UniProtKB - P28048 (LAA_XENLA)
Protein
Lupus La protein homolog A
Gene
ssb-a
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts (By similarity).By similarity
Miscellaneous
There are two forms of La, LaA and LaB, in Xenopus.
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- RNA processing Source: InterPro
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Lupus La protein homolog AAlternative name(s): La autoantigen homolog A La ribonucleoprotein A |
Gene namesi | Name:ssb-a Synonyms:laa1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-6254453, ssb.S |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- ribonucleoprotein complex Source: InterPro
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207603 | 1 – 428 | Lupus La protein homolog AAdd BLAST | 428 |
Post-translational modificationi
Phosphorylated.Curated
Keywords - PTMi
PhosphoproteinExpressioni
Developmental stagei
Barely detectable in stage I/II oocytes, accumulate in stage III/IV oocytes, then exhibit a roughly constant steady state level in mature oocytes, eggs, and early embryos.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 99 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 111 – 203 | RRMPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 227 – 349 | xRRMPROSITE-ProRule annotationAdd BLAST | 123 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 196 – 212 | Nuclear localization signalSequence analysisAdd BLAST | 17 | |
Motifi | 316 – 332 | Nuclear localization signalSequence analysisAdd BLAST | 17 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006630, La_HTH IPR014886, La_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF00076, RRM_1, 1 hit PF08777, RRM_3, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit PS51939, XRRM, 1 hit |
i Sequence
Sequence statusi: Complete.
P28048-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAENGDKEQK LDSDTKICEQ IEYYFGDHNL PRDKFLKQQI LLDDGWVPLE
60 70 80 90 100
TMIKFNRLSK LTTDFNTILQ ALKKSKTELL EINEEKCKIR RSPAKPLPEL
110 120 130 140 150
NDEYKNSLKH KSVYIKGFPT SAILDDVKEW LKDKGPIENI QMRRTLQREF
160 170 180 190 200
KGSIFIIFNT DDDAKKFLEN RNLKYKDNDM TVLSREEYHA KKNEERKLNK
210 220 230 240 250
SEEKAKSKQV KKEAQKQAED AERKLVEERV GSLLKFSGDL DNMTSREDLH
260 270 280 290 300
ALFQTHGDIE WIDFSRGAKE GIVLFKMNAK EALDKAKAAN SDNLKLKGKD
310 320 330 340 350
VKWELIEGDT EKEALKKILE GKQESFNKRK GRDGRKFKGK GRGGKGNDSS
360 370 380 390 400
SRKRTQFQGK KKTFDSSDDE DDMEESESPQ KASVKAEESA GTKNGAAAAP
410 420
GSPKKRSLDD KAEDGPAVKQ SKTEVGDQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68817 mRNA Translation: CAA48715.1 |
PIRi | S33818 |
RefSeqi | NP_001081021.1, NM_001087552.1 |
Genome annotation databases
GeneIDi | 394333 |
KEGGi | xla:394333 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68817 mRNA Translation: CAA48715.1 |
PIRi | S33818 |
RefSeqi | NP_001081021.1, NM_001087552.1 |
3D structure databases
SMRi | P28048 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 394333 |
KEGGi | xla:394333 |
Organism-specific databases
CTDi | 394333 |
Xenbasei | XB-GENE-6254453, ssb.S |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006630, La_HTH IPR014886, La_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF00076, RRM_1, 1 hit PF08777, RRM_3, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit PS51939, XRRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAA_XENLA | |
Accessioni | P28048Primary (citable) accession number: P28048 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |