UniProtKB - P28067 (DMA_HUMAN)
Protein
HLA class II histocompatibility antigen, DM alpha chain
Gene
HLA-DMA
Organism
Homo sapiens (Human)
Status
Functioni
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.3 Publications
GO - Molecular functioni
- MHC class II protein complex binding Source: UniProtKB
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- peptide antigen assembly with MHC class II protein complex Source: UniProtKB
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
Reactomei | R-HSA-2132295 MHC class II antigen presentation |
SIGNORi | P28067 |
Names & Taxonomyi
Protein namesi | Recommended name: HLA class II histocompatibility antigen, DM alpha chainAlternative name(s): MHC class II antigen DMA Really interesting new gene 6 protein |
Gene namesi | Name:HLA-DMA Synonyms:DMA, RING6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4934 HLA-DMA |
MIMi | 142855 gene |
neXtProti | NX_P28067 |
Subcellular locationi
Endosome
Lysosome
Note: Localizes to late endocytic compartment. Associates with lysosome membranes.
Endosome
- late endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: Reactome
Plasma Membrane
- MHC class II protein complex Source: UniProtKB
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 233 | LumenalSequence analysisAdd BLAST | 207 | |
Transmembranei | 234 – 254 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 261 | CytoplasmicSequence analysis | 7 |
Keywords - Cellular componenti
Endosome, Lysosome, Membrane, MHC IIPathology & Biotechi
Organism-specific databases
DisGeNETi | 3108 |
Miscellaneous databases
Pharosi | P28067 |
Polymorphism and mutation databases
BioMutai | HLA-DMA |
DMDMi | 133158 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000018958 | 27 – 261 | HLA class II histocompatibility antigen, DM alpha chainAdd BLAST | 235 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 50 ↔ 105 | |||
Disulfide bondi | 147 ↔ 202 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P28067 |
jPOSTi | P28067 |
MassIVEi | P28067 |
MaxQBi | P28067 |
PaxDbi | P28067 |
PeptideAtlasi | P28067 |
PRIDEi | P28067 |
ProteomicsDBi | 54442 |
PTM databases
iPTMneti | P28067 |
PhosphoSitePlusi | P28067 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204257 Expressed in 207 organ(s), highest expression level in small intestine Peyer's patch |
ExpressionAtlasi | P28067 baseline and differential |
Genevisiblei | P28067 HS |
Organism-specific databases
HPAi | HPA012750 HPA017295 |
Interactioni
Subunit structurei
Heterodimer of an alpha chain (DMA) and a beta chain (DMB).
2 PublicationsBinary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
P28068 | 21 | EBI-3865396,EBI-2877138 |
Protein-protein interaction databases
DIPi | DIP-6184N |
IntActi | P28067, 10 interactors |
MINTi | P28067 |
STRINGi | 9606.ENSP00000363976 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P28067 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28067 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 215 | Ig-like C1-typeAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 124 | Alpha-1Add BLAST | 98 | |
Regioni | 125 – 217 | Alpha-2Add BLAST | 93 | |
Regioni | 218 – 233 | Connecting peptideSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the MHC class II family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IR26 Eukaryota ENOG410YJDD LUCA |
HOGENOMi | HOG000126882 |
InParanoidi | P28067 |
PhylomeDBi | P28067 |
TreeFami | TF333797 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N |
Pfami | View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All
P28067-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC
60 70 80 90 100
QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF
110 120 130 140 150
DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS
160 170 180 190 200
NLFPPMLTVN WHDHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF
210 220 230 240 250
SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL
260
IIYFRKPCSG D
Computationally mapped potential isoform sequencesi
There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y732 | H0Y732_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
Q5SP00 | Q5SP00_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 227 | Annotation score: | ||
A0A140T9G2 | A0A140T9G2_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 227 | Annotation score: | ||
A0A140T9H8 | A0A140T9H8_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 261 | Annotation score: | ||
A2AAT8 | A2AAT8_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 166 | Annotation score: | ||
A0A140T9K8 | A0A140T9K8_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
A0A140T9N9 | A0A140T9N9_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
A0A140T9T3 | A0A140T9T3_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
A0A140T9V7 | A0A140T9V7_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
A0A140T9X4 | A0A140T9X4_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
There are more potential isoformsShow all |
Polymorphismi
The following alleles of DMA are known: DMA*01:01, DMA*01:02, DMA*01:03 (DMA3.2) and DMA*01:04 (DMA3.4). The sequence shown is that of DMA*01:01.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016746 | 162 | H → Q in allele DMA*01:03 and allele DMA*01:04. | 1 | |
Natural variantiVAR_016747 | 163 | D → H in allele DMA*01:03 and allele DMA*01:04. | 1 | |
Natural variantiVAR_016748 | 166 | V → I in allele DMA*01:02 and allele DMA*01:04. Corresponds to variant dbSNP:rs1063478Ensembl. | 1 | |
Natural variantiVAR_016749 | 181 | G → A in allele DMA*01:03. Corresponds to variant dbSNP:rs6926628Ensembl. | 1 | |
Natural variantiVAR_016750 | 210 | R → C in allele DMA*01:04. Corresponds to variant dbSNP:rs17214044Ensembl. | 1 | |
Natural variantiVAR_016751 | 210 | R → H in allele DMA*01:03. Corresponds to variant dbSNP:rs41555121Ensembl. | 1 | |
Natural variantiVAR_056544 | 235 | V → M. Corresponds to variant dbSNP:rs9469319Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62744 mRNA Translation: CAA44606.1 AL935042 Genomic DNA No translation available. Z24753 Genomic DNA No translation available. U04878 Genomic DNA Translation: AAA56994.1 U04877 Genomic DNA Translation: AAA56993.1 |
CCDSi | CCDS4761.1 |
PIRi | I38490 S17886 |
Genome annotation databases
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62744 mRNA Translation: CAA44606.1 AL935042 Genomic DNA No translation available. Z24753 Genomic DNA No translation available. U04878 Genomic DNA Translation: AAA56994.1 U04877 Genomic DNA Translation: AAA56993.1 |
CCDSi | CCDS4761.1 |
PIRi | I38490 S17886 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HDM | X-ray | 2.50 | A | 27-230 | [»] | |
2BC4 | X-ray | 2.27 | A/C | 27-229 | [»] | |
4FQX | X-ray | 2.60 | C | 27-225 | [»] | |
4GBX | X-ray | 3.00 | C | 27-225 | [»] | |
SMRi | P28067 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-6184N |
IntActi | P28067, 10 interactors |
MINTi | P28067 |
STRINGi | 9606.ENSP00000363976 |
PTM databases
iPTMneti | P28067 |
PhosphoSitePlusi | P28067 |
Polymorphism and mutation databases
BioMutai | HLA-DMA |
DMDMi | 133158 |
Proteomic databases
EPDi | P28067 |
jPOSTi | P28067 |
MassIVEi | P28067 |
MaxQBi | P28067 |
PaxDbi | P28067 |
PeptideAtlasi | P28067 |
PRIDEi | P28067 |
ProteomicsDBi | 54442 |
Genome annotation databases
Organism-specific databases
DisGeNETi | 3108 |
GeneCardsi | HLA-DMA |
HGNCi | HGNC:4934 HLA-DMA |
HPAi | HPA012750 HPA017295 |
MIMi | 142855 gene |
neXtProti | NX_P28067 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IR26 Eukaryota ENOG410YJDD LUCA |
HOGENOMi | HOG000126882 |
InParanoidi | P28067 |
PhylomeDBi | P28067 |
TreeFami | TF333797 |
Enzyme and pathway databases
Reactomei | R-HSA-2132295 MHC class II antigen presentation |
SIGNORi | P28067 |
Miscellaneous databases
ChiTaRSi | HLA-DMA human |
EvolutionaryTracei | P28067 |
Pharosi | P28067 |
PROi | PR:P28067 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204257 Expressed in 207 organ(s), highest expression level in small intestine Peyer's patch |
ExpressionAtlasi | P28067 baseline and differential |
Genevisiblei | P28067 HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N |
Pfami | View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DMA_HUMAN | |
Accessioni | P28067Primary (citable) accession number: P28067 Secondary accession number(s): Q29639, Q29640 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | September 18, 2019 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references