Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-1 receptor type 2

Gene

IL1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-6783783 Interleukin-10 signaling
R-HSA-9020702 Interleukin-1 signaling
SIGNORiP27930

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 2
Short name:
IL-1R-2
Short name:
IL-1RT-2
Short name:
IL-1RT2
Alternative name(s):
CD121 antigen-like family member B
CDw121b
IL-1 type II receptor
Interleukin-1 receptor beta
Short name:
IL-1R-beta
Interleukin-1 receptor type II
CD_antigen: CD121b
Cleaved into the following 2 chains:
Interleukin-1 receptor type 2, membrane form
Short name:
mIL-1R2
Short name:
mIL-1RII
Interleukin-1 receptor type 2, soluble form
Short name:
sIL-1R2
Short name:
sIL-1RII
Gene namesi
Name:IL1R2
Synonyms:IL1RB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115590.13
HGNCiHGNC:5994 IL1R2
MIMi147811 gene
neXtProtiNX_P27930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 343ExtracellularSequence analysisAdd BLAST330
Transmembranei344 – 369HelicalSequence analysisAdd BLAST26
Topological domaini370 – 398CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7850
OpenTargetsiENSG00000115590
PharmGKBiPA29810

Polymorphism and mutation databases

BioMutaiIL1R2
DMDMi124310

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13Sequence analysisAdd BLAST13
ChainiPRO_000001543914 – 398Interleukin-1 receptor type 2, membrane formAdd BLAST385
ChainiPRO_000041534814 – ?Interleukin-1 receptor type 2, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 116PROSITE-ProRule annotation1 Publication
Disulfide bondi50 ↔ 108PROSITE-ProRule annotation1 Publication
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi152 ↔ 207PROSITE-ProRule annotation1 Publication
Glycosylationi219N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi258 ↔ 326PROSITE-ProRule annotation1 Publication
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP27930
PaxDbiP27930
PeptideAtlasiP27930
PRIDEiP27930
ProteomicsDBi54427
54428 [P27930-2]

PTM databases

iPTMnetiP27930
PhosphoSitePlusiP27930

Expressioni

Gene expression databases

BgeeiENSG00000115590 Expressed in 185 organ(s), highest expression level in decidua
CleanExiHS_IL1R2
ExpressionAtlasiP27930 baseline and differential
GenevisibleiP27930 HS

Organism-specific databases

HPAiHPA027597
HPA027598

Interactioni

Subunit structurei

Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IL1AP015834EBI-2831568,EBI-1749782

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113605, 43 interactors
DIPiDIP-61267N
IntActiP27930, 4 interactors
MINTiP27930
STRINGi9606.ENSP00000330959

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP27930
SMRiP27930
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27930

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 124Ig-like C2-type 1Add BLAST107
Domaini134 – 223Ig-like C2-type 2Add BLAST90
Domaini237 – 349Ig-like C2-type 3Add BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni329 – 343Contains proteolytic cleavage siteCuratedAdd BLAST15

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJCQ Eukaryota
ENOG410YQDP LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113036
HOVERGENiHBG052104
InParanoidiP27930
KOiK04387
OMAiCKVFLGA
OrthoDBiEOG091G077L
PhylomeDBiP27930
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR004077 IL-1_rcpt_II-typ
IPR013151 Immunoglobulin
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PRINTSiPR01539 INTRLEUKN1R2
PR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: P27930-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRLYVLVMG VSAFTLQPAA HTGAARSCRF RGRHYKREFR LEGEPVALRC
60 70 80 90 100
PQVPYWLWAS VSPRINLTWH KNDSARTVPG EEETRMWAQD GALWLLPALQ
110 120 130 140 150
EDSGTYVCTT RNASYCDKMS IELRVFENTD AFLPFISYPQ ILTLSTSGVL
160 170 180 190 200
VCPDLSEFTR DKTDVKIQWY KDSLLLDKDN EKFLSVRGTT HLLVHDVALE
210 220 230 240 250
DAGYYRCVLT FAHEGQQYNI TRSIELRIKK KKEETIPVII SPLKTISASL
260 270 280 290 300
GSRLTIPCKV FLGTGTPLTT MLWWTANDTH IESAYPGGRV TEGPRQEYSE
310 320 330 340 350
NNENYIEVPL IFDPVTREDL HMDFKCVVHN TLSFQTLRTT VKEASSTFSW
360 370 380 390
GIVLAPLSLA FLVLGGIWMH RRCKHRTGKA DGLTVLWPHH QDFQSYPK
Length:398
Mass (Da):45,421
Last modified:August 1, 1992 - v1
Checksum:i2C2A03ADA6F3AC5B
GO
Isoform Short (identifier: P27930-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     297-398: Missing.

Show »
Length:296
Mass (Da):33,622
Checksum:i581AA026BB7DACD5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JNR0C9JNR0_HUMAN
Interleukin-1 receptor type 2
IL1R2
229Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123L → F in AAD00242 (PubMed:8702856).Curated1
Sequence conflicti171K → R in AAD00242 (PubMed:8702856).Curated1
Sequence conflicti199L → Q in AAD00242 (PubMed:8702856).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019132181E → K1 PublicationCorresponds to variant dbSNP:rs28385682Ensembl.1
Natural variantiVAR_019133292E → K1 PublicationCorresponds to variant dbSNP:rs3218976Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042222297 – 398Missing in isoform Short. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59770 mRNA Translation: CAA42441.1
U64094 mRNA Translation: AAB05878.1
U74649 mRNA Translation: AAD00242.1
AY124010 Genomic DNA Translation: AAM64221.1
AC007165 Genomic DNA Translation: AAK52072.1
CH471127 Genomic DNA Translation: EAX01800.1
CH471127 Genomic DNA Translation: EAX01801.1
CH471127 Genomic DNA Translation: EAX01802.1
CH471127 Genomic DNA Translation: EAX01803.1
BC039031 mRNA Translation: AAH39031.1
CCDSiCCDS2054.1 [P27930-1]
CCDS58719.1 [P27930-2]
PIRiS17428
RefSeqiNP_001248348.1, NM_001261419.1 [P27930-2]
NP_004624.1, NM_004633.3 [P27930-1]
XP_006712797.1, XM_006712734.3 [P27930-1]
XP_011510106.1, XM_011511804.2 [P27930-1]
UniGeneiHs.25333

Genome annotation databases

EnsembliENST00000332549; ENSP00000330959; ENSG00000115590 [P27930-1]
ENST00000393414; ENSP00000377066; ENSG00000115590 [P27930-1]
ENST00000441002; ENSP00000414611; ENSG00000115590 [P27930-2]
GeneIDi7850
KEGGihsa:7850
UCSCiuc002tbm.4 human [P27930-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59770 mRNA Translation: CAA42441.1
U64094 mRNA Translation: AAB05878.1
U74649 mRNA Translation: AAD00242.1
AY124010 Genomic DNA Translation: AAM64221.1
AC007165 Genomic DNA Translation: AAK52072.1
CH471127 Genomic DNA Translation: EAX01800.1
CH471127 Genomic DNA Translation: EAX01801.1
CH471127 Genomic DNA Translation: EAX01802.1
CH471127 Genomic DNA Translation: EAX01803.1
BC039031 mRNA Translation: AAH39031.1
CCDSiCCDS2054.1 [P27930-1]
CCDS58719.1 [P27930-2]
PIRiS17428
RefSeqiNP_001248348.1, NM_001261419.1 [P27930-2]
NP_004624.1, NM_004633.3 [P27930-1]
XP_006712797.1, XM_006712734.3 [P27930-1]
XP_011510106.1, XM_011511804.2 [P27930-1]
UniGeneiHs.25333

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O4OX-ray3.30C14-343[»]
ProteinModelPortaliP27930
SMRiP27930
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113605, 43 interactors
DIPiDIP-61267N
IntActiP27930, 4 interactors
MINTiP27930
STRINGi9606.ENSP00000330959

PTM databases

iPTMnetiP27930
PhosphoSitePlusiP27930

Polymorphism and mutation databases

BioMutaiIL1R2
DMDMi124310

Proteomic databases

EPDiP27930
PaxDbiP27930
PeptideAtlasiP27930
PRIDEiP27930
ProteomicsDBi54427
54428 [P27930-2]

Protocols and materials databases

DNASUi7850
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332549; ENSP00000330959; ENSG00000115590 [P27930-1]
ENST00000393414; ENSP00000377066; ENSG00000115590 [P27930-1]
ENST00000441002; ENSP00000414611; ENSG00000115590 [P27930-2]
GeneIDi7850
KEGGihsa:7850
UCSCiuc002tbm.4 human [P27930-1]

Organism-specific databases

CTDi7850
DisGeNETi7850
EuPathDBiHostDB:ENSG00000115590.13
GeneCardsiIL1R2
HGNCiHGNC:5994 IL1R2
HPAiHPA027597
HPA027598
MIMi147811 gene
neXtProtiNX_P27930
OpenTargetsiENSG00000115590
PharmGKBiPA29810
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJCQ Eukaryota
ENOG410YQDP LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113036
HOVERGENiHBG052104
InParanoidiP27930
KOiK04387
OMAiCKVFLGA
OrthoDBiEOG091G077L
PhylomeDBiP27930
TreeFamiTF325519

Enzyme and pathway databases

ReactomeiR-HSA-6783783 Interleukin-10 signaling
R-HSA-9020702 Interleukin-1 signaling
SIGNORiP27930

Miscellaneous databases

ChiTaRSiIL1R2 human
EvolutionaryTraceiP27930
GeneWikiiInterleukin_1_receptor,_type_II
GenomeRNAii7850
PROiPR:P27930
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115590 Expressed in 185 organ(s), highest expression level in decidua
CleanExiHS_IL1R2
ExpressionAtlasiP27930 baseline and differential
GenevisibleiP27930 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR004077 IL-1_rcpt_II-typ
IPR013151 Immunoglobulin
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PRINTSiPR01539 INTRLEUKN1R2
PR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIL1R2_HUMAN
AccessioniPrimary (citable) accession number: P27930
Secondary accession number(s): D3DVJ5, Q6LCE6, Q9UE68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 7, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again