UniProtKB - P27870 (VAV_MOUSE)
Proto-oncogene vav
Vav1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 515 – 564 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 50 |
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: MGI
- metal ion binding Source: UniProtKB-KW
- phosphorylation-dependent protein binding Source: UniProtKB
- phosphotyrosine residue binding Source: MGI
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: MGI
- immune response Source: MGI
- integrin-mediated signaling pathway Source: MGI
- intracellular signal transduction Source: MGI
- neutrophil chemotaxis Source: MGI
- phagocytosis Source: MGI
- positive regulation of cell adhesion Source: MGI
- positive regulation of GTPase activity Source: MGI
- positive regulation of natural killer cell mediated cytotoxicity Source: MGI
- reactive oxygen species metabolic process Source: MGI
- regulation of cell size Source: Ensembl
- regulation of GTPase activity Source: MGI
- small GTPase mediated signal transduction Source: InterPro
- T cell activation Source: MGI
- T cell differentiation Source: MGI
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-114604, GPVI-mediated activation cascade R-MMU-1257604, PIP3 activates AKT signaling R-MMU-1433557, Signaling by SCF-KIT R-MMU-193648, NRAGE signals death through JNK R-MMU-194840, Rho GTPase cycle R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-2871796, FCERI mediated MAPK activation R-MMU-2871809, FCERI mediated Ca+2 mobilization R-MMU-389359, CD28 dependent Vav1 pathway R-MMU-416482, G alpha (12/13) signalling events R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-MMU-5218920, VEGFR2 mediated vascular permeability R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-9027284, Erythropoietin activates RAS R-MMU-912631, Regulation of signaling by CBL R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Names & Taxonomyi
Protein namesi | Recommended name: Proto-oncogene vavAlternative name(s): p95vav |
Gene namesi | Name:Vav1 Synonyms:Vav |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98923, Vav1 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 529 | C → S: Abolishes transforming activity. 1 Publication | 1 | |
Mutagenesisi | 532 | C → S: Abolishes transforming activity. 1 Publication | 1 | |
Mutagenesisi | 554 | H → D: Abolishes transforming activity. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogenePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080981 | 1 – 845 | Proto-oncogene vavAdd BLAST | 845 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 826 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 844 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P27870 |
jPOSTi | P27870 |
PaxDbi | P27870 |
PeptideAtlasi | P27870 |
PRIDEi | P27870 |
ProteomicsDBi | 298277 |
PTM databases
iPTMneti | P27870 |
PhosphoSitePlusi | P27870 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000034116, Expressed in frontal cortex and 191 other tissues |
ExpressionAtlasi | P27870, baseline and differential |
Genevisiblei | P27870, MM |
Interactioni
Subunit structurei
Interacts with SHB (By similarity).
Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK.
Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion.
Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:10646609, PubMed:10646608). May interact with CCPG1 (PubMed:17000758).
Interacts with CLNK (PubMed:11463797).
Interacts with THEMIS2 (PubMed:20644716).
Interacts with NEK3 and this interaction is prolactin-dependent.
Interacts with ITK.
Interacts with PTK2B/PYK2 (By similarity).
Interacts with HCK.
Interacts with PTK2B/PYK2.
Interacts (via SH2 domain) with SYK (By similarity).
Interacts with ANKRD54 (PubMed:19064729).
Interacts with CD6 (PubMed:24584089).
Interacts with isoform 2 of CRACR2A (By similarity).
By similarity9 PublicationsBinary interactionsi
P27870
With | #Exp. | IntAct |
---|---|---|
NCF2 [P19878] from Homo sapiens. | 4 | EBI-1697,EBI-489611 |
GO - Molecular functioni
- phosphorylation-dependent protein binding Source: UniProtKB
- phosphotyrosine residue binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204500, 28 interactors |
DIPi | DIP-31010N |
IntActi | P27870, 14 interactors |
MINTi | P27870 |
STRINGi | 10090.ENSMUSP00000005889 |
Miscellaneous databases
RNActi | P27870, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P27870 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P27870 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 119 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 194 – 373 | DHPROSITE-ProRule annotationAdd BLAST | 180 | |
Domaini | 402 – 504 | PHPROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 592 – 660 | SH3 1PROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 671 – 765 | SH2PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 782 – 842 | SH3 2PROSITE-ProRule annotationAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 99 | Leu-richAdd BLAST | 67 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 515 – 564 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 50 |
Keywords - Domaini
Repeat, SH2 domain, SH3 domain, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2996, Eukaryota |
GeneTreei | ENSGT00940000159125 |
HOGENOMi | CLU_013787_0_0_1 |
InParanoidi | P27870 |
OrthoDBi | 710582at2759 |
PhylomeDBi | P27870 |
TreeFami | TF316171 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd01223, PH_Vav, 1 hit cd00160, RhoGEF, 1 hit cd10405, SH2_Vav1, 1 hit cd11979, SH3_VAV1_1, 1 hit cd11976, SH3_VAV1_2, 1 hit |
Gene3Di | 1.10.418.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR022613, CAMSAP_CH IPR001715, CH-domain IPR036872, CH_dom_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037832, PH_Vav IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003096, SM22_calponin IPR028530, Vav1 IPR035879, VAV1_SH2 IPR035730, VAV1_SH3_1 IPR035729, VAV1_SH3_2 |
PANTHERi | PTHR45818:SF2, PTHR45818:SF2, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF11971, CAMSAP_CH, 1 hit PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00033, CH, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL
60 70 80 90 100
LPQAINLREV NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF
110 120 130 140 150
DVQDFGKVIY TLSALSWTPI AQNKGIMPFP TEDSALNDED IYSGLSDQID
160 170 180 190 200
DTAEEDEDLY DCVENEEAEG DEIYEDLMRL ESVPTPPKMT EYDKRCCCLR
210 220 230 240 250
EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDMETIFVNI EELFSVHTHF
260 270 280 290 300
LKELKDALAG PGATTLYQVF IKYKERFLVY GRYCSQVESA SKHLDQVATA
310 320 330 340 350
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDA
360 370 380 390 400
TEKENLRLAL DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLANY
410 420 430 440 450
GRPKIDGELK ITSVERRSKT DRYAFLLDKA LLICKRRGDS YDLKASVNLH
460 470 480 490 500
SFQVRDDSSG ERDNKKWSHM FLLIEDQGAQ GYELFFKTRE LKKKWMEQFE
510 520 530 540 550
MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF YQGYRCYRCR
560 570 580 590 600
APAHKECLGR VPPCGRHGQD FAGTMKKDKL HRRAQDKKRN ELGLPKMEVF
610 620 630 640 650
QEYYGIPPPP GAFGPFLRLN PGDIVELTKA EAEHNWWEGR NTATNEVGWF
660 670 680 690 700
PCNRVHPYVH GPPQDLSVHL WYAGPMERAG AEGILTNRSD GTYLVRQRVK
710 720 730 740 750
DTAEFAISIK YNVEVKHIKI MTSEGLYRIT EKKAFRGLLE LVEFYQQNSL
760 770 780 790 800
KDCFKSLDTT LQFPYKEPER RAISKPPAGS TKYFGTAKAR YDFCARDRSE
810 820 830 840
LSLKEGDIIK ILNKKGQQGW WRGEIYGRIG WFPSNYVEED YSEYC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PXI0 | E9PXI0_MOUSE | Proto-oncogene vav | Vav1 | 821 | Annotation score: | ||
Q8VDU4 | Q8VDU4_MOUSE | Proto-oncogene vav | Vav1 | 806 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 29 | Q → E in AAA63402 (PubMed:2005887).Curated | 1 | |
Sequence conflicti | 226 | R → L in BAC40436 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64361 mRNA Translation: CAA45713.1 AK088586 mRNA Translation: BAC40436.1 M59833 mRNA Translation: AAA63402.1 |
CCDSi | CCDS28931.1 |
PIRi | A61187, TVMSVV |
RefSeqi | NP_035821.3, NM_011691.4 |
Genome annotation databases
Ensembli | ENSMUST00000005889; ENSMUSP00000005889; ENSMUSG00000034116 |
GeneIDi | 22324 |
KEGGi | mmu:22324 |
UCSCi | uc008dep.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64361 mRNA Translation: CAA45713.1 AK088586 mRNA Translation: BAC40436.1 M59833 mRNA Translation: AAA63402.1 |
CCDSi | CCDS28931.1 |
PIRi | A61187, TVMSVV |
RefSeqi | NP_035821.3, NM_011691.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F5X | NMR | - | A | 170-375 | [»] | |
1GCP | X-ray | 2.10 | A/B/C/D | 595-660 | [»] | |
1GCQ | X-ray | 1.68 | C | 595-660 | [»] | |
1K1Z | NMR | - | A | 583-660 | [»] | |
2KBT | NMR | - | A | 784-844 | [»] | |
2VRW | X-ray | 1.85 | B | 170-575 | [»] | |
SMRi | P27870 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204500, 28 interactors |
DIPi | DIP-31010N |
IntActi | P27870, 14 interactors |
MINTi | P27870 |
STRINGi | 10090.ENSMUSP00000005889 |
PTM databases
iPTMneti | P27870 |
PhosphoSitePlusi | P27870 |
Proteomic databases
EPDi | P27870 |
jPOSTi | P27870 |
PaxDbi | P27870 |
PeptideAtlasi | P27870 |
PRIDEi | P27870 |
ProteomicsDBi | 298277 |
Protocols and materials databases
Antibodypediai | 665, 742 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000005889; ENSMUSP00000005889; ENSMUSG00000034116 |
GeneIDi | 22324 |
KEGGi | mmu:22324 |
UCSCi | uc008dep.2, mouse |
Organism-specific databases
CTDi | 7409 |
MGIi | MGI:98923, Vav1 |
Phylogenomic databases
eggNOGi | KOG2996, Eukaryota |
GeneTreei | ENSGT00940000159125 |
HOGENOMi | CLU_013787_0_0_1 |
InParanoidi | P27870 |
OrthoDBi | 710582at2759 |
PhylomeDBi | P27870 |
TreeFami | TF316171 |
Enzyme and pathway databases
Reactomei | R-MMU-114604, GPVI-mediated activation cascade R-MMU-1257604, PIP3 activates AKT signaling R-MMU-1433557, Signaling by SCF-KIT R-MMU-193648, NRAGE signals death through JNK R-MMU-194840, Rho GTPase cycle R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-2871796, FCERI mediated MAPK activation R-MMU-2871809, FCERI mediated Ca+2 mobilization R-MMU-389359, CD28 dependent Vav1 pathway R-MMU-416482, G alpha (12/13) signalling events R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-MMU-5218920, VEGFR2 mediated vascular permeability R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-9027284, Erythropoietin activates RAS R-MMU-912631, Regulation of signaling by CBL R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Miscellaneous databases
BioGRID-ORCSi | 22324, 2 hits in 52 CRISPR screens |
ChiTaRSi | Vav1, mouse |
EvolutionaryTracei | P27870 |
PROi | PR:P27870 |
RNActi | P27870, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034116, Expressed in frontal cortex and 191 other tissues |
ExpressionAtlasi | P27870, baseline and differential |
Genevisiblei | P27870, MM |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd01223, PH_Vav, 1 hit cd00160, RhoGEF, 1 hit cd10405, SH2_Vav1, 1 hit cd11979, SH3_VAV1_1, 1 hit cd11976, SH3_VAV1_2, 1 hit |
Gene3Di | 1.10.418.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR022613, CAMSAP_CH IPR001715, CH-domain IPR036872, CH_dom_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037832, PH_Vav IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003096, SM22_calponin IPR028530, Vav1 IPR035879, VAV1_SH2 IPR035730, VAV1_SH3_1 IPR035729, VAV1_SH3_2 |
PANTHERi | PTHR45818:SF2, PTHR45818:SF2, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF11971, CAMSAP_CH, 1 hit PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00033, CH, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VAV_MOUSE | |
Accessioni | P27870Primary (citable) accession number: P27870 Secondary accession number(s): Q8BTV7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 214 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references