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Protein

Protein Wnt-7b

Gene

Wnt7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells (PubMed:15923619). Required for normal fusion of the chorion and the allantois during placenta development (PubMed:11543617).2 Publications

GO - Molecular functioni

  • chemoattractant activity involved in axon guidance Source: ParkinsonsUK-UCL
  • frizzled binding Source: MGI
  • receptor ligand activity Source: MGI

GO - Biological processi

  • activation of JUN kinase activity Source: MGI
  • anatomical structure regression Source: MGI
  • angiogenesis Source: MGI
  • apoptotic process involved in blood vessel morphogenesis Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell fate commitment Source: GO_Central
  • cell proliferation in forebrain Source: BHF-UCL
  • cellular metabolic process Source: MGI
  • central nervous system vasculogenesis Source: MGI
  • chemoattraction of dopaminergic neuron axon Source: ParkinsonsUK-UCL
  • chorio-allantoic fusion Source: MGI
  • developmental growth involved in morphogenesis Source: MGI
  • embryonic organ development Source: MGI
  • embryonic placenta morphogenesis Source: MGI
  • establishment or maintenance of polarity of embryonic epithelium Source: MGI
  • forebrain regionalization Source: UniProtKB
  • homeostatic process Source: MGI
  • inner medullary collecting duct development Source: MGI
  • in utero embryonic development Source: MGI
  • lobar bronchus development Source: MGI
  • lung-associated mesenchyme development Source: MGI
  • lung development Source: MGI
  • lung epithelium development Source: MGI
  • lung morphogenesis Source: MGI
  • metanephric collecting duct development Source: MGI
  • metanephric epithelium development Source: MGI
  • metanephric loop of Henle development Source: MGI
  • metanephros morphogenesis Source: MGI
  • negative regulation of neurogenesis Source: BHF-UCL
  • negative regulation of smoothened signaling pathway Source: MGI
  • neuron projection development Source: MGI
  • neuron projection morphogenesis Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • outer medullary collecting duct development Source: MGI
  • oxygen homeostasis Source: MGI
  • planar cell polarity pathway involved in axon guidance Source: ParkinsonsUK-UCL
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of JNK cascade Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • regulation of cell projection size Source: MGI
  • renal inner medulla development Source: MGI
  • renal outer medulla development Source: MGI
  • smooth muscle cell differentiation Source: MGI
  • stem cell development Source: BHF-UCL
  • synapse organization Source: MGI
  • trachea cartilage morphogenesis Source: MGI
  • vasculature development Source: MGI
  • Wnt signaling pathway Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-7b
Gene namesi
Name:Wnt7b
Synonyms:Wnt-7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98962 Wnt7b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004144525 – 349Protein Wnt-7bAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi73 ↔ 84By similarity
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi123 ↔ 131By similarity
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 152By similarity
Disulfide bondi200 ↔ 214By similarity
Disulfide bondi202 ↔ 209By similarity
Lipidationi206O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiP28047
PaxDbiP28047
PRIDEiP28047

PTM databases

iPTMnetiP28047
PhosphoSitePlusiP28047

Expressioni

Developmental stagei

At 7.5 and 8.5 dpc, detected in extraembryonic membranes and cells that form the chorionic plate.1 Publication

Gene expression databases

BgeeiENSMUSG00000022382
CleanExiMM_WNT7B
ExpressionAtlasiP28047 baseline and differential
GenevisibleiP28047 MM

Interactioni

Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD1 and FZD10 (PubMed:15923619). Interacts with FZD4 (in vitro) (PubMed:15923619). Interacts with PORCN (PubMed:10866835).By similarity2 Publications

GO - Molecular functioni

  • chemoattractant activity involved in axon guidance Source: ParkinsonsUK-UCL
  • frizzled binding Source: MGI
  • receptor ligand activity Source: MGI

Protein-protein interaction databases

BioGridi204581, 5 interactors
IntActiP28047, 1 interactor
STRINGi10090.ENSMUSP00000105051

Structurei

3D structure databases

ProteinModelPortaliP28047
SMRiP28047
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
HOGENOMiHOG000039528
HOVERGENiHBG001595
InParanoidiP28047
KOiK00572
PhylomeDBiP28047

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013300 Wnt7
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01891 WNT7PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA
60 70 80 90 100
ICQSRPDAII VIGEGAQMGI DECQHQFRFG RWNCSALGEK TVFGQELRVG
110 120 130 140 150
SREAAFTYAI TAAGVAHAVT AACSQGNLSN CGCDREKQGY YNQAEGWKWG
160 170 180 190 200
GCSADVRYGI DFSRRFVDAR EIKKNARRLM NLHNNEAGRK VLEDRMKLEC
210 220 230 240 250
KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV VRASRLRQPT
260 270 280 290 300
FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG
310 320 330 340
ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK
Length:349
Mass (Da):39,302
Last modified:August 1, 1992 - v1
Checksum:iBDD82AB020DC680E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33G → V in AAH52018 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89802 mRNA Translation: AAA40571.1
BC052018 mRNA Translation: AAH52018.2
CCDSiCCDS37171.1
PIRiH36470
RefSeqiNP_001157105.1, NM_001163633.1
NP_001157106.1, NM_001163634.1
NP_033554.3, NM_009528.3
UniGeneiMm.306946

Genome annotation databases

EnsembliENSMUST00000109424; ENSMUSP00000105051; ENSMUSG00000022382
GeneIDi22422
KEGGimmu:22422
UCSCiuc007xdf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiWNT7B_MOUSE
AccessioniPrimary (citable) accession number: P28047
Secondary accession number(s): Q80US5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 20, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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