UniProtKB - P28065 (PSB9_HUMAN)
Proteasome subunit beta type-9
PSMB9
Functioni
Miscellaneous
Catalytic activityi
- Cleavage of peptide bonds with very broad specificity. EC:3.4.25.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 21 | Nucleophile | 1 |
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
- threonine-type endopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- post-translational protein modification Source: Reactome
- proteasomal protein catabolic process Source: GO_Central
- proteasomal ubiquitin-independent protein catabolic process Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of cysteine-type endopeptidase activity Source: UniProtKB
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- viral process Source: UniProtKB-KW
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Molecular function | Hydrolase, Protease, Threonine protease |
Biological process | Host-virus interaction, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P28065 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P28065 |
Protein family/group databases
MEROPSi | T01.013 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit beta type-9 (EC:3.4.25.1)Alternative name(s): Low molecular mass protein 2 Macropain chain 7 Multicatalytic endopeptidase complex chain 7 Proteasome chain 7 Proteasome subunit beta-1i Really interesting new gene 12 protein |
Gene namesi | Name:PSMB9 Synonyms:LMP2, PSMB6i, RING12 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9546, PSMB9 |
MIMi | 177045, gene |
neXtProti | NX_P28065 |
VEuPathDBi | HostDB:ENSG00000240065.7 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- proteasome complex Source: ProtInc
- proteasome core complex Source: UniProtKB
- proteasome core complex, beta-subunit complex Source: UniProtKB
- spermatoproteasome complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Involvement in diseasei
Proteasome-associated autoinflammatory syndrome 3 (PRAAS3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075258 | 165 | G → D in PRAAS3; digenic inheritance; patient also carries a mutation in PSMB4; patients' cells show reduction of proteasome content and cysteine-type endopeptidase activity of the proteasome. 1 PublicationCorresponds to variant dbSNP:rs369359789EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 20 | G → A: Impairs correct processing at the consensus site. 1 Publication | 1 | |
Mutagenesisi | 21 | T → A: Impairs correct processing at the consensus site. 1 Publication | 1 | |
Mutagenesisi | 53 | K → A: Impairs correct processing at the consensus site. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5698 |
MalaCardsi | PSMB9 |
MIMi | 617591, phenotype |
NIAGADSi | ENSG00000240065 |
OpenTargetsi | ENSG00000240065 |
PharmGKBi | PA33891 |
Miscellaneous databases
Pharosi | P28065, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1944495 |
DrugBanki | DB08889, Carfilzomib |
GuidetoPHARMACOLOGYi | 2409 |
Genetic variation databases
BioMutai | PSMB9 |
DMDMi | 417529 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000026619 | 1 – 20 | Removed in mature formAdd BLAST | 20 | |
ChainiPRO_0000026620 | 21 – 219 | Proteasome subunit beta type-9Add BLAST | 199 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 109 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 20 – 21 | Cleavage; by autolysisBy similarity | 2 |
Keywords - PTMi
Acetylation, ZymogenProteomic databases
EPDi | P28065 |
jPOSTi | P28065 |
MassIVEi | P28065 |
PaxDbi | P28065 |
PeptideAtlasi | P28065 |
PRIDEi | P28065 |
ProteomicsDBi | 54439 [P28065-1] 54440 [P28065-2] |
2D gel databases
OGPi | P28065 |
PTM databases
iPTMneti | P28065 |
PhosphoSitePlusi | P28065 |
Expressioni
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000240065, Expressed in granulocyte and 199 other tissues |
ExpressionAtlasi | P28065, baseline and differential |
Genevisiblei | P28065, HS |
Organism-specific databases
HPAi | ENSG00000240065, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB6.
Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
1 Publication(Microbial infection) Interacts with HIV-1 TAT protein.
1 PublicationBinary interactionsi
Hide detailsP28065
Protein-protein interaction databases
BioGRIDi | 111671, 85 interactors |
IntActi | P28065, 67 interactors |
MINTi | P28065 |
STRINGi | 9606.ENSP00000363993 |
Chemistry databases
BindingDBi | P28065 |
Miscellaneous databases
RNActi | P28065, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P28065 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0174, Eukaryota |
GeneTreei | ENSGT00940000159897 |
InParanoidi | P28065 |
OMAi | GWDHREG |
PhylomeDBi | P28065 |
TreeFami | TF106221 |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR000243, Pept_T1A_subB IPR034383, Proteasome_beta9 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF50, PTHR11599:SF50, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PRINTSi | PR00141, PROTEASOME |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRAGAPTGD LPRAGEVHTG TTIMAVEFDG GVVMGSDSRV SAGEAVVNRV
60 70 80 90 100
FDKLSPLHER IYCALSGSAA DAQAVADMAA YQLELHGIEL EEPPLVLAAA
110 120 130 140 150
NVVRNISYKY REDLSAHLMV AGWDQREGGQ VYGTLGGMLT RQPFAIGGSG
160 170 180 190 200
STFIYGYVDA AYKPGMSPEE CRRFTTDAIA LAMSRDGSSG GVIYLVTITA
210
AGVDHRVILG NELPKFYDE
The sequence of this isoform differs from the canonical sequence as follows:
4-13: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2ACR0 | A2ACR0_HUMAN | Low molecular mass protein 2 | PSMB9 | 131 | Annotation score: | ||
A0A0G2JJQ0 | A0A0G2JJQ0_HUMAN | Low molecular mass protein 2 | PSMB9 | 131 | Annotation score: | ||
A2ACR1 | A2ACR1_HUMAN | Proteasome subunit beta | PSMB9 hCG_17510 | 196 | Annotation score: | ||
A0A0G2JJA7 | A0A0G2JJA7_HUMAN | Proteasome subunit beta | PSMB9 | 196 | Annotation score: | ||
A0A0G2JHI2 | A0A0G2JHI2_HUMAN | Proteasome subunit beta type-9 | PSMB9 | 178 | Annotation score: | ||
A0A0G2JJ13 | A0A0G2JJ13_HUMAN | Proteasome subunit beta type-9 | PSMB9 | 178 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051551 | 9 | G → E. Corresponds to variant dbSNP:rs35100697Ensembl. | 1 | |
Natural variantiVAR_051552 | 32 | V → I. Corresponds to variant dbSNP:rs241419Ensembl. | 1 | |
Natural variantiVAR_013578 | 60 | R → H2 PublicationsCorresponds to variant dbSNP:rs17587Ensembl. | 1 | |
Natural variantiVAR_075258 | 165 | G → D in PRAAS3; digenic inheritance; patient also carries a mutation in PSMB4; patients' cells show reduction of proteasome content and cysteine-type endopeptidase activity of the proteasome. 1 PublicationCorresponds to variant dbSNP:rs369359789EnsemblClinVar. | 1 | |
Natural variantiVAR_051553 | 173 | R → C. Corresponds to variant dbSNP:rs17213861Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005288 | 4 – 13 | Missing in isoform LMP2.S. 1 Publication | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66401 Genomic DNA Translation: CAA47024.1 X62741 mRNA Translation: CAA44603.1 Z14977 Genomic DNA Translation: CAA78700.1 X87344 Genomic DNA Translation: CAA60784.1 U01025 mRNA Translation: AAC50154.1 S75169 mRNA Translation: AAC60646.1 CR541656 mRNA Translation: CAG46457.1 AL669918 Genomic DNA No translation available. AL935043 Genomic DNA No translation available. BX088556 Genomic DNA No translation available. BX927138 Genomic DNA No translation available. CR753889 Genomic DNA No translation available. CR762476 Genomic DNA No translation available. CR933844 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03654.1 BC065513 mRNA Translation: AAH65513.1 |
CCDSi | CCDS4759.1 [P28065-1] |
PIRi | A55632 S27332 |
RefSeqi | NP_002791.1, NM_002800.4 [P28065-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66401 Genomic DNA Translation: CAA47024.1 X62741 mRNA Translation: CAA44603.1 Z14977 Genomic DNA Translation: CAA78700.1 X87344 Genomic DNA Translation: CAA60784.1 U01025 mRNA Translation: AAC50154.1 S75169 mRNA Translation: AAC60646.1 CR541656 mRNA Translation: CAG46457.1 AL669918 Genomic DNA No translation available. AL935043 Genomic DNA No translation available. BX088556 Genomic DNA No translation available. BX927138 Genomic DNA No translation available. CR753889 Genomic DNA No translation available. CR762476 Genomic DNA No translation available. CR933844 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03654.1 BC065513 mRNA Translation: AAH65513.1 |
CCDSi | CCDS4759.1 [P28065-1] |
PIRi | A55632 S27332 |
RefSeqi | NP_002791.1, NM_002800.4 [P28065-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AVO | electron microscopy | 3.80 | A/F | 21-219 | [»] | |
6E5B | X-ray | 2.77 | N/b | 1-219 | [»] | |
SMRi | P28065 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111671, 85 interactors |
IntActi | P28065, 67 interactors |
MINTi | P28065 |
STRINGi | 9606.ENSP00000363993 |
Chemistry databases
BindingDBi | P28065 |
ChEMBLi | CHEMBL1944495 |
DrugBanki | DB08889, Carfilzomib |
GuidetoPHARMACOLOGYi | 2409 |
Protein family/group databases
MEROPSi | T01.013 |
PTM databases
iPTMneti | P28065 |
PhosphoSitePlusi | P28065 |
Genetic variation databases
BioMutai | PSMB9 |
DMDMi | 417529 |
2D gel databases
OGPi | P28065 |
Proteomic databases
EPDi | P28065 |
jPOSTi | P28065 |
MassIVEi | P28065 |
PaxDbi | P28065 |
PeptideAtlasi | P28065 |
PRIDEi | P28065 |
ProteomicsDBi | 54439 [P28065-1] 54440 [P28065-2] |
Protocols and materials databases
Antibodypediai | 28726, 418 antibodies |
DNASUi | 5698 |
Genome annotation databases
Organism-specific databases
CTDi | 5698 |
DisGeNETi | 5698 |
GeneCardsi | PSMB9 |
HGNCi | HGNC:9546, PSMB9 |
HPAi | ENSG00000240065, Tissue enhanced (blood, lymphoid tissue) |
MalaCardsi | PSMB9 |
MIMi | 177045, gene 617591, phenotype |
neXtProti | NX_P28065 |
NIAGADSi | ENSG00000240065 |
OpenTargetsi | ENSG00000240065 |
PharmGKBi | PA33891 |
VEuPathDBi | HostDB:ENSG00000240065.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0174, Eukaryota |
GeneTreei | ENSGT00940000159897 |
InParanoidi | P28065 |
OMAi | GWDHREG |
PhylomeDBi | P28065 |
TreeFami | TF106221 |
Enzyme and pathway databases
PathwayCommonsi | P28065 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P28065 |
Miscellaneous databases
BioGRID-ORCSi | 5698, 8 hits in 881 CRISPR screens |
GeneWikii | PSMB9 |
GenomeRNAii | 5698 |
Pharosi | P28065, Tchem |
PROi | PR:P28065 |
RNActi | P28065, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000240065, Expressed in granulocyte and 199 other tissues |
ExpressionAtlasi | P28065, baseline and differential |
Genevisiblei | P28065, HS |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR000243, Pept_T1A_subB IPR034383, Proteasome_beta9 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF50, PTHR11599:SF50, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PRINTSi | PR00141, PROTEASOME |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSB9_HUMAN | |
Accessioni | P28065Primary (citable) accession number: P28065 Secondary accession number(s): B0V0T1, Q16523, Q5JNW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | October 1, 1993 | |
Last modified: | February 10, 2021 | |
This is version 224 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families