UniProtKB - P27816 (MAP4_HUMAN)
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>sp|P27816|MAP4_HUMAN Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3 MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWP EDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSP CNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALE IMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDM ALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPI KMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQ ANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQ LPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEM EVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKG ISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSE LSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQ PTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK APEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE GKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST TPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKT EAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGG GNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHL PAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREA QTLDSQIQETSICommunity curation ()Add a publicationFeedback
Microtubule-associated protein 4
MAP4
Annotation score:5 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.11"Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization."
Kitazawa H., Iida J., Uchida A., Haino-Fukushima K., Itoh T.J., Hotani H., Ookata K., Murofushi H., Bulinski J.C., Kishimoto T., Hisanaga S.
Cell Struct. Funct. 25:33-39(2000) [PubMed] [Europe PMC] [Abstract]Cited for: PHOSPHORYLATION AT SER-696 AND SER-787, FUNCTION, MUTAGENESIS OF SER-696 AND SER-787.
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- microtubule binding Source: GO_Central
<p>Inferred from Biological aspect of Ancestor</p>
<p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p>
Inferred from biological aspect of ancestori
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
- RNA binding Source: UniProtKBInferred from high throughput direct assayi
- "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins."
Castello A., Fischer B., Eichelbaum K., Horos R., Beckmann B.M., Strein C., Davey N.E., Humphreys D.T., Preiss T., Steinmetz L.M., Krijgsveld J., Hentze M.W.
Cell 149:1393-1406(2012) [PubMed] [Europe PMC] [Abstract] - "The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts."
Baltz A.G., Munschauer M., Schwanhausser B., Vasile A., Murakawa Y., Schueler M., Youngs N., Penfold-Brown D., Drew K., Milek M., Wyler E., Bonneau R., Selbach M., Dieterich C., Landthaler M.
Mol Cell 46:674-690(2012) [PubMed] [Europe PMC] [Abstract]
- structural molecule activity Source: ProtInc
<p>Traceable Author Statement</p>
<p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p>
Traceable author statementi
- Ref.9"Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau."
Chapin S.J., Bulinski J.C.
J. Cell Sci. 98:27-36(1991) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 102-1152 (ISOFORM 1).
GO - Biological processi
- cell division Source: MGI
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p>
Inferred from mutant phenotypei
- "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis."
Samora C.P., Mogessie B., Conway L., Ross J.L., Straube A., McAinsh A.D.
Nat Cell Biol 13:1040-1050(2011) [PubMed] [Europe PMC] [Abstract]
- establishment of spindle orientation Source: MGIInferred from mutant phenotypei
- "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis."
Samora C.P., Mogessie B., Conway L., Ross J.L., Straube A., McAinsh A.D.
Nat Cell Biol 13:1040-1050(2011) [PubMed] [Europe PMC] [Abstract]
- microtubule cytoskeleton organization Source: ARUK-UCL
- microtubule sliding Source: MGIInferred from mutant phenotypei
- "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis."
Samora C.P., Mogessie B., Conway L., Ross J.L., Straube A., McAinsh A.D.
Nat Cell Biol 13:1040-1050(2011) [PubMed] [Europe PMC] [Abstract]
- mitotic spindle organization Source: MGIInferred from mutant phenotypei
- "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis."
Samora C.P., Mogessie B., Conway L., Ross J.L., Straube A., McAinsh A.D.
Nat Cell Biol 13:1040-1050(2011) [PubMed] [Europe PMC] [Abstract]
- negative regulation of non-motile cilium assembly Source: GO_CentralInferred from mutant phenotypei
- "Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length."
Ghossoub R., Hu Q., Failler M., Rouyez M.C., Spitzbarth B., Mostowy S., Wolfrum U., Saunier S., Cossart P., Jamesnelson W., Benmerah A.
J Cell Sci 126:2583-2594(2013) [PubMed] [Europe PMC] [Abstract]
- neuron projection development Source: GO_CentralInferred from biological aspect of ancestori
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
Enzyme and pathway databases
Pathway Commons web resource for biological pathway data More...PathwayCommonsi | P27816 |
SIGNOR Signaling Network Open Resource More...SIGNORi | P27816 |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Microtubule-associated protein 4Short name: MAP-4 |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi | Name:MAP4 |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Homo sapiens (Human) |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 9606 [NCBI] |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi |
|
Organism-specific databases
Human Gene Nomenclature Database More...HGNCi | HGNC:6862, MAP4 |
Online Mendelian Inheritance in Man (OMIM) More...MIMi | 157132, gene |
neXtProt; the human protein knowledge platform More...neXtProti | NX_P27816 |
Eukaryotic Pathogen, Vector and Host Database Resources More...VEuPathDBi | HostDB:ENSG00000047849.21 |
<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
Cytoskeleton
Cytoskeleton
- axoneme Source: GO_Central
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p>
Inferred from direct assayi
- "Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length."
Ghossoub R., Hu Q., Failler M., Rouyez M.C., Spitzbarth B., Mostowy S., Wolfrum U., Saunier S., Cossart P., Jamesnelson W., Benmerah A.
J Cell Sci 126:2583-2594(2013) [PubMed] [Europe PMC] [Abstract]
- microtubule Source: UniProtKB-KW
- microtubule associated complex Source: ProtIncTraceable author statementi
- Ref.9"Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau."
Chapin S.J., Bulinski J.C.
J. Cell Sci. 98:27-36(1991) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 102-1152 (ISOFORM 1).
- microtubule cytoskeleton Source: HPA
- mitotic spindle Source: MGIInferred from direct assayi
- "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis."
Samora C.P., Mogessie B., Conway L., Ross J.L., Straube A., McAinsh A.D.
Nat Cell Biol 13:1040-1050(2011) [PubMed] [Europe PMC] [Abstract]
- axoneme Source: GO_Central
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p>
Inferred from direct assayi
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- axon Source: ARUK-UCL
- neuron projection Source: GO_CentralInferred from biological aspect of ancestori
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Microtubule<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 696 | S → E: No change in microtubule binding; no change in microtubule polymerization activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 787 | S → E: No change in microtubule binding; reduced microtubule polymerization activity. 1 Publication Manual assertion based on experiment ini
| 1 |
Organism-specific databases
DisGeNET More...DisGeNETi | 4134 |
Open Targets More...OpenTargetsi | ENSG00000047849 |
The Pharmacogenetics and Pharmacogenomics Knowledge Base More...PharmGKBi | PA30608 |
Miscellaneous databases
Pharos NIH Druggable Genome Knowledgebase More...Pharosi | P27816, Tbio |
Chemistry databases
Drug and drug target database More...DrugBanki | DB11638, Artenimol DB01248, Docetaxel DB01229, Paclitaxel |
Genetic variation databases
BioMuta curated single-nucleotide variation and disease association database More...BioMutai | MAP4 |
Domain mapping of disease mutations (DMDM) More...DMDMi | 269849673 |
<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methioninei | RemovedCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| |||
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000072751 | 2 – 1152 | Microtubule-associated protein 4Add BLAST | 1151 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 2 | N-acetylalanineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | ||
Modified residuei | 5 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 14 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 60 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 99 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 253 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | ||
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 269 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
Modified residuei | 280 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 282 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 354 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 358 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 380 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 384 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 440 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 442 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 507 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 510 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 521 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 526 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 571 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 580 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 585 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 624 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 636 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 643 | PhosphoserineBy similarity Manual assertion inferred from sequence similarity toi | 1 | ||
Modified residuei | 687 | PhosphothreonineBy similarity Manual assertion inferred from sequence similarity toi | 1 | ||
Modified residuei | 696 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | ||
Modified residuei | 713 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 723 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 787 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | ||
Modified residuei | 797 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 825 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 827 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Cross-linki | 838 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
Modified residuei | 853 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 928 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 941 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 942 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 1000 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 1073 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 1145 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 1151 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Isoform 4 (identifier: P27816-4) | |||||
Modified residuei | 28 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 269 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Isoform 3 (identifier: P27816-3) | |||||
Modified residuei | 337 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Modified residuei | 338 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
Isoform 5 (identifier: P27816-5) | |||||
Modified residuei | 803 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 |
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi
Manual assertion based on experiment ini
- Ref.11"Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization."
Kitazawa H., Iida J., Uchida A., Haino-Fukushima K., Itoh T.J., Hotani H., Ookata K., Murofushi H., Bulinski J.C., Kishimoto T., Hisanaga S.
Cell Struct. Funct. 25:33-39(2000) [PubMed] [Europe PMC] [Abstract]Cited for: PHOSPHORYLATION AT SER-696 AND SER-787, FUNCTION, MUTAGENESIS OF SER-696 AND SER-787.
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
Encyclopedia of Proteome Dynamics More...EPDi | P27816 |
jPOST - Japan Proteome Standard Repository/Database More...jPOSTi | P27816 |
MassIVE - Mass Spectrometry Interactive Virtual Environment More...MassIVEi | P27816 |
MaxQB - The MaxQuant DataBase More...MaxQBi | P27816 |
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | P27816 |
PeptideAtlas More...PeptideAtlasi | P27816 |
PRoteomics IDEntifications database More...PRIDEi | P27816 |
ProteomicsDB: a multi-organism proteome resource More...ProteomicsDBi | 54418 [P27816-1] 54419 [P27816-2] 54420 [P27816-3] 54421 [P27816-4] 54422 [P27816-5] 54423 [P27816-6] 54424 [P27816-7] |
PTM databases
GlyGen: Computational and Informatics Resources for Glycoscience More...GlyGeni | P27816, 1 site, 1 O-linked glycan (1 site) |
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | P27816 |
MetOSite database of methionine sulfoxide sites More...MetOSitei | P27816 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | P27816 |
SwissPalm database of S-palmitoylation events More...SwissPalmi | P27816 |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSG00000047849, Expressed in medial globus pallidus and 250 other tissues |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | P27816, baseline and differential |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | P27816, HS |
Organism-specific databases
Human Protein Atlas More...HPAi | ENSG00000047849, Tissue enhanced (brain, skeletal muscle) |
<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei
Interacts with SEPTIN2; this interaction impedes tubulin-binding.
Interacts with TRAF3IP1 (By similarity).
By similarityManual assertion inferred from sequence similarity toi
1 PublicationManual assertion based on experiment ini
- Ref.14"Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4."
Kremer B.E., Haystead T., Macara I.G.
Mol. Biol. Cell 16:4648-4659(2005) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH SEPTIN2.
<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi
P27816
With | #Exp. | IntAct |
---|---|---|
NCK1 [P16333] | 2 | EBI-715255,EBI-389883 |
GO - Molecular functioni
- microtubule binding Source: GO_CentralInferred from biological aspect of ancestori
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGRID) More...BioGRIDi | 110306, 112 interactors |
Protein interaction database and analysis system More...IntActi | P27816, 42 interactors |
Molecular INTeraction database More...MINTi | P27816 |
STRING: functional protein association networks More...STRINGi | 9606.ENSP00000353375 |
Miscellaneous databases
RNAct, Protein-RNA interaction predictions for model organisms. More...RNActi | P27816, protein |
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
3D structure databases
Biological Magnetic Resonance Data Bank More...BMRBi | P27816 |
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | P27816 |
Database of comparative protein structure models More...ModBasei | Search... |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati | 248 – 261 | 1Add BLAST | 14 | |
Repeati | 262 – 275 | 2Add BLAST | 14 | |
Repeati | 276 – 289 | 3Add BLAST | 14 | |
Repeati | 290 – 303 | 4Add BLAST | 14 | |
Repeati | 304 – 317 | 5Add BLAST | 14 | |
Repeati | 318 – 331 | 6Add BLAST | 14 | |
Repeati | 332 – 345 | 7Add BLAST | 14 | |
Repeati | 346 – 351 | 8; truncated | 6 | |
Repeati | 352 – 377 | 26 residues 1Add BLAST | 26 | |
Repeati | 378 – 403 | 26 residues 2Add BLAST | 26 | |
Repeati | 408 – 421 | 9Add BLAST | 14 | |
Repeati | 422 – 433 | 10Add BLAST | 12 | |
Repeati | 434 – 447 | 11Add BLAST | 14 | |
Repeati | 448 – 461 | 12Add BLAST | 14 | |
Repeati | 462 – 475 | 13Add BLAST | 14 | |
Repeati | 476 – 489 | 14Add BLAST | 14 | |
Repeati | 490 – 503 | 15Add BLAST | 14 | |
Repeati | 504 – 517 | 16Add BLAST | 14 | |
Repeati | 532 – 545 | 17Add BLAST | 14 | |
Repeati | 923 – 953 | Tau/MAP 1Add BLAST | 31 | |
Repeati | 992 – 1022 | Tau/MAP 2Add BLAST | 31 | |
Repeati | 1023 – 1053 | Tau/MAP 3Add BLAST | 31 | |
Repeati | 1054 – 1085 | Tau/MAP 4Add BLAST | 32 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 248 – 545 | 17 X 14 AA tandem repeatsAdd BLAST | 298 |
Keywords - Domaini
RepeatPhylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG2418, Eukaryota |
Ensembl GeneTree More...GeneTreei | ENSGT00940000159742 |
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms More...HOGENOMi | CLU_012370_0_0_1 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | P27816 |
Database of Orthologous Groups More...OrthoDBi | 1630535at2759 |
Database for complete collections of gene phylogenies More...PhylomeDBi | P27816 |
TreeFam database of animal gene trees More...TreeFami | TF316358 |
Family and domain databases
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR027323, MAP4 IPR001084, MAP_tubulin-bd_rpt |
The PANTHER Classification System More...PANTHERi | PTHR11501:SF16, PTHR11501:SF16, 2 hits |
Pfam protein domain database More...Pfami | View protein in Pfam PF00418, Tubulin-binding, 4 hits |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS00229, TAU_MAP_1, 4 hits PS51491, TAU_MAP_2, 4 hits |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.
This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basketAdded to basketThis entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL
60 70 80 90 100
LDVDEKTGNS ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTGSP
110 120 130 140 150
TEFLEEKMAY QEYPNSQNWP EDTNFCFQPE QVVDPIQTDP FKMYHDDDLA
160 170 180 190 200
DLVFPSSATA DTSIFAGQND PLKDSYGMSP CNTAVVPQGW SVEALNSPHS
210 220 230 240 250
ESFVSPEAVA EPPQPTAVPL ELAKEIEMAS EERPPAQALE IMMGLKTTDM
260 270 280 290 300
APSKETEMAL AKDMALATKT EVALAKDMES PTKLDVTLAK DMQPSMESDM
310 320 330 340 350
ALVKDMELPT EKEVALVKDV RWPTETDVSS AKNVVLPTET EVAPAKDVTL
360 370 380 390 400
LKETERASPI KMDLAPSKDM GPPKENKKET ERASPIKMDL APSKDMGPPK
410 420 430 440 450
ENKIVPAKDL VLLSEIEVAQ ANDIISSTEI SSAEKVALSS ETEVALARDM
460 470 480 490 500
TLPPETNVIL TKDKALPLEA EVAPVKDMAQ LPETEIAPAK DVAPSTVKEV
510 520 530 540 550
GLLKDMSPLS ETEMALGKDV TPPPETEVVL IKNVCLPPEM EVALTEDQVP
560 570 580 590 600
ALKTEAPLAK DGVLTLANNV TPAKDVPPLS ETEATPVPIK DMEIAQTQKG
610 620 630 640 650
ISEDSHLESL QDVGQSAAPT FMISPETVTG TGKKCSLPAE EDSVLEKLGE
660 670 680 690 700
RKPCNSQPSE LSSETSGIAR PEEGRPVVSG TGNDITTPPN KELPPSPEKK
710 720 730 740 750
TKPLATTQPA KTSTSKAKTQ PTSLPKQPAP TTIGGLNKKP MSLASGLVPA
760 770 780 790 800
APPKRPAVAS ARPSILPSKD VKPKPIADAK APEKRASPSK PASAPASRSG
810 820 830 840 850
SKSTQTVAKT TTAAAVASTG PSSRSPSTLL PKKPTAIKTE GKPAEVKKMT
860 870 880 890 900
AKSVPADLSR PKSTSTSSMK KTTTLSGTAP AAGVVPSRVK ATPMPSRPST
910 920 930 940 950
TPFIDKKPTS AKPSSTTPRL SRLATNTSAP DLKNVRSKVG STENIKHQPG
960 970 980 990 1000
GGRAKVEKKT EAAATTRKPE SNAVTKTAGP IASAQKQPAG KVQIVSKKVS
1010 1020 1030 1040 1050
YSHIQSKCGS KDNIKHVPGG GNVQIQNKKV DISKVSSKCG SKANIKHKPG
1060 1070 1080 1090 1100
GGDVKIESQK LNFKEKAQAK VGSLDNVGHL PAGGAVKTEG GGSEAPLCPG
1110 1120 1130 1140 1150
PPAGEEPAIS EAAPEAGAPT SASGLNGHPT LSGGGDQREA QTLDSQIQET
SI
The sequence of this isoform differs from the canonical sequence as follows:
558-730: Missing.
10 20 30 40 50
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL
60 70 80 90 100
LDVDEKTGNS ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTGSP
110 120 130 140 150
TEFLEEKMAY QEYPNSQNWP EDTNFCFQPE QVVDPIQTDP FKMYHDDDLA
160 170 180 190 200
DLVFPSSATA DTSIFAGQND PLKDSYGMSP CNTAVVPQGW SVEALNSPHS
210 220 230 240 250
ESFVSPEAVA EPPQPTAVPL ELAKEIEMAS EERPPAQALE IMMGLKTTDM
260 270 280 290 300
APSKETEMAL AKDMALATKT EVALAKDMES PTKLDVTLAK DMQPSMESDM
310 320 330 340 350
ALVKDMELPT EKEVALVKDV RWPTETDVSS AKNVVLPTET EVAPAKDVTL
360 370 380 390 400
LKETERASPI KMDLAPSKDM GPPKENKKET ERASPIKMDL APSKDMGPPK
410 420 430 440 450
ENKIVPAKDL VLLSEIEVAQ ANDIISSTEI SSAEKVALSS ETEVALARDM
460 470 480 490 500
TLPPETNVIL TKDKALPLEA EVAPVKDMAQ LPETEIAPAK DVAPSTVKEV
510 520 530 540 550
GLLKDMSPLS ETEMALGKDV TPPPETEVVL IKNVCLPPEM EVALTEDQVP
560 570 580 590 600
ALKTEAPTTI GGLNKKPMSL ASGLVPAAPP KRPAVASARP SILPSKDVKP
610 620 630 640 650
KPIADAKAPE KRASPSKPAS APASRSGSKS TQTVAKTTTA AAVASTGPSS
660 670 680 690 700
RSPSTLLPKK PTAIKTEGKP AEVKKMTAKS VPADLSRPKS TSTSSMKKTT
710 720 730 740 750
TLSGTAPAAG VVPSRVKATP MPSRPSTTPF IDKKPTSAKP SSTTPRLSRL
760 770 780 790 800
ATNTSAPDLK NVRSKVGSTE NIKHQPGGGR AKVEKKTEAA ATTRKPESNA
810 820 830 840 850
VTKTAGPIAS AQKQPAGKVQ IVSKKVSYSH IQSKCGSKDN IKHVPGGGNV
860 870 880 890 900
QIQNKKVDIS KVSSKCGSKA NIKHKPGGGD VKIESQKLNF KEKAQAKVGS
910 920 930 940 950
LDNVGHLPAG GAVKTEGGGS EAPLCPGPPA GEEPAISEAA PEAGAPTSAS
960 970
GLNGHPTLSG GGDQREAQTL DSQIQETSI
The sequence of this isoform differs from the canonical sequence as follows:
1-151: Missing.
152-437: LVFPSSATAD...TEISSAEKVA → MSLSDKQTAS...IRDHDKELEK
441-631: ETEVALARDM...MISPETVTGT → TEEAVLNQAP...EKQPGQTALA
635-666: CSLPAEEDSVLEKLGERKPCNSQPSELSSETS → EIEVTATQSTPSFLFEKPPRD
703-716: PLATTQPAKTSTSK → VGARMVVIFYCHNF
717-1152: Missing.
10 20 30 40 50
MSLSDKQTAS LTAAYGQLSK GKPAECRMDS PKEISQAGFE WQRTEGKLNE
60 70 80 90 100
IGLNVSMDGQ PKDGLVKNAS FLEQNKLCFF EGKLDKELSI EMQDKDCQEA
110 120 130 140 150
SGHLESRYVI SETCHPLEGN SVHQKTSEFH LGLIEGPDKN KTIPVQGKVA
160 170 180 190 200
GKNGLETKSQ SDLDFPGAAD IPTRYVKEQE TSVWNPSFHP VAQGSLGSRE
210 220 230 240 250
ATPGEMENSI TPGCPVIGVV NDNSEQLKCE SPLLVSLAHP APIIEHSPTT
260 270 280 290 300
IPPITMVFTQ EHLNASCHIR DHDKELEKLS STEEAVLNQA PQQKKAVRRA
310 320 330 340 350
LSECSHLSVP PAVNLADKYP ELPAREEPSS GLLPPPSSPM PSPTPGKLGA
360 370 380 390 400
PAMKRSMTVG EEQTASYKLS PGKLPILSTK EIPPFICEEP VAKKREELAH
410 420 430 440 450
FSNSSSNSGK KELGTAGLYL HSKLEQIPEG SSKEKGQEDF SETRIDSCSQ
460 470 480 490 500
VCQRGEKQPG QTALAGKKEI EVTATQSTPS FLFEKPPRDG IARPEEGRPV
510 520 530
VSGTGNDITT PPNKELPPSP EKKTKVGARM VVIFYCHNF
The sequence of this isoform differs from the canonical sequence as follows:
1-82: Missing.
83-221: LLANGGHGVE...PPQPTAVPLE → METTGDQGIE...VKEGDSFPDT
225-271: EIEMASEERP...KDMALATKTE → NGQEIAPAQI...AVVPSTSTGG
275-666: AKDMESPTKL...QPSELSSETS → PITTAIETVN...QERHKQLKSA
939-953: Missing.
10 20 30 40 50
METTGDQGIE GMAYMDENRN ITFTCPRTPS ELINKSSPLE VLGSAACEKL
60 70 80 90 100
PTPTPQVVKE GDSFPDTLAK NGQEIAPAQI SKSLMVDNYT KDGVPGQERP
110 120 130 140 150
KGPSAVVPST STGGVALPIT TAIETVNIHG DHSLKNKAEL ADSMKNEAGI
160 170 180 190 200
DEGHVIGESE SVHSGASKHS VEKVTELAKG HLLPGVPVED QSLPGEARAL
210 220 230 240 250
EGYADRGNFP AHPVNEEKET KEGSVAVQIP DLLEDKAQKL SFCEDQNAQD
260 270 280 290 300
RNSKGSDSLN KKVDLTLLSP KSENDKLKEI SLACKITELE SVSLPTPEIQ
310 320 330 340 350
SDFLHSKVEA PPSEVADTLV IMTASKGVRL PEPKDKILET PQKMTEKSES
360 370 380 390 400
KTPGEGKKED KSRMAEPMKG YMRPTKSRGL TPLLPKSTIQ EQERHKQLKS
410 420 430 440 450
AGIARPEEGR PVVSGTGNDI TTPPNKELPP SPEKKTKPLA TTQPAKTSTS
460 470 480 490 500
KAKTQPTSLP KQPAPTTIGG LNKKPMSLAS GLVPAAPPKR PAVASARPSI
510 520 530 540 550
LPSKDVKPKP IADAKAPEKR ASPSKPASAP ASRSGSKSTQ TVAKTTTAAA
560 570 580 590 600
VASTGPSSRS PSTLLPKKPT AIKTEGKPAE VKKMTAKSVP ADLSRPKSTS
610 620 630 640 650
TSSMKKTTTL SGTAPAAGVV PSRVKATPMP SRPSTTPFID KKPTSAKPSS
660 670 680 690 700
TTPRLSRLAT NTSAPDLKNV RSKAKVEKKT EAAATTRKPE SNAVTKTAGP
710 720 730 740 750
IASAQKQPAG KVQIVSKKVS YSHIQSKCGS KDNIKHVPGG GNVQIQNKKV
760 770 780 790 800
DISKVSSKCG SKANIKHKPG GGDVKIESQK LNFKEKAQAK VGSLDNVGHL
810 820 830 840 850
PAGGAVKTEG GGSEAPLCPG PPAGEEPAIS EAAPEAGAPT SASGLNGHPT
860 870
LSGGGDQREA QTLDSQIQET SI
The sequence of this isoform differs from the canonical sequence as follows:
322-666: WPTETDVSSA...QPSELSSETS → LPEPKDKILE...QERHKQLKSA
954-1022: Missing.
1151-1152: SI → N
10 20 30 40 50
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL
60 70 80 90 100
LDVDEKTGNS ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTGSP
110 120 130 140 150
TEFLEEKMAY QEYPNSQNWP EDTNFCFQPE QVVDPIQTDP FKMYHDDDLA
160 170 180 190 200
DLVFPSSATA DTSIFAGQND PLKDSYGMSP CNTAVVPQGW SVEALNSPHS
210 220 230 240 250
ESFVSPEAVA EPPQPTAVPL ELAKEIEMAS EERPPAQALE IMMGLKTTDM
260 270 280 290 300
APSKETEMAL AKDMALATKT EVALAKDMES PTKLDVTLAK DMQPSMESDM
310 320 330 340 350
ALVKDMELPT EKEVALVKDV RLPEPKDKIL ETPQKMTEKS ESKTPGEGKK
360 370 380 390 400
EDKSRMAEPM KGYMRPTKSR GLTPLLPKST IQEQERHKQL KSAGIARPEE
410 420 430 440 450
GRPVVSGTGN DITTPPNKEL PPSPEKKTKP LATTQPAKTS TSKAKTQPTS
460 470 480 490 500
LPKQPAPTTI GGLNKKPMSL ASGLVPAAPP KRPAVASARP SILPSKDVKP
510 520 530 540 550
KPIADAKAPE KRASPSKPAS APASRSGSKS TQTVAKTTTA AAVASTGPSS
560 570 580 590 600
RSPSTLLPKK PTAIKTEGKP AEVKKMTAKS VPADLSRPKS TSTSSMKKTT
610 620 630 640 650
TLSGTAPAAG VVPSRVKATP MPSRPSTTPF IDKKPTSAKP SSTTPRLSRL
660 670 680 690 700
ATNTSAPDLK NVRSKVGSTE NIKHQPGGGR VQIQNKKVDI SKVSSKCGSK
710 720 730 740 750
ANIKHKPGGG DVKIESQKLN FKEKAQAKVG SLDNVGHLPA GGAVKTEGGG
760 770 780 790 800
SEAPLCPGPP AGEEPAISEA APEAGAPTSA SGLNGHPTLS GGGDQREAQT
LDSQIQETN
The sequence of this isoform differs from the canonical sequence as follows:
1088-1152: TEGGGSEAPL...LDSQIQETSI → IETYRLTFRA...VLGPLSRAVH
10 20 30 40 50
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL
60 70 80 90 100
LDVDEKTGNS ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTGSP
110 120 130 140 150
TEFLEEKMAY QEYPNSQNWP EDTNFCFQPE QVVDPIQTDP FKMYHDDDLA
160 170 180 190 200
DLVFPSSATA DTSIFAGQND PLKDSYGMSP CNTAVVPQGW SVEALNSPHS
210 220 230 240 250
ESFVSPEAVA EPPQPTAVPL ELAKEIEMAS EERPPAQALE IMMGLKTTDM
260 270 280 290 300
APSKETEMAL AKDMALATKT EVALAKDMES PTKLDVTLAK DMQPSMESDM
310 320 330 340 350
ALVKDMELPT EKEVALVKDV RWPTETDVSS AKNVVLPTET EVAPAKDVTL
360 370 380 390 400
LKETERASPI KMDLAPSKDM GPPKENKKET ERASPIKMDL APSKDMGPPK
410 420 430 440 450
ENKIVPAKDL VLLSEIEVAQ ANDIISSTEI SSAEKVALSS ETEVALARDM
460 470 480 490 500
TLPPETNVIL TKDKALPLEA EVAPVKDMAQ LPETEIAPAK DVAPSTVKEV
510 520 530 540 550
GLLKDMSPLS ETEMALGKDV TPPPETEVVL IKNVCLPPEM EVALTEDQVP
560 570 580 590 600
ALKTEAPLAK DGVLTLANNV TPAKDVPPLS ETEATPVPIK DMEIAQTQKG
610 620 630 640 650
ISEDSHLESL QDVGQSAAPT FMISPETVTG TGKKCSLPAE EDSVLEKLGE
660 670 680 690 700
RKPCNSQPSE LSSETSGIAR PEEGRPVVSG TGNDITTPPN KELPPSPEKK
710 720 730 740 750
TKPLATTQPA KTSTSKAKTQ PTSLPKQPAP TTIGGLNKKP MSLASGLVPA
760 770 780 790 800
APPKRPAVAS ARPSILPSKD VKPKPIADAK APEKRASPSK PASAPASRSG
810 820 830 840 850
SKSTQTVAKT TTAAAVASTG PSSRSPSTLL PKKPTAIKTE GKPAEVKKMT
860 870 880 890 900
AKSVPADLSR PKSTSTSSMK KTTTLSGTAP AAGVVPSRVK ATPMPSRPST
910 920 930 940 950
TPFIDKKPTS AKPSSTTPRL SRLATNTSAP DLKNVRSKVG STENIKHQPG
960 970 980 990 1000
GGRAKVEKKT EAAATTRKPE SNAVTKTAGP IASAQKQPAG KVQIVSKKVS
1010 1020 1030 1040 1050
YSHIQSKCGS KDNIKHVPGG GNVQIQNKKV DISKVSSKCG SKANIKHKPG
1060 1070 1080 1090 1100
GGDVKIESQK LNFKEKAQAK VGSLDNVGHL PAGGAVKIET YRLTFRANAR
1110 1120 1130
ARTDHGADIV SRPPHFPGGP NSGSRVLGPL SRAVH
The sequence of this isoform differs from the canonical sequence as follows:
98-99: GS → EA
100-1152: Missing.
10 20 30 40 50
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL
60 70 80 90
LDVDEKTGNS ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTEA
<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketEntry | Entry name | Protein names | Gene names | Length | Annotation | ||
---|---|---|---|---|---|---|---|
E7EVA0 | E7EVA0_HUMAN | Microtubule-associated protein Microtubule-associated protein | MAP4 | 2,297 | Annotation score: Annotation score:2 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
H7C456 | H7C456_HUMAN | Microtubule-associated protein 4 Microtubule-associated protein 4 | MAP4 | 283 | Annotation score: Annotation score:2 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
F8W9U4 | F8W9U4_HUMAN | Microtubule-associated protein Microtubule-associated protein | MAP4 | 828 | Annotation score: Annotation score:2 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
H0Y2V1 | H0Y2V1_HUMAN | Microtubule-associated protein Microtubule-associated protein | MAP4 | 463 | Annotation score: Annotation score:2 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
H7C4C5 | H7C4C5_HUMAN | Microtubule-associated protein Microtubule-associated protein | MAP4 | 493 | Annotation score: Annotation score:2 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
B5MEG9 | B5MEG9_HUMAN | Microtubule-associated protein 4 Microtubule-associated protein 4 | MAP4 | 760 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
A0A0J9YVV8 | A0A0J9YVV8_HUMAN | Microtubule-associated protein 4 Microtubule-associated protein 4 | MAP4 | 76 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
A0A0J9YW37 | A0A0J9YW37_HUMAN | Microtubule-associated protein 4 Microtubule-associated protein 4 | MAP4 | 140 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> |
<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 160 | A → R in AAA59553 (PubMed:1718985).Curated | 1 | |
Sequence conflicti | 319 | D → G in CAH18346 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1109 | I → V in CAH18346 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039566 | 23 | R → Q. Corresponds to variant dbSNP:rs11711953Ensembl. | 1 | |
Natural variantiVAR_039567 | 366 | P → L. Corresponds to variant dbSNP:rs13097415Ensembl. | 1 | |
Natural variantiVAR_039568 | 367 | S → P. Corresponds to variant dbSNP:rs13096947Ensembl. | 1 | |
Natural variantiVAR_039569 | 409 | D → G. Corresponds to variant dbSNP:rs13076542Ensembl. | 1 | |
Natural variantiVAR_020361 | 427 | S → Y1 Publication Manual assertion based on experiment ini
| 1 | |
Natural variantiVAR_020362 | 441 | E → Q. Corresponds to variant dbSNP:rs2230169Ensembl. | 1 | |
Natural variantiVAR_039570 | 628 | V → ICombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | |
Natural variantiVAR_039571 | 994 | I → V. Corresponds to variant dbSNP:rs35736893Ensembl. | 1 |
Alternative sequence
Sequence databases
Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | M64571 mRNA Translation: AAA59553.1 U19727 mRNA Translation: AAA67361.1 AK054696 mRNA Translation: BAB70795.1 AK125245 mRNA Translation: BAC86099.1 AB209377 mRNA Translation: BAD92614.1 Different initiation. AC124916 Genomic DNA No translation available. AC139667 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64839.1 BC008715 mRNA Translation: AAH08715.1 BC012794 mRNA Translation: AAH12794.1 BC015149 mRNA Translation: AAH15149.1 BC051843 mRNA Translation: AAH51843.1 CR749544 mRNA Translation: CAH18346.1 |
The Consensus CDS (CCDS) project More...CCDSi | CCDS33750.1 [P27816-1] CCDS46818.1 [P27816-6] CCDS46821.1 [P27816-7] |
Protein sequence database of the Protein Information Resource More...PIRi | A41206, A33183 |
NCBI Reference Sequences More...RefSeqi | NP_001127836.1, NM_001134364.1 [P27816-6] NP_002366.2, NM_002375.4 [P27816-1] NP_112147.2, NM_030885.3 [P27816-7] |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENST00000360240; ENSP00000353375; ENSG00000047849 [P27816-1] ENST00000395734; ENSP00000379083; ENSG00000047849 [P27816-6] ENST00000434267; ENSP00000402767; ENSG00000047849 [P27816-7] ENST00000439356; ENSP00000397414; ENSG00000047849 [P27816-7] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 4134 |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | hsa:4134 |
UCSC genome browser More...UCSCi | uc003csb.3, human [P27816-1] |
Keywords - Coding sequence diversityi
Alternative splicing<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
Protein | Similar proteins | Species | Score | Length | Source | |
---|---|---|---|---|---|---|
P27816-7 | MAP4 isoform 10 | 99 | UniRef100_A0A6D2Y525 | |||
Uncharacterized protein | 99 | |||||
Microtubule associated protein 4 | 99 |
Protein | Similar proteins | Species | Score | Length | Source | |
---|---|---|---|---|---|---|
P27816 | Microtubule-associated protein | 1152 | UniRef90_P27816 | |||
Microtubule-associated protein | 1152 | |||||
Microtubule-associated protein (Fragment) | 1143 | |||||
Isoform 6 of Microtubule-associated protein 4 | 1135 | |||||
Microtubule-associated protein | 1152 | |||||
+31 | ||||||
P27816-7 | MAP4 isoform 10 | 99 | UniRef90_A0A6D2Y525 | |||
Uncharacterized protein | 99 | |||||
Uncharacterized protein | 99 | |||||
Uncharacterized protein | 99 | |||||
Uncharacterized protein | 99 | |||||
+3 |
<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64571 mRNA Translation: AAA59553.1 U19727 mRNA Translation: AAA67361.1 AK054696 mRNA Translation: BAB70795.1 AK125245 mRNA Translation: BAC86099.1 AB209377 mRNA Translation: BAD92614.1 Different initiation. AC124916 Genomic DNA No translation available. AC139667 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64839.1 BC008715 mRNA Translation: AAH08715.1 BC012794 mRNA Translation: AAH12794.1 BC015149 mRNA Translation: AAH15149.1 BC051843 mRNA Translation: AAH51843.1 CR749544 mRNA Translation: CAH18346.1 |
CCDSi | CCDS33750.1 [P27816-1] CCDS46818.1 [P27816-6] CCDS46821.1 [P27816-7] |
PIRi | A41206, A33183 |
RefSeqi | NP_001127836.1, NM_001134364.1 [P27816-6] NP_002366.2, NM_002375.4 [P27816-1] NP_112147.2, NM_030885.3 [P27816-7] |
3D structure databases
BMRBi | P27816 |
SMRi | P27816 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110306, 112 interactors |
IntActi | P27816, 42 interactors |
MINTi | P27816 |
STRINGi | 9606.ENSP00000353375 |
Chemistry databases
DrugBanki | DB11638, Artenimol DB01248, Docetaxel DB01229, Paclitaxel |
PTM databases
GlyGeni | P27816, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P27816 |
MetOSitei | P27816 |
PhosphoSitePlusi | P27816 |
SwissPalmi | P27816 |
Genetic variation databases
BioMutai | MAP4 |
DMDMi | 269849673 |
Proteomic databases
EPDi | P27816 |
jPOSTi | P27816 |
MassIVEi | P27816 |
MaxQBi | P27816 |
PaxDbi | P27816 |
PeptideAtlasi | P27816 |
PRIDEi | P27816 |
ProteomicsDBi | 54418 [P27816-1] 54419 [P27816-2] 54420 [P27816-3] 54421 [P27816-4] 54422 [P27816-5] 54423 [P27816-6] 54424 [P27816-7] |
Protocols and materials databases
Antibodypedia a portal for validated antibodies More...Antibodypediai | 29982, 349 antibodies |
The DNASU plasmid repository More...DNASUi | 4134 |
Genome annotation databases
Ensembli | ENST00000360240; ENSP00000353375; ENSG00000047849 [P27816-1] ENST00000395734; ENSP00000379083; ENSG00000047849 [P27816-6] ENST00000434267; ENSP00000402767; ENSG00000047849 [P27816-7] ENST00000439356; ENSP00000397414; ENSG00000047849 [P27816-7] |
GeneIDi | 4134 |
KEGGi | hsa:4134 |
UCSCi | uc003csb.3, human [P27816-1] |
Organism-specific databases
Comparative Toxicogenomics Database More...CTDi | 4134 |
DisGeNETi | 4134 |
GeneCards: human genes, protein and diseases More...GeneCardsi | MAP4 |
HGNCi | HGNC:6862, MAP4 |
HPAi | ENSG00000047849, Tissue enhanced (brain, skeletal muscle) |
MIMi | 157132, gene |
neXtProti | NX_P27816 |
OpenTargetsi | ENSG00000047849 |
PharmGKBi | PA30608 |
VEuPathDBi | HostDB:ENSG00000047849.21 |
GenAtlas: human gene database More...GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2418, Eukaryota |
GeneTreei | ENSGT00940000159742 |
HOGENOMi | CLU_012370_0_0_1 |
InParanoidi | P27816 |
OrthoDBi | 1630535at2759 |
PhylomeDBi | P27816 |
TreeFami | TF316358 |
Enzyme and pathway databases
PathwayCommonsi | P27816 |
SIGNORi | P27816 |
Miscellaneous databases
BioGRID ORCS database of CRISPR phenotype screens More...BioGRID-ORCSi | 4134, 5 hits in 881 CRISPR screens |
ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data More...ChiTaRSi | MAP4, human |
The Gene Wiki collection of pages on human genes and proteins More...GeneWikii | MAP4 |
Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens More...GenomeRNAii | 4134 |
Pharosi | P27816, Tbio |
Protein Ontology More...PROi | PR:P27816 |
RNActi | P27816, protein |
The Stanford Online Universal Resource for Clones and ESTs More...SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000047849, Expressed in medial globus pallidus and 250 other tissues |
ExpressionAtlasi | P27816, baseline and differential |
Genevisiblei | P27816, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027323, MAP4 IPR001084, MAP_tubulin-bd_rpt |
PANTHERi | PTHR11501:SF16, PTHR11501:SF16, 2 hits |
Pfami | View protein in Pfam PF00418, Tubulin-binding, 4 hits |
PROSITEi | View protein in PROSITE PS00229, TAU_MAP_1, 4 hits PS51491, TAU_MAP_2, 4 hits |
ProtoNet; Automatic hierarchical classification of proteins More...ProtoNeti | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi
<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei | MAP4_HUMAN | |
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>Accessioni | P27816Primary (citable) accession number: P27816 Secondary accession number(s): Q13082 , Q59FT2, Q68D74, Q6ZUW9, Q86V26, Q96A76, Q96NS9 | |
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | November 24, 2009 | |
Last modified: | February 10, 2021 | |
This is version 204 of the entry and version 3 of the sequence. See complete history. | ||
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot