQSC
Length:620
Mass (Da):69,602
Last modified:December 1, 1992 - v2
Checksum:i30641B0DA2B48A68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10549 mRNA Translation: BAA01406.1
PIRiJU0273

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10549 mRNA Translation: BAA01406.1
PIRiJU0273

3D structure databases

ProteinModelPortaliP28081
SMRiP28081
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEMA_MEASY
AccessioniPrimary (citable) accession number: P28081
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 1, 1992
Last modified: October 25, 2017
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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