HLA-DMA

Functionⁱ

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.3 Publications

GO - Molecular functionⁱ

MHC class II protein complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22733780

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
immune response Source: InterPro
peptide antigen assembly with MHC class II protein complex
Source: UniProtKB
Inferred from direct assayⁱ
- 22733780
- 7606781

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity

Biological process

Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2132295 MHC class II antigen presentation
SIGNORⁱ	P28067

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HLA class II histocompatibility antigen, DM alpha chain Alternative name(s): MHC class II antigen DMA Really interesting new gene 6 protein
Gene namesⁱ	Name:HLA-DMA Synonyms:DMA, RING6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204257.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4934 HLA-DMA
MIMⁱ	142855 gene
neXtProtⁱ	NX_P28067

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 233	LumenalSequence analysisAdd BLAST	207
Transmembraneⁱ	234 – 254	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	255 – 261	CytoplasmicSequence analysis	7

Keywords - Cellular componentⁱ

Endosome, Lysosome, Membrane, MHC II

Pathology & Biotechⁱ

Organism-specific databases

DisGeNETⁱ

3108

Polymorphism and mutation databases

DMDMⁱ	133158

DMDMⁱ

133158

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000018958	27 – 261	HLA class II histocompatibility antigen, DM alpha chainAdd BLAST		235

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	41	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	50 ↔ 105
Disulfide bondⁱ	147 ↔ 202

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P28067
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28067
PaxDbⁱ	P28067
PeptideAtlas More...PeptideAtlasⁱ	P28067
PRIDEⁱ	P28067
ProteomicsDBⁱ	54442

PTM databases

iPTMnetⁱ	P28067
PhosphoSitePlusⁱ	P28067

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000204257
CleanExⁱ	HS_HLA-DMA
ExpressionAtlasⁱ	P28067 baseline and differential
Genevisibleⁱ	P28067 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012750 HPA017295

HPAⁱ

HPA012750
HPA017295

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha chain (DMA) and a beta chain (DMB).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
HLA-DMB	P28068	17	EBI-3865396,EBI-2877138

With

Entry

#Exp.

IntAct

Notes

HLA-DMB

P28068

17

EBI-3865396,EBI-2877138

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-6184N
IntActⁱ	P28067, 7 interactors
Molecular INTeraction database More...MINTⁱ	P28067
STRINGⁱ	9606.ENSP00000363976

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	41 – 63	Combined sources	23
Beta strandⁱ	66 – 72	Combined sources	7
Turnⁱ	73 – 76	Combined sources	4
Beta strandⁱ	77 – 82	Combined sources	6
Helixⁱ	83 – 85	Combined sources	3
Helixⁱ	87 – 89	Combined sources	3
Helixⁱ	95 – 110	Combined sources	16
Turnⁱ	114 – 116	Combined sources	3
Turnⁱ	117 – 119	Combined sources	3
Beta strandⁱ	122 – 124	Combined sources	3
Beta strandⁱ	128 – 135	Combined sources	8
Beta strandⁱ	143 – 155	Combined sources	13
Beta strandⁱ	157 – 163	Combined sources	7
Beta strandⁱ	166 – 168	Combined sources	3
Beta strandⁱ	175 – 179	Combined sources	5
Turnⁱ	180 – 182	Combined sources	3
Beta strandⁱ	183 – 192	Combined sources	10
Beta strandⁱ	200 – 206	Combined sources	7
Turnⁱ	207 – 210	Combined sources	4
Beta strandⁱ	211 – 217	Combined sources	7

3D structure databases

ProteinModelPortalⁱ	P28067
SMRⁱ	P28067
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P28067

EvolutionaryTraceⁱ

P28067

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	121 – 215	Ig-like C1-typeAdd BLAST		95

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	27 – 124	Alpha-1Add BLAST	98
Regionⁱ	125 – 217	Alpha-2Add BLAST	93
Regionⁱ	218 – 233	Connecting peptideSequence analysisAdd BLAST	16

Sequence similaritiesⁱ

Belongs to the MHC class II family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IR26 Eukaryota ENOG410YJDD LUCA
HOGENOMⁱ	HOG000126882
HOVERGENⁱ	HBG001688
InParanoidⁱ	P28067
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LMN
PhylomeDBⁱ	P28067
TreeFamⁱ	TF333797

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.320.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P28067-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC 
        60         70         80         90        100
QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF 
       110        120        130        140        150
DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS 
       160        170        180        190        200
NLFPPMLTVN WHDHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF 
       210        220        230        240        250
SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL 
       260 
IIYFRKPCSG D

Length:261

Mass (Da):29,194

Last modified:August 1, 1992 - v1

Checksum:ⁱ1986C3C1989F02E9

GO

Polymorphismⁱ

The following alleles of DMA are known: DMA*01:01, DMA*01:02, DMA*01:03 (DMA3.2) and DMA*01:04 (DMA3.4). The sequence shown is that of DMA*01:01.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_016746	162	H → Q in allele DMA01:03 and allele DMA01:04.	1
Natural variantⁱVAR_016747	163	D → H in allele DMA01:03 and allele DMA01:04.	1
Natural variantⁱVAR_016748	166	V → I in allele DMA01:02 and allele DMA01:04. Corresponds to variant dbSNP:rs1063478Ensembl.	1
Natural variantⁱVAR_016749	181	G → A in allele DMA*01:03. Corresponds to variant dbSNP:rs6926628Ensembl.	1
Natural variantⁱVAR_016750	210	R → C in allele DMA*01:04. Corresponds to variant dbSNP:rs17214044Ensembl.	1
Natural variantⁱVAR_016751	210	R → H in allele DMA*01:03. Corresponds to variant dbSNP:rs41555121Ensembl.	1
Natural variantⁱVAR_056544	235	V → M. Corresponds to variant dbSNP:rs9469319Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62744 mRNA Translation: CAA44606.1 AL935042 Genomic DNA No translation available. Z24753 Genomic DNA No translation available. U04878 Genomic DNA Translation: AAA56994.1 U04877 Genomic DNA Translation: AAA56993.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4761.1
PIRⁱ	I38490 S17886
UniGeneⁱ	Hs.728759

Genome annotation databases

Ensemblⁱ	ENST00000374843; ENSP00000363976; ENSG00000204257 ENST00000383230; ENSP00000372717; ENSG00000243215 ENST00000434337; ENSP00000407198; ENSG00000242361 ENST00000441375; ENSP00000410591; ENSG00000239463 ENST00000450601; ENSP00000392842; ENSG00000242685 ENST00000452615; ENSP00000395349; ENSG00000243189 ENST00000453490; ENSP00000404018; ENSG00000243719

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P28067	UPI00062A7857		NOMLE		293
Major histocompatibility complex, class II, DM alpha		PANPA		268
UPI0007DBE132		PANTR		267
Major histocompatibility complex, class II, DM alpha		PAPAN		266
HLA class II histocompatibility antigen, DM alpha chain (Fragment)		MACMU		93
+53

Protein	Similar proteins		Species	Score	Length
P28067	UPI00062A7857		NOMLE		293
Major histocompatibility complex, class II, DM alpha		PANPA		268
UPI0007DBE132		PANTR		267
Major histocompatibility complex, class II, DM alpha		PAPAN		266
HLA class II histocompatibility antigen, DM alpha chain (Fragment)		MACMU		93
+107

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62744 mRNA Translation: CAA44606.1 AL935042 Genomic DNA No translation available. Z24753 Genomic DNA No translation available. U04878 Genomic DNA Translation: AAA56994.1 U04877 Genomic DNA Translation: AAA56993.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4761.1
PIRⁱ	I38490 S17886
UniGeneⁱ	Hs.728759

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HDM	X-ray	2.50	A	27-230	[»]
	2BC4	X-ray	2.27	A/C	27-229	[»]
	4FQX	X-ray	2.60	C	27-225	[»]
	4GBX	X-ray	3.00	C	27-225	[»]
ProteinModelPortalⁱ	P28067
SMRⁱ	P28067
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-6184N
IntActⁱ	P28067, 7 interactors
Molecular INTeraction database More...MINTⁱ	P28067
STRINGⁱ	9606.ENSP00000363976

PTM databases

iPTMnetⁱ	P28067
PhosphoSitePlusⁱ	P28067

Polymorphism and mutation databases

DMDMⁱ	133158

DMDMⁱ

133158

Proteomic databases

EPDⁱ	P28067
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28067
PaxDbⁱ	P28067
PeptideAtlas More...PeptideAtlasⁱ	P28067
PRIDEⁱ	P28067
ProteomicsDBⁱ	54442

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000374843; ENSP00000363976; ENSG00000204257 ENST00000383230; ENSP00000372717; ENSG00000243215 ENST00000434337; ENSP00000407198; ENSG00000242361 ENST00000441375; ENSP00000410591; ENSG00000239463 ENST00000450601; ENSP00000392842; ENSG00000242685 ENST00000452615; ENSP00000395349; ENSG00000243189 ENST00000453490; ENSP00000404018; ENSG00000243719

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3108
EuPathDBⁱ	HostDB:ENSG00000204257.14
GeneCardsⁱ	HLA-DMA
H-InvDBⁱ	HIX0207683
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4934 HLA-DMA
Human Protein Atlas More...HPAⁱ	HPA012750 HPA017295
MIMⁱ	142855 gene
neXtProtⁱ	NX_P28067
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IR26 Eukaryota ENOG410YJDD LUCA
HOGENOMⁱ	HOG000126882
HOVERGENⁱ	HBG001688
InParanoidⁱ	P28067
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LMN
PhylomeDBⁱ	P28067
TreeFamⁱ	TF333797

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2132295 MHC class II antigen presentation
SIGNORⁱ	P28067

Miscellaneous databases

ChiTaRSⁱ	HLA-DMA human
EvolutionaryTraceⁱ	P28067
Protein Ontology More...PROⁱ	PR:P28067
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204257
CleanExⁱ	HS_HLA-DMA
ExpressionAtlasⁱ	P28067 baseline and differential
Genevisibleⁱ	P28067 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.320.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DMA_HUMAN
Accessionⁱ	P28067Primary (citable) accession number: P28067 Secondary accession number(s): Q29639, Q29640
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	August 1, 1992
	Last modified:	July 18, 2018
	This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniRef

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Supporting data

UniProtKB - P28067 (DMA_HUMAN)

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HLA class II histocompatibility antigen, DM alpha chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Endosome

Endosome

Lysosome

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ