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Entry version 144 (13 Nov 2019)
Sequence version 4 (11 Oct 2004)
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Protein

Probable transport protein YifK

Gene

yifK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable amino-acid or metabolite transport protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:YIFK-MONOMER
ECOL316407:JW5595-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.1.15 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable transport protein YifK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yifK
Ordered Locus Names:b3795, JW5595
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 39PeriplasmicSequence analysis2
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 96CytoplasmicSequence analysisAdd BLAST36
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 122PeriplasmicSequence analysis5
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 155CytoplasmicSequence analysisAdd BLAST12
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 200PeriplasmicSequence analysisAdd BLAST24
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 243CytoplasmicSequence analysisAdd BLAST22
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 277PeriplasmicSequence analysisAdd BLAST13
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 332CytoplasmicSequence analysisAdd BLAST34
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 359PeriplasmicSequence analysis6
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 400CytoplasmicSequence analysisAdd BLAST20
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 429PeriplasmicSequence analysis8
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 461CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542181 – 461Probable transport protein YifKAdd BLAST461

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P27837

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27837

PRoteomics IDEntifications database

More...
PRIDEi
P27837

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4261339, 151 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3795

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C85 Bacteria
COG1113 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261849

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27837

KEGG Orthology (KO)

More...
KOi
K03293

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006060 AA_transporter, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P27837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADNKPELQR GLEARHIELI ALGGTIGVGL FMGAASTLKW AGPSVLLAYI
60 70 80 90 100
IAGLFVFFIM RSMGEMLFLE PVTGSFAVYA HRYMSPFFGY LTAWSYWFMW
110 120 130 140 150
MAVGISEITA IGVYVQFWFP EMAQWIPALI AVALVALANL AAVRLYGEIE
160 170 180 190 200
FWFAMIKVTT IIVMIVIGLG VIFFGFGNGG QSIGFSNLTE HGGFFAGGWK
210 220 230 240 250
GFLTALCIVV ASYQGVELIG ITAGEAKNPQ VTLRSAVGKV LWRILIFYVG
260 270 280 290 300
AIFVIVTIFP WNEIGSNGSP FVLTFAKIGI TAAAGIINFV VLTAALSGCN
310 320 330 340 350
SGMYSCGRML YALAKNRQLP AAMAKVSRHG VPVAGVAVSI AILLIGSCLN
360 370 380 390 400
YIIPNPQRVF VYVYSASVLP GMVPWFVILI SQLRFRRAHK AAIASHPFRS
410 420 430 440 450
ILFPWANYVT MAFLICVLIG MYFNEDTRMS LFVGIIFMLA VTAIYKVFGL
460
NRHGKAHKLE E
Length:461
Mass (Da):50,399
Last modified:October 11, 2004 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62EE13158BC8EE3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74 – 75GS → VA in AAA67595 (PubMed:1379743).Curated2
Sequence conflicti346 – 349GSCL → AHAW in AAA67595 (PubMed:1379743).Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M87049 Genomic DNA Translation: AAA67595.1
U00096 Genomic DNA Translation: AAT48216.1
AP009048 Genomic DNA Translation: BAE77502.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H65183

NCBI Reference Sequences

More...
RefSeqi
WP_000774731.1, NZ_STEB01000021.1
YP_026258.1, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAT48216; AAT48216; b3795
BAE77502; BAE77502; BAE77502

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945400

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5595
eco:b3795

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2910

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA Translation: AAA67595.1
U00096 Genomic DNA Translation: AAT48216.1
AP009048 Genomic DNA Translation: BAE77502.1
PIRiH65183
RefSeqiWP_000774731.1, NZ_STEB01000021.1
YP_026258.1, NC_000913.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi4261339, 151 interactors
STRINGi511145.b3795

Protein family/group databases

TCDBi2.A.3.1.15 the amino acid-polyamine-organocation (apc) family

Proteomic databases

jPOSTiP27837
PaxDbiP27837
PRIDEiP27837

Genome annotation databases

EnsemblBacteriaiAAT48216; AAT48216; b3795
BAE77502; BAE77502; BAE77502
GeneIDi945400
KEGGiecj:JW5595
eco:b3795
PATRICifig|1411691.4.peg.2910

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1428

Phylogenomic databases

eggNOGiENOG4105C85 Bacteria
COG1113 LUCA
HOGENOMiHOG000261849
InParanoidiP27837
KOiK03293
PhylomeDBiP27837

Enzyme and pathway databases

BioCyciEcoCyc:YIFK-MONOMER
ECOL316407:JW5595-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P27837

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYIFK_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27837
Secondary accession number(s): P76756, Q2M8A4, Q6BEZ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 11, 2004
Last modified: November 13, 2019
This is version 144 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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