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UniProtKB - P27835 (WZYE_ECOLI)
Protein
Probable ECA polymerase
Gene
wzyE
Organism
Escherichia coli (strain K12)
Status
Functioni
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units. Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC)).
1 PublicationCaution
Was originally thought to be WecF, the 4-alpha-L-fucosyltransferase.1 Publication
: enterobacterial common antigen biosynthesis Pathwayi
This protein is involved in the pathway enterobacterial common antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation1 PublicationView all proteins of this organism that are known to be involved in the pathway enterobacterial common antigen biosynthesis and in Bacterial outer membrane biogenesis.
GO - Biological processi
- enterobacterial common antigen biosynthetic process Source: EcoCyc
Enzyme and pathway databases
BioCyci | EcoCyc:FUC4NACTRANS-MONOMER |
UniPathwayi | UPA00566 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ECA polymeraseUniRule annotationCurated |
Gene namesi | Name:wzyEUniRule annotation Synonyms:wzy Ordered Locus Names:b3793, JW3769 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotationCurated; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB-UniRule
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 37 – 57 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 63 – 83 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 118 – 138 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 155 – 175 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 181 – 201 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 207 – 227 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 228 – 248 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 341 – 361 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 378 – 398 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 410 – 430 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208536 | 1 – 450 | Probable ECA polymeraseAdd BLAST | 450 |
Proteomic databases
PaxDbi | P27835 |
PRIDEi | P27835 |
Interactioni
Subunit structurei
Probably part of a complex composed of WzxE, WzyE and WzzE.
UniRule annotation1 PublicationProtein-protein interaction databases
BioGRIDi | 4263518, 286 interactors |
STRINGi | 511145.b3793 |
Structurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502Z7MA, Bacteria |
HOGENOMi | CLU_049711_0_0_6 |
PhylomeDBi | P27835 |
Family and domain databases
HAMAPi | MF_01003, WzyE, 1 hit |
InterProi | View protein in InterPro IPR010691, WzyE |
Pfami | View protein in Pfam PF06899, WzyE, 1 hit |
i Sequence
Sequence statusi: Complete.
P27835-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLLQFSGLF VVWLLCTLFI ATLTWFEFRR VRFNFNVFFS LLFLLTFFFG
60 70 80 90 100
FPLTSVLVFR FDVGVAPPEI LLQALLSAGC FYAVYYVTYK TRLRKRVADV
110 120 130 140 150
PRRPLFTMNR VETNLTWVIL MGIALVSVGI FFMHNGFLLF RLNSYSQIFS
160 170 180 190 200
SEVSGVALKR FFYFFIPAML VVYFLRQDSK AWLFFLVSTV AFGLLTYMIV
210 220 230 240 250
GGTRANIIIA FAIFLFIGII RGWISLWMLA AAGVLGIVGM FWLALKRYGM
260 270 280 290 300
NVSGDEAFYT FLYLTRDTFS PWENLALLLQ NYDNIDFQGL APIVRDFYVF
310 320 330 340 350
IPSWLWPGRP SMVLNSANYF TWEVLNNHSG LAISPTLIGS LVVMGGALFI
360 370 380 390 400
PLGAIVVGLI IKWFDWLYEL GNREPNRYKA AILHSFCFGA IFNMIVLARE
410 420 430 440 450
GLDSFVSRVV FFIVVFGACL MIAKLLYWLF ESAGLIHKRT KSSLRTQVEG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 283 | D → H in AAK62973 (PubMed:11673418).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF375882 Genomic DNA Translation: AAK62973.1 M87049 Genomic DNA Translation: AAA67593.1 Frameshift. U00096 Genomic DNA Translation: AAC76800.1 AP009048 Genomic DNA Translation: BAE77504.1 |
PIRi | F65183 S30687 |
RefSeqi | NP_418241.1, NC_000913.3 WP_000055129.1, NZ_SSZK01000025.1 |
Genome annotation databases
EnsemblBacteriai | AAC76800; AAC76800; b3793 BAE77504; BAE77504; BAE77504 |
GeneIDi | 66672303 948293 |
KEGGi | ecj:JW3769 eco:b3793 |
PATRICi | fig|511145.12.peg.3910 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF375882 Genomic DNA Translation: AAK62973.1 M87049 Genomic DNA Translation: AAA67593.1 Frameshift. U00096 Genomic DNA Translation: AAC76800.1 AP009048 Genomic DNA Translation: BAE77504.1 |
PIRi | F65183 S30687 |
RefSeqi | NP_418241.1, NC_000913.3 WP_000055129.1, NZ_SSZK01000025.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4263518, 286 interactors |
STRINGi | 511145.b3793 |
Proteomic databases
PaxDbi | P27835 |
PRIDEi | P27835 |
Genome annotation databases
EnsemblBacteriai | AAC76800; AAC76800; b3793 BAE77504; BAE77504; BAE77504 |
GeneIDi | 66672303 948293 |
KEGGi | ecj:JW3769 eco:b3793 |
PATRICi | fig|511145.12.peg.3910 |
Organism-specific databases
EchoBASEi | EB1426 |
Phylogenomic databases
eggNOGi | ENOG502Z7MA, Bacteria |
HOGENOMi | CLU_049711_0_0_6 |
PhylomeDBi | P27835 |
Enzyme and pathway databases
UniPathwayi | UPA00566 |
BioCyci | EcoCyc:FUC4NACTRANS-MONOMER |
Miscellaneous databases
PROi | PR:P27835 |
Family and domain databases
HAMAPi | MF_01003, WzyE, 1 hit |
InterProi | View protein in InterPro IPR010691, WzyE |
Pfami | View protein in Pfam PF06899, WzyE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WZYE_ECOLI | |
Accessioni | P27835Primary (citable) accession number: P27835 Secondary accession number(s): Q2M8A2, Q93DX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | July 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 140 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families