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UniProtKB - P27844 (RARD_ECOLI)

Entry version 145 (02 Jun 2021)
Sequence version 2 (01 Apr 1993)
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Protein

Protein RarD

Gene

rarD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG11466-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.7.7.2, the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein RarD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rarD
Ordered Locus Names:b3819, JW5589
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Topological domaini35 – 37PeriplasmicSequence analysis3
Transmembranei38 – 60HelicalSequence analysisAdd BLAST23
Topological domaini61 – 72CytoplasmicSequence analysisAdd BLAST12
Transmembranei73 – 95HelicalSequence analysisAdd BLAST23
Topological domaini96 – 99PeriplasmicSequence analysis4
Transmembranei100 – 122HelicalSequence analysisAdd BLAST23
Topological domaini123 – 128CytoplasmicSequence analysis6
Transmembranei129 – 146HelicalSequence analysisAdd BLAST18
Topological domaini147 – 149PeriplasmicSequence analysis3
Transmembranei150 – 167HelicalSequence analysisAdd BLAST18
Topological domaini168 – 179CytoplasmicSequence analysisAdd BLAST12
Transmembranei180 – 197HelicalSequence analysisAdd BLAST18
Topological domaini198 – 211PeriplasmicSequence analysisAdd BLAST14
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23
Topological domaini235 – 238CytoplasmicSequence analysis4
Transmembranei239 – 261HelicalSequence analysisAdd BLAST23
Topological domaini262 – 270PeriplasmicSequence analysis9
Transmembranei271 – 290HelicalSequence analysisAdd BLAST20
Topological domaini291 – 296CytoplasmicSequence analysis6

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001081521 – 296Protein RarDAdd BLAST296

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P27844

PRoteomics IDEntifications database

More...PRIDEi		P27844

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261790, 13 interactors

Protein interaction database and analysis system

More...IntActi		P27844, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b3819

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 145EamAAdd BLAST128

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EamA transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2962, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_054508_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P27844

Database for complete collections of gene phylogenies

More...PhylomeDBi		P27844

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000620, EamA_dom
IPR004626, RarD

The PANTHER Classification System

More...PANTHERi		PTHR22911:SF114, PTHR22911:SF114, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00892, EamA, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00688, rarD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P27844-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAKQTRQGV LLALAAYFIW GIAPAYFKLI YYVPADEILT HRVIWSFFFM 
        60         70         80         90        100
VVLMSICRQW SYLKTLIQTP QKIFMLAVSA VLIGGNWLLF IWAVNNHHML 
       110        120        130        140        150
EASLGYFINP LVNIVLGMIF LGERFRRMQW LAVILAICGV LVQLWTFGSL 
       160        170        180        190        200
PIIALGLAFS FAFYGLVRKK IAVEAQTGML IETMWLLPVA AIYLFAIADS 
       210        220        230        240        250
STSHMGQNPM SLNLLLIAAG IVTTVPLLCF TAAATRLRLS TLGFFQYIGP 
       260        270        280        290 
TLMFLLAVTF YGEKPGADKM VTFAFIWVAL AIFVMDAIYT QRRTSK
Length:296
Mass (Da):33,283
Last modified:April 1, 1993 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4E462C1E154912D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102A → R in AAA67615 (PubMed:1379743).Curated1
Sequence conflicti123 – 124ER → DG in AAA67615 (PubMed:1379743).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L02122 Genomic DNA Translation: AAD15041.1
M87049 Genomic DNA Translation: AAA67615.1
U00096 Genomic DNA Translation: AAT48220.1
AP009048 Genomic DNA Translation: BAE77482.1

Protein sequence database of the Protein Information Resource

More...PIRi		S30709
S30746

NCBI Reference Sequences

More...RefSeqi		WP_000339104.1, NZ_STEB01000021.1
YP_026262.1, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAT48220; AAT48220; b3819
BAE77482; BAE77482; BAE77482

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW5589
eco:b3819

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2888

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02122 Genomic DNA Translation: AAD15041.1
M87049 Genomic DNA Translation: AAA67615.1
U00096 Genomic DNA Translation: AAT48220.1
AP009048 Genomic DNA Translation: BAE77482.1
PIRiS30709
S30746
RefSeqiWP_000339104.1, NZ_STEB01000021.1
YP_026262.1, NC_000913.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4261790, 13 interactors
IntActiP27844, 1 interactor
STRINGi511145.b3819

Protein family/group databases

TCDBi2.A.7.7.2, the drug/metabolite transporter (dmt) superfamily

Proteomic databases

PaxDbiP27844
PRIDEiP27844

Genome annotation databases

EnsemblBacteriaiAAT48220; AAT48220; b3819
BAE77482; BAE77482; BAE77482
GeneIDi948330
KEGGiecj:JW5589
eco:b3819
PATRICifig|1411691.4.peg.2888

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1434

Phylogenomic databases

eggNOGiCOG2962, Bacteria
HOGENOMiCLU_054508_1_0_6
InParanoidiP27844
PhylomeDBiP27844

Enzyme and pathway databases

BioCyciEcoCyc:EG11466-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P27844

Family and domain databases

InterProiView protein in InterPro
IPR000620, EamA_dom
IPR004626, RarD
PANTHERiPTHR22911:SF114, PTHR22911:SF114, 1 hit
PfamiView protein in Pfam
PF00892, EamA, 2 hits
TIGRFAMsiTIGR00688, rarD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRARD_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27844
Secondary accession number(s): Q2M8C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 1, 1993
Last modified: June 2, 2021
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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