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UniProtKB - P27816 (MAP4_HUMAN)

Entry version 204 (10 Feb 2021)
Sequence version 3 (24 Nov 2009)
Previous versions | rss
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Protein

Microtubule-associated protein 4

Gene

MAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-neuronal microtubule-associated protein. Promotes microtubule assembly.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P27816

SIGNOR Signaling Network Open Resource

More...SIGNORi		P27816

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 4
Short name:
MAP-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6862, MAP4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		157132, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P27816

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000047849.21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi696S → E: No change in microtubule binding; no change in microtubule polymerization activity. 1 Publication1
Mutagenesisi787S → E: No change in microtubule binding; reduced microtubule polymerization activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4134

Open Targets

More...OpenTargetsi		ENSG00000047849

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30608

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P27816, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB11638, Artenimol
DB01248, Docetaxel
DB01229, Paclitaxel

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAP4

Domain mapping of disease mutations (DMDM)

More...DMDMi		269849673

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000727512 – 1152Microtubule-associated protein 4Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei5PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei253PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki269Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei280PhosphoserineCombined sources1
Modified residuei282PhosphothreonineCombined sources1
Modified residuei354PhosphothreonineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei380PhosphothreonineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei442PhosphothreonineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei510PhosphoserineCombined sources1
Modified residuei521PhosphothreonineCombined sources1
Modified residuei526PhosphothreonineCombined sources1
Modified residuei571PhosphothreonineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei585PhosphothreonineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei643PhosphoserineBy similarity1
Modified residuei687PhosphothreonineBy similarity1
Modified residuei696PhosphoserineCombined sources1 Publication1
Modified residuei713PhosphoserineCombined sources1
Modified residuei723PhosphoserineCombined sources1
Modified residuei787PhosphoserineCombined sources1 Publication1
Modified residuei797PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei827PhosphoserineCombined sources1
Cross-linki838Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei853PhosphoserineCombined sources1
Modified residuei928PhosphoserineCombined sources1
Modified residuei941PhosphoserineCombined sources1
Modified residuei942PhosphothreonineCombined sources1
Modified residuei1000PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1151PhosphoserineCombined sources1
Isoform 4 (identifier: P27816-4)
Modified residuei28PhosphothreonineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Isoform 3 (identifier: P27816-3)
Modified residuei337PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Isoform 5 (identifier: P27816-5)
Modified residuei803PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.By similarity1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P27816

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P27816

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P27816

MaxQB - The MaxQuant DataBase

More...MaxQBi		P27816

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P27816

PeptideAtlas

More...PeptideAtlasi		P27816

PRoteomics IDEntifications database

More...PRIDEi		P27816

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54418 [P27816-1]
54419 [P27816-2]
54420 [P27816-3]
54421 [P27816-4]
54422 [P27816-5]
54423 [P27816-6]
54424 [P27816-7]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P27816, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P27816

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P27816

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P27816

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P27816

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000047849, Expressed in medial globus pallidus and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P27816, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P27816, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000047849, Tissue enhanced (brain, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SEPTIN2; this interaction impedes tubulin-binding.

Interacts with TRAF3IP1 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110306, 112 interactors

Protein interaction database and analysis system

More...IntActi		P27816, 42 interactors

Molecular INTeraction database

More...MINTi		P27816

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000353375

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P27816, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P27816

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P27816

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati248 – 2611Add BLAST14
Repeati262 – 2752Add BLAST14
Repeati276 – 2893Add BLAST14
Repeati290 – 3034Add BLAST14
Repeati304 – 3175Add BLAST14
Repeati318 – 3316Add BLAST14
Repeati332 – 3457Add BLAST14
Repeati346 – 3518; truncated6
Repeati352 – 37726 residues 1Add BLAST26
Repeati378 – 40326 residues 2Add BLAST26
Repeati408 – 4219Add BLAST14
Repeati422 – 43310Add BLAST12
Repeati434 – 44711Add BLAST14
Repeati448 – 46112Add BLAST14
Repeati462 – 47513Add BLAST14
Repeati476 – 48914Add BLAST14
Repeati490 – 50315Add BLAST14
Repeati504 – 51716Add BLAST14
Repeati532 – 54517Add BLAST14
Repeati923 – 953Tau/MAP 1Add BLAST31
Repeati992 – 1022Tau/MAP 2Add BLAST31
Repeati1023 – 1053Tau/MAP 3Add BLAST31
Repeati1054 – 1085Tau/MAP 4Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni248 – 54517 X 14 AA tandem repeatsAdd BLAST298

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2418, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159742

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012370_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P27816

Database of Orthologous Groups

More...OrthoDBi		1630535at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P27816

TreeFam database of animal gene trees

More...TreeFami		TF316358

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027323, MAP4
IPR001084, MAP_tubulin-bd_rpt

The PANTHER Classification System

More...PANTHERi		PTHR11501:SF16, PTHR11501:SF16, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00418, Tubulin-binding, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00229, TAU_MAP_1, 4 hits
PS51491, TAU_MAP_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P27816-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL 
        60         70         80         90        100
LDVDEKTGNS ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTGSP 
       110        120        130        140        150
TEFLEEKMAY QEYPNSQNWP EDTNFCFQPE QVVDPIQTDP FKMYHDDDLA 
       160        170        180        190        200
DLVFPSSATA DTSIFAGQND PLKDSYGMSP CNTAVVPQGW SVEALNSPHS 
       210        220        230        240        250
ESFVSPEAVA EPPQPTAVPL ELAKEIEMAS EERPPAQALE IMMGLKTTDM 
       260        270        280        290        300
APSKETEMAL AKDMALATKT EVALAKDMES PTKLDVTLAK DMQPSMESDM 
       310        320        330        340        350
ALVKDMELPT EKEVALVKDV RWPTETDVSS AKNVVLPTET EVAPAKDVTL 
       360        370        380        390        400
LKETERASPI KMDLAPSKDM GPPKENKKET ERASPIKMDL APSKDMGPPK 
       410        420        430        440        450
ENKIVPAKDL VLLSEIEVAQ ANDIISSTEI SSAEKVALSS ETEVALARDM 
       460        470        480        490        500
TLPPETNVIL TKDKALPLEA EVAPVKDMAQ LPETEIAPAK DVAPSTVKEV 
       510        520        530        540        550
GLLKDMSPLS ETEMALGKDV TPPPETEVVL IKNVCLPPEM EVALTEDQVP 
       560        570        580        590        600
ALKTEAPLAK DGVLTLANNV TPAKDVPPLS ETEATPVPIK DMEIAQTQKG 
       610        620        630        640        650
ISEDSHLESL QDVGQSAAPT FMISPETVTG TGKKCSLPAE EDSVLEKLGE 
       660        670        680        690        700
RKPCNSQPSE LSSETSGIAR PEEGRPVVSG TGNDITTPPN KELPPSPEKK 
       710        720        730        740        750
TKPLATTQPA KTSTSKAKTQ PTSLPKQPAP TTIGGLNKKP MSLASGLVPA 
       760        770        780        790        800
APPKRPAVAS ARPSILPSKD VKPKPIADAK APEKRASPSK PASAPASRSG 
       810        820        830        840        850
SKSTQTVAKT TTAAAVASTG PSSRSPSTLL PKKPTAIKTE GKPAEVKKMT 
       860        870        880        890        900
AKSVPADLSR PKSTSTSSMK KTTTLSGTAP AAGVVPSRVK ATPMPSRPST 
       910        920        930        940        950
TPFIDKKPTS AKPSSTTPRL SRLATNTSAP DLKNVRSKVG STENIKHQPG 
       960        970        980        990       1000
GGRAKVEKKT EAAATTRKPE SNAVTKTAGP IASAQKQPAG KVQIVSKKVS 
      1010       1020       1030       1040       1050
YSHIQSKCGS KDNIKHVPGG GNVQIQNKKV DISKVSSKCG SKANIKHKPG 
      1060       1070       1080       1090       1100
GGDVKIESQK LNFKEKAQAK VGSLDNVGHL PAGGAVKTEG GGSEAPLCPG 
      1110       1120       1130       1140       1150
PPAGEEPAIS EAAPEAGAPT SASGLNGHPT LSGGGDQREA QTLDSQIQET 

SI
Length:1,152
Mass (Da):121,005
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i061A69AC18593339
GO
Isoform 2 (identifier: P27816-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     558-730: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:979
Mass (Da):102,906
Checksum:i04F3054281DA91E7
GO
Isoform 3 (identifier: P27816-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     152-437: LVFPSSATAD...TEISSAEKVA → MSLSDKQTAS...IRDHDKELEK
     441-631: ETEVALARDM...MISPETVTGT → TEEAVLNQAP...EKQPGQTALA
     635-666: CSLPAEEDSVLEKLGERKPCNSQPSELSSETS → EIEVTATQSTPSFLFEKPPRD
     703-716: PLATTQPAKTSTSK → VGARMVVIFYCHNF
     717-1152: Missing.

Show »
Length:539
Mass (Da):58,557
Checksum:i6B67BBE02C4F946D
GO
Isoform 4 (identifier: P27816-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     83-221: LLANGGHGVE...PPQPTAVPLE → METTGDQGIE...VKEGDSFPDT
     225-271: EIEMASEERP...KDMALATKTE → NGQEIAPAQI...AVVPSTSTGG
     275-666: AKDMESPTKL...QPSELSSETS → PITTAIETVN...QERHKQLKSA
     939-953: Missing.

Show »
Length:872
Mass (Da):91,154
Checksum:i777E25AE88E22090
GO
Isoform 5 (identifier: P27816-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-666: WPTETDVSSA...QPSELSSETS → LPEPKDKILE...QERHKQLKSA
     954-1022: Missing.
     1151-1152: SI → N

Show »
Length:809
Mass (Da):85,252
Checksum:iF259E4B688F2B44F
GO
Isoform 6 (identifier: P27816-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1152: TEGGGSEAPL...LDSQIQETSI → IETYRLTFRA...VLGPLSRAVH

Show »
Length:1,135
Mass (Da):119,958
Checksum:i9FDE4697ADAD05D5
GO
Isoform 7 (identifier: P27816-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-99: GS → EA
     100-1152: Missing.

Show »
Length:99
Mass (Da):10,441
Checksum:i2D295214DAA6FB37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVA0E7EVA0_HUMAN
Microtubule-associated protein
MAP4
2,297Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C456H7C456_HUMAN
Microtubule-associated protein 4
MAP4
283Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9U4F8W9U4_HUMAN
Microtubule-associated protein
MAP4
828Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2V1H0Y2V1_HUMAN
Microtubule-associated protein
MAP4
463Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4C5H7C4C5_HUMAN
Microtubule-associated protein
MAP4
493Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MEG9B5MEG9_HUMAN
Microtubule-associated protein 4
MAP4
760Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVV8A0A0J9YVV8_HUMAN
Microtubule-associated protein 4
MAP4
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YW37A0A0J9YW37_HUMAN
Microtubule-associated protein 4
MAP4
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92614 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160A → R in AAA59553 (PubMed:1718985).Curated1
Sequence conflicti319D → G in CAH18346 (PubMed:17974005).Curated1
Sequence conflicti1109I → V in CAH18346 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03956623R → Q. Corresponds to variant dbSNP:rs11711953Ensembl.1
Natural variantiVAR_039567366P → L. Corresponds to variant dbSNP:rs13097415Ensembl.1
Natural variantiVAR_039568367S → P. Corresponds to variant dbSNP:rs13096947Ensembl.1
Natural variantiVAR_039569409D → G. Corresponds to variant dbSNP:rs13076542Ensembl.1
Natural variantiVAR_020361427S → Y1 PublicationCorresponds to variant dbSNP:rs1060407Ensembl.1
Natural variantiVAR_020362441E → Q. Corresponds to variant dbSNP:rs2230169Ensembl.1
Natural variantiVAR_039570628V → ICombined sources1 PublicationCorresponds to variant dbSNP:rs1137524Ensembl.1
Natural variantiVAR_039571994I → V. Corresponds to variant dbSNP:rs35736893Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0320651 – 151Missing in isoform 3. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_0320661 – 82Missing in isoform 4. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_03206783 – 221LLANG…AVPLE → METTGDQGIEGMAYMDENRN ITFTCPRTPSELINKSSPLE VLGSAACEKLPTPTPQVVKE GDSFPDT in isoform 4. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_04324098 – 99GS → EA in isoform 7. 1 Publication2
Alternative sequenceiVSP_043241100 – 1152Missing in isoform 7. 1 PublicationAdd BLAST1053
Alternative sequenceiVSP_032068152 – 437LVFPS…AEKVA → MSLSDKQTASLTAAYGQLSK GKPAECRMDSPKEISQAGFE WQRTEGKLNEIGLNVSMDGQ PKDGLVKNASFLEQNKLCFF EGKLDKELSIEMQDKDCQEA SGHLESRYVISETCHPLEGN SVHQKTSEFHLGLIEGPDKN KTIPVQGKVAGKNGLETKSQ SDLDFPGAADIPTRYVKEQE TSVWNPSFHPVAQGSLGSRE ATPGEMENSITPGCPVIGVV NDNSEQLKCESPLLVSLAHP APIIEHSPTTIPPITMVFTQ EHLNASCHIRDHDKELEK in isoform 3. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_032069225 – 271EIEMA…ATKTE → NGQEIAPAQISKSLMVDNYT KDGVPGQERPKGPSAVVPST STGG in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_032070275 – 666AKDME…SSETS → PITTAIETVNIHGDHSLKNK AELADSMKNEAGIDEGHVIG ESESVHSGASKHSVEKVTEL AKGHLLPGVPVEDQSLPGEA RALEGYADRGNFPAHPVNEE KETKEGSVAVQIPDLLEDKA QKLSFCEDQNAQDRNSKGSD SLNKKVDLTLLSPKSENDKL KEISLACKITELESVSLPTP EIQSDFLHSKVEAPPSEVAD TLVIMTASKGVRLPEPKDKI LETPQKMTEKSESKTPGEGK KEDKSRMAEPMKGYMRPTKS RGLTPLLPKSTIQEQERHKQ LKSA in isoform 4. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_032071322 – 666WPTET…SSETS → LPEPKDKILETPQKMTEKSE SKTPGEGKKEDKSRMAEPMK GYMRPTKSRGLTPLLPKSTI QEQERHKQLKSA in isoform 5. 1 PublicationAdd BLAST345
Alternative sequenceiVSP_032072441 – 631ETEVA…TVTGT → TEEAVLNQAPQQKKAVRRAL SECSHLSVPPAVNLADKYPE LPAREEPSSGLLPPPSSPMP SPTPGKLGAPAMKRSMTVGE EQTASYKLSPGKLPILSTKE IPPFICEEPVAKKREELAHF SNSSSNSGKKELGTAGLYLH SKLEQIPEGSSKEKGQEDFS ETRIDSCSQVCQRGEKQPGQ TALA in isoform 3. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_003200558 – 730Missing in isoform 2. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_032073635 – 666CSLPA…SSETS → EIEVTATQSTPSFLFEKPPR D in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_032074703 – 716PLATT…TSTSK → VGARMVVIFYCHNF in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_032075717 – 1152Missing in isoform 3. 1 PublicationAdd BLAST436
Alternative sequenceiVSP_032076939 – 953Missing in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_032077954 – 1022Missing in isoform 5. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_0320781088 – 1152TEGGG…QETSI → IETYRLTFRANARARTDHGA DIVSRPPHFPGGPNSGSRVL GPLSRAVH in isoform 6. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_0320791151 – 1152SI → N in isoform 5. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M64571 mRNA Translation: AAA59553.1
U19727 mRNA Translation: AAA67361.1
AK054696 mRNA Translation: BAB70795.1
AK125245 mRNA Translation: BAC86099.1
AB209377 mRNA Translation: BAD92614.1 Different initiation.
AC124916 Genomic DNA No translation available.
AC139667 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64839.1
BC008715 mRNA Translation: AAH08715.1
BC012794 mRNA Translation: AAH12794.1
BC015149 mRNA Translation: AAH15149.1
BC051843 mRNA Translation: AAH51843.1
CR749544 mRNA Translation: CAH18346.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33750.1 [P27816-1]
CCDS46818.1 [P27816-6]
CCDS46821.1 [P27816-7]

Protein sequence database of the Protein Information Resource

More...PIRi		A41206, A33183

NCBI Reference Sequences

More...RefSeqi		NP_001127836.1, NM_001134364.1 [P27816-6]
NP_002366.2, NM_002375.4 [P27816-1]
NP_112147.2, NM_030885.3 [P27816-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360240; ENSP00000353375; ENSG00000047849 [P27816-1]
ENST00000395734; ENSP00000379083; ENSG00000047849 [P27816-6]
ENST00000434267; ENSP00000402767; ENSG00000047849 [P27816-7]
ENST00000439356; ENSP00000397414; ENSG00000047849 [P27816-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4134

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4134

UCSC genome browser

More...UCSCi		uc003csb.3, human [P27816-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64571 mRNA Translation: AAA59553.1
U19727 mRNA Translation: AAA67361.1
AK054696 mRNA Translation: BAB70795.1
AK125245 mRNA Translation: BAC86099.1
AB209377 mRNA Translation: BAD92614.1 Different initiation.
AC124916 Genomic DNA No translation available.
AC139667 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64839.1
BC008715 mRNA Translation: AAH08715.1
BC012794 mRNA Translation: AAH12794.1
BC015149 mRNA Translation: AAH15149.1
BC051843 mRNA Translation: AAH51843.1
CR749544 mRNA Translation: CAH18346.1
CCDSiCCDS33750.1 [P27816-1]
CCDS46818.1 [P27816-6]
CCDS46821.1 [P27816-7]
PIRiA41206, A33183
RefSeqiNP_001127836.1, NM_001134364.1 [P27816-6]
NP_002366.2, NM_002375.4 [P27816-1]
NP_112147.2, NM_030885.3 [P27816-7]

3D structure databases

BMRBiP27816
SMRiP27816
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110306, 112 interactors
IntActiP27816, 42 interactors
MINTiP27816
STRINGi9606.ENSP00000353375

Chemistry databases

DrugBankiDB11638, Artenimol
DB01248, Docetaxel
DB01229, Paclitaxel

PTM databases

GlyGeniP27816, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP27816
MetOSiteiP27816
PhosphoSitePlusiP27816
SwissPalmiP27816

Genetic variation databases

BioMutaiMAP4
DMDMi269849673

Proteomic databases

EPDiP27816
jPOSTiP27816
MassIVEiP27816
MaxQBiP27816
PaxDbiP27816
PeptideAtlasiP27816
PRIDEiP27816
ProteomicsDBi54418 [P27816-1]
54419 [P27816-2]
54420 [P27816-3]
54421 [P27816-4]
54422 [P27816-5]
54423 [P27816-6]
54424 [P27816-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29982, 349 antibodies

The DNASU plasmid repository

More...DNASUi		4134

Genome annotation databases

EnsembliENST00000360240; ENSP00000353375; ENSG00000047849 [P27816-1]
ENST00000395734; ENSP00000379083; ENSG00000047849 [P27816-6]
ENST00000434267; ENSP00000402767; ENSG00000047849 [P27816-7]
ENST00000439356; ENSP00000397414; ENSG00000047849 [P27816-7]
GeneIDi4134
KEGGihsa:4134
UCSCiuc003csb.3, human [P27816-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4134
DisGeNETi4134

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAP4
HGNCiHGNC:6862, MAP4
HPAiENSG00000047849, Tissue enhanced (brain, skeletal muscle)
MIMi157132, gene
neXtProtiNX_P27816
OpenTargetsiENSG00000047849
PharmGKBiPA30608
VEuPathDBiHostDB:ENSG00000047849.21

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2418, Eukaryota
GeneTreeiENSGT00940000159742
HOGENOMiCLU_012370_0_0_1
InParanoidiP27816
OrthoDBi1630535at2759
PhylomeDBiP27816
TreeFamiTF316358

Enzyme and pathway databases

PathwayCommonsiP27816
SIGNORiP27816

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4134, 5 hits in 881 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAP4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4134
PharosiP27816, Tbio

Protein Ontology

More...PROi		PR:P27816
RNActiP27816, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000047849, Expressed in medial globus pallidus and 250 other tissues
ExpressionAtlasiP27816, baseline and differential
GenevisibleiP27816, HS

Family and domain databases

InterProiView protein in InterPro
IPR027323, MAP4
IPR001084, MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF16, PTHR11501:SF16, 2 hits
PfamiView protein in Pfam
PF00418, Tubulin-binding, 4 hits
PROSITEiView protein in PROSITE
PS00229, TAU_MAP_1, 4 hits
PS51491, TAU_MAP_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27816
Secondary accession number(s): Q13082
, Q59FT2, Q68D74, Q6ZUW9, Q86V26, Q96A76, Q96NS9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 24, 2009
Last modified: February 10, 2021
This is version 204 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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