UniProtKB - P28066 (PSA5_HUMAN)
Proteasome subunit alpha type-5
PSMA5
Functioni
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- neutrophil degranulation Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- post-translational protein modification Source: Reactome
- pre-replicative complex assembly Source: Reactome
- proteasomal ubiquitin-independent protein catabolic process Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | P28066 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P28066 |
Protein family/group databases
MEROPSi | T01.975 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit alpha type-5Alternative name(s): Macropain zeta chain Multicatalytic endopeptidase complex zeta chain Proteasome zeta chain |
Gene namesi | Name:PSMA5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9534, PSMA5 |
MIMi | 176844, gene |
neXtProti | NX_P28066 |
VEuPathDBi | HostDB:ENSG00000143106.12 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- ficolin-1-rich granule lumen Source: Reactome
- proteasome complex Source: UniProtKB
- proteasome core complex Source: UniProtKB
- proteasome core complex, alpha-subunit complex Source: UniProtKB
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Organism-specific databases
DisGeNETi | 5686 |
OpenTargetsi | ENSG00000143106 |
PharmGKBi | PA33879 |
Miscellaneous databases
Pharosi | P28066, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364701 CHEMBL3831201 |
DrugBanki | DB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE |
Genetic variation databases
BioMutai | PSMA5 |
DMDMi | 38258905 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124117 | 1 – 241 | Proteasome subunit alpha type-5Add BLAST | 241 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 55 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Modified residuei | 63 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 198 | O-linked (GlcNAc) serineBy similarity | 1 |
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P28066 |
jPOSTi | P28066 |
MassIVEi | P28066 |
MaxQBi | P28066 |
PaxDbi | P28066 |
PeptideAtlasi | P28066 |
PRIDEi | P28066 |
ProteomicsDBi | 54441 [P28066-1] 5854 |
TopDownProteomicsi | P28066-1 [P28066-1] |
2D gel databases
DOSAC-COBS-2DPAGEi | P28066 |
REPRODUCTION-2DPAGEi | IPI00291922 |
SWISS-2DPAGEi | P28066 |
PTM databases
GlyGeni | P28066, 1 site |
iPTMneti | P28066 |
MetOSitei | P28066 |
PhosphoSitePlusi | P28066 |
SwissPalmi | P28066 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000143106, Expressed in oocyte and 236 other tissues |
ExpressionAtlasi | P28066, baseline and differential |
Genevisiblei | P28066, HS |
Organism-specific databases
HPAi | ENSG00000143106, Low tissue specificity |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly.
6 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 111659, 189 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P28066 |
DIPi | DIP-29368N |
IntActi | P28066, 54 interactors |
MINTi | P28066 |
STRINGi | 9606.ENSP00000271308 |
Chemistry databases
BindingDBi | P28066 |
Miscellaneous databases
RNActi | P28066, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P28066 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0176, Eukaryota |
GeneTreei | ENSGT00550000074958 |
HOGENOMi | CLU_035750_4_2_1 |
InParanoidi | P28066 |
OMAi | FQVEYAR |
PhylomeDBi | P28066 |
TreeFami | TF106211 |
Family and domain databases
CDDi | cd03753, proteasome_alpha_type_5, 1 hit |
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR023332, Proteasome_alpha-type IPR033812, Proteasome_alpha_type_5 IPR000426, Proteasome_asu_N IPR001353, Proteasome_sua/b |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit PF10584, Proteasome_A_N, 1 hit |
SMARTi | View protein in SMART SM00948, Proteasome_A_N, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00388, PROTEASOME_ALPHA_1, 1 hit PS51475, PROTEASOME_ALPHA_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGI QTSEGVCLAV
60 70 80 90 100
EKRITSPLME PSSIEKIVEI DAHIGCAMSG LIADAKTLID KARVETQNHW
110 120 130 140 150
FTYNETMTVE SVTQAVSNLA LQFGEEDADP GAMSRPFGVA LLFGGVDEKG
160 170 180 190 200
PQLFHMDPSG TFVQCDARAI GSASEGAQSS LQEVYHKSMT LKEAIKSSLI
210 220 230 240
ILKQVMEEKL NATNIELATV QPGQNFHMFT KEELEEVIKD I
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | A → D in CAA43962 (PubMed:1888762).Curated | 1 | |
Sequence conflicti | 184 | V → L in CAA43962 (PubMed:1888762).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046241 | 1 – 58 | Missing in isoform 2. 1 PublicationAdd BLAST | 58 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61970 mRNA Translation: CAA43962.1 CR456847 mRNA Translation: CAG33128.1 AK304448 mRNA Translation: BAG65266.1 AK313351 mRNA Translation: BAG36153.1 AL356735 Genomic DNA No translation available. AL390252 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56381.1 CH471122 Genomic DNA Translation: EAW56383.1 BC102018 mRNA Translation: AAI02019.1 BC102019 mRNA Translation: AAI02020.1 BC102020 mRNA Translation: AAI02021.1 BC103751 mRNA Translation: AAI03752.1 |
CCDSi | CCDS55619.1 [P28066-2] CCDS799.1 [P28066-1] |
PIRi | S17521 |
RefSeqi | NP_001186701.1, NM_001199772.1 [P28066-2] NP_001186702.1, NM_001199773.1 [P28066-2] NP_001186703.1, NM_001199774.1 [P28066-2] NP_002781.2, NM_002790.3 [P28066-1] |
Genome annotation databases
Ensembli | ENST00000271308; ENSP00000271308; ENSG00000143106 [P28066-1] ENST00000538610; ENSP00000440618; ENSG00000143106 [P28066-2] |
GeneIDi | 5686 |
KEGGi | hsa:5686 |
UCSCi | uc001dxn.4, human [P28066-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61970 mRNA Translation: CAA43962.1 CR456847 mRNA Translation: CAG33128.1 AK304448 mRNA Translation: BAG65266.1 AK313351 mRNA Translation: BAG36153.1 AL356735 Genomic DNA No translation available. AL390252 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56381.1 CH471122 Genomic DNA Translation: EAW56383.1 BC102018 mRNA Translation: AAI02019.1 BC102019 mRNA Translation: AAI02020.1 BC102020 mRNA Translation: AAI02021.1 BC103751 mRNA Translation: AAI03752.1 |
CCDSi | CCDS55619.1 [P28066-2] CCDS799.1 [P28066-1] |
PIRi | S17521 |
RefSeqi | NP_001186701.1, NM_001199772.1 [P28066-2] NP_001186702.1, NM_001199773.1 [P28066-2] NP_001186703.1, NM_001199774.1 [P28066-2] NP_002781.2, NM_002790.3 [P28066-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4R3O | X-ray | 2.60 | E/S | 8-241 | [»] | |
4R67 | X-ray | 2.89 | E/S/g/u | 8-241 | [»] | |
5A0Q | electron microscopy | 3.50 | E/S | 1-241 | [»] | |
5GJQ | electron microscopy | 4.50 | F/l | 1-241 | [»] | |
5GJR | electron microscopy | 3.50 | F/l | 1-241 | [»] | |
5L4G | electron microscopy | 4.02 | E/R | 1-241 | [»] | |
5LE5 | X-ray | 1.80 | D/R | 1-241 | [»] | |
5LEX | X-ray | 2.20 | D/R | 1-241 | [»] | |
5LEY | X-ray | 1.90 | D/R | 1-241 | [»] | |
5LEZ | X-ray | 2.19 | D/R | 1-241 | [»] | |
5LF0 | X-ray | 2.41 | D/R | 1-241 | [»] | |
5LF1 | X-ray | 2.00 | D/R | 1-241 | [»] | |
5LF3 | X-ray | 2.10 | D/R | 1-241 | [»] | |
5LF4 | X-ray | 1.99 | D/R | 1-241 | [»] | |
5LF6 | X-ray | 2.07 | D/R | 1-241 | [»] | |
5LF7 | X-ray | 2.00 | D/R | 1-241 | [»] | |
5LN3 | electron microscopy | 6.80 | E | 1-241 | [»] | |
5M32 | electron microscopy | 3.80 | D/R | 1-241 | [»] | |
5T0C | electron microscopy | 3.80 | AK/BK | 2-241 | [»] | |
5T0G | electron microscopy | 4.40 | K | 2-241 | [»] | |
5T0H | electron microscopy | 6.80 | K | 2-241 | [»] | |
5T0I | electron microscopy | 8.00 | K | 2-241 | [»] | |
5T0J | electron microscopy | 8.00 | K | 2-241 | [»] | |
5VFO | electron microscopy | 3.50 | K/k | 8-241 | [»] | |
5VFP | electron microscopy | 4.20 | K/k | 8-241 | [»] | |
5VFQ | electron microscopy | 4.20 | K/k | 8-241 | [»] | |
5VFR | electron microscopy | 4.90 | K/k | 8-241 | [»] | |
5VFS | electron microscopy | 3.60 | K/k | 8-241 | [»] | |
5VFT | electron microscopy | 7.00 | K/k | 8-241 | [»] | |
5VFU | electron microscopy | 5.80 | K/k | 8-241 | [»] | |
6AVO | electron microscopy | 3.80 | H/M | 1-241 | [»] | |
6E5B | X-ray | 2.77 | D/R | 1-241 | [»] | |
6KWY | electron microscopy | 2.72 | D/R | 1-241 | [»] | |
6MSB | electron microscopy | 3.00 | K/k | 2-241 | [»] | |
6MSD | electron microscopy | 3.20 | K/k | 2-241 | [»] | |
6MSE | electron microscopy | 3.30 | Y | 170-218 | [»] | |
6MSG | electron microscopy | 3.50 | K/k | 2-241 | [»] | |
6MSH | electron microscopy | 3.60 | K/k | 2-241 | [»] | |
6MSJ | electron microscopy | 3.30 | K/k | 2-241 | [»] | |
6MSK | electron microscopy | 3.20 | K/k | 2-241 | [»] | |
6R70 | electron microscopy | 3.50 | D/R | 9-241 | [»] | |
6REY | electron microscopy | 3.00 | E/S | 1-241 | [»] | |
6RGQ | electron microscopy | 2.60 | E/S | 1-241 | [»] | |
6WJD | electron microscopy | 4.80 | K/k | 2-241 | [»] | |
6WJN | electron microscopy | 5.70 | K/k | 8-241 | [»] | |
6XMJ | electron microscopy | 3.00 | E | 8-241 | [»] | |
SMRi | P28066 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111659, 189 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P28066 |
DIPi | DIP-29368N |
IntActi | P28066, 54 interactors |
MINTi | P28066 |
STRINGi | 9606.ENSP00000271308 |
Chemistry databases
BindingDBi | P28066 |
ChEMBLi | CHEMBL2364701 CHEMBL3831201 |
DrugBanki | DB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE |
Protein family/group databases
MEROPSi | T01.975 |
PTM databases
GlyGeni | P28066, 1 site |
iPTMneti | P28066 |
MetOSitei | P28066 |
PhosphoSitePlusi | P28066 |
SwissPalmi | P28066 |
Genetic variation databases
BioMutai | PSMA5 |
DMDMi | 38258905 |
2D gel databases
DOSAC-COBS-2DPAGEi | P28066 |
REPRODUCTION-2DPAGEi | IPI00291922 |
SWISS-2DPAGEi | P28066 |
Proteomic databases
EPDi | P28066 |
jPOSTi | P28066 |
MassIVEi | P28066 |
MaxQBi | P28066 |
PaxDbi | P28066 |
PeptideAtlasi | P28066 |
PRIDEi | P28066 |
ProteomicsDBi | 54441 [P28066-1] 5854 |
TopDownProteomicsi | P28066-1 [P28066-1] |
Protocols and materials databases
Antibodypediai | 20062, 451 antibodies |
DNASUi | 5686 |
Genome annotation databases
Ensembli | ENST00000271308; ENSP00000271308; ENSG00000143106 [P28066-1] ENST00000538610; ENSP00000440618; ENSG00000143106 [P28066-2] |
GeneIDi | 5686 |
KEGGi | hsa:5686 |
UCSCi | uc001dxn.4, human [P28066-1] |
Organism-specific databases
CTDi | 5686 |
DisGeNETi | 5686 |
GeneCardsi | PSMA5 |
HGNCi | HGNC:9534, PSMA5 |
HPAi | ENSG00000143106, Low tissue specificity |
MIMi | 176844, gene |
neXtProti | NX_P28066 |
OpenTargetsi | ENSG00000143106 |
PharmGKBi | PA33879 |
VEuPathDBi | HostDB:ENSG00000143106.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0176, Eukaryota |
GeneTreei | ENSGT00550000074958 |
HOGENOMi | CLU_035750_4_2_1 |
InParanoidi | P28066 |
OMAi | FQVEYAR |
PhylomeDBi | P28066 |
TreeFami | TF106211 |
Enzyme and pathway databases
PathwayCommonsi | P28066 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P28066 |
Miscellaneous databases
BioGRID-ORCSi | 5686, 784 hits in 1002 CRISPR screens |
ChiTaRSi | PSMA5, human |
GeneWikii | PSMA5 |
GenomeRNAii | 5686 |
Pharosi | P28066, Tbio |
PROi | PR:P28066 |
RNActi | P28066, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143106, Expressed in oocyte and 236 other tissues |
ExpressionAtlasi | P28066, baseline and differential |
Genevisiblei | P28066, HS |
Family and domain databases
CDDi | cd03753, proteasome_alpha_type_5, 1 hit |
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR023332, Proteasome_alpha-type IPR033812, Proteasome_alpha_type_5 IPR000426, Proteasome_asu_N IPR001353, Proteasome_sua/b |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit PF10584, Proteasome_A_N, 1 hit |
SMARTi | View protein in SMART SM00948, Proteasome_A_N, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00388, PROTEASOME_ALPHA_1, 1 hit PS51475, PROTEASOME_ALPHA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSA5_HUMAN | |
Accessioni | P28066Primary (citable) accession number: P28066 Secondary accession number(s): B2R8F6 Q6IBF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | October 31, 2003 | |
Last modified: | April 7, 2021 | |
This is version 228 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families