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UniProtKB - P27816 (MAP4_HUMAN)

Protein

Microtubule-associated protein 4

Gene

MAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-neuronal microtubule-associated protein. Promotes microtubule assembly.1 Publication

GO - Molecular functioni

  • microtubule binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • structural molecule activity Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SIGNORiP27816

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 4
Short name:
MAP-4
Gene namesi
Name:MAP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000047849.21
HGNCiHGNC:6862 MAP4
MIMi157132 gene
neXtProtiNX_P27816

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi696S → E: No change in microtubule binding; no change in microtubule polymerization activity. 1 Publication1
Mutagenesisi787S → E: No change in microtubule binding; reduced microtubule polymerization activity. 1 Publication1

Organism-specific databases

DisGeNETi4134
OpenTargetsiENSG00000047849
PharmGKBiPA30608

Chemistry databases

DrugBankiDB01248 Docetaxel
DB01229 Paclitaxel

Polymorphism and mutation databases

BioMutaiMAP4
DMDMi269849673

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000727512 – 1152Microtubule-associated protein 4Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei5PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei253PhosphoserineBy similarity1
Cross-linki269Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei280PhosphoserineCombined sources1
Modified residuei282PhosphothreonineCombined sources1
Modified residuei354PhosphothreonineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei380PhosphothreonineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei442PhosphothreonineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei510PhosphoserineCombined sources1
Modified residuei521PhosphothreonineCombined sources1
Modified residuei526PhosphothreonineCombined sources1
Modified residuei571PhosphothreonineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei585PhosphothreonineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei643PhosphoserineBy similarity1
Modified residuei687PhosphothreonineBy similarity1
Modified residuei696PhosphoserineCombined sources1 Publication1
Modified residuei713PhosphoserineCombined sources1
Modified residuei723PhosphoserineCombined sources1
Modified residuei787PhosphoserineCombined sources1 Publication1
Modified residuei797PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei827PhosphoserineCombined sources1
Cross-linki838Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei853PhosphoserineCombined sources1
Modified residuei928PhosphoserineCombined sources1
Modified residuei941PhosphoserineCombined sources1
Modified residuei942PhosphothreonineCombined sources1
Modified residuei1000PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1151PhosphoserineCombined sources1
Isoform 4 (identifier: P27816-4)
Modified residuei28PhosphothreonineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Isoform 3 (identifier: P27816-3)
Modified residuei337PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Isoform 5 (identifier: P27816-5)
Modified residuei803PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.By similarity1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP27816
MaxQBiP27816
PaxDbiP27816
PeptideAtlasiP27816
PRIDEiP27816
ProteomicsDBi54418
54419 [P27816-2]
54420 [P27816-3]
54421 [P27816-4]
54422 [P27816-5]
54423 [P27816-6]
54424 [P27816-7]

PTM databases

iPTMnetiP27816
PhosphoSitePlusiP27816
SwissPalmiP27816

Miscellaneous databases

PMAP-CutDBiP27816

Expressioni

Gene expression databases

BgeeiENSG00000047849 Expressed in 238 organ(s), highest expression level in medial globus pallidus
CleanExiHS_MAP4
ExpressionAtlasiP27816 baseline and differential
GenevisibleiP27816 HS

Organism-specific databases

HPAiHPA038149
HPA038150

Interactioni

Subunit structurei

Interacts with SEPT2; this interaction impedes tubulin-binding. Interacts with TRAF3IP1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-715255,EBI-389883

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi110306, 66 interactors
IntActiP27816, 28 interactors
MINTiP27816
STRINGi9606.ENSP00000353375

Structurei

3D structure databases

ProteinModelPortaliP27816
SMRiP27816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati248 – 2611Add BLAST14
Repeati262 – 2752Add BLAST14
Repeati276 – 2893Add BLAST14
Repeati290 – 3034Add BLAST14
Repeati304 – 3175Add BLAST14
Repeati318 – 3316Add BLAST14
Repeati332 – 3457Add BLAST14
Repeati346 – 3518; truncated6
Repeati352 – 37726 residues 1Add BLAST26
Repeati378 – 40326 residues 2Add BLAST26
Repeati408 – 4219Add BLAST14
Repeati422 – 43310Add BLAST12
Repeati434 – 44711Add BLAST14
Repeati448 – 46112Add BLAST14
Repeati462 – 47513Add BLAST14
Repeati476 – 48914Add BLAST14
Repeati490 – 50315Add BLAST14
Repeati504 – 51716Add BLAST14
Repeati532 – 54517Add BLAST14
Repeati923 – 953Tau/MAP 1Add BLAST31
Repeati992 – 1022Tau/MAP 2Add BLAST31
Repeati1023 – 1053Tau/MAP 3Add BLAST31
Repeati1054 – 1085Tau/MAP 4Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni248 – 54517 X 14 AA tandem repeatsAdd BLAST298

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IG6M Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00530000063491
HOGENOMiHOG000139406
HOVERGENiHBG006323
InParanoidiP27816
KOiK10431
PhylomeDBiP27816
TreeFamiTF316358

Family and domain databases

InterProiView protein in InterPro
IPR001084 MAP_tubulin-bd_rpt
PfamiView protein in Pfam
PF00418 Tubulin-binding, 4 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 4 hits
PS51491 TAU_MAP_2, 4 hits

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P27816-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL 
        60         70         80         90        100
LDVDEKTGNS ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTGSP 
       110        120        130        140        150
TEFLEEKMAY QEYPNSQNWP EDTNFCFQPE QVVDPIQTDP FKMYHDDDLA 
       160        170        180        190        200
DLVFPSSATA DTSIFAGQND PLKDSYGMSP CNTAVVPQGW SVEALNSPHS 
       210        220        230        240        250
ESFVSPEAVA EPPQPTAVPL ELAKEIEMAS EERPPAQALE IMMGLKTTDM 
       260        270        280        290        300
APSKETEMAL AKDMALATKT EVALAKDMES PTKLDVTLAK DMQPSMESDM 
       310        320        330        340        350
ALVKDMELPT EKEVALVKDV RWPTETDVSS AKNVVLPTET EVAPAKDVTL 
       360        370        380        390        400
LKETERASPI KMDLAPSKDM GPPKENKKET ERASPIKMDL APSKDMGPPK 
       410        420        430        440        450
ENKIVPAKDL VLLSEIEVAQ ANDIISSTEI SSAEKVALSS ETEVALARDM 
       460        470        480        490        500
TLPPETNVIL TKDKALPLEA EVAPVKDMAQ LPETEIAPAK DVAPSTVKEV 
       510        520        530        540        550
GLLKDMSPLS ETEMALGKDV TPPPETEVVL IKNVCLPPEM EVALTEDQVP 
       560        570        580        590        600
ALKTEAPLAK DGVLTLANNV TPAKDVPPLS ETEATPVPIK DMEIAQTQKG 
       610        620        630        640        650
ISEDSHLESL QDVGQSAAPT FMISPETVTG TGKKCSLPAE EDSVLEKLGE 
       660        670        680        690        700
RKPCNSQPSE LSSETSGIAR PEEGRPVVSG TGNDITTPPN KELPPSPEKK 
       710        720        730        740        750
TKPLATTQPA KTSTSKAKTQ PTSLPKQPAP TTIGGLNKKP MSLASGLVPA 
       760        770        780        790        800
APPKRPAVAS ARPSILPSKD VKPKPIADAK APEKRASPSK PASAPASRSG 
       810        820        830        840        850
SKSTQTVAKT TTAAAVASTG PSSRSPSTLL PKKPTAIKTE GKPAEVKKMT 
       860        870        880        890        900
AKSVPADLSR PKSTSTSSMK KTTTLSGTAP AAGVVPSRVK ATPMPSRPST 
       910        920        930        940        950
TPFIDKKPTS AKPSSTTPRL SRLATNTSAP DLKNVRSKVG STENIKHQPG 
       960        970        980        990       1000
GGRAKVEKKT EAAATTRKPE SNAVTKTAGP IASAQKQPAG KVQIVSKKVS 
      1010       1020       1030       1040       1050
YSHIQSKCGS KDNIKHVPGG GNVQIQNKKV DISKVSSKCG SKANIKHKPG 
      1060       1070       1080       1090       1100
GGDVKIESQK LNFKEKAQAK VGSLDNVGHL PAGGAVKTEG GGSEAPLCPG 
      1110       1120       1130       1140       1150
PPAGEEPAIS EAAPEAGAPT SASGLNGHPT LSGGGDQREA QTLDSQIQET 

SI
Length:1,152
Mass (Da):121,005
Last modified:November 24, 2009 - v3
Checksum:i061A69AC18593339
GO
Isoform 2 (identifier: P27816-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     558-730: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:979
Mass (Da):102,906
Checksum:i04F3054281DA91E7
GO
Isoform 3 (identifier: P27816-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     152-437: LVFPSSATAD...TEISSAEKVA → MSLSDKQTAS...IRDHDKELEK
     441-631: ETEVALARDM...MISPETVTGT → TEEAVLNQAP...EKQPGQTALA
     635-666: CSLPAEEDSVLEKLGERKPCNSQPSELSSETS → EIEVTATQSTPSFLFEKPPRD
     703-716: PLATTQPAKTSTSK → VGARMVVIFYCHNF
     717-1152: Missing.

Show »
Length:539
Mass (Da):58,557
Checksum:i6B67BBE02C4F946D
GO
Isoform 4 (identifier: P27816-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     83-221: LLANGGHGVE...PPQPTAVPLE → METTGDQGIE...VKEGDSFPDT
     225-271: EIEMASEERP...KDMALATKTE → NGQEIAPAQI...AVVPSTSTGG
     275-666: AKDMESPTKL...QPSELSSETS → PITTAIETVN...QERHKQLKSA
     939-953: Missing.

Show »
Length:872
Mass (Da):91,154
Checksum:i777E25AE88E22090
GO
Isoform 5 (identifier: P27816-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-666: WPTETDVSSA...QPSELSSETS → LPEPKDKILE...QERHKQLKSA
     954-1022: Missing.
     1151-1152: SI → N

Show »
Length:809
Mass (Da):85,252
Checksum:iF259E4B688F2B44F
GO
Isoform 6 (identifier: P27816-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1152: TEGGGSEAPL...LDSQIQETSI → IETYRLTFRA...VLGPLSRAVH

Note: No experimental confirmation available.
Show »
Length:1,135
Mass (Da):119,958
Checksum:i9FDE4697ADAD05D5
GO
Isoform 7 (identifier: P27816-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-99: GS → EA
     100-1152: Missing.

Note: No experimental confirmation available.
Show »
Length:99
Mass (Da):10,441
Checksum:i2D295214DAA6FB37
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVA0E7EVA0_HUMAN
Microtubule-associated protein
MAP4
2,297Annotation score:
H7C456H7C456_HUMAN
Microtubule-associated protein 4
MAP4
283Annotation score:
F8W9U4F8W9U4_HUMAN
Microtubule-associated protein
MAP4
828Annotation score:
H0Y2V1H0Y2V1_HUMAN
Microtubule-associated protein
MAP4
463Annotation score:
H7C4C5H7C4C5_HUMAN
Microtubule-associated protein
MAP4
493Annotation score:
B5MEG9B5MEG9_HUMAN
Microtubule-associated protein 4
MAP4
760Annotation score:
A0A0J9YVV8A0A0J9YVV8_HUMAN
Microtubule-associated protein 4
MAP4
76Annotation score:
A0A0J9YW37A0A0J9YW37_HUMAN
Microtubule-associated protein 4
MAP4
140Annotation score:

Sequence cautioni

The sequence BAD92614 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160A → R in AAA59553 (PubMed:1718985).Curated1
Sequence conflicti319D → G in CAH18346 (PubMed:17974005).Curated1
Sequence conflicti1109I → V in CAH18346 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03956623R → Q. Corresponds to variant dbSNP:rs11711953Ensembl.1
Natural variantiVAR_039567366P → L. Corresponds to variant dbSNP:rs13097415Ensembl.1
Natural variantiVAR_039568367S → P. Corresponds to variant dbSNP:rs13096947Ensembl.1
Natural variantiVAR_039569409D → G. Corresponds to variant dbSNP:rs13076542Ensembl.1
Natural variantiVAR_020361427S → Y1 PublicationCorresponds to variant dbSNP:rs1060407Ensembl.1
Natural variantiVAR_020362441E → Q. Corresponds to variant dbSNP:rs2230169Ensembl.1
Natural variantiVAR_039570628V → ICombined sources1 PublicationCorresponds to variant dbSNP:rs1137524Ensembl.1
Natural variantiVAR_039571994I → V. Corresponds to variant dbSNP:rs35736893Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0320651 – 151Missing in isoform 3. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_0320661 – 82Missing in isoform 4. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_03206783 – 221LLANG…AVPLE → METTGDQGIEGMAYMDENRN ITFTCPRTPSELINKSSPLE VLGSAACEKLPTPTPQVVKE GDSFPDT in isoform 4. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_04324098 – 99GS → EA in isoform 7. 1 Publication2
Alternative sequenceiVSP_043241100 – 1152Missing in isoform 7. 1 PublicationAdd BLAST1053
Alternative sequenceiVSP_032068152 – 437LVFPS…AEKVA → MSLSDKQTASLTAAYGQLSK GKPAECRMDSPKEISQAGFE WQRTEGKLNEIGLNVSMDGQ PKDGLVKNASFLEQNKLCFF EGKLDKELSIEMQDKDCQEA SGHLESRYVISETCHPLEGN SVHQKTSEFHLGLIEGPDKN KTIPVQGKVAGKNGLETKSQ SDLDFPGAADIPTRYVKEQE TSVWNPSFHPVAQGSLGSRE ATPGEMENSITPGCPVIGVV NDNSEQLKCESPLLVSLAHP APIIEHSPTTIPPITMVFTQ EHLNASCHIRDHDKELEK in isoform 3. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_032069225 – 271EIEMA…ATKTE → NGQEIAPAQISKSLMVDNYT KDGVPGQERPKGPSAVVPST STGG in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_032070275 – 666AKDME…SSETS → PITTAIETVNIHGDHSLKNK AELADSMKNEAGIDEGHVIG ESESVHSGASKHSVEKVTEL AKGHLLPGVPVEDQSLPGEA RALEGYADRGNFPAHPVNEE KETKEGSVAVQIPDLLEDKA QKLSFCEDQNAQDRNSKGSD SLNKKVDLTLLSPKSENDKL KEISLACKITELESVSLPTP EIQSDFLHSKVEAPPSEVAD TLVIMTASKGVRLPEPKDKI LETPQKMTEKSESKTPGEGK KEDKSRMAEPMKGYMRPTKS RGLTPLLPKSTIQEQERHKQ LKSA in isoform 4. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_032071322 – 666WPTET…SSETS → LPEPKDKILETPQKMTEKSE SKTPGEGKKEDKSRMAEPMK GYMRPTKSRGLTPLLPKSTI QEQERHKQLKSA in isoform 5. 1 PublicationAdd BLAST345
Alternative sequenceiVSP_032072441 – 631ETEVA…TVTGT → TEEAVLNQAPQQKKAVRRAL SECSHLSVPPAVNLADKYPE LPAREEPSSGLLPPPSSPMP SPTPGKLGAPAMKRSMTVGE EQTASYKLSPGKLPILSTKE IPPFICEEPVAKKREELAHF SNSSSNSGKKELGTAGLYLH SKLEQIPEGSSKEKGQEDFS ETRIDSCSQVCQRGEKQPGQ TALA in isoform 3. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_003200558 – 730Missing in isoform 2. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_032073635 – 666CSLPA…SSETS → EIEVTATQSTPSFLFEKPPR D in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_032074703 – 716PLATT…TSTSK → VGARMVVIFYCHNF in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_032075717 – 1152Missing in isoform 3. 1 PublicationAdd BLAST436
Alternative sequenceiVSP_032076939 – 953Missing in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_032077954 – 1022Missing in isoform 5. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_0320781088 – 1152TEGGG…QETSI → IETYRLTFRANARARTDHGA DIVSRPPHFPGGPNSGSRVL GPLSRAVH in isoform 6. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_0320791151 – 1152SI → N in isoform 5. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64571 mRNA Translation: AAA59553.1
U19727 mRNA Translation: AAA67361.1
AK054696 mRNA Translation: BAB70795.1
AK125245 mRNA Translation: BAC86099.1
AB209377 mRNA Translation: BAD92614.1 Different initiation.
AC124916 Genomic DNA No translation available.
AC139667 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64839.1
BC008715 mRNA Translation: AAH08715.1
BC012794 mRNA Translation: AAH12794.1
BC015149 mRNA Translation: AAH15149.1
BC051843 mRNA Translation: AAH51843.1
CR749544 mRNA Translation: CAH18346.1
CCDSiCCDS33750.1 [P27816-1]
CCDS46818.1 [P27816-6]
CCDS46821.1 [P27816-7]
PIRiA41206 A33183
RefSeqiNP_001127836.1, NM_001134364.1 [P27816-6]
NP_002366.2, NM_002375.4 [P27816-1]
NP_112147.2, NM_030885.3 [P27816-7]
UniGeneiHs.517949

Genome annotation databases

EnsembliENST00000360240; ENSP00000353375; ENSG00000047849 [P27816-1]
ENST00000395734; ENSP00000379083; ENSG00000047849 [P27816-6]
ENST00000434267; ENSP00000402767; ENSG00000047849 [P27816-7]
ENST00000439356; ENSP00000397414; ENSG00000047849 [P27816-7]
GeneIDi4134
KEGGihsa:4134
UCSCiuc003csb.3 human [P27816-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64571 mRNA Translation: AAA59553.1
U19727 mRNA Translation: AAA67361.1
AK054696 mRNA Translation: BAB70795.1
AK125245 mRNA Translation: BAC86099.1
AB209377 mRNA Translation: BAD92614.1 Different initiation.
AC124916 Genomic DNA No translation available.
AC139667 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64839.1
BC008715 mRNA Translation: AAH08715.1
BC012794 mRNA Translation: AAH12794.1
BC015149 mRNA Translation: AAH15149.1
BC051843 mRNA Translation: AAH51843.1
CR749544 mRNA Translation: CAH18346.1
CCDSiCCDS33750.1 [P27816-1]
CCDS46818.1 [P27816-6]
CCDS46821.1 [P27816-7]
PIRiA41206 A33183
RefSeqiNP_001127836.1, NM_001134364.1 [P27816-6]
NP_002366.2, NM_002375.4 [P27816-1]
NP_112147.2, NM_030885.3 [P27816-7]
UniGeneiHs.517949

3D structure databases

ProteinModelPortaliP27816
SMRiP27816
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110306, 66 interactors
IntActiP27816, 28 interactors
MINTiP27816
STRINGi9606.ENSP00000353375

Chemistry databases

DrugBankiDB01248 Docetaxel
DB01229 Paclitaxel

PTM databases

iPTMnetiP27816
PhosphoSitePlusiP27816
SwissPalmiP27816

Polymorphism and mutation databases

BioMutaiMAP4
DMDMi269849673

Proteomic databases

EPDiP27816
MaxQBiP27816
PaxDbiP27816
PeptideAtlasiP27816
PRIDEiP27816
ProteomicsDBi54418
54419 [P27816-2]
54420 [P27816-3]
54421 [P27816-4]
54422 [P27816-5]
54423 [P27816-6]
54424 [P27816-7]

Protocols and materials databases

DNASUi4134
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360240; ENSP00000353375; ENSG00000047849 [P27816-1]
ENST00000395734; ENSP00000379083; ENSG00000047849 [P27816-6]
ENST00000434267; ENSP00000402767; ENSG00000047849 [P27816-7]
ENST00000439356; ENSP00000397414; ENSG00000047849 [P27816-7]
GeneIDi4134
KEGGihsa:4134
UCSCiuc003csb.3 human [P27816-1]

Organism-specific databases

CTDi4134
DisGeNETi4134
EuPathDBiHostDB:ENSG00000047849.21
GeneCardsiMAP4
HGNCiHGNC:6862 MAP4
HPAiHPA038149
HPA038150
MIMi157132 gene
neXtProtiNX_P27816
OpenTargetsiENSG00000047849
PharmGKBiPA30608
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6M Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00530000063491
HOGENOMiHOG000139406
HOVERGENiHBG006323
InParanoidiP27816
KOiK10431
PhylomeDBiP27816
TreeFamiTF316358

Enzyme and pathway databases

SIGNORiP27816

Miscellaneous databases

ChiTaRSiMAP4 human
GeneWikiiMAP4
GenomeRNAii4134
PMAP-CutDBiP27816
PROiPR:P27816
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000047849 Expressed in 238 organ(s), highest expression level in medial globus pallidus
CleanExiHS_MAP4
ExpressionAtlasiP27816 baseline and differential
GenevisibleiP27816 HS

Family and domain databases

InterProiView protein in InterPro
IPR001084 MAP_tubulin-bd_rpt
PfamiView protein in Pfam
PF00418 Tubulin-binding, 4 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 4 hits
PS51491 TAU_MAP_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMAP4_HUMAN
AccessioniPrimary (citable) accession number: P27816
Secondary accession number(s): Q13082
, Q59FT2, Q68D74, Q6ZUW9, Q86V26, Q96A76, Q96NS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 24, 2009
Last modified: September 12, 2018
This is version 186 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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