UniProtKB - P28062 (PSB8_HUMAN)
Proteasome subunit beta type-8
PSMB8
Functioni
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119).
Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.
5 PublicationsCatalytic activityi
- Cleavage of peptide bonds with very broad specificity. EC:3.4.25.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
- threonine-type endopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- antigen processing and presentation Source: Ensembl
- fat cell differentiation Source: UniProtKB
- proteasomal protein catabolic process Source: GO_Central
- regulation of endopeptidase activity Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Threonine protease |
Biological process | Differentiation, Host-virus interaction, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P28062 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8932339, ROS sensing by NFE2L2 R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-909733, Interferon alpha/beta signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | P28062 |
SIGNORi | P28062 |
Protein family/group databases
MEROPSi | T01.015 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit beta type-8 (EC:3.4.25.1)Alternative name(s): Low molecular mass protein 7 Macropain subunit C13 Multicatalytic endopeptidase complex subunit C13 Proteasome component C13 Proteasome subunit beta-5i Really interesting new gene 10 protein |
Gene namesi | Name:PSMB8 Synonyms:LMP7, PSMB5i, RING10, Y2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9545, PSMB8 |
MIMi | 177046, gene |
neXtProti | NX_P28062 |
VEuPathDBi | HostDB:ENSG00000204264 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- proteasome complex Source: UniProtKB
- proteasome core complex Source: UniProtKB
- proteasome core complex, beta-subunit complex Source: UniProtKB
- spermatoproteasome complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Involvement in diseasei
Proteasome-associated autoinflammatory syndrome 1 (PRAAS1)6 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065291 | 75 | T → M in PRAAS1; markedly decreased chymotrypsin-like activity consistent with a decrease in proteasomal activity and loss of function; some patients are heterozygotes for this mutation and also carry a mutation in PSMA3; patients' cells show reduction of proteasome content and endopeptidase activity of the proteasome. 2 PublicationsCorresponds to variant dbSNP:rs748082671EnsemblClinVar. | 1 | |
Natural variantiVAR_075256 | 94 | A → P in PRAAS1; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_075257 | 105 | K → Q in PRAAS1; some patients are heterozygotes for this mutation and also carry a mutation in PSMB4. 1 PublicationCorresponds to variant dbSNP:rs1554239543EnsemblClinVar. | 1 | |
Natural variantiVAR_066449 | 201 | G → V in PRAAS1; affects immunoproteasome assembly; reduced proteasome levels; reduced chymotrypsin-like activity consistent with a decrease in proteasomal activity. 2 PublicationsCorresponds to variant dbSNP:rs387906680EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 5696 |
MalaCardsi | PSMB8 |
MIMi | 256040, phenotype |
NIAGADSi | ENSG00000204264 |
OpenTargetsi | ENSG00000204264 |
Orphaneti | 324977, Proteasome-associated autoinflammatory syndrome |
PharmGKBi | PA33890 |
Miscellaneous databases
Pharosi | P28062, Tclin |
Chemistry databases
ChEMBLi | CHEMBL5620 |
DrugBanki | DB08889, Carfilzomib |
DrugCentrali | P28062 |
GuidetoPHARMACOLOGYi | 2408 |
Genetic variation databases
BioMutai | PSMB8 |
DMDMi | 334302881 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000026597 | 1 – 72 | Removed in mature formBy similarityAdd BLAST | 72 | |
ChainiPRO_0000026598 | 73 – 276 | Proteasome subunit beta type-8Add BLAST | 204 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: P28062-2) | |||||
Modified residuei | 5 | PhosphothreonineCurated | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 72 – 73 | Cleavage; by autolysisBy similarity | 2 |
Keywords - PTMi
Phosphoprotein, ZymogenProteomic databases
EPDi | P28062 |
jPOSTi | P28062 |
MassIVEi | P28062 |
MaxQBi | P28062 |
PaxDbi | P28062 |
PeptideAtlasi | P28062 |
PRIDEi | P28062 |
ProteomicsDBi | 54437 [P28062-1] 54438 [P28062-2] |
PTM databases
iPTMneti | P28062 |
PhosphoSitePlusi | P28062 |
SwissPalmi | P28062 |
Expressioni
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000204264, Expressed in granulocyte and 200 other tissues |
ExpressionAtlasi | P28062, baseline and differential |
Genevisiblei | P28062, HS |
Organism-specific databases
HPAi | ENSG00000204264, Low tissue specificity |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB5.
Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Directly interacts with POMP.
Interacts with TAP1.
2 Publications(Microbial infection) Interacts with HIV-1 TAT protein.
1 PublicationBinary interactionsi
P28062
With | #Exp. | IntAct |
---|---|---|
Serine protease/helicase NS3 (PRO_0000037573) from Hepatitis C virus genotype 1a (isolate H77). | 4 | EBI-372294,EBI-3649474 |
Isoform 2 [P28062-2]
Protein-protein interaction databases
BioGRIDi | 111669, 103 interactors |
IntActi | P28062, 36 interactors |
MINTi | P28062 |
STRINGi | 9606.ENSP00000364016 |
Chemistry databases
BindingDBi | P28062 |
Miscellaneous databases
RNActi | P28062, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P28062 |
SMRi | P28062 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0175, Eukaryota |
GeneTreei | ENSGT00940000157293 |
HOGENOMi | CLU_035750_7_1_1 |
InParanoidi | P28062 |
OMAi | IQIEMAH |
PhylomeDBi | P28062 |
TreeFami | TF106223 |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR000243, Pept_T1A_subB IPR035705, Proteasome_beta8 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF53, PTHR11599:SF53, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PRINTSi | PR00141, PROTEASOME |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALLDVCGAP RGQRPESALP VAGSGRRSDP GHYSFSMRSP ELALPRGMQP
60 70 80 90 100
TEFFQSLGGD GERNVQIEMA HGTTTLAFKF QHGVIAAVDS RASAGSYISA
110 120 130 140 150
LRVNKVIEIN PYLLGTMSGC AADCQYWERL LAKECRLYYL RNGERISVSA
160 170 180 190 200
ASKLLSNMMC QYRGMGLSMG SMICGWDKKG PGLYYVDEHG TRLSGNMFST
210 220 230 240 250
GSGNTYAYGV MDSGYRPNLS PEEAYDLGRR AIAYATHRDS YSGGVVNMYH
260 270
MKEDGWVKVE STDVSDLLHQ YREANQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX5D2R7 | X5D2R7_HUMAN | Proteasome subunit beta | PSMB8 PSM8 | 276 | Annotation score: | ||
Q5JNW7 | Q5JNW7_HUMAN | Proteasome subunit beta type-8 | PSMB8 | 252 | Annotation score: | ||
A0A140T998 | A0A140T998_HUMAN | Proteasome subunit beta type-8 | PSMB8 | 252 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006488 | 8 | G → R in allele LMP7C. Corresponds to variant dbSNP:rs114772012EnsemblClinVar. | 1 | |
Natural variantiVAR_006489 | 30 – 32 | PGH → RPD in allele LPM7C. | 3 | |
Natural variantiVAR_065204 | 49 | Q → K1 PublicationCorresponds to variant dbSNP:rs2071543EnsemblClinVar. | 1 | |
Natural variantiVAR_057046 | 74 | T → S. Corresponds to variant dbSNP:rs17220206EnsemblClinVar. | 1 | |
Natural variantiVAR_065291 | 75 | T → M in PRAAS1; markedly decreased chymotrypsin-like activity consistent with a decrease in proteasomal activity and loss of function; some patients are heterozygotes for this mutation and also carry a mutation in PSMA3; patients' cells show reduction of proteasome content and endopeptidase activity of the proteasome. 2 PublicationsCorresponds to variant dbSNP:rs748082671EnsemblClinVar. | 1 | |
Natural variantiVAR_075256 | 94 | A → P in PRAAS1; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_075257 | 105 | K → Q in PRAAS1; some patients are heterozygotes for this mutation and also carry a mutation in PSMB4. 1 PublicationCorresponds to variant dbSNP:rs1554239543EnsemblClinVar. | 1 | |
Natural variantiVAR_066449 | 201 | G → V in PRAAS1; affects immunoproteasome assembly; reduced proteasome levels; reduced chymotrypsin-like activity consistent with a decrease in proteasomal activity. 2 PublicationsCorresponds to variant dbSNP:rs387906680EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005287 | 1 – 49 | MALLD…PRGMQ → MLIGTPTPRDTTPSSWLTSS LLVEAAPLDDTTLPTPVSSG CPGLE in isoform 2. 2 PublicationsAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66401 Genomic DNA Translation: CAA47026.1 X62598 mRNA Translation: CAA44482.1 Z14982 Genomic DNA Translation: CAA78705.1 Z14982 Genomic DNA Translation: CAA78706.1 L11045 Genomic DNA No translation available. X87344 Genomic DNA Translation: CAA60786.1 X87344 Genomic DNA Translation: CAA60787.1 U17496 mRNA Translation: AAA56777.1 U17497 mRNA Translation: AAA56778.1 AL671681 Genomic DNA No translation available. AL669918 Genomic DNA No translation available. AL935043 Genomic DNA No translation available. BX682530 Genomic DNA No translation available. BX088556 Genomic DNA No translation available. CT009502 Genomic DNA No translation available. BX927138 Genomic DNA No translation available. CR762476 Genomic DNA No translation available. CR753889 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03644.1 CH471081 Genomic DNA Translation: EAX03645.1 BC001114 mRNA Translation: AAH01114.1 U32863 Genomic DNA Translation: AAA80235.1 U32862 Genomic DNA Translation: AAA80234.1 |
CCDSi | CCDS4756.1 [P28062-2] CCDS4757.1 [P28062-1] |
PIRi | A44324 C44324 G01564 G02018 |
RefSeqi | NP_004150.1, NM_004159.4 [P28062-2] NP_683720.2, NM_148919.3 [P28062-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66401 Genomic DNA Translation: CAA47026.1 X62598 mRNA Translation: CAA44482.1 Z14982 Genomic DNA Translation: CAA78705.1 Z14982 Genomic DNA Translation: CAA78706.1 L11045 Genomic DNA No translation available. X87344 Genomic DNA Translation: CAA60786.1 X87344 Genomic DNA Translation: CAA60787.1 U17496 mRNA Translation: AAA56777.1 U17497 mRNA Translation: AAA56778.1 AL671681 Genomic DNA No translation available. AL669918 Genomic DNA No translation available. AL935043 Genomic DNA No translation available. BX682530 Genomic DNA No translation available. BX088556 Genomic DNA No translation available. CT009502 Genomic DNA No translation available. BX927138 Genomic DNA No translation available. CR762476 Genomic DNA No translation available. CR753889 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03644.1 CH471081 Genomic DNA Translation: EAX03645.1 BC001114 mRNA Translation: AAH01114.1 U32863 Genomic DNA Translation: AAA80235.1 U32862 Genomic DNA Translation: AAA80234.1 |
CCDSi | CCDS4756.1 [P28062-2] CCDS4757.1 [P28062-1] |
PIRi | A44324 C44324 G01564 G02018 |
RefSeqi | NP_004150.1, NM_004159.4 [P28062-2] NP_683720.2, NM_148919.3 [P28062-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5L5A | X-ray | 2.40 | K/Y | 73-210 | [»] | |
5L5B | X-ray | 2.80 | K/Y | 73-210 | [»] | |
5L5D | X-ray | 2.80 | K/Y | 73-210 | [»] | |
5L5E | X-ray | 2.90 | K/Y | 73-210 | [»] | |
5L5F | X-ray | 2.50 | K/Y | 73-210 | [»] | |
5L5H | X-ray | 2.60 | K/Y | 73-210 | [»] | |
5L5I | X-ray | 2.90 | K/Y | 73-210 | [»] | |
5L5J | X-ray | 2.90 | K/Y | 73-210 | [»] | |
5L5O | X-ray | 2.60 | K/Y | 73-210 | [»] | |
5L5P | X-ray | 2.80 | K/Y | 73-210 | [»] | |
5L5Q | X-ray | 2.80 | K/Y | 73-210 | [»] | |
5L5R | X-ray | 2.90 | K/Y | 73-210 | [»] | |
5L5S | X-ray | 2.60 | K/Y | 73-210 | [»] | |
5L5T | X-ray | 2.90 | K/Y | 73-210 | [»] | |
5L5U | X-ray | 2.60 | K/Y | 73-210 | [»] | |
5L5V | X-ray | 2.70 | K/Y | 73-210 | [»] | |
5LTT | X-ray | 2.70 | K/Y | 73-210 | [»] | |
5M2B | X-ray | 2.70 | K/Y | 73-210 | [»] | |
6AVO | electron microscopy | 3.80 | C/D | 73-276 | [»] | |
6E5B | X-ray | 2.77 | K/Y | 1-276 | [»] | |
7AWE | X-ray | 2.29 | L/Z | 73-275 | [»] | |
7B12 | X-ray | 2.43 | L/Z | 73-275 | [»] | |
AlphaFoldDBi | P28062 | |||||
SMRi | P28062 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111669, 103 interactors |
IntActi | P28062, 36 interactors |
MINTi | P28062 |
STRINGi | 9606.ENSP00000364016 |
Chemistry databases
BindingDBi | P28062 |
ChEMBLi | CHEMBL5620 |
DrugBanki | DB08889, Carfilzomib |
DrugCentrali | P28062 |
GuidetoPHARMACOLOGYi | 2408 |
Protein family/group databases
MEROPSi | T01.015 |
PTM databases
iPTMneti | P28062 |
PhosphoSitePlusi | P28062 |
SwissPalmi | P28062 |
Genetic variation databases
BioMutai | PSMB8 |
DMDMi | 334302881 |
Proteomic databases
EPDi | P28062 |
jPOSTi | P28062 |
MassIVEi | P28062 |
MaxQBi | P28062 |
PaxDbi | P28062 |
PeptideAtlasi | P28062 |
PRIDEi | P28062 |
ProteomicsDBi | 54437 [P28062-1] 54438 [P28062-2] |
Protocols and materials databases
Antibodypediai | 28713, 409 antibodies from 41 providers |
DNASUi | 5696 |
Genome annotation databases
Organism-specific databases
CTDi | 5696 |
DisGeNETi | 5696 |
GeneCardsi | PSMB8 |
HGNCi | HGNC:9545, PSMB8 |
HPAi | ENSG00000204264, Low tissue specificity |
MalaCardsi | PSMB8 |
MIMi | 177046, gene 256040, phenotype |
neXtProti | NX_P28062 |
NIAGADSi | ENSG00000204264 |
OpenTargetsi | ENSG00000204264 |
Orphaneti | 324977, Proteasome-associated autoinflammatory syndrome |
PharmGKBi | PA33890 |
VEuPathDBi | HostDB:ENSG00000204264 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0175, Eukaryota |
GeneTreei | ENSGT00940000157293 |
HOGENOMi | CLU_035750_7_1_1 |
InParanoidi | P28062 |
OMAi | IQIEMAH |
PhylomeDBi | P28062 |
TreeFami | TF106223 |
Enzyme and pathway databases
PathwayCommonsi | P28062 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8932339, ROS sensing by NFE2L2 R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-909733, Interferon alpha/beta signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | P28062 |
SIGNORi | P28062 |
Miscellaneous databases
BioGRID-ORCSi | 5696, 11 hits in 1090 CRISPR screens |
ChiTaRSi | PSMB8, human |
GeneWikii | PSMB8 |
GenomeRNAii | 5696 |
Pharosi | P28062, Tclin |
PROi | PR:P28062 |
RNActi | P28062, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204264, Expressed in granulocyte and 200 other tissues |
ExpressionAtlasi | P28062, baseline and differential |
Genevisiblei | P28062, HS |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR000243, Pept_T1A_subB IPR035705, Proteasome_beta8 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF53, PTHR11599:SF53, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PRINTSi | PR00141, PROTEASOME |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PSB8_HUMAN | |
Accessioni | P28062Primary (citable) accession number: P28062 Secondary accession number(s): B0UZC0 Q96J48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | May 31, 2011 | |
Last modified: | May 25, 2022 | |
This is version 234 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families