UniProtKB - P28070 (PSB4_HUMAN)
Proteasome subunit beta type-4
PSMB4
Functioni
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
4 PublicationsCaution
GO - Molecular functioni
- lipopolysaccharide binding Source: Ensembl
- threonine-type endopeptidase activity Source: InterPro
GO - Biological processi
- negative regulation of inflammatory response to antigenic stimulus Source: Ensembl
- proteasomal protein catabolic process Source: GO_Central
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P28070 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8932339, ROS sensing by NFE2L2 R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | P28070 |
SIGNORi | P28070 |
Protein family/group databases
MEROPSi | T01.987 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit beta type-4Alternative name(s): 26 kDa prosomal protein Short name: HsBPROS26 Short name: PROS-26 Macropain beta chain Multicatalytic endopeptidase complex beta chain Proteasome beta chain Proteasome chain 3 Short name: HsN3 |
Gene namesi | Name:PSMB4 Synonyms:PROS26 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9541, PSMB4 |
MIMi | 602177, gene |
neXtProti | NX_P28070 |
VEuPathDBi | HostDB:ENSG00000159377 |
Subcellular locationi
Cytoskeleton
- ciliary basal body Source: GO_Central
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- proteasome complex Source: UniProtKB
- proteasome core complex Source: UniProtKB
- proteasome core complex, beta-subunit complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Involvement in diseasei
Proteasome-associated autoinflammatory syndrome 3 (PRAAS3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075255 | 212 – 214 | Missing in PRAAS3; decreased protein maturation; changed proteasome assembly; poor incorporation into 20S and 26S proteasomes. 1 Publication | 3 | |
Natural variantiVAR_081126 | 222 – 264 | Missing in PRAAS3; digenic inheritance; patient also carries a mutation in PSMB8; no effect on protein abundance; changed proteasome assembly; poor incorporation into 20S and 26S proteasomes. 1 PublicationAdd BLAST | 43 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 5692 |
MalaCardsi | PSMB4 |
MIMi | 617591, phenotype |
OpenTargetsi | ENSG00000159377 |
PharmGKBi | PA33886 |
Miscellaneous databases
Pharosi | P28070, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364701 CHEMBL3831201 |
DrugBanki | DB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE |
Genetic variation databases
BioMutai | PSMB4 |
DMDMi | 116242733 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000026579 | 1 – 45 | 2 PublicationsAdd BLAST | 45 | |
ChainiPRO_0000026580 | 46 – 264 | Proteasome subunit beta type-4Add BLAST | 219 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 102 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P28070 |
jPOSTi | P28070 |
MassIVEi | P28070 |
MaxQBi | P28070 |
PaxDbi | P28070 |
PeptideAtlasi | P28070 |
PRIDEi | P28070 |
ProteomicsDBi | 54446 |
TopDownProteomicsi | P28070 |
2D gel databases
DOSAC-COBS-2DPAGEi | P28070 |
OGPi | P28070 |
REPRODUCTION-2DPAGEi | IPI00555956 |
SWISS-2DPAGEi | P28070 |
PTM databases
GlyGeni | P28070, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P28070 |
MetOSitei | P28070 |
PhosphoSitePlusi | P28070 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000159377, Expressed in testis and 241 other tissues |
ExpressionAtlasi | P28070, baseline and differential |
Genevisiblei | P28070, HS |
Organism-specific databases
HPAi | ENSG00000159377, Low tissue specificity |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
Forms a ternary complex with SMAD1 and OAZ1 before PSMB4 is incorporated into the 20S proteasome.
Interacts with PRPF19 (PubMed:11571290, PubMed:12097147).
9 Publications(Microbial infection) Interacts with HTLV-1 Tax protein.
1 Publication(Microbial infection) Interacts with HIV-1 Nef and Tat proteins.
2 PublicationsBinary interactionsi
P28070
Protein-protein interaction databases
BioGRIDi | 111665, 165 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P28070 |
DIPi | DIP-33844N |
IntActi | P28070, 91 interactors |
MINTi | P28070 |
STRINGi | 9606.ENSP00000290541 |
Chemistry databases
BindingDBi | P28070 |
Miscellaneous databases
RNActi | P28070, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P28070 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0185, Eukaryota |
GeneTreei | ENSGT00390000000698 |
HOGENOMi | CLU_072435_2_0_1 |
InParanoidi | P28070 |
OMAi | TNWGRPR |
OrthoDBi | 1228942at2759 |
PhylomeDBi | P28070 |
TreeFami | TF106220 |
Family and domain databases
CDDi | cd03760, proteasome_beta_type_4, 1 hit |
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR016295, Proteasome_beta4 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF5, PTHR11599:SF5, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PIRSFi | PIRSF001213, Psome_endopept_beta, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MEAFLGSRSG LWAGGPAPGQ FYRIPSTPDS FMDPASALYR GPITRTQNPM
60 70 80 90 100
VTGTSVLGVK FEGGVVIAAD MLGSYGSLAR FRNISRIMRV NNSTMLGASG
110 120 130 140 150
DYADFQYLKQ VLGQMVIDEE LLGDGHSYSP RAIHSWLTRA MYSRRSKMNP
160 170 180 190 200
LWNTMVIGGY ADGESFLGYV DMLGVAYEAP SLATGYGAYL AQPLLREVLE
210 220 230 240 250
KQPVLSQTEA RDLVERCMRV LYYRDARSYN RFQIATVTEK GVEIEGPLST
260
ETNWDIAHMI SGFE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 264 | E → D in CAG33101 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012072 | 95 | M → I. Corresponds to variant dbSNP:rs1804241Ensembl. | 1 | |
Natural variantiVAR_075255 | 212 – 214 | Missing in PRAAS3; decreased protein maturation; changed proteasome assembly; poor incorporation into 20S and 26S proteasomes. 1 Publication | 3 | |
Natural variantiVAR_081126 | 222 – 264 | Missing in PRAAS3; digenic inheritance; patient also carries a mutation in PSMB8; no effect on protein abundance; changed proteasome assembly; poor incorporation into 20S and 26S proteasomes. 1 PublicationAdd BLAST | 43 | |
Natural variantiVAR_013115 | 234 | I → T5 PublicationsCorresponds to variant dbSNP:rs4603Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26600 mRNA Translation: BAA05647.1 AK313825 mRNA Translation: BAG36560.1 CR456820 mRNA Translation: CAG33101.1 BT006917 mRNA Translation: AAP35563.1 AL589764 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53442.1 S71381 mRNA Translation: AAB31085.1 |
CCDSi | CCDS996.1 |
PIRi | S08186 S45719 S50147 |
RefSeqi | NP_002787.2, NM_002796.2 |
Genome annotation databases
Ensembli | ENST00000290541; ENSP00000290541; ENSG00000159377 |
GeneIDi | 5692 |
KEGGi | hsa:5692 |
MANE-Selecti | ENST00000290541.7; ENSP00000290541.6; NM_002796.3; NP_002787.2 |
UCSCi | uc001eyc.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26600 mRNA Translation: BAA05647.1 AK313825 mRNA Translation: BAG36560.1 CR456820 mRNA Translation: CAG33101.1 BT006917 mRNA Translation: AAP35563.1 AL589764 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53442.1 S71381 mRNA Translation: AAB31085.1 |
CCDSi | CCDS996.1 |
PIRi | S08186 S45719 S50147 |
RefSeqi | NP_002787.2, NM_002796.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4R3O | X-ray | 2.60 | 2/N | 46-262 | [»] | |
4R67 | X-ray | 2.89 | 2/N/b/p | 46-262 | [»] | |
5A0Q | electron microscopy | 3.50 | N/b | 46-264 | [»] | |
5GJQ | electron microscopy | 4.50 | g/u | 1-264 | [»] | |
5GJR | electron microscopy | 3.50 | g/u | 1-264 | [»] | |
5L4G | electron microscopy | 4.02 | 4/X | 1-264 | [»] | |
5LE5 | X-ray | 1.80 | M/a | 46-264 | [»] | |
5LEX | X-ray | 2.20 | M/a | 46-264 | [»] | |
5LEY | X-ray | 1.90 | M/a | 46-264 | [»] | |
5LEZ | X-ray | 2.19 | M/a | 46-264 | [»] | |
5LF0 | X-ray | 2.41 | M/a | 46-264 | [»] | |
5LF1 | X-ray | 2.00 | M/a | 46-264 | [»] | |
5LF3 | X-ray | 2.10 | M/a | 46-264 | [»] | |
5LF4 | X-ray | 1.99 | M/a | 46-264 | [»] | |
5LF6 | X-ray | 2.07 | M/a | 46-264 | [»] | |
5LF7 | X-ray | 2.00 | M/a | 46-264 | [»] | |
5LN3 | electron microscopy | 6.80 | 7 | 1-264 | [»] | |
5M32 | electron microscopy | 3.80 | M/a | 1-264 | [»] | |
5T0C | electron microscopy | 3.80 | AT/BT | 2-264 | [»] | |
5T0G | electron microscopy | 4.40 | T | 2-264 | [»] | |
5T0H | electron microscopy | 6.80 | T | 2-264 | [»] | |
5T0I | electron microscopy | 8.00 | T | 2-264 | [»] | |
5T0J | electron microscopy | 8.00 | T | 2-264 | [»] | |
5VFO | electron microscopy | 3.50 | T/t | 46-260 | [»] | |
5VFP | electron microscopy | 4.20 | T/t | 46-260 | [»] | |
5VFQ | electron microscopy | 4.20 | T/t | 46-260 | [»] | |
5VFR | electron microscopy | 4.90 | T/t | 46-260 | [»] | |
5VFS | electron microscopy | 3.60 | T/t | 46-260 | [»] | |
5VFT | electron microscopy | 7.00 | T/t | 46-260 | [»] | |
5VFU | electron microscopy | 5.80 | T/t | 46-260 | [»] | |
6AVO | electron microscopy | 3.80 | W/a | 46-264 | [»] | |
6E5B | X-ray | 2.77 | M/a | 1-264 | [»] | |
6KWY | electron microscopy | 2.72 | M/a | 1-264 | [»] | |
6MSB | electron microscopy | 3.00 | T/t | 2-264 | [»] | |
6MSD | electron microscopy | 3.20 | T/t | 2-264 | [»] | |
6MSE | electron microscopy | 3.30 | B | 108-158 | [»] | |
6MSG | electron microscopy | 3.50 | T/t | 2-264 | [»] | |
6MSH | electron microscopy | 3.60 | T/t | 2-264 | [»] | |
6MSJ | electron microscopy | 3.30 | T/t | 2-264 | [»] | |
6MSK | electron microscopy | 3.20 | T/t | 2-264 | [»] | |
6R70 | electron microscopy | 3.50 | M/a | 46-261 | [»] | |
6REY | electron microscopy | 3.00 | N/b | 46-264 | [»] | |
6RGQ | electron microscopy | 2.60 | N/b | 46-264 | [»] | |
6WJD | electron microscopy | 4.80 | T/t | 2-264 | [»] | |
6WJN | electron microscopy | 5.70 | T/t | 46-260 | [»] | |
6XMJ | electron microscopy | 3.00 | N | 46-262 | [»] | |
7AWE | X-ray | 2.29 | N/b | 46-259 | [»] | |
7LXV | electron microscopy | 3.40 | M/a | 46-264 | [»] | |
7NHT | electron microscopy | 2.80 | M | 1-264 | [»] | |
7PG9 | electron microscopy | 3.70 | N/b | 46-264 | [»] | |
7V5G | electron microscopy | 4.47 | G/N | 46-264 | [»] | |
7V5M | electron microscopy | 3.88 | N/b | 46-264 | [»] | |
SMRi | P28070 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111665, 165 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P28070 |
DIPi | DIP-33844N |
IntActi | P28070, 91 interactors |
MINTi | P28070 |
STRINGi | 9606.ENSP00000290541 |
Chemistry databases
BindingDBi | P28070 |
ChEMBLi | CHEMBL2364701 CHEMBL3831201 |
DrugBanki | DB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE |
Protein family/group databases
MEROPSi | T01.987 |
PTM databases
GlyGeni | P28070, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P28070 |
MetOSitei | P28070 |
PhosphoSitePlusi | P28070 |
Genetic variation databases
BioMutai | PSMB4 |
DMDMi | 116242733 |
2D gel databases
DOSAC-COBS-2DPAGEi | P28070 |
OGPi | P28070 |
REPRODUCTION-2DPAGEi | IPI00555956 |
SWISS-2DPAGEi | P28070 |
Proteomic databases
EPDi | P28070 |
jPOSTi | P28070 |
MassIVEi | P28070 |
MaxQBi | P28070 |
PaxDbi | P28070 |
PeptideAtlasi | P28070 |
PRIDEi | P28070 |
ProteomicsDBi | 54446 |
TopDownProteomicsi | P28070 |
Protocols and materials databases
Antibodypediai | 1673, 445 antibodies from 35 providers |
DNASUi | 5692 |
Genome annotation databases
Ensembli | ENST00000290541; ENSP00000290541; ENSG00000159377 |
GeneIDi | 5692 |
KEGGi | hsa:5692 |
MANE-Selecti | ENST00000290541.7; ENSP00000290541.6; NM_002796.3; NP_002787.2 |
UCSCi | uc001eyc.2, human |
Organism-specific databases
CTDi | 5692 |
DisGeNETi | 5692 |
GeneCardsi | PSMB4 |
HGNCi | HGNC:9541, PSMB4 |
HPAi | ENSG00000159377, Low tissue specificity |
MalaCardsi | PSMB4 |
MIMi | 602177, gene 617591, phenotype |
neXtProti | NX_P28070 |
OpenTargetsi | ENSG00000159377 |
PharmGKBi | PA33886 |
VEuPathDBi | HostDB:ENSG00000159377 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0185, Eukaryota |
GeneTreei | ENSGT00390000000698 |
HOGENOMi | CLU_072435_2_0_1 |
InParanoidi | P28070 |
OMAi | TNWGRPR |
OrthoDBi | 1228942at2759 |
PhylomeDBi | P28070 |
TreeFami | TF106220 |
Enzyme and pathway databases
PathwayCommonsi | P28070 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8932339, ROS sensing by NFE2L2 R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | P28070 |
SIGNORi | P28070 |
Miscellaneous databases
BioGRID-ORCSi | 5692, 802 hits in 1058 CRISPR screens |
ChiTaRSi | PSMB4, human |
GeneWikii | PSMB4 |
GenomeRNAii | 5692 |
Pharosi | P28070, Tbio |
PROi | PR:P28070 |
RNActi | P28070, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159377, Expressed in testis and 241 other tissues |
ExpressionAtlasi | P28070, baseline and differential |
Genevisiblei | P28070, HS |
Family and domain databases
CDDi | cd03760, proteasome_beta_type_4, 1 hit |
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR016295, Proteasome_beta4 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF5, PTHR11599:SF5, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PIRSFi | PIRSF001213, Psome_endopept_beta, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PSB4_HUMAN | |
Accessioni | P28070Primary (citable) accession number: P28070 Secondary accession number(s): B2R9L3 Q969L6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 232 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families