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UniProtKB - P28073 (PSB6_RAT)

Entry version 177 (02 Dec 2020)
Sequence version 3 (20 Dec 2005)
Previous versions | rss
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Protein

Proteasome subunit beta type-6

Gene

Psmb6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei34NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-1169091, Activation of NF-kappaB in B cells
R-RNO-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-RNO-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-RNO-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-RNO-174154, APC/C:Cdc20 mediated degradation of Securin
R-RNO-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-RNO-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-RNO-187577, SCF(Skp2)-mediated degradation of p27/p21
R-RNO-195253, Degradation of beta-catenin by the destruction complex
R-RNO-202424, Downstream TCR signaling
R-RNO-2467813, Separation of Sister Chromatids
R-RNO-2871837, FCERI mediated NF-kB activation
R-RNO-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-RNO-350562, Regulation of ornithine decarboxylase (ODC)
R-RNO-382556, ABC-family proteins mediated transport
R-RNO-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-RNO-4608870, Asymmetric localization of PCP proteins
R-RNO-4641257, Degradation of AXIN
R-RNO-4641258, Degradation of DVL
R-RNO-5358346, Hedgehog ligand biogenesis
R-RNO-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764, CLEC7A (Dectin-1) signaling
R-RNO-5610780, Degradation of GLI1 by the proteasome
R-RNO-5610785, GLI3 is processed to GLI3R by the proteasome
R-RNO-5632684, Hedgehog 'on' state
R-RNO-5658442, Regulation of RAS by GAPs
R-RNO-5668541, TNFR2 non-canonical NF-kB pathway
R-RNO-5676590, NIK-->noncanonical NF-kB signaling
R-RNO-5687128, MAPK6/MAPK4 signaling
R-RNO-5689603, UCH proteinases
R-RNO-5689880, Ub-specific processing proteases
R-RNO-68827, CDT1 association with the CDC6:ORC:origin complex
R-RNO-68949, Orc1 removal from chromatin
R-RNO-69017, CDK-mediated phosphorylation and removal of Cdc6
R-RNO-69481, G2/M Checkpoints
R-RNO-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-RNO-75815, Ubiquitin-dependent degradation of Cyclin D
R-RNO-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-RNO-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-8939902, Regulation of RUNX2 expression and activity
R-RNO-8941858, Regulation of RUNX3 expression and activity
R-RNO-8948751, Regulation of PTEN stability and activity
R-RNO-8951664, Neddylation
R-RNO-9020702, Interleukin-1 signaling
R-RNO-983168, Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPS protease database

More...MEROPSi		T01.010

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome subunit beta type-6 (EC:3.4.25.1By similarity)
Alternative name(s):
Macropain delta chain
Multicatalytic endopeptidase complex delta chain
Proteasome chain 5
Proteasome delta chain
Proteasome subunit Y
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Psmb6
Synonyms:Psmb6l
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...RGDi		61881, Psmb6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000266172 – 33Removed in mature form1 PublicationAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002661834 – 238Proteasome subunit beta type-6Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei68PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein, Zymogen

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P28073

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P28073

PRoteomics IDEntifications database

More...PRIDEi		P28073

2D gel databases

The World-2DPAGE database

More...World-2DPAGEi		0004:P28073

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P28073

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000019551, Expressed in quadriceps femoris and 18 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P28073, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		248287, 3 interactors

Protein interaction database and analysis system

More...IntActi		P28073, 1 interactor

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000026507

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P28073

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0174, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155114

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035750_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P28073

Identification of Orthologs from Complete Genome Data

More...OMAi		DWINAPH

Database of Orthologous Groups

More...OrthoDBi		1172133at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P28073

TreeFam database of animal gene trees

More...TreeFami		TF106221

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR000243, Pept_T1A_subB
IPR035140, Proteasome_beta6
IPR016050, Proteasome_bsu_CS
IPR001353, Proteasome_sua/b
IPR023333, Proteasome_suB-type

The PANTHER Classification System

More...PANTHERi		PTHR11599:SF46, PTHR11599:SF46, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00227, Proteasome, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00141, PROTEASOME

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56235, SSF56235, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00854, PROTEASOME_BETA_1, 1 hit
PS51476, PROTEASOME_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P28073-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAALAVRGA VSAPAFGPEA LTPDWENREV STGTTIMAVQ FDGGVVLGAD 
        60         70         80         90        100
SRTTTGSYIA NRVTDKLTPI HDHIFCCRSG SAADTQAVAD AVTYQLGFHS 
       110        120        130        140        150
IELNEPPLVH TAASLFKEMC YRYREDLMAG IIIAGWDPQE GGQVYSVPMG 
       160        170        180        190        200
GMMVRQSFAI GGSGSSYIYG YVDATYREGM TKDECLQFTA NALALAMERD 
       210        220        230 
GSSGGVIRLA AIQQSGVERQ VLLGDQIPKV TISTLPPP
Length:238
Mass (Da):25,290
Last modified:December 20, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B051AF11D78E49B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA01586 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC058451 mRNA Translation: AAH58451.1
AABR03076595 Genomic DNA No translation available.
D10754 mRNA Translation: BAA01586.1 Different initiation.
BN000325 mRNA Translation: CAE48380.1

Protein sequence database of the Protein Information Resource

More...PIRi		JX0228
S09086

NCBI Reference Sequences

More...RefSeqi		NP_001316812.1, NM_001329883.1
NP_476440.2, NM_057099.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000026507; ENSRNOP00000026507; ENSRNOG00000019551

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100360846
29666

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:100360846
rno:29666

UCSC genome browser

More...UCSCi		RGD:61881, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058451 mRNA Translation: AAH58451.1
AABR03076595 Genomic DNA No translation available.
D10754 mRNA Translation: BAA01586.1 Different initiation.
BN000325 mRNA Translation: CAE48380.1
PIRiJX0228
S09086
RefSeqiNP_001316812.1, NM_001329883.1
NP_476440.2, NM_057099.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EPCelectron microscopy12.3011-238[»]
6EPDelectron microscopy15.4011-238[»]
6EPEelectron microscopy12.8011-238[»]
6EPFelectron microscopy11.8011-238[»]
6TU3electron microscopy2.70H/V1-238[»]
SMRiP28073
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi248287, 3 interactors
IntActiP28073, 1 interactor
STRINGi10116.ENSRNOP00000026507

Protein family/group databases

MEROPSiT01.010

PTM databases

PhosphoSitePlusiP28073

2D gel databases

World-2DPAGEi0004:P28073

Proteomic databases

jPOSTiP28073
PaxDbiP28073
PRIDEiP28073

Genome annotation databases

EnsembliENSRNOT00000026507; ENSRNOP00000026507; ENSRNOG00000019551
GeneIDi100360846
29666
KEGGirno:100360846
rno:29666
UCSCiRGD:61881, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5694
RGDi61881, Psmb6

Phylogenomic databases

eggNOGiKOG0174, Eukaryota
GeneTreeiENSGT00940000155114
HOGENOMiCLU_035750_5_1_1
InParanoidiP28073
OMAiDWINAPH
OrthoDBi1172133at2759
PhylomeDBiP28073
TreeFamiTF106221

Enzyme and pathway databases

ReactomeiR-RNO-1169091, Activation of NF-kappaB in B cells
R-RNO-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-RNO-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-RNO-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-RNO-174154, APC/C:Cdc20 mediated degradation of Securin
R-RNO-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-RNO-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-RNO-187577, SCF(Skp2)-mediated degradation of p27/p21
R-RNO-195253, Degradation of beta-catenin by the destruction complex
R-RNO-202424, Downstream TCR signaling
R-RNO-2467813, Separation of Sister Chromatids
R-RNO-2871837, FCERI mediated NF-kB activation
R-RNO-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-RNO-350562, Regulation of ornithine decarboxylase (ODC)
R-RNO-382556, ABC-family proteins mediated transport
R-RNO-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-RNO-4608870, Asymmetric localization of PCP proteins
R-RNO-4641257, Degradation of AXIN
R-RNO-4641258, Degradation of DVL
R-RNO-5358346, Hedgehog ligand biogenesis
R-RNO-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764, CLEC7A (Dectin-1) signaling
R-RNO-5610780, Degradation of GLI1 by the proteasome
R-RNO-5610785, GLI3 is processed to GLI3R by the proteasome
R-RNO-5632684, Hedgehog 'on' state
R-RNO-5658442, Regulation of RAS by GAPs
R-RNO-5668541, TNFR2 non-canonical NF-kB pathway
R-RNO-5676590, NIK-->noncanonical NF-kB signaling
R-RNO-5687128, MAPK6/MAPK4 signaling
R-RNO-5689603, UCH proteinases
R-RNO-5689880, Ub-specific processing proteases
R-RNO-68827, CDT1 association with the CDC6:ORC:origin complex
R-RNO-68949, Orc1 removal from chromatin
R-RNO-69017, CDK-mediated phosphorylation and removal of Cdc6
R-RNO-69481, G2/M Checkpoints
R-RNO-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-RNO-75815, Ubiquitin-dependent degradation of Cyclin D
R-RNO-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-RNO-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-8939902, Regulation of RUNX2 expression and activity
R-RNO-8941858, Regulation of RUNX3 expression and activity
R-RNO-8948751, Regulation of PTEN stability and activity
R-RNO-8951664, Neddylation
R-RNO-9020702, Interleukin-1 signaling
R-RNO-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...PROi		PR:P28073

Gene expression databases

BgeeiENSRNOG00000019551, Expressed in quadriceps femoris and 18 other tissues
GenevisibleiP28073, RN

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR000243, Pept_T1A_subB
IPR035140, Proteasome_beta6
IPR016050, Proteasome_bsu_CS
IPR001353, Proteasome_sua/b
IPR023333, Proteasome_suB-type
PANTHERiPTHR11599:SF46, PTHR11599:SF46, 1 hit
PfamiView protein in Pfam
PF00227, Proteasome, 1 hit
PRINTSiPR00141, PROTEASOME
SUPFAMiSSF56235, SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854, PROTEASOME_BETA_1, 1 hit
PS51476, PROTEASOME_BETA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSB6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28073
Secondary accession number(s): Q6IE68, Q6PDW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 20, 2005
Last modified: December 2, 2020
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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