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UniProtKB - P27884 (CAC1A_RABIT)

Entry version 152 (02 Jun 2021)
Sequence version 1 (01 Jul 1993)
Previous versions | rss
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Protein

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Gene

CACNA1A

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity).

They are however insensitive to dihydropyridines (DHP).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei318Calcium ion selectivity and permeabilityBy similarity1
Sitei668Calcium ion selectivity and permeabilityBy similarity1
Sitei1469Calcium ion selectivity and permeabilityBy similarity1
Sitei1658Binds to omega-Aga-IVA1
Sitei1765Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi1849 – 1860By similarityAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Alternative name(s):
Brain calcium channel I
Short name:
BI
Calcium channel, L type, alpha-1 polypeptide isoform 4
Voltage-gated calcium channel subunit alpha Cav2.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1A
Synonyms:CACH4, CACN3, CACNL1A4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 98CytoplasmicSequence analysisAdd BLAST98
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei99 – 117Helical; Name=S1 of repeat ISequence analysisAdd BLAST19
Topological domaini118 – 135ExtracellularSequence analysisAdd BLAST18
Transmembranei136 – 155Helical; Name=S2 of repeat ISequence analysisAdd BLAST20
Topological domaini156 – 167CytoplasmicSequence analysisAdd BLAST12
Transmembranei168 – 185Helical; Name=S3 of repeat ISequence analysisAdd BLAST18
Topological domaini186 – 190ExtracellularSequence analysis5
Transmembranei191 – 209Helical; Name=S4 of repeat ISequence analysisAdd BLAST19
Topological domaini210 – 228CytoplasmicSequence analysisAdd BLAST19
Transmembranei229 – 248Helical; Name=S5 of repeat ISequence analysisAdd BLAST20
Topological domaini249 – 335ExtracellularSequence analysisAdd BLAST87
Transmembranei336 – 360Helical; Name=S6 of repeat ISequence analysisAdd BLAST25
Topological domaini361 – 487CytoplasmicSequence analysisAdd BLAST127
Transmembranei488 – 506Helical; Name=S1 of repeat IISequence analysisAdd BLAST19
Topological domaini507 – 521ExtracellularSequence analysisAdd BLAST15
Transmembranei522 – 541Helical; Name=S2 of repeat IISequence analysisAdd BLAST20
Topological domaini542 – 549CytoplasmicSequence analysis8
Transmembranei550 – 568Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini569 – 578ExtracellularSequence analysis10
Transmembranei579 – 597Helical; Name=S4 of repeat IISequence analysisAdd BLAST19
Topological domaini598 – 616CytoplasmicSequence analysisAdd BLAST19
Transmembranei617 – 636Helical; Name=S5 of repeat IISequence analysisAdd BLAST20
Topological domaini637 – 689ExtracellularSequence analysisAdd BLAST53
Transmembranei690 – 714Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini715 – 1253CytoplasmicSequence analysisAdd BLAST539
Transmembranei1254 – 1272Helical; Name=S1 of repeat IIISequence analysisAdd BLAST19
Topological domaini1273 – 1288ExtracellularSequence analysisAdd BLAST16
Transmembranei1289 – 1308Helical; Name=S2 of repeat IIISequence analysisAdd BLAST20
Topological domaini1309 – 1320CytoplasmicSequence analysisAdd BLAST12
Transmembranei1321 – 1339Helical; Name=S3 of repeat IIISequence analysisAdd BLAST19
Topological domaini1340 – 1350ExtracellularSequence analysisAdd BLAST11
Transmembranei1351 – 1369Helical; Name=S4 of repeat IIISequence analysisAdd BLAST19
Topological domaini1370 – 1388CytoplasmicSequence analysisAdd BLAST19
Transmembranei1389 – 1408Helical; Name=S5 of repeat IIISequence analysisAdd BLAST20
Topological domaini1409 – 1495ExtracellularSequence analysisAdd BLAST87
Transmembranei1496 – 1520Helical; Name=S6 of repeat IIISequence analysisAdd BLAST25
Topological domaini1521 – 1575CytoplasmicSequence analysisAdd BLAST55
Transmembranei1576 – 1604Helical; Name=S1 of repeat IVSequence analysisAdd BLAST29
Topological domaini1605 – 1609ExtracellularSequence analysis5
Transmembranei1610 – 1629Helical; Name=S2 of repeat IVSequence analysisAdd BLAST20
Topological domaini1630 – 1637CytoplasmicSequence analysis8
Transmembranei1638 – 1656Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1657 – 1665ExtracellularSequence analysis9
Transmembranei1666 – 1684Helical; Name=S4 of repeat IVSequence analysisAdd BLAST19
Topological domaini1685 – 1703CytoplasmicSequence analysisAdd BLAST19
Transmembranei1704 – 1723Helical; Name=S5 of repeat IVSequence analysisAdd BLAST20
Topological domaini1724 – 1795ExtracellularSequence analysisAdd BLAST72
Transmembranei1796 – 1820Helical; Name=S6 of repeat IVSequence analysisAdd BLAST25
Topological domaini1821 – 2424CytoplasmicSequence analysisAdd BLAST604

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi188E → K: No change in inhibition by omega-Aga-IVA. 1 Publication1
Mutagenesisi386E → S: Reduced beta-subunit interaction. 1 Publication1
Mutagenesisi389L → H: Reduced beta-subunit interaction. 1 Publication1
Mutagenesisi392Y → S: Reduced beta-subunit interaction. 1 Publication1
Mutagenesisi400E → A: No effect on beta-subunit interaction. 1 Publication1
Mutagenesisi1658E → K: Loss of inhibition by omega-Aga-IVA. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539181 – 2424Voltage-dependent P/Q-type calcium channel subunit alpha-1AAdd BLAST2424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei409PhosphothreonineBy similarity1
Modified residuei448PhosphoserineBy similarity1
Modified residuei451PhosphoserineBy similarity1
Modified residuei750PhosphoserineBy similarity1
Modified residuei753PhosphoserineBy similarity1
Modified residuei790PhosphoserineBy similarity1
Modified residuei1091PhosphoserineBy similarity1
Modified residuei1104PhosphoserineBy similarity1
Glycosylationi1665N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1993PhosphothreonineBy similarity1
Modified residuei2054PhosphoserineBy similarity1
Modified residuei2072PhosphoserineBy similarity1
Modified residuei2084PhosphoserineBy similarity1
Modified residuei2086PhosphoserineBy similarity1
Modified residuei2127PhosphoserineBy similarity1
Modified residuei2148PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P27884

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain specific. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Interacts with CABP1 (By similarity).

Interacts with the spider omega-agatoxin-IVA (AC P30288).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		1172286, 4 interactors

Database of interacting proteins

More...DIPi		DIP-29591N

Protein interaction database and analysis system

More...IntActi		P27884, 3 interactors

STRING: functional protein association networks

More...STRINGi		9986.ENSOCUP00000010319

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P27884

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P27884

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P27884

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati85 – 363IAdd BLAST279
Repeati473 – 717IIAdd BLAST245
Repeati1240 – 1523IIIAdd BLAST284
Repeati1560 – 1823IVAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni383 – 400Binding to the beta subunitAdd BLAST18
Regioni819 – 1229DisorderedSequence analysisAdd BLAST411
Regioni1997 – 2424DisorderedSequence analysisAdd BLAST428

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi828 – 843Polar residuesSequence analysisAdd BLAST16
Compositional biasi853 – 874Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi896 – 910Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi957 – 997Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi1018 – 1044Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1047 – 1065Polar residuesSequence analysisAdd BLAST19
Compositional biasi1104 – 1138Polar residuesSequence analysisAdd BLAST35
Compositional biasi1149 – 1171Polar residuesSequence analysisAdd BLAST23
Compositional biasi1202 – 1221Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi2037 – 2051Polar residuesSequence analysisAdd BLAST15
Compositional biasi2143 – 2162Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi2213 – 2231Basic residuesSequence analysisAdd BLAST19
Compositional biasi2281 – 2302Basic residuesSequence analysisAdd BLAST22
Compositional biasi2369 – 2389Pro residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2301, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P27884

Identification of Orthologs from Complete Genome Data

More...OMAi		QEMSQKV

Database of Orthologous Groups

More...OrthoDBi		172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005448, CACNA1A
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00167, CACHANNEL
PR01632, PQVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform BI-2 (identifier: P27884-1) [UniParc]FASTAAdd to basket
Also known as: 1A-2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARFGDEMPA RYGGGGAGAA AGVVVGAAGG RGAGGSRQGG QPGAQRMYKQ 
        60         70         80         90        100
SMAQRARTMA LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF 
       110        120        130        140        150
EYMILATIIA NCIVLALEQH LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI 
       160        170        180        190        200
KIIALGFAFH KGSYLRNGWN VMDFVVVLTG ILATVGTEFD LRTLRAVRVL 
       210        220        230        240        250
RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF AIIGLEFYMG 
       260        270        280        290        300
KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTRCQPY WEGPNNGITQ 
       310        320        330        340        350
FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF 
       360        370        380        390        400
MLNLVLGVLS GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE 
       410        420        430        440        450
EVILAEDETD VEQRHPFDGA LRRATIKKSK TDLLHPEEAE DQLADIASVG 
       460        470        480        490        500
SPFARASIKS AKLENSSFFH KKERRMRFYI RRMVKTQAFY WTVLSLVALN 
       510        520        530        540        550
TLCVAIVHYN QPEWLSDFLY YAEFIFLGLF MSEMFIKMYG LGTRPYFHSS 
       560        570        580        590        600
FNCFDCGVII GSIFEVIWAV IKPGTSFGIS VLRALRLLRI FKVTKYWASL 
       610        620        630        640        650
RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFDEGTPPTN 
       660        670        680        690        700
FDTFPAAIMT VFQILTGEDW NEVMYDGIKS QGGVQGGMVF SIYFIVLTLF 
       710        720        730        740        750
GNYTLLNVFL AIAVDNLANA QELTKDEQEE EEAVNQKLAL QKAKEVAEVS 
       760        770        780        790        800
PLSAANMSIA MKEQQKNQKP AKSVWEQRTS EMRKQNLLAS REALYSEMDP 
       810        820        830        840        850
EERWKASYAR HLRPDMKTHL DRPLVVDPQE NRNNNTNKSR VAEPTVDQRL 
       860        870        880        890        900
GQQRAEDFLR KQARHHDRAR DPSAHAAAGL DARRPWAGSQ EAELSREGPY 
       910        920        930        940        950
GRESDHQARE GGLEPPGFWE GEAERGKAGD PHRRHAHRQG VGGSGGSRSG 
       960        970        980        990       1000
SPRTGTADGE PRRHRVHRRP GEDGPDDKAE RRGRHREGSR PARSGEGEAE 
      1010       1020       1030       1040       1050
GPDGGGGGGG ERRRRHRHGP PPAYDPDARR DDRERRHRRR KDTQGSGVPV 
      1060       1070       1080       1090       1100
SGPNLSTTRP IQQDLSRQEP PLAEDMDNLK NSRLATAEPV SPHENLSHAG 
      1110       1120       1130       1140       1150
LPQSPAKMGS STDPAGPTPA TAANPQNSTA SRRTPNNPGN PSNPGPPKTP 
      1160       1170       1180       1190       1200
ENSLIVTNPS TAQTNSAKTA RKPDHTTVEI PPACPPPLNH TVVQVNKNAN 
      1210       1220       1230       1240       1250
PDPLPKKEDE KKEEVDEGPG EDGPKPMPPY SSMFILSTTN PLRRLCHYIL 
      1260       1270       1280       1290       1300
NLRYFEMCIL MVIAMSSIAL AAEDPVQPNA PRNNVLRYFD YVFTGVFTFE 
      1310       1320       1330       1340       1350
MVIKMIDLGL VLHQGAYFRD LWNILDFIVV SGALVAFAFT GNSKGKDINT 
      1360       1370       1380       1390       1400
IKSLRVLRVL RPLKTIKRLP KLKAVFDCVV NSLKNVFNIL IVYMLFMFIF 
      1410       1420       1430       1440       1450
AVVAVQLFKG KFFHCTDESK EFEKDCRGKY LLYEKNEVKA RDREWKKYEF 
      1460       1470       1480       1490       1500
HYDNVLWALL TLFTVSTGEG WPQVLKHSVD ATFENQGPSP GYRMEMSIFY 
      1510       1520       1530       1540       1550
VVYFVVFPFF FVNIFVALII ITFQEQGDKM MEEYSLEKNE RACIDFAISA 
      1560       1570       1580       1590       1600
KPLTRHMPQN KQSFQYRMWQ FVVSPPFEYT IMAMIALNTI VLMMKFYGAS 
      1610       1620       1630       1640       1650
VAYDNALKVF NIVFTSLFSL ECLLKVLAFG ILNYFRDAWN IFDFVTVLGS 
      1660       1670       1680       1690       1700
ITDILVTEFG NNFINLSFLR LFRAARLIKL LRQGYTIRIL LWTFVQSFKA 
      1710       1720       1730       1740       1750
LPYVCLLIAM LFFIYAIIGM QVFGNIGIDM EDEDSDEDEF QITEHNNFRT 
      1760       1770       1780       1790       1800
FFQALMLLFR SATGEAWHNI MLSCLSGKPC DKNSGILTPE CGNEFAYFYF 
      1810       1820       1830       1840       1850
VSFIFLCSFL MLNLFVAVIM DNFEYLTRDS SILGPHHLDE YVRVWAEYDP 
      1860       1870       1880       1890       1900
AAWGRMLYRD MYAMLRHMPP PLGLGKNCPA RVAYKRLLRM DLPVADDNTV 
      1910       1920       1930       1940       1950
HFNSTLMALI RTALDIKIAK GGADKQQMDA ELRKEMMAIW PNLSQKTLDL 
      1960       1970       1980       1990       2000
LVTPHKSTDL TVGKIYAAMM IMEYYRQSKA KKLQAMREEQ NRTPLMFQRM 
      2010       2020       2030       2040       2050
EPPPDEGGAG QNALPSTQLD PAGGLMAHED GLKDSPSWVT QRAQEMFQKT 
      2060       2070       2080       2090       2100
GTWSPERAPP ADMADSQPKP QSVEMREMSQ DGYSDSEHCL PMEGQARAAS 
      2110       2120       2130       2140       2150
MPRLPAENQR RRGRPRGSDL STICDTSPMK RSASVLGPKA SRRLDDYSLE 
      2160       2170       2180       2190       2200
RVPPEENQRH HPRRRERAHR TSERSLGRYT DVDTGLGTDL SMTTQSGDLP 
      2210       2220       2230       2240       2250
SREREQERGR PKDRKHRPHH HHHHHHHPGR GPGRVSPGVS ARRRRRGPVA 
      2260       2270       2280       2290       2300
RVRPARAPAL AHARARARAP ARLLPELRLR RARRPRPRQR RRPRRRRGGG 
      2310       2320       2330       2340       2350
GRALRRAPGP REPLAQDSPG RGPSVCLARA ARPAGPQRLL PGPRTGQAPR 
      2360       2370       2380       2390       2400
ARLPQKPARS VQRERRGLVL SPPPPPPGEL APRAHPARTP RPGPGDSRSR 
      2410       2420 
RGGRRWTASA GKGGGGPRAS APSP
Length:2,424
Mass (Da):273,231
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7CC4D0AB4B45604
GO
Isoform BI-1 (identifier: P27884-2) [UniParc]FASTAAdd to basket
Also known as: 1A-1

The sequence of this isoform differs from the canonical sequence as follows:
     2230-2273: RGPGRVSPGV...RARARAPARL → PAAADKERYG...EGREHTTHRQ
     2274-2424: Missing.

Show »
Length:2,273
Mass (Da):257,351
Checksum:iB14B3FA4E801D8D4
GO
Isoform CBP101 (identifier: P27884-3) [UniParc]FASTAAdd to basket
Also known as: CBP109

The sequence of this isoform differs from the canonical sequence as follows:
     1857-1884: LYRDMYAMLRHMPPPLGLGKNCPARVAY → HYKDMYSLLRVISPPLGLGKKCPHRVAC

Show »
Length:2,424
Mass (Da):273,179
Checksum:iFADE1090207B5822
GO
Isoform CBP103 (identifier: P27884-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     772-1120: Missing.

Show »
Length:2,075
Mass (Da):234,541
Checksum:i7EB161F547B14151
GO
Isoform CBP107 (identifier: P27884-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     772-1051: Missing.

Show »
Length:2,144
Mass (Da):241,749
Checksum:i726B65549B57B475
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti419Missing in isoform CBP315. 1
Natural varianti877A → T in isoform CBS. 1
Natural varianti1104S → N in isoform CBS. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000877772 – 1120Missing in isoform CBP103. CuratedAdd BLAST349
Alternative sequenceiVSP_000876772 – 1051Missing in isoform CBP107. CuratedAdd BLAST280
Alternative sequenceiVSP_0008781857 – 1884LYRDM…ARVAY → HYKDMYSLLRVISPPLGLGK KCPHRVAC in isoform CBP101. CuratedAdd BLAST28
Alternative sequenceiVSP_0008792230 – 2273RGPGR…APARL → PAAADKERYGPQDRPDHGHG RARARDQRWSRSPSEGREHT THRQ in isoform BI-1. CuratedAdd BLAST44
Alternative sequenceiVSP_0008802274 – 2424Missing in isoform BI-1. CuratedAdd BLAST151

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X57477 mRNA Translation: CAA40715.1
X57689 mRNA Translation: CAA40872.1
X57476 mRNA Translation: CAA40714.1
X57688 mRNA Translation: CAA40871.1

Protein sequence database of the Protein Information Resource

More...PIRi		I46477
I46480

NCBI Reference Sequences

More...RefSeqi		NP_001095163.1, NM_001101693.1 [P27884-2]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100009265

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ocu:100009265

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57477 mRNA Translation: CAA40715.1
X57689 mRNA Translation: CAA40872.1
X57476 mRNA Translation: CAA40714.1
X57688 mRNA Translation: CAA40871.1
PIRiI46477
I46480
RefSeqiNP_001095163.1, NM_001101693.1 [P27884-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DVMX-ray2.60B1963-1982[»]
BMRBiP27884
SMRiP27884
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi1172286, 4 interactors
DIPiDIP-29591N
IntActiP27884, 3 interactors
STRINGi9986.ENSOCUP00000010319

Proteomic databases

PRIDEiP27884

Genome annotation databases

GeneIDi100009265
KEGGiocu:100009265

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		773

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
InParanoidiP27884
OMAiQEMSQKV
OrthoDBi172471at2759

Miscellaneous databases

EvolutionaryTraceiP27884

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005448, CACNA1A
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01632, PQVDCCALPHA1
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1A_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27884
Secondary accession number(s): P27883
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 2, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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