UniProtKB - P28065 (PSB9_HUMAN)
Proteasome subunit beta type-9
PSMB9
Functioni
Miscellaneous
Catalytic activityi
- Cleavage of peptide bonds with very broad specificity. EC:3.4.25.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 21 | Nucleophile | 1 |
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
- threonine-type endopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- post-translational protein modification Source: Reactome
- proteasomal protein catabolic process Source: GO_Central
- proteasomal ubiquitin-independent protein catabolic process Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of cysteine-type endopeptidase activity Source: UniProtKB
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- viral process Source: UniProtKB-KW
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Molecular function | Hydrolase, Protease, Threonine protease |
Biological process | Host-virus interaction, Immunity |
Enzyme and pathway databases
Reactomei | R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974 ER-Phagosome pathway R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534 Vpu mediated degradation of CD4 R-HSA-180585 Vif-mediated degradation of APOBEC3G R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253 Degradation of beta-catenin by the destruction complex R-HSA-202424 Downstream TCR signaling R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813 Separation of Sister Chromatids R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562 Regulation of ornithine decarboxylase (ODC) R-HSA-382556 ABC-family proteins mediated transport R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870 Asymmetric localization of PCP proteins R-HSA-4641257 Degradation of AXIN R-HSA-4641258 Degradation of DVL R-HSA-5358346 Hedgehog ligand biogenesis R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-5610780 Degradation of GLI1 by the proteasome R-HSA-5610783 Degradation of GLI2 by the proteasome R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome R-HSA-5632684 Hedgehog 'on' state R-HSA-5658442 Regulation of RAS by GAPs R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5676590 NIK-->noncanonical NF-kB signaling R-HSA-5678895 Defective CFTR causes cystic fibrosis R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689603 UCH proteinases R-HSA-5689880 Ub-specific processing proteases R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex R-HSA-68949 Orc1 removal from chromatin R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481 G2/M Checkpoints R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902 Regulation of RUNX2 expression and activity R-HSA-8941858 Regulation of RUNX3 expression and activity R-HSA-8948751 Regulation of PTEN stability and activity R-HSA-8951664 Neddylation R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-9020702 Interleukin-1 signaling R-HSA-9604323 Negative regulation of NOTCH4 signaling R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P28065 |
Protein family/group databases
MEROPSi | T01.013 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit beta type-9 (EC:3.4.25.1)Alternative name(s): Low molecular mass protein 2 Macropain chain 7 Multicatalytic endopeptidase complex chain 7 Proteasome chain 7 Proteasome subunit beta-1i Really interesting new gene 12 protein |
Gene namesi | Name:PSMB9 Synonyms:LMP2, PSMB6i, RING12 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9546 PSMB9 |
MIMi | 177045 gene |
neXtProti | NX_P28065 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- proteasome complex Source: ProtInc
- proteasome core complex Source: UniProtKB
- proteasome core complex, beta-subunit complex Source: UniProtKB
- spermatoproteasome complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Involvement in diseasei
Proteasome-associated autoinflammatory syndrome 3 (PRAAS3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075258 | 165 | G → D in PRAAS3; digenic inheritance; patient also carries a mutation in PSMB4; patients' cells show reduction of proteasome content and cysteine-type endopeptidase activity of the proteasome. 1 PublicationCorresponds to variant dbSNP:rs369359789EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 20 | G → A: Impairs correct processing at the consensus site. 1 Publication | 1 | |
Mutagenesisi | 21 | T → A: Impairs correct processing at the consensus site. 1 Publication | 1 | |
Mutagenesisi | 53 | K → A: Impairs correct processing at the consensus site. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5698 |
MalaCardsi | PSMB9 |
MIMi | 617591 phenotype |
NIAGADSi | ENSG00000240065 |
OpenTargetsi | ENSG00000240065 |
PharmGKBi | PA33891 |
Miscellaneous databases
Pharosi | P28065 |
Chemistry databases
ChEMBLi | CHEMBL1944495 |
DrugBanki | DB08889 Carfilzomib |
GuidetoPHARMACOLOGYi | 2409 |
Polymorphism and mutation databases
BioMutai | PSMB9 |
DMDMi | 417529 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000026619 | 1 – 20 | Removed in mature formAdd BLAST | 20 | |
ChainiPRO_0000026620 | 21 – 219 | Proteasome subunit beta type-9Add BLAST | 199 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 109 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 20 – 21 | Cleavage; by autolysisBy similarity | 2 |
Keywords - PTMi
Acetylation, ZymogenProteomic databases
EPDi | P28065 |
jPOSTi | P28065 |
MassIVEi | P28065 |
PaxDbi | P28065 |
PeptideAtlasi | P28065 |
PRIDEi | P28065 |
ProteomicsDBi | 54439 [P28065-1] 54440 [P28065-2] |
2D gel databases
OGPi | P28065 |
PTM databases
iPTMneti | P28065 |
PhosphoSitePlusi | P28065 |
Expressioni
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000240065 Expressed in 183 organ(s), highest expression level in leukocyte |
ExpressionAtlasi | P28065 baseline and differential |
Genevisiblei | P28065 HS |
Organism-specific databases
HPAi | CAB015180 HPA042818 HPA053280 |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB6.
Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
1 Publication(Microbial infection) Interacts with HIV-1 TAT protein.
1 PublicationBinary interactionsi
Protein-protein interaction databases
BioGridi | 111671, 73 interactors |
IntActi | P28065, 66 interactors |
MINTi | P28065 |
STRINGi | 9606.ENSP00000363993 |
Chemistry databases
BindingDBi | P28065 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0174 Eukaryota ENOG410XS23 LUCA |
GeneTreei | ENSGT00940000159897 |
HOGENOMi | HOG000091079 |
InParanoidi | P28065 |
KOi | K02741 |
OMAi | GWDHREG |
OrthoDBi | 1172133at2759 |
PhylomeDBi | P28065 |
TreeFami | TF106221 |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055 Ntn_hydrolases_N IPR000243 Pept_T1A_subB IPR034383 Proteasome_beta9 IPR016050 Proteasome_bsu_CS IPR001353 Proteasome_sua/b IPR023333 Proteasome_suB-type |
PANTHERi | PTHR11599:SF50 PTHR11599:SF50, 1 hit |
Pfami | View protein in Pfam PF00227 Proteasome, 1 hit |
PRINTSi | PR00141 PROTEASOME |
SUPFAMi | SSF56235 SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854 PROTEASOME_BETA_1, 1 hit PS51476 PROTEASOME_BETA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRAGAPTGD LPRAGEVHTG TTIMAVEFDG GVVMGSDSRV SAGEAVVNRV
60 70 80 90 100
FDKLSPLHER IYCALSGSAA DAQAVADMAA YQLELHGIEL EEPPLVLAAA
110 120 130 140 150
NVVRNISYKY REDLSAHLMV AGWDQREGGQ VYGTLGGMLT RQPFAIGGSG
160 170 180 190 200
STFIYGYVDA AYKPGMSPEE CRRFTTDAIA LAMSRDGSSG GVIYLVTITA
210
AGVDHRVILG NELPKFYDE
The sequence of this isoform differs from the canonical sequence as follows:
4-13: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2ACR1 | A2ACR1_HUMAN | Proteasome subunit beta | PSMB9 hCG_17510 | 196 | Annotation score: | ||
A0A0G2JJA7 | A0A0G2JJA7_HUMAN | Proteasome subunit beta | PSMB9 | 196 | Annotation score: | ||
A2ACR0 | A2ACR0_HUMAN | Proteasome subunit beta type-9 | PSMB9 | 131 | Annotation score: | ||
A0A0G2JJQ0 | A0A0G2JJQ0_HUMAN | Proteasome subunit beta type-9 | PSMB9 | 131 | Annotation score: | ||
A0A0G2JHI2 | A0A0G2JHI2_HUMAN | Proteasome subunit beta type-9 | PSMB9 | 178 | Annotation score: | ||
A0A0G2JJ13 | A0A0G2JJ13_HUMAN | Proteasome subunit beta type-9 | PSMB9 | 178 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051551 | 9 | G → E. Corresponds to variant dbSNP:rs35100697Ensembl. | 1 | |
Natural variantiVAR_051552 | 32 | V → I. Corresponds to variant dbSNP:rs241419Ensembl. | 1 | |
Natural variantiVAR_013578 | 60 | R → H2 PublicationsCorresponds to variant dbSNP:rs17587Ensembl. | 1 | |
Natural variantiVAR_075258 | 165 | G → D in PRAAS3; digenic inheritance; patient also carries a mutation in PSMB4; patients' cells show reduction of proteasome content and cysteine-type endopeptidase activity of the proteasome. 1 PublicationCorresponds to variant dbSNP:rs369359789EnsemblClinVar. | 1 | |
Natural variantiVAR_051553 | 173 | R → C. Corresponds to variant dbSNP:rs17213861Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005288 | 4 – 13 | Missing in isoform LMP2.S. 1 Publication | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66401 Genomic DNA Translation: CAA47024.1 X62741 mRNA Translation: CAA44603.1 Z14977 Genomic DNA Translation: CAA78700.1 X87344 Genomic DNA Translation: CAA60784.1 U01025 mRNA Translation: AAC50154.1 S75169 mRNA Translation: AAC60646.1 CR541656 mRNA Translation: CAG46457.1 AL669918 Genomic DNA No translation available. AL935043 Genomic DNA No translation available. BX088556 Genomic DNA No translation available. BX927138 Genomic DNA No translation available. CR753889 Genomic DNA No translation available. CR762476 Genomic DNA No translation available. CR933844 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03654.1 BC065513 mRNA Translation: AAH65513.1 |
CCDSi | CCDS4759.1 [P28065-1] |
PIRi | A55632 S27332 |
RefSeqi | NP_002791.1, NM_002800.4 [P28065-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66401 Genomic DNA Translation: CAA47024.1 X62741 mRNA Translation: CAA44603.1 Z14977 Genomic DNA Translation: CAA78700.1 X87344 Genomic DNA Translation: CAA60784.1 U01025 mRNA Translation: AAC50154.1 S75169 mRNA Translation: AAC60646.1 CR541656 mRNA Translation: CAG46457.1 AL669918 Genomic DNA No translation available. AL935043 Genomic DNA No translation available. BX088556 Genomic DNA No translation available. BX927138 Genomic DNA No translation available. CR753889 Genomic DNA No translation available. CR762476 Genomic DNA No translation available. CR933844 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03654.1 BC065513 mRNA Translation: AAH65513.1 |
CCDSi | CCDS4759.1 [P28065-1] |
PIRi | A55632 S27332 |
RefSeqi | NP_002791.1, NM_002800.4 [P28065-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AVO | electron microscopy | 3.80 | A/F | 21-219 | [»] | |
6E5B | X-ray | 2.77 | N/b | 1-219 | [»] | |
SMRi | P28065 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 111671, 73 interactors |
IntActi | P28065, 66 interactors |
MINTi | P28065 |
STRINGi | 9606.ENSP00000363993 |
Chemistry databases
BindingDBi | P28065 |
ChEMBLi | CHEMBL1944495 |
DrugBanki | DB08889 Carfilzomib |
GuidetoPHARMACOLOGYi | 2409 |
Protein family/group databases
MEROPSi | T01.013 |
PTM databases
iPTMneti | P28065 |
PhosphoSitePlusi | P28065 |
Polymorphism and mutation databases
BioMutai | PSMB9 |
DMDMi | 417529 |
2D gel databases
OGPi | P28065 |
Proteomic databases
EPDi | P28065 |
jPOSTi | P28065 |
MassIVEi | P28065 |
PaxDbi | P28065 |
PeptideAtlasi | P28065 |
PRIDEi | P28065 |
ProteomicsDBi | 54439 [P28065-1] 54440 [P28065-2] |
Protocols and materials databases
DNASUi | 5698 |
Genome annotation databases
Organism-specific databases
CTDi | 5698 |
DisGeNETi | 5698 |
GeneCardsi | PSMB9 |
HGNCi | HGNC:9546 PSMB9 |
HPAi | CAB015180 HPA042818 HPA053280 |
MalaCardsi | PSMB9 |
MIMi | 177045 gene 617591 phenotype |
neXtProti | NX_P28065 |
NIAGADSi | ENSG00000240065 |
OpenTargetsi | ENSG00000240065 |
PharmGKBi | PA33891 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0174 Eukaryota ENOG410XS23 LUCA |
GeneTreei | ENSGT00940000159897 |
HOGENOMi | HOG000091079 |
InParanoidi | P28065 |
KOi | K02741 |
OMAi | GWDHREG |
OrthoDBi | 1172133at2759 |
PhylomeDBi | P28065 |
TreeFami | TF106221 |
Enzyme and pathway databases
Reactomei | R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974 ER-Phagosome pathway R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534 Vpu mediated degradation of CD4 R-HSA-180585 Vif-mediated degradation of APOBEC3G R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253 Degradation of beta-catenin by the destruction complex R-HSA-202424 Downstream TCR signaling R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813 Separation of Sister Chromatids R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562 Regulation of ornithine decarboxylase (ODC) R-HSA-382556 ABC-family proteins mediated transport R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870 Asymmetric localization of PCP proteins R-HSA-4641257 Degradation of AXIN R-HSA-4641258 Degradation of DVL R-HSA-5358346 Hedgehog ligand biogenesis R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-5610780 Degradation of GLI1 by the proteasome R-HSA-5610783 Degradation of GLI2 by the proteasome R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome R-HSA-5632684 Hedgehog 'on' state R-HSA-5658442 Regulation of RAS by GAPs R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5676590 NIK-->noncanonical NF-kB signaling R-HSA-5678895 Defective CFTR causes cystic fibrosis R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689603 UCH proteinases R-HSA-5689880 Ub-specific processing proteases R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex R-HSA-68949 Orc1 removal from chromatin R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481 G2/M Checkpoints R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902 Regulation of RUNX2 expression and activity R-HSA-8941858 Regulation of RUNX3 expression and activity R-HSA-8948751 Regulation of PTEN stability and activity R-HSA-8951664 Neddylation R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-9020702 Interleukin-1 signaling R-HSA-9604323 Negative regulation of NOTCH4 signaling R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P28065 |
Miscellaneous databases
GeneWikii | PSMB9 |
GenomeRNAii | 5698 |
Pharosi | P28065 |
PROi | PR:P28065 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000240065 Expressed in 183 organ(s), highest expression level in leukocyte |
ExpressionAtlasi | P28065 baseline and differential |
Genevisiblei | P28065 HS |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055 Ntn_hydrolases_N IPR000243 Pept_T1A_subB IPR034383 Proteasome_beta9 IPR016050 Proteasome_bsu_CS IPR001353 Proteasome_sua/b IPR023333 Proteasome_suB-type |
PANTHERi | PTHR11599:SF50 PTHR11599:SF50, 1 hit |
Pfami | View protein in Pfam PF00227 Proteasome, 1 hit |
PRINTSi | PR00141 PROTEASOME |
SUPFAMi | SSF56235 SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854 PROTEASOME_BETA_1, 1 hit PS51476 PROTEASOME_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSB9_HUMAN | |
Accessioni | P28065Primary (citable) accession number: P28065 Secondary accession number(s): B0V0T1, Q16523, Q5JNW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | October 1, 1993 | |
Last modified: | November 13, 2019 | |
This is version 216 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references