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Protein

Proto-oncogene vav

Gene

Vav1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri515 – 564Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • phosphotyrosine residue binding Source: MGI
  • Rac guanyl-nucleotide exchange factor activity Source: MGI
  • Rho guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • immune response Source: MGI
  • integrin-mediated signaling pathway Source: MGI
  • intracellular signal transduction Source: MGI
  • neutrophil chemotaxis Source: MGI
  • phagocytosis Source: MGI
  • positive regulation of cell adhesion Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of natural killer cell mediated cytotoxicity Source: MGI
  • reactive oxygen species metabolic process Source: MGI
  • regulation of cell size Source: Ensembl
  • regulation of GTPase activity Source: MGI
  • regulation of Rho protein signal transduction Source: InterPro
  • small GTPase mediated signal transduction Source: InterPro
  • T cell activation Source: MGI
  • T cell differentiation Source: MGI

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1433557 Signaling by SCF-KIT
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-389359 CD28 dependent Vav1 pathway
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-512988 Interleukin-3, 5 and GM-CSF signaling
R-MMU-5218920 VEGFR2 mediated vascular permeability
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-912631 Regulation of signaling by CBL
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene vav
Alternative name(s):
p95vav
Gene namesi
Name:Vav1
Synonyms:Vav
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98923 Vav1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi529C → S: Abolishes transforming activity. 1 Publication1
Mutagenesisi532C → S: Abolishes transforming activity. 1 Publication1
Mutagenesisi554H → D: Abolishes transforming activity. 1 Publication1

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809811 – 845Proto-oncogene vavAdd BLAST845

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei826PhosphotyrosineBy similarity1
Modified residuei844PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated by FYN (By similarity). Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS).By similarity3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP27870
PaxDbiP27870
PeptideAtlasiP27870
PRIDEiP27870

PTM databases

iPTMnetiP27870
PhosphoSitePlusiP27870

Expressioni

Tissue specificityi

Widely expressed in hematopoietic cells but not in other cell types. Found in the spleen and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000034116
CleanExiMM_VAV1
ExpressionAtlasiP27870 baseline and differential
GenevisibleiP27870 MM

Interactioni

Subunit structurei

Interacts with SHB (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:10646609, PubMed:10646608). May interact with CCPG1 (PubMed:17000758). Interacts with CLNK (PubMed:11463797). Interacts with THEMIS2 (PubMed:20644716). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK (By similarity). Interacts with ANKRD54 (PubMed:19064729). Interacts with CD6 (PubMed:24584089).By similarity9 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: MGI
  • phosphotyrosine residue binding Source: MGI
  • Rac guanyl-nucleotide exchange factor activity Source: MGI
  • Rho guanyl-nucleotide exchange factor activity Source: MGI

Protein-protein interaction databases

BioGridi204500, 9 interactors
DIPiDIP-31010N
IntActiP27870, 15 interactors
MINTiP27870
STRINGi10090.ENSMUSP00000005889

Structurei

Secondary structure

1845
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi170 – 177Combined sources8
Turni178 – 180Combined sources3
Helixi191 – 219Combined sources29
Helixi221 – 224Combined sources4
Turni225 – 227Combined sources3
Helixi230 – 237Combined sources8
Helixi240 – 259Combined sources20
Helixi261 – 263Combined sources3
Helixi266 – 273Combined sources8
Helixi276 – 278Combined sources3
Helixi279 – 300Combined sources22
Helixi302 – 316Combined sources15
Helixi322 – 325Combined sources4
Helixi328 – 333Combined sources6
Helixi336 – 346Combined sources11
Helixi350 – 389Combined sources40
Beta strandi390 – 392Combined sources3
Helixi397 – 400Combined sources4
Beta strandi402 – 412Combined sources11
Beta strandi420 – 437Combined sources18
Beta strandi440 – 448Combined sources9
Turni449 – 451Combined sources3
Beta strandi452 – 455Combined sources4
Beta strandi469 – 475Combined sources7
Beta strandi481 – 488Combined sources8
Helixi489 – 506Combined sources18
Turni509 – 512Combined sources4
Helixi513 – 515Combined sources3
Beta strandi518 – 521Combined sources4
Turni530 – 532Combined sources3
Beta strandi538 – 541Combined sources4
Beta strandi543 – 546Combined sources4
Turni547 – 549Combined sources3
Helixi555 – 560Combined sources6
Turni585 – 587Combined sources3
Beta strandi596 – 599Combined sources4
Beta strandi603 – 607Combined sources5
Helixi610 – 612Combined sources3
Beta strandi624 – 629Combined sources6
Beta strandi635 – 641Combined sources7
Turni642 – 644Combined sources3
Beta strandi647 – 651Combined sources5
Helixi652 – 654Combined sources3
Beta strandi655 – 657Combined sources3
Beta strandi786 – 791Combined sources6
Beta strandi796 – 800Combined sources5
Beta strandi808 – 813Combined sources6
Beta strandi817 – 825Combined sources9
Beta strandi828 – 833Combined sources6
Beta strandi836 – 841Combined sources6

3D structure databases

ProteinModelPortaliP27870
SMRiP27870
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27870

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 119Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST119
Domaini194 – 373DHPROSITE-ProRule annotationAdd BLAST180
Domaini402 – 504PHPROSITE-ProRule annotationAdd BLAST103
Domaini592 – 660SH3 1PROSITE-ProRule annotationAdd BLAST69
Domaini671 – 765SH2PROSITE-ProRule annotationAdd BLAST95
Domaini782 – 842SH3 2PROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 99Leu-richAdd BLAST67

Domaini

The DH domain is involved in interaction with CCPG1.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri515 – 564Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG2996 Eukaryota
ENOG410XPH6 LUCA
GeneTreeiENSGT00920000148946
HOGENOMiHOG000234364
HOVERGENiHBG018066
InParanoidiP27870
KOiK05730
OMAiDKRECCL
OrthoDBiEOG091G01O3
PhylomeDBiP27870
TreeFamiTF316171

Family and domain databases

CDDicd00029 C1, 1 hit
cd01223 PH_Vav, 1 hit
cd00160 RhoGEF, 1 hit
cd10405 SH2_Vav1, 1 hit
cd11979 SH3_VAV1_1, 1 hit
cd11976 SH3_VAV1_2, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037832 PH_Vav
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR003096 SM22_calponin
IPR028530 Vav1
IPR035879 VAV1_SH2
IPR035730 VAV1_SH3_1
IPR035729 VAV1_SH3_2
PANTHERiPTHR22826:SF112 PTHR22826:SF112, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P27870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL
60 70 80 90 100
LPQAINLREV NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF
110 120 130 140 150
DVQDFGKVIY TLSALSWTPI AQNKGIMPFP TEDSALNDED IYSGLSDQID
160 170 180 190 200
DTAEEDEDLY DCVENEEAEG DEIYEDLMRL ESVPTPPKMT EYDKRCCCLR
210 220 230 240 250
EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDMETIFVNI EELFSVHTHF
260 270 280 290 300
LKELKDALAG PGATTLYQVF IKYKERFLVY GRYCSQVESA SKHLDQVATA
310 320 330 340 350
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDA
360 370 380 390 400
TEKENLRLAL DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLANY
410 420 430 440 450
GRPKIDGELK ITSVERRSKT DRYAFLLDKA LLICKRRGDS YDLKASVNLH
460 470 480 490 500
SFQVRDDSSG ERDNKKWSHM FLLIEDQGAQ GYELFFKTRE LKKKWMEQFE
510 520 530 540 550
MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF YQGYRCYRCR
560 570 580 590 600
APAHKECLGR VPPCGRHGQD FAGTMKKDKL HRRAQDKKRN ELGLPKMEVF
610 620 630 640 650
QEYYGIPPPP GAFGPFLRLN PGDIVELTKA EAEHNWWEGR NTATNEVGWF
660 670 680 690 700
PCNRVHPYVH GPPQDLSVHL WYAGPMERAG AEGILTNRSD GTYLVRQRVK
710 720 730 740 750
DTAEFAISIK YNVEVKHIKI MTSEGLYRIT EKKAFRGLLE LVEFYQQNSL
760 770 780 790 800
KDCFKSLDTT LQFPYKEPER RAISKPPAGS TKYFGTAKAR YDFCARDRSE
810 820 830 840
LSLKEGDIIK ILNKKGQQGW WRGEIYGRIG WFPSNYVEED YSEYC
Length:845
Mass (Da):98,137
Last modified:August 1, 1992 - v1
Checksum:i3666DCCD1C5229DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29Q → E in AAA63402 (PubMed:2005887).Curated1
Sequence conflicti226R → L in BAC40436 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64361 mRNA Translation: CAA45713.1
AK088586 mRNA Translation: BAC40436.1
M59833 mRNA Translation: AAA63402.1
CCDSiCCDS28931.1
PIRiA61187 TVMSVV
RefSeqiNP_035821.3, NM_011691.4
UniGeneiMm.248172

Genome annotation databases

EnsembliENSMUST00000005889; ENSMUSP00000005889; ENSMUSG00000034116
GeneIDi22324
KEGGimmu:22324
UCSCiuc008dep.2 mouse

Similar proteinsi

Entry informationi

Entry nameiVAV_MOUSE
AccessioniPrimary (citable) accession number: P27870
Secondary accession number(s): Q8BTV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 18, 2018
This is version 196 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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