Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HLA class II histocompatibility antigen, DM alpha chain

Gene

HLA-DMA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.3 Publications

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
SIGNORiP28067

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DM alpha chain
Alternative name(s):
MHC class II antigen DMA
Really interesting new gene 6 protein
Gene namesi
Name:HLA-DMA
Synonyms:DMA, RING6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204257.14
HGNCiHGNC:4934 HLA-DMA
MIMi142855 gene
neXtProtiNX_P28067

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 233LumenalSequence analysisAdd BLAST207
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 261CytoplasmicSequence analysis7

Keywords - Cellular componenti

Endosome, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

DisGeNETi3108

Polymorphism and mutation databases

DMDMi133158

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001895827 – 261HLA class II histocompatibility antigen, DM alpha chainAdd BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi50 ↔ 105
Disulfide bondi147 ↔ 202

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP28067
MaxQBiP28067
PaxDbiP28067
PeptideAtlasiP28067
PRIDEiP28067
ProteomicsDBi54442

PTM databases

iPTMnetiP28067
PhosphoSitePlusiP28067

Expressioni

Gene expression databases

BgeeiENSG00000204257 Expressed in 207 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_HLA-DMA
ExpressionAtlasiP28067 baseline and differential
GenevisibleiP28067 HS

Organism-specific databases

HPAiHPA012750
HPA017295

Interactioni

Subunit structurei

Heterodimer of an alpha chain (DMA) and a beta chain (DMB).2 Publications

Protein-protein interaction databases

DIPiDIP-6184N
IntActiP28067, 7 interactors
MINTiP28067
STRINGi9606.ENSP00000363976

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP28067
SMRiP28067
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28067

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 215Ig-like C1-typeAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 124Alpha-1Add BLAST98
Regioni125 – 217Alpha-2Add BLAST93
Regioni218 – 233Connecting peptideSequence analysisAdd BLAST16

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR26 Eukaryota
ENOG410YJDD LUCA
HOGENOMiHOG000126882
HOVERGENiHBG001688
InParanoidiP28067
OrthoDBiEOG091G0LMN
PhylomeDBiP28067
TreeFamiTF333797

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All

P28067-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC
60 70 80 90 100
QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF
110 120 130 140 150
DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS
160 170 180 190 200
NLFPPMLTVN WHDHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF
210 220 230 240 250
SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL
260
IIYFRKPCSG D
Length:261
Mass (Da):29,194
Last modified:August 1, 1992 - v1
Checksum:i1986C3C1989F02E9
GO

Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y732H0Y732_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
290Annotation score:
Q5SP00Q5SP00_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
227Annotation score:
A0A140T9G2A0A140T9G2_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
227Annotation score:
A0A140T9H8A0A140T9H8_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
261Annotation score:
A2AAT8A2AAT8_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
166Annotation score:
A0A140T9K8A0A140T9K8_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
290Annotation score:
A0A140T9T3A0A140T9T3_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
290Annotation score:
A0A140T9X4A0A140T9X4_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
290Annotation score:
A0A140T9N9A0A140T9N9_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
290Annotation score:
A0A140T9V7A0A140T9V7_HUMAN
HLA class II histocompatibility ant...
HLA-DMA
290Annotation score:
There are more potential isoformsShow all

Polymorphismi

The following alleles of DMA are known: DMA*01:01, DMA*01:02, DMA*01:03 (DMA3.2) and DMA*01:04 (DMA3.4). The sequence shown is that of DMA*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016746162H → Q in allele DMA*01:03 and allele DMA*01:04. 1
Natural variantiVAR_016747163D → H in allele DMA*01:03 and allele DMA*01:04. 1
Natural variantiVAR_016748166V → I in allele DMA*01:02 and allele DMA*01:04. Corresponds to variant dbSNP:rs1063478Ensembl.1
Natural variantiVAR_016749181G → A in allele DMA*01:03. Corresponds to variant dbSNP:rs6926628Ensembl.1
Natural variantiVAR_016750210R → C in allele DMA*01:04. Corresponds to variant dbSNP:rs17214044Ensembl.1
Natural variantiVAR_016751210R → H in allele DMA*01:03. Corresponds to variant dbSNP:rs41555121Ensembl.1
Natural variantiVAR_056544235V → M. Corresponds to variant dbSNP:rs9469319Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62744 mRNA Translation: CAA44606.1
AL935042 Genomic DNA No translation available.
Z24753 Genomic DNA No translation available.
U04878 Genomic DNA Translation: AAA56994.1
U04877 Genomic DNA Translation: AAA56993.1
CCDSiCCDS4761.1
PIRiI38490
S17886
UniGeneiHs.728759

Genome annotation databases

EnsembliENST00000374843; ENSP00000363976; ENSG00000204257
ENST00000383230; ENSP00000372717; ENSG00000243215
ENST00000434337; ENSP00000407198; ENSG00000242361
ENST00000441375; ENSP00000410591; ENSG00000239463
ENST00000450601; ENSP00000392842; ENSG00000242685
ENST00000452615; ENSP00000395349; ENSG00000243189
ENST00000453490; ENSP00000404018; ENSG00000243719

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62744 mRNA Translation: CAA44606.1
AL935042 Genomic DNA No translation available.
Z24753 Genomic DNA No translation available.
U04878 Genomic DNA Translation: AAA56994.1
U04877 Genomic DNA Translation: AAA56993.1
CCDSiCCDS4761.1
PIRiI38490
S17886
UniGeneiHs.728759

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HDMX-ray2.50A27-230[»]
2BC4X-ray2.27A/C27-229[»]
4FQXX-ray2.60C27-225[»]
4GBXX-ray3.00C27-225[»]
ProteinModelPortaliP28067
SMRiP28067
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6184N
IntActiP28067, 7 interactors
MINTiP28067
STRINGi9606.ENSP00000363976

PTM databases

iPTMnetiP28067
PhosphoSitePlusiP28067

Polymorphism and mutation databases

DMDMi133158

Proteomic databases

EPDiP28067
MaxQBiP28067
PaxDbiP28067
PeptideAtlasiP28067
PRIDEiP28067
ProteomicsDBi54442

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374843; ENSP00000363976; ENSG00000204257
ENST00000383230; ENSP00000372717; ENSG00000243215
ENST00000434337; ENSP00000407198; ENSG00000242361
ENST00000441375; ENSP00000410591; ENSG00000239463
ENST00000450601; ENSP00000392842; ENSG00000242685
ENST00000452615; ENSP00000395349; ENSG00000243189
ENST00000453490; ENSP00000404018; ENSG00000243719

Organism-specific databases

DisGeNETi3108
EuPathDBiHostDB:ENSG00000204257.14
GeneCardsiHLA-DMA
H-InvDBiHIX0207683
HGNCiHGNC:4934 HLA-DMA
HPAiHPA012750
HPA017295
MIMi142855 gene
neXtProtiNX_P28067
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR26 Eukaryota
ENOG410YJDD LUCA
HOGENOMiHOG000126882
HOVERGENiHBG001688
InParanoidiP28067
OrthoDBiEOG091G0LMN
PhylomeDBiP28067
TreeFamiTF333797

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
SIGNORiP28067

Miscellaneous databases

ChiTaRSiHLA-DMA human
EvolutionaryTraceiP28067
PROiPR:P28067
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204257 Expressed in 207 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_HLA-DMA
ExpressionAtlasiP28067 baseline and differential
GenevisibleiP28067 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDMA_HUMAN
AccessioniPrimary (citable) accession number: P28067
Secondary accession number(s): Q29639, Q29640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 12, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again