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Entry version 145 (12 Aug 2020)
Sequence version 1 (01 Aug 1992)
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Protein

Hexokinase-3

Gene

Hk3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:5871820). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:5871820).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Hexokinase is an allosteric enzyme inhibited by its product D-glucose 6-phosphate.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=6 µM for D-glucose1 Publication
  2. KM=1.2 mM for D-fructose1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: hexose metabolism

    This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

    Pathwayi: glycolysis

    This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.1 Publication
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. Hexokinase, Hexokinase (Hk3), Hexokinase-4 (Gck), Hexokinase-2 (Hk2), Phosphotransferase (Gck), Hexokinase-3 (Hk3), Hexokinase (Hk1), Hexokinase (Hk3), Phosphotransferase (Gck), Hexokinase-1 (Hk1), Hexokinase
    2. Glucose-6-phosphate isomerase (Gpi)
    3. ATP-dependent 6-phosphofructokinase (Pfkm), ATP-dependent 6-phosphofructokinase (Pfkp), ATP-dependent 6-phosphofructokinase (Pfkl), ATP-dependent 6-phosphofructokinase, muscle type (Pfkm), ATP-dependent 6-phosphofructokinase, liver type (Pfkl), ATP-dependent 6-phosphofructokinase, platelet type (Pfkp), ATP-dependent 6-phosphofructokinase (Pfkm), ATP-dependent 6-phosphofructokinase (Pfkp)
    4. Fructose-bisphosphate aldolase (Aldoc), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (Aldoart2), Fructose-bisphosphate aldolase B (Aldob), Fructose-bisphosphate aldolase A (Aldoa), Fructose-bisphosphate aldolase (Aldoc), Fructose-bisphosphate aldolase C (Aldoc), Fructose-bisphosphate aldolase (Aldoc), Fructose-bisphosphate aldolase (Aldob)
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei168Substrate 1By similarity1
    Binding sitei222Glucose-6-phosphate 1By similarity1
    Binding sitei245Glucose-6-phosphate 1By similarity1
    Binding sitei248Substrate 1By similarity1
    Binding sitei273Substrate 1By similarity1
    Binding sitei664Glucose-6-phosphate 2By similarity1
    Binding sitei687ATP 2By similarity1
    Binding sitei687Glucose-6-phosphate 2By similarity1
    Binding sitei715Substrate 2By similarity1
    Binding sitei749Substrate 2By similarity1
    Binding sitei904Glucose-6-phosphate 2By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi95 – 102ATP 1By similarity8
    Nucleotide bindingi438 – 439ATP 1By similarity2
    Nucleotide bindingi542 – 547ATP 2By similarity6
    Nucleotide bindingi754 – 755ATP 2By similarity2
    Nucleotide bindingi791 – 795ATP 2By similarity5
    Nucleotide bindingi870 – 874ATP 2By similarity5

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAllosteric enzyme, Kinase, Transferase
    Biological processGlycolysis
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-RNO-6798695, Neutrophil degranulation
    R-RNO-70171, Glycolysis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P27926

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00109;UER00180
    UPA00242

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Hexokinase-3Curated (EC:2.7.1.11 Publication)
    Alternative name(s):
    Hexokinase type III1 Publication
    Short name:
    HK III1 Publication
    Hexokinase-C1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Hk3Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

    Organism-specific databases

    Rat genome database

    More...
    RGDi
    2798, Hk3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3632

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001975921 – 924Hexokinase-3Add BLAST924

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P27926

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P27926

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P27926

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P27926

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P27926

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    247137, 10 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    10116.ENSRNOP00000031587

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P27926

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 471Hexokinase 1PROSITE-ProRule annotationAdd BLAST445
    Domaini477 – 913Hexokinase 2PROSITE-ProRule annotationAdd BLAST437

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 220Hexokinase small subdomain 1PROSITE-ProRule annotationAdd BLAST137
    Regioni95 – 104Glucose-6-phosphate 1 bindingBy similarity10
    Regioni185 – 186Substrate 1 bindingBy similarity2
    Regioni221 – 460Hexokinase large subdomain 1PROSITE-ProRule annotationAdd BLAST240
    Regioni221 – 222Substrate 1 bindingBy similarity2
    Regioni304 – 307Substrate 1 bindingBy similarity4
    Regioni426 – 428Glucose-6-phosphate 1 bindingBy similarity3
    Regioni531 – 662Hexokinase small subdomain 2PROSITE-ProRule annotationAdd BLAST132
    Regioni542 – 546Glucose-6-phosphate 2 bindingBy similarity5
    Regioni610 – 611Substrate 2 bindingBy similarity2
    Regioni627 – 628Substrate 2 bindingBy similarity2
    Regioni663 – 902Hexokinase large subdomain 2PROSITE-ProRule annotationAdd BLAST240
    Regioni663 – 664Substrate 2 bindingBy similarity2
    Regioni689 – 690Substrate 2 bindingBy similarity2
    Regioni868 – 870Glucose-6-phosphate 2 bindingBy similarity3

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The N- and C-terminal halves of this hexokinase contain a hexokinase domain. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.By similarity

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1369, Eukaryota

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P27926

    KEGG Orthology (KO)

    More...
    KOi
    K00844

    Database of Orthologous Groups

    More...
    OrthoDBi
    1153545at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P27926

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314238

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR043129, ATPase_NBD
    IPR001312, Hexokinase
    IPR019807, Hexokinase_BS
    IPR022673, Hexokinase_C
    IPR022672, Hexokinase_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR19443, PTHR19443, 2 hits

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00349, Hexokinase_1, 2 hits
    PF03727, Hexokinase_2, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53067, SSF53067, 4 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00378, HEXOKINASE_1, 2 hits
    PS51748, HEXOKINASE_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    P27926-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAAIEPSGLH PGERDSSCPQ EGIPRPSGSL ELAQEYLQQF KVTMTQLQQI
    60 70 80 90 100
    QASLLCSMEQ ALKGQDSPAP SVRMLPTYVR STPHGTEQGD FLVLELGATG
    110 120 130 140 150
    ASLRVLWVTL TGTKEHSVET RSQEFVIPQE VILGAGQQLF DFAARCLSEF
    160 170 180 190 200
    LDAYPVENQG LKLGFNFSFP CHQTGLDKST LISWTKGFRC SGVEGQDVVQ
    210 220 230 240 250
    LLRDAIQRQG TYNIDVVAMV NDTVGTMMGC ELGTRPCEVG LIVDTGTNAC
    260 270 280 290 300
    YMEEARHVAA LDEDRGRTCV SIEWGSFYDE EALGPVLTTF DDALDHESLV
    310 320 330 340 350
    PGAQRFEKMI GGLYLGELVR LVLVHLSQHG VLFGGCASPA LLSQNSILLE
    360 370 380 390 400
    HVAKMEDPAT GIAHVHTVLQ GLGLSPQASD AELVQRVCMA VCTRAAQLCA
    410 420 430 440 450
    SALAAVLSRL QHSREQQTLH VAVATGGRVF EWHPRFLCIL KETVMLLAPE
    460 470 480 490 500
    CDVSFIPSVD GGGRGVAMVT AVAARLATHR RILEETLAPF QLSLEQLTAV
    510 520 530 540 550
    QAQMREAMIR GLQGESSSLR MLPTYVRATP DGSERGDFLA LDLGGTNFRV
    560 570 580 590 600
    LLVRVAEGSV QITNQVYSIP EYVAQGSGQK LFDHIVDCIV DFQKRQGLSG
    610 620 630 640 650
    QSLPLGFTFS FPCKQLGLDQ GILLNWTKGF NASGCEGQDV VYLLREAIRR
    660 670 680 690 700
    RQAVELNVVA IVNDTVGTMM SCGYDDPCCE MGLIVGTGTN ACYMEELRNV
    710 720 730 740 750
    ASVPGDSGHM CINMEWGAFG DDGSLSMLGT CFDASVDQAS INPGKQRFEK
    760 770 780 790 800
    MISGMYLGEI VRHILLHLTS LGVLFRGQKT QCLQTRDIFK TKFLSEIESD
    810 820 830 840 850
    SLALRQVRAI LEDLGLTLTS DDALMVLEVC QAVSRRAAQL CGAGVAAVVE
    860 870 880 890 900
    KIRENRGLQE LTVSVGVDGT LYKLHPHFSR LVSVTVRKLA PQCTVTFLQS
    910 920
    EDGSGKGAAL VTRVACRLTQ MACV
    Length:924
    Mass (Da):100,254
    Last modified:August 1, 1992 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0162C1591AF040AC
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0G2JST6A0A0G2JST6_RAT
    Hexokinase
    Hk3 rCG_24230
    924Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0G2JTY2A0A0G2JTY2_RAT
    Hexokinase
    Hk3
    963Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti913R → A in AAI00649 (PubMed:15489334).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U73859 mRNA Translation: AAB18253.1
    BC100648 mRNA Translation: AAI00649.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S13913

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_071515.1, NM_022179.2
    XP_006253664.1, XM_006253602.3
    XP_006253665.1, XM_006253603.3
    XP_008769706.1, XM_008771484.1

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    25060

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    rno:25060

    UCSC genome browser

    More...
    UCSCi
    RGD:2798, rat

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U73859 mRNA Translation: AAB18253.1
    BC100648 mRNA Translation: AAI00649.1
    PIRiS13913
    RefSeqiNP_071515.1, NM_022179.2
    XP_006253664.1, XM_006253602.3
    XP_006253665.1, XM_006253603.3
    XP_008769706.1, XM_008771484.1

    3D structure databases

    SMRiP27926
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi247137, 10 interactors
    STRINGi10116.ENSRNOP00000031587

    Chemistry databases

    ChEMBLiCHEMBL3632

    PTM databases

    iPTMnetiP27926
    PhosphoSitePlusiP27926

    Proteomic databases

    jPOSTiP27926
    PaxDbiP27926
    PRIDEiP27926

    Genome annotation databases

    GeneIDi25060
    KEGGirno:25060
    UCSCiRGD:2798, rat

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    3101
    RGDi2798, Hk3

    Phylogenomic databases

    eggNOGiKOG1369, Eukaryota
    InParanoidiP27926
    KOiK00844
    OrthoDBi1153545at2759
    PhylomeDBiP27926
    TreeFamiTF314238

    Enzyme and pathway databases

    UniPathwayiUPA00109;UER00180
    UPA00242
    ReactomeiR-RNO-6798695, Neutrophil degranulation
    R-RNO-70171, Glycolysis
    SABIO-RKiP27926

    Miscellaneous databases

    Protein Ontology

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    PROi
    PR:P27926

    Family and domain databases

    InterProiView protein in InterPro
    IPR043129, ATPase_NBD
    IPR001312, Hexokinase
    IPR019807, Hexokinase_BS
    IPR022673, Hexokinase_C
    IPR022672, Hexokinase_N
    PANTHERiPTHR19443, PTHR19443, 2 hits
    PfamiView protein in Pfam
    PF00349, Hexokinase_1, 2 hits
    PF03727, Hexokinase_2, 2 hits
    SUPFAMiSSF53067, SSF53067, 4 hits
    PROSITEiView protein in PROSITE
    PS00378, HEXOKINASE_1, 2 hits
    PS51748, HEXOKINASE_2, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXK3_RAT
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27926
    Secondary accession number(s): Q497A1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: August 12, 2020
    This is version 145 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
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