Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P27829 (WECC_ECOLI)

Entry version 164 (12 Aug 2020)
Sequence version 4 (11 Oct 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

UDP-N-acetyl-D-mannosamine dehydrogenase

Gene

wecC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD+ and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by N-acetylglucosamine-1-P or K+ at low UDP-ManNAc concentrations.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.22 mM for UDP-ManNAc (in the presence of 1 mM N-acetylglucosamine-1-P)1 Publication
  2. KM=0.11 mM for UDP-ManNAc (in the presence of 150 mM KCl)1 Publication
  3. KM=0.38 mM for UDP-ManNAc (in the absence of activators)1 Publication
  4. KM=0.21 mM for NAD+1 Publication

    pH dependencei

    Optimum pH is 10.0.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: enterobacterial common antigen biosynthesis

    This protein is involved in the pathway enterobacterial common antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation1 Publication
    View all proteins of this organism that are known to be involved in the pathway enterobacterial common antigen biosynthesis and in Bacterial outer membrane biogenesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei212Proton donor/acceptorUniRule annotationBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei212SubstrateUniRule annotationBy similarity1
    Binding sitei263Substrate; via amide nitrogenUniRule annotationBy similarity1
    Active sitei266NucleophileUniRule annotationBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 15NADUniRule annotationBy similarity6

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    • enterobacterial common antigen biosynthetic process Source: EcoCyc
    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNAD

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		EcoCyc:UDPMANNACADEHYDROG-MONOMER
    ECOL316407:JW5599-MONOMER
    MetaCyc:UDPMANNACADEHYDROG-MONOMER

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P27829

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00566

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    UDP-N-acetyl-D-mannosamine dehydrogenase1 PublicationUniRule annotation (EC:1.1.1.336UniRule annotation1 Publication)
    Alternative name(s):
    UDP-ManNAc 6-dehydrogenaseUniRule annotationCurated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:wecCUniRule annotation
    Synonyms:rffD1 Publication
    Ordered Locus Names:b3787, JW5599
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Complete GO annotation on QuickGO ...

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Mutants do not synthesize Und-PP-GlcNAc-ManNAcA (lipid II) and enterobacterial common antigen (ECA).1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000740771 – 420UDP-N-acetyl-D-mannosamine dehydrogenaseAdd BLAST420

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P27829

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P27829

    PRoteomics IDEntifications database

    More...    PRIDEi    		P27829

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		4262604, 229 interactors

    STRING: functional protein association networks

    More...    STRINGi    		511145.b3787

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P27829

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni160 – 161Substrate bindingUniRule annotationBy similarity2
    Regioni216 – 219Substrate bindingUniRule annotationBy similarity4
    Regioni250 – 252Substrate binding; shared with dimeric partnerUniRule annotationBy similarity3
    Regioni330 – 331Substrate bindingUniRule annotationBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.UniRule annotationCurated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		COG0677, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_023810_3_2_6

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P27829

    KEGG Orthology (KO)

    More...    KOi    		K02472

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P27829

    Family and domain databases

    HAMAP database of protein families

    More...    HAMAPi    		MF_02029, WecC_RffD, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR008927, 6-PGluconate_DH-like_C_sf
    IPR036291, NAD(P)-bd_dom_sf
    IPR017476, UDP-Glc/GDP-Man
    IPR014027, UDP-Glc/GDP-Man_DH_C
    IPR036220, UDP-Glc/GDP-Man_DH_C_sf
    IPR014026, UDP-Glc/GDP-Man_DH_dimer
    IPR001732, UDP-Glc/GDP-Man_DH_N
    IPR028359, UDP_ManNAc/GlcNAc_DH
    IPR032891, WecC

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00984, UDPG_MGDP_dh, 1 hit
    PF03720, UDPG_MGDP_dh_C, 1 hit
    PF03721, UDPG_MGDP_dh_N, 1 hit

    PIRSF; a whole-protein classification database

    More...    PIRSFi    		PIRSF500136, UDP_ManNAc_DH, 1 hit
    PIRSF000124, UDPglc_GDPman_dh, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00984, UDPG_MGDP_dh_C, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF48179, SSF48179, 1 hit
    SSF51735, SSF51735, 1 hit
    SSF52413, SSF52413, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR03026, NDP-sugDHase, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P27829-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSFATISVIG LGYIGLPTAA AFASRQKQVI GVDINQHAVD TINRGEIHIV 
            60         70         80         90        100
    EPDLASVVKT AVEGGFLRAS TTPVEADAWL IAVPTPFKGD HEPDMTYVES 
           110        120        130        140        150
    AARSIAPVLK KGALVILEST SPVGSTEKMA EWLAEMRPDL TFPQQVGEQA 
           160        170        180        190        200
    DVNIAYCPER VLPGQVMVEL IKNDRVIGGM TPVCSARASE LYKIFLEGEC 
           210        220        230        240        250
    VVTNSRTAEM CKLTENSFRD VNIAFANELS LICADQGINV WELIRLANRH 
           260        270        280        290        300
    PRVNILQPGP GVGGHCIAVD PWFIVAQNPQ QARLIRTARE VNDHKPFWVI 
           310        320        330        340        350
    DQVKAAVADC LAATDKRASE LKIACFGLAF KPNIDDLRES PAMEIAELIA 
           360        370        380        390        400
    QWHSGETLVV EPNIHQLPKK LTGLCTLAQL DEALATADVL VMLVDHSQFK 
           410        420
    VINGDNVHQQ YVVDAKGVWR
    Length:420
    Mass (Da):45,839
    Last modified:October 11, 2004 - v4
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDD63F572FDEA463
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA67587 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78A → R in AAA67587 (PubMed:1379743).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		L18799 Unassigned DNA No translation available.
    M87049 Genomic DNA Translation: AAA67587.1 Frameshift.
    U00096 Genomic DNA Translation: AAT48212.1
    AP009048 Genomic DNA Translation: BAE77511.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		F65182

    NCBI Reference Sequences

    More...    RefSeqi    		WP_000006621.1, NZ_STEB01000021.1
    YP_026254.1, NC_000913.3

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...    EnsemblBacteriai    		AAT48212; AAT48212; b3787
    BAE77511; BAE77511; BAE77511

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		48108328
    948977

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		ecj:JW5599
    eco:b3787

    Pathosystems Resource Integration Center (PATRIC)

    More...    PATRICi    		fig|1411691.4.peg.2919

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		L18799 Unassigned DNA No translation available.
    M87049 Genomic DNA Translation: AAA67587.1 Frameshift.
    U00096 Genomic DNA Translation: AAT48212.1
    AP009048 Genomic DNA Translation: BAE77511.1
    PIRiF65182
    RefSeqiWP_000006621.1, NZ_STEB01000021.1
    YP_026254.1, NC_000913.3

    3D structure databases

    SMRiP27829
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi4262604, 229 interactors
    STRINGi511145.b3787

    Proteomic databases

    jPOSTiP27829
    PaxDbiP27829
    PRIDEiP27829

    Genome annotation databases

    EnsemblBacteriaiAAT48212; AAT48212; b3787
    BAE77511; BAE77511; BAE77511
    GeneIDi48108328
    948977
    KEGGiecj:JW5599
    eco:b3787
    PATRICifig|1411691.4.peg.2919

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...    EchoBASEi    		EB1421

    Phylogenomic databases

    eggNOGiCOG0677, Bacteria
    HOGENOMiCLU_023810_3_2_6
    InParanoidiP27829
    KOiK02472
    PhylomeDBiP27829

    Enzyme and pathway databases

    UniPathwayiUPA00566
    BioCyciEcoCyc:UDPMANNACADEHYDROG-MONOMER
    ECOL316407:JW5599-MONOMER
    MetaCyc:UDPMANNACADEHYDROG-MONOMER
    SABIO-RKiP27829

    Miscellaneous databases

    Protein Ontology

    More...    PROi    		PR:P27829

    Family and domain databases

    HAMAPiMF_02029, WecC_RffD, 1 hit
    InterProiView protein in InterPro
    IPR008927, 6-PGluconate_DH-like_C_sf
    IPR036291, NAD(P)-bd_dom_sf
    IPR017476, UDP-Glc/GDP-Man
    IPR014027, UDP-Glc/GDP-Man_DH_C
    IPR036220, UDP-Glc/GDP-Man_DH_C_sf
    IPR014026, UDP-Glc/GDP-Man_DH_dimer
    IPR001732, UDP-Glc/GDP-Man_DH_N
    IPR028359, UDP_ManNAc/GlcNAc_DH
    IPR032891, WecC
    PfamiView protein in Pfam
    PF00984, UDPG_MGDP_dh, 1 hit
    PF03720, UDPG_MGDP_dh_C, 1 hit
    PF03721, UDPG_MGDP_dh_N, 1 hit
    PIRSFiPIRSF500136, UDP_ManNAc_DH, 1 hit
    PIRSF000124, UDPglc_GDPman_dh, 1 hit
    SMARTiView protein in SMART
    SM00984, UDPG_MGDP_dh_C, 1 hit
    SUPFAMiSSF48179, SSF48179, 1 hit
    SSF51735, SSF51735, 1 hit
    SSF52413, SSF52413, 1 hit
    TIGRFAMsiTIGR03026, NDP-sugDHase, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWECC_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27829
    Secondary accession number(s): Q2M895
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: October 11, 2004
    Last modified: August 12, 2020
    This is version 164 of the entry and version 4 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again